List of works - Johannes D Veldhuis

Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human

scientific article published in December 1998

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

scientific article

Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations

scientific article published on January 1987

Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.

scientific article

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

scientific article

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

scientific article

Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.

scientific article

Endocrine control of body composition in infancy, childhood, and puberty

scientific article

Twenty-Four Hour Cortisol Release Profiles in Patients With Alzheimer's and Parkinson's Disease Compared to Normal Controls: Ultradian Secretory Pulsatility and Diurnal Variation

scientific article published on May 1, 1997

Motivations and methods for analyzing pulsatile hormone secretion

scientific article

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity1

scientific article published on June 1, 1998

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes

scientific article published in February 2002

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans

scientific article published in June 2005

Relationship between beta-cell mass and fasting blood glucose concentration in humans

scientific article published in March 2006

Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition

scientific article

Pulsatile insulin secretion: detection, regulation, and role in diabetes

scientific article

Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men.

scientific article

Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults

scientific article published in August 2002

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets

scientific article published in January 2007

Saltation and stasis: a model of human growth

scientific article published on October 30, 1992

An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women

scientific article published in July 1996

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

scientific article

Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.

scientific article

Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality

scientific article published in April 2010

Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon

scientific article published on March 1987

Altered neuroendocrine regulation of gonadotropin secretion in women distance runners

scientific article published on September 1985

Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men

scientific article published on April 1, 1992

Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis

scientific article

Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages

scientific article

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay

scientific article published on November 1, 1995

Sensitivity and specificity of pulse detection using a new deconvolution method

scientific article

Pulsatile growth hormone release in normal women during the menstrual cycle

scientific article published on June 1, 1992

Direct measurement of pulsatile insulin secretion from the portal vein in human subjects

scientific article published in December 2000

Sex differences in circulating human leptin pulse amplitude: clinical implications

scientific article

Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans

scientific article

Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man.

scientific article

Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus

scientific article published in August 1989

Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy

scientific article

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

scientific article

Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis

scientific article published in June 1999

Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings

scientific article

Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig

scientific article published in September 2001

Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm

scientific article

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis

scientific article published in April 2006

Clinical review 171: The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations

scientific article

Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis

scientific article published on May 8, 2003

Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin

scientific article

Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts

scientific article

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone

scientific article published in May 2002

Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys

scientific article

List of works by Johannes D Veldhuis

Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations

Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.

Endocrine control of body composition in infancy, childhood, and puberty

Twenty-Four Hour Cortisol Release Profiles in Patients With Alzheimer's and Parkinson's Disease Compared to Normal Controls: Ultradian Secretory Pulsatility and Diurnal Variation

Motivations and methods for analyzing pulsatile hormone secretion

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity1

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans

Relationship between beta-cell mass and fasting blood glucose concentration in humans

Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition

Pulsatile insulin secretion: detection, regulation, and role in diabetes

Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men.

Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets

Saltation and stasis: a model of human growth

An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.

Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality

Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon

Altered neuroendocrine regulation of gonadotropin secretion in women distance runners

Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men

Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis

Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay

Sensitivity and specificity of pulse detection using a new deconvolution method

Pulsatile growth hormone release in normal women during the menstrual cycle

Direct measurement of pulsatile insulin secretion from the portal vein in human subjects

Sex differences in circulating human leptin pulse amplitude: clinical implications

Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans

Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man.

Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus

Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis

Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings

Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig

Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis

Clinical review 171: The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations

Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis

Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin

Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone

Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys