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Authors whose works are in public domain in at least one jurisdiction

List of works by Karl Malcolm

A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings.

scientific article

A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine.

scientific article published on 21 November 2012

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action ⬇️

scientific article published on December 21, 2012

Beyond HIV microbicides: multipurpose prevention technology products

scientific article

Characterisation of protein stability in rod-insert vaginal rings.

scientific article

Characterization of silicone elastomer vaginal rings containing HIV microbicide TMC120 by Raman spectroscopy.

scientific article published in February 2007

Characterization of the rheological, mucoadhesive, and drug release properties of highly structured gel platforms for intravaginal drug delivery.

scientific article

Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device.

scientific article published on 12 February 2016

Design of a silicone reservoir intravaginal ring for the delivery of oxybutynin.

scientific article published in September 2003

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES

scientific article published on 15 April 2019

Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140

scientific article published on 15 February 2012

Development of liposome-based freeze-dried rods for vaginal vaccine delivery against HIV-1 ⬇️

scientific article published on November 20, 2010

Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.

scientific article published on 21 March 2012

Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions

scientific article published on 11 May 2019

High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix

scientific article published on 01 September 2005

High-performance liquid chromatographic determination of 17beta-estradiol and 17beta-estradiol-3-acetate solubilities and diffusion coefficents in silicone elastromeric intravaginal rings

scientific article published on 01 July 2000

Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques

scientific article published on 25 August 2018

In vitro release of nonoxynol-9 from silicone matrix intravaginal rings

scientific article published in September 2003

In vitro release testing methods for drug-releasing vaginal rings

scientific article published on 15 October 2019

Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings.

scientific article

Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses

scientific article published on 20 January 2017

Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms

scientific article

Intravaginal rings for continuous low-dose administration of cervical ripening agents

scientific article published on 24 July 2018

Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques

scientific article published on 01 February 2015

Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings.

scientific article published on 9 September 2005

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel.

scientific article published on 26 July 2016

Mechanical testing methods for drug-releasing vaginal rings

scientific article published on 19 January 2019

Microbicide delivery: formulation technologies and strategies.

scientific article published on September 2008

Microbicide vaginal rings: Technological challenges and clinical development.

scientific article published on 29 January 2016

Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations.

scientific article published on 07 August 2012

Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.

scientific article published on March 2014

Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form.

scientific article published on 21 February 2012

Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.

scientific article published on 12 August 2011

Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring.

scientific article published on 26 April 2017

Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques ⬇️

scientific article published on October 30, 2012

Pharmacokinetics of the protein microbicide 5P12-RANTES in sheep following single dose vaginal gel administration

scientific article published on 07 August 2017

Post-use ring weight and residual drug content as potential objective measures of user adherence to a contraceptive progesterone vaginal ring

scientific article published on 24 June 2019

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.

scientific article published on 26 May 2014

Preformulation and Development of a Once-Daily Sustained-Release Tenofovir Vaginal Tablet Tablet Containing A Single Excipient ⬇️

scientific article published on April 9, 2013

Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women

scientific article published on 01 August 2009

Self-Ordering within Thin Films of Poly(olefin sulfone)s ⬇️

scientific article published on July 28, 1998

Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system

scientific article published on 20 July 2018

Sustained release of proteins from a modified vaginal ring device.

scientific article

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

scientific article

Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ring

scientific article published on 19 January 2016

The pharmacology of HIV-1 antiretrovirals differs between macaques and humans

scientific article published on 17 June 2022

Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

scientific article published on 26 July 2019

Vaginal gel drug delivery systems: understanding rheological characteristics and performance.

scientific article published on 05 July 2011

Vaginal microbicides for the prevention of HIV transmission.

scientific article published on January 2004

Vaginal rings for delivery of HIV microbicides.

scientific article

Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES

article

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