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List of works by David L Selwood

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.

scientific article published on 28 September 2014

A bifurcated proteoglycan binding small molecule carrier for siRNA delivery.

scientific article

A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan

scientific article published on 30 September 2019

A new small molecule inhibitor of soluble guanylate cyclase

scientific article published on 4 August 2015

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

scientific article published on 10 January 2016

Architecture and Hydration of the Arginine Binding Site of Neuropilin-1.

scientific article published on 12 February 2018

Beyond the hundred dollar genome--drug discovery futures.

scientific article published in January 2013

Big conductance calcium-activated potassium channel openers control spasticity without sedation.

scientific article published on 5 July 2017

Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands

scientific article published on 10 October 2018

Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing

scientific article

Correction to Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis.

scientific article published on 7 April 2015

Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin-1 binding of small molecules

scientific article published on 20 January 2020

Emerging small-molecule treatments for multiple sclerosis: focus on B cells

scientific article published on 01 March 2019

Endothelial C-type natriuretic peptide maintains vascular homeostasis

scientific article

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA.

scientific article

Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein

scientific article

HIV-1 capsid is involved in post-nuclear entry steps

scientific article published on 23 April 2016

HIV-1 evades innate immune recognition through specific cofactor recruitment

scientific article

IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection

scientific article published on 20 September 2017

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

scientific article published on 01 November 2018

Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.

scientific article

Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds

scientific article

Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy

scientific article

Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses.

scientific article published on 17 January 2017

Macrocycles, the edge of drug-likeness chemical space or Goldilocks zone?

scientific article published on 01 February 2017

Marvellous Chemical Biology Tools and Other Matters ⬇️

scientific article published on January 1, 2012

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

scientific article published on 06 December 2018

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

scientific journal article

N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity.

scientific article

N10 -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

scientific article published on 12 June 2019

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.

scientific article published on 20 July 2016

Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice

scientific article

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

scientific article published on 17 December 2015

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.

scientific article published on 12 April 2018

Small steps to new drugs for bugs

scientific article

Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations

scientific article published on 03 September 2018

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

scientific article published on 08 December 2013

Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators

scientific article

The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing

scientific article published on 04 July 2019

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

scientific article published on 24 May 2022

Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway

scientific article published on 18 September 2013

Two- and three-dimensional rings in drugs.

scientific article

VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins

scientific article published in 2022

siRNA Delivery: From Lipids to Cell‐penetrating Peptides and Their Mimics ⬇️

scientific article published on December 1, 2012

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