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List of works by John Knight

A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes ⬇️

scientific article published on November 28, 2011

A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

scientific article

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

scientific article

Active regulator of SIRT1 is required for ribosome biogenesis and function.

scientific article published on 5 March 2013

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

scientific article published on 11 March 2019

Calcium signalling links MYC to NUAK1.

scientific article published on 6 November 2017

Control of translation in the cold: implications for therapeutic hypothermia.

scientific article published on June 2015

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.

scientific article published on 8 February 2016

Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.

scientific article published on 24 November 2010

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24 Mouse

scientific article published in 2022

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

scientific article published in January 2015

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

scientific article published on 05 February 2019

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

scientific article published on 12 May 2014

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

scientific article published on 16 December 2020

RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.

scientific article

SIRT1, metabolism and cancer ⬇️

scientific article published on January 1, 2012

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

scientific article published on 10 July 2017

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

scientific article published on 07 January 2021

The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.

scientific article published on March 2014

Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication

scientific article published on January 2015

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

scientific article

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