Search filters

List of works by Philipp W Messer

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population

scientific article published on 14 September 2020

A community-maintained standard library of population genetic models

scientific article published on 23 June 2020

A framework for identifying fertility gene targets for mammalian pest control

scientific article published in June 2023

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

scientific article published in 2022

A toxin-antidote CRISPR gene drive system for regional population modification

scientific article published on 27 February 2020

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

scientific article

CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect

scientific article published on 27 March 2019

Can Population Genetics Adapt to Rapid Evolution?

scientific article published on 13 May 2016

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

scientific article published on 04 March 2020

CorGen--measuring and generating long-range correlations for DNA sequence analysis.

scientific article published on July 2006

DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage.

scientific article

Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives

scientific article published on 01 December 2020

Effects of long-range correlations in DNA on sequence alignment score statistics.

scientific article published on June 2007

Estimating the strength of selective sweeps from deep population diversity data.

scientific article

Evaluating the performance of selection scans to detect selective sweeps in domestic dogs

scientific article

Evidence that adaptation in Drosophila is not limited by mutation at single sites

scientific article published on 17 June 2010

Evolution of Resistance Against CRISPR/Cas9 Gene Drive.

scientific article

Evolutionary Modeling in SLiM 3 for Beginners

scientific article published on 01 May 2019

Evolutionary genomics. Conundrum of jumbled mosquito genomes.

scientific article published in January 2015

Faster than neutral evolution of constrained sequences: the complex interplay of mutational biases and weak selection. ⬇️

scientific article

Frequent adaptation and the McDonald-Kreitman test.

scientific article published on 6 May 2013

Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).

scientific article

Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila

scientific article

Genome-wide signals of positive selection in human evolution

scientific article

Heterozygote advantage as a natural consequence of adaptation in diploids

scientific article published on 5 December 2011

Incorporating ecology into gene drive modelling

scientific article published in 2023

Inferring the strength of selection in Drosophila under complex demographic models.

scientific article

Maximum Likelihood Estimation of Fitness Components in Experimental Evolution

scientific article published on 24 January 2019

Measuring the rates of spontaneous mutation from deep and large-scale polymorphism data

scientific article

Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction

scientific article

Molecular safeguarding of CRISPR gene drive experiments

article

Narrow thermal tolerance and low dispersal drive higher speciation in tropical mountains

article published in the Proceedings of the National Academy of Sciences of the United States of America

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations.

scientific article published on 20 July 2017

Plumage Genes and Little Else Distinguish the Genomes of Hybridizing Warblers.

scientific article

Population genomics of rapid adaptation by soft selective sweeps.

scientific article published on 25 September 2013

Predicting the genomic resolution of bulk segregant analysis

scientific article published in 2022

Quantification of GC-biased gene conversion in the human genome

scientific article published on 20 May 2015

Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps

scientific article

Reducing resistance allele formation in CRISPR gene drive

article

SLiM 2: Flexible, Interactive Forward Genetic Simulations

scientific article

SLiM 3: Forward Genetic Simulations Beyond the Wright-Fisher Model

scientific article published on 01 March 2019

SLiM: simulating evolution with selection and linkage.

scientific article published on 24 May 2013

Signatures of Insecticide Selection in the Genome of

scientific article published on 06 November 2018

Soft selective sweeps in complex demographic scenarios.

scientific article

Solvable sequence evolution models and genomic correlations

scientific article published on 08 April 2005

The majority of recent short DNA insertions in the human genome are tandem duplications.

scientific article published on 24 February 2007

The role of the vaginal microbiome in gynaecological cancer.

scientific article published on 9 March 2017

Tree-sequence recording in SLiM opens new horizons for forward-time simulation of whole genomes

scientific article published on 21 February 2019

asymptoticMK: A Web-Based Tool for the Asymptotic McDonald-Kreitman Test

scientific article published on 24 March 2017

Paulina is supported by:

About Paulina

Help