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List of works by Martin Fussenegger

6-hydroxy-nicotine-inducible multilevel transgene control in mammalian cells

scientific article published on 22 July 2006

A CRISPR/Cas9-based central processing unit to program complex logic computation in human cells

scientific article

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice ⬇️

scientific article published on June 24, 2011

A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes

scientific article published on February 2017

A biotin-triggered genetic switch in mammalian cells and mice

scientific article

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.

scientific article published on 16 May 2018

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

scientific article published on January 2013

A designer cell-based histamine-specific human allergy profiler

scientific article

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms ⬇️

scientific article published on November 23, 2010

A fully human transgene switch to regulate therapeutic protein production by cooling sensation

scientific article published on 08 July 2019

A gas-inducible expression system in HEK.EBNA cells applied to controlled proliferation studies by expression of p27(Kip1).

scientific article published on April 2007

A general design strategy for protein-responsive riboswitches in mammalian cells

scientific article

A general strategy for the production of difficult-to-express inducer-dependent bacterial repressor proteins in Escherichia coli

scientific article

A genetic redox sensor for mammalian cells

scientific article published on 13 February 2006

A genetic time-delay circuitry in mammalian cells

scientific article published in November 2007

A modular degron library for synthetic circuits in mammalian cells

scientific article published on 01 May 2019

A novel binary adenovirus-based dual-regulated expression system for independent transcription control of two different transgenes

scientific article published in December 2005

A novel hybrid dual-channel catalytic-biological sensor system for assessment of fruit quality

scientific article published on February 2009

A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells

scientific article published in August 2004

A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1.

scientific article

A novel reporter system for bacterial and mammalian cells based on the non-ribosomal peptide indigoidine

scientific article published on 21 April 2012

A novel synthetic mammalian promoter derived from an internal ribosome entry site

scientific article published on November 2006

A novel system for trigger-controlled drug release from polymer capsules

scientific article

A novel vector platform for vitamin H-inducible transgene expression in mammalian cells

scientific article published on 23 June 2007

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

scientific article

A synthetic biology-based device prevents liver injury in mice

scientific article published on 08 April 2016

A synthetic cGMP-sensitive gene switch providing Viagra(®)-controlled gene expression in mammalian cells and mice

scientific article published on 2 April 2015

A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection

scientific article published on 18 March 2015

A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice

A synthetic low-frequency mammalian oscillator

scientific article

A synthetic mammalian gene circuit reveals antituberculosis compounds

scientific article

A synthetic metabolite-based mammalian inter-cell signaling system

scientific article

A synthetic multifunctional mammalian pH sensor and CO2 transgene-control device

scientific article

A synthetic time-delay circuit in mammalian cells and mice

scholarly article

A tunable synthetic mammalian oscillator

scientific article

Adeno-associated viral vectors engineered for macrolide-adjustable transgene expression in mammalian cells and mice

scientific article

Adenoviral vector platform for transduction of constitutive and regulated tricistronic or triple-transcript transgene expression in mammalian cells and microtissues

scientific article published on October 2006

Adenovirus-mediated transduction of auto- and dual-regulated transgene expression in mammalian cells

scientific article

Adult stem cell therapy of female stress urinary incontinence

scientific article published on 23 July 2007

Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction

scientific article

Advances in heterologous protein production

scientific article published on 14 July 2005

An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice

scientific article

An engineered epigenetic transgene switch in mammalian cells

scientific article

An engineered mammalian band-pass network

scientific article

An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases

scientific article published on 30 August 2013

Antagonistic control of a dual-input mammalian gene switch by food additives

scientific article

Approaches for trigger-inducible viral transgene regulation in gene-based tissue engineering

scientific article published in October 2004

Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering

scientific article

Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells

scientific article published on September 2003

Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients

scientific article published on 30 August 2007

Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: a randomised controlled trial

retracted scientific article published in The Lancet

Autoregulated, bidirectional and multicistronic gas-inducible mammalian as well as lentiviral expression vectors

scientific article published on 18 July 2005

Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells

scientific article

Bile acid-controlled transgene expression in mammalian cells and mice

scientific article published on 24 November 2013

BioLogic gates enable logical transcription control in mammalian cells

scientific article

Biomedically relevant circuit-design strategies in mammalian synthetic biology

scientific article

Broad-spectrum protein biosensors for class-specific detection of antibiotics

scientific article published in January 2005

Building sophisticated sensors of extracellular cues that enable mammalian cells to work as "doctors" in the body

scientific article published on 17 March 2020

Caffeine-inducible gene switches controlling experimental diabetes.

