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List of works by Boris Freidlin

A general inefficacy interim monitoring rule for randomized clinical trials

scientific article published on 27 April 2010

A model too far.

scientific article published on 7 January 2014

A note on controlling the number of false positives

scientific article published on 26 September 2007

A posterior tale

scientific article published in June 2007

A testing procedure for survival data with few responders

scientific article

Accrual Experience of National Cancer Institute Cooperative Group Phase III Trials Activated From 2000 to 2007 ⬇️

scientific article published on November 8, 2010

Adaptive Clinical Trials: Advantages and Disadvantages of Various Adaptive Design Elements

scientific article published in June 2017

Adaptive randomization versus interim monitoring

scientific article published on 22 January 2013

An Audit Strategy for Progression-Free Survival ⬇️

scientific article published on January 6, 2011

An audit strategy for time-to-event outcomes measured with error: Application to five randomized controlled trials in oncology ⬇️

scientific article published on 09 August 2013

Assessing treatment benefit with competing risks not affected by the randomized treatment

scientific article

Bias, Operational Bias, and Generalizability in Phase II/III Trials

scientific article published on 26 April 2018

Biomarker enrichment strategies: matching trial design to biomarker credentials

scientific article

Biomarker-adaptive threshold design: a procedure for evaluating treatment with possible biomarker-defined subset effect

scientific article published on 27 June 2007

Blinded independent central review of progression-free survival in phase III clinical trials: important design element or unnecessary expense?

scientific article published on August 2008

Borrowing Information across Subgroups in Phase II Trials: Is It Useful? ⬇️

scientific article published on January 9, 2013

Comments on 'maintaining confidentiality of interim data to enhance trial integrity and credibility' by TR Fleming et al.

scientific article published in January 2008

Comparison of futility monitoring guidelines using completed phase III oncology trials

scientific article

Complexities in interpretation of osteosarcoma clinical trial results.

scientific article

Conditional power calculations for clinical trials with historical controls

scientific article published in September 2006

Data monitoring and large apparent treatment effects

scientific article published in February 2004

Design Issues in Randomized Clinical Trials of Maintenance Therapies

scientific article published on 18 August 2015

Design issues in randomized phase II/III trials

scientific article published on 23 January 2012

Design issues of randomized phase II trials and a proposal for phase II screening trials

scientific article published on October 2005

Efficiency robust tests for mapping quantitative trait loci using extremely discordant sib pairs

scientific article published on January 2003

Inefficacy Interim Monitoring Procedures in Randomized Clinical Trials: The Need to Report ⬇️

scientific article published on March 1, 2011

Information time scales for interim analyses of randomized clinical trials

scientific article

Marker Sequential Test (MaST) design

scientific article published on October 2013

Measurement error in the timing of events: effect on survival analyses in randomized clinical trials ⬇️

scientific article published on September 6, 2010

Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data

scientific article

Monitoring for lack of benefit: a critical component of a randomized clinical trial

scientific article published on 08 December 2008

Multi-arm clinical trials of new agents: some design considerations

scientific article published on July 2008

Multinomial phase II trial designs

scientific article published in January 2002

NCI–RTOG Translational Program Strategic Guidelines for the Early-Stage Development of Radiosensitizers ⬇️

scientific article published on December 10, 2012

New challenges for comparative effectiveness in oncology: choice of primary end points for randomized clinical trials

scientific article published on September 2013

Non-factorial analyses of two-by-two factorial trial designs

scientific article published on 19 July 2016

Outcome-Adaptive Randomization: Is It Useful? ⬇️

scientific article published on December 20, 2010

Overall Survival As the Outcome for Randomized Clinical Trials With Effective Subsequent Therapies ⬇️

scientific article published on May 9, 2011

Phase III Clinical Trials That Integrate Treatment and Biomarker Evaluation ⬇️

scientific article published on 08 April 2013

Preliminary data release for randomized clinical trials of noninferiority: a new proposal

scientific article

Proposal for the use of progression-free survival in unblinded randomized trials

scientific article published on May 2007

Quantitative assessment of a prognostic or predictive biomarker panel

scientific article published on 30 October 2017

RE: Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval

scientific article published on 24 February 2016

Randomized clinical trials with biomarkers: design issues

scientific article

Randomized phase II trial designs with biomarkers ⬇️

scientific article

Re: Designing a Randomized Clinical Trial to Evaluate Personalized Medicine: A New Approach Based on Risk Prediction ⬇️

scientific article published on January 12, 2011

Release of data from an ongoing randomized clinical trial for sample size adjustment or planning

scientific article

Robust genomic control for association studies

scientific article

Sample size adjustment designs with time-to-event outcomes: A caution

scientific article published on August 2017

Statistical and practical considerations for clinical evaluation of predictive biomarkers

scientific article published on 17 October 2013

Statistical challenges in the evaluation of treatments for small patient populations

scientific article published on March 2013

Stopping clinical trials early for benefit: impact on estimation

scientific article published in April 2009

Stopping or reporting early for positive results in randomized clinical trials: the National Cancer Institute Cooperative Group experience from 1990 to 2005.

scientific article published on 23 February 2009

Strength of accumulating evidence and data monitoring committee decision making

scientific article

Targeting epidermal growth factor receptor--are we missing the mark?

scientific article

Testing treatment effects in the presence of competing risks

scientific article

The likelihood as statistical evidence in multiple comparisons in clinical trials: no free lunch

scientific article published in June 2006

Transparency in interim monitoring.

scientific article

Twenty-five years of clinical research for patients with limited-stage small cell lung carcinoma in North America

scientific article

Two-by-Two Factorial Cancer Treatment Trials: Is Sufficient Attention Being Paid to Possible Interactions?

scientific article published in September 2017

Two-stage adaptive cutoff design for building and validating a prognostic biomarker signature

scientific article

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