scientific article

CellMAC: a novel technology for encapsulation of mammalian cells in cellulose sulfate/pDADMAC capsules assembled on a transient alginate/Ca2+ scaffold

scientific article published in November 2004

Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system

scientific article

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

scholarly article

Cosmetics-triggered percutaneous remote control of transgene expression in mice

scientific article

De novo design and construction of an inducible gene expression system in mammalian cells

scientific article published on January 2011

Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression

scientific article published on 16 July 2004

Design of Multipartite Transcription Factors for Multiplexed Logic Genome Integration Control in Mammalian Cells

scientific article published on 14 October 2020

Design of Synthetic Promoters for Gene Circuits in Mammalian Cells

scientific article

Design of artificial myocardial microtissues

scientific article published in January 2004

Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units

scientific article published on August 2006

Design of high-throughput-compatible protocols for microencapsulation, cryopreservation and release of bovine spermatozoa

scientific article published on 13 December 2005

Design of synthetic mammalian quorum-sensing systems

scientific article published on January 2011

Designed cell consortia as fragrance-programmable analog-to-digital converters

scientific article

Designer cells programming quorum-sensing interference with microbes.

scientific article published on 8 May 2018

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment.

scientific article

Designing cell function: assembly of synthetic gene circuits for cell biology applications

scientific article published on 01 August 2018

Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles

scientific article published on 15 August 2005

Drug-sensing hydrogels for the inducible release of biopharmaceuticals

scientific article published on 10 August 2008

Dual-regulated expression of C/EBP-alpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts

scientific article published on 02 January 2004

Dual-regulated myoD- and msx1-based interventions in C2C12-derived cells enable precise myogenic/osteogenic/adipogenic lineage control

scientific article published on October 2004

Ectopic expression of delta FBJ murine osteosarcoma viral oncogene homolog B mediates transdifferentiation of adipose-like spheroids into osteo-like microtissues

scientific article published on August 2008

Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells ⬇️

scientific article published on November 10, 2010

Editorial Special Issue on the Occasion of Prof. Dr. Alf Pühler's 75th birthday

scientific article published in September 2017

Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization

scientific article

Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice

scientific article published on 01 May 2020

Emerging biomedical applications of synthetic biology

scientific article

Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control in mammalian cells and adjustable transcription control in mice.

scientific article

Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture

scientific article published on 16 September 2014

Engineering Gene Circuits for Mammalian Cell-Based Applications

scientific article published on 18 May 2016

Engineering Molecular Circuits Using Synthetic Biology in Mammalian Cells ⬇️

scientific article published on March 29, 2012

Engineering Whole Mammalian Cells for Target-Cell-Specific Invasion/Fusion

scientific article published on 08 May 2018

Engineering a ribozyme cleavage-induced split fluorescent aptamer complementation assay

scientific article published on 02 March 2016

Engineering of ribozyme-based riboswitches for mammalian cells

scientific article published on 28 January 2012

Engineering of synthetic gene circuits for (re-)balancing physiological processes in chronic diseases

scientific article published on 24 June 2016

Engineering of synthetic intercellular communication systems ⬇️

scientific article published on December 14, 2012

Engineering of synthetic mammalian gene networks

scientific article published on March 2009

Engineering synergy in biotechnology

scientific article published on May 2014

Epigenetic engineering of ribosomal RNA genes enhances protein production

scientific article

Ethical and societal implications of cellular health-monitoring devices

scientific article published on 01 May 2020

From gene switches to mammalian designer cells: present and future prospects ⬇️

scientific article published on December 13, 2012

Functional cross-kingdom conservation of mammalian and moss (Physcomitrella patens) transcription, translation and secretion machineries

scientific article published on 8 October 2008

G protein-coupled receptors revisited: therapeutic applications inspired by synthetic biology

scientific article published on 11 October 2013

Gas-inducible product gene expression in bioreactors

scientific article published in May 2005

Gas-inducible transgene expression in mammalian cells and mice

scientific article

Generalized extracellular molecule sensor platform for programming cellular behavior.

scientific article published on 23 April 2018

Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network

scientific article published on 21 July 2017

Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection

scientific article published on 6 December 2009

Heterogeneity of baseline neural marker expression by undifferentiated mesenchymal stem cells may be correlated to donor age.

scientific article published on 28 January 2014

Heterologous protein production capacity of mammalian cells cultivated as monolayers and microtissues

scientific article published on January 2006

Human whole-blood culture system for ex vivo characterization of designer-cell function

scientific article published on 8 September 2015

Hysteresis in a synthetic mammalian gene network

scientific article

Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation

scientific article published on 19 October 2015

Identification of a novel proliferation-inducing determinant using lentiviral expression cloning

scientific article

Impact of RNA interference on gene networks

scientific article published on 4 August 2006

Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media

scientific article published in December 2002

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

scientific article published on December 2015

Improved transgene expression fine-tuning in mammalian cells using a novel transcription-translation network

scientific article published on 20 February 2006

In vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines

scientific article

In vitro vascularization of human connective microtissues.

scientific article

In vivo transduction of HIV-1-derived lentiviral particles engineered for macrolide-adjustable transgene expression

scientific article published on November 2005

InXy and SeXy, compact heterologous reporter proteins for mammalian cells

scientific article published on October 2007

Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species

scientific article

Inducible gene expression in mammalian cells and mice

scientific article published on January 2004

Inducible product gene expression technology tailored to bioprocess engineering

scientific article published on 22 October 2007

Inorganic nanoparticles for transfection of mammalian cells and removal of viruses from aqueous solutions

scientific article published on December 2007

Integration-free reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) without viral vectors, recombinant DNA, and genetic modification

scientific article published on January 2014

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

scientific article published on 16 July 2008

Life after the synthetic cell

scientific article

Ligand-dependent regulatory RNA parts for Synthetic Biology in eukaryotes

scientific article published on 16 July 2010

Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology

scientific article published on 30 September 2018

Macrolide- and tetracycline-adjustable siRNA-mediated gene silencing in mammalian cells using polymerase II-dependent promoter derivatives

scientific article published on November 2004

Macrolide-based transgene control in mammalian cells and mice

scientific article published on 19 August 2002

Magnet-guided transduction of mammalian cells and mice using engineered magnetic lentiviral particles

scientific article

Mammalian designer cells: Engineering principles and biomedical applications

scientific article published on 26 May 2015

Mammalian synthetic biology--from tools to therapies

scientific article published on April 2010

Mammalian synthetic biology: engineering of sophisticated gene networks

scientific article published on 24 May 2007

Metabolic engineering II. Eukaryotic systems

scientific article published in September 2002

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

scientific article published on July 2003

Microscale tissue engineering using gravity-enforced cell assembly

scientific article published on April 2004

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

scientific article

Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa

scientific article

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression

scientific article published in December 2008

Modulation of translation-initiation in CHO-K1 cells by rapamycin-induced heterodimerization of engineered eIF4G fusion proteins

scientific article

Molecular diversity--the toolbox for synthetic gene switches and networks

scientific article published on 04 April 2011

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

scientific article published in March 2009

Multi-gene engineering: simultaneous expression and knockdown of six genes off a single platform

scientific article published in April 2007

New-generation multicistronic expression platform: pTRIDENT vectors containing size-optimized IRES elements enable homing endonuclease-based cistron swapping into lentiviral expression vectors

scientific article published on April 2004

Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation

scientific article published on 13 November 2017

Novel CNBP- and La-based translation control systems for mammalian cells

scientific article

Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice

scientific article published on December 2003

Novel promoter/transactivator configurations for macrolide- and streptogramin-responsive transgene expression in mammalian cells

scientific article published on November 2002

Novel theranostic agents for next-generation personalized medicine: small molecules, nanoparticles, and engineered mammalian cells

scientific article published on 5 June 2015

Optogenetic Therapeutic Cell Implants ⬇️

scientific article published on June 18, 2012

Overexpression of YY1 increases the protein production in mammalian cells

scientific article published on 10 December 2015

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

scientific article published on 17 December 2012

Pharmacologic transgene control systems for gene therapy

scientific article

Phenylethyl Butyrate Enhances the Potency of Second-Line Drugs against Clinical Isolates of Mycobacterium tuberculosis ⬇️

scientific article published on November 21, 2011

Phosphoregulated orthogonal signal transduction in mammalian cells

scientific article published on 18 June 2020

Programmable full-adder computations in communicating three-dimensional cell cultures

scientific article

Programmable single-cell mammalian biocomputers ⬇️

scientific article published on July 5, 2012

Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders

scientific article

Protein expression by engineering of yeast, plant and animal cells

scientific article published in October 2007

Quorum-Quenching Human Designer Cells for Closed-Loop Control of Pseudomonas aeruginosa Biofilms

scientific article published on 13 July 2017

Quorum-sensing-based toolbox for regulatable transgene and siRNA expression in mammalian cells

scientific article

Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells

scientific article published on 8 October 2011

Recent advances in mammalian synthetic biology-design of synthetic transgene control networks

scientific article published on August 2009

RepTAGs: universal tags for isolation and labeling of proteins, for labeling live mammalian cells and for drug discovery

scientific article

Reprogrammed cell delivery for personalized medicine ⬇️

scientific article published on June 19, 2012

Reward-based hypertension control by a synthetic brain-dopamine interface

scientific article published on 14 October 2013

Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks

scientific article published on 25 April 2012

Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

scientific article published on 30 January 2020

SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase

scientific article published on January 2002

Scaffold-free cell delivery for use in regenerative medicine

scientific article published on 11 February 2010

Self-assembly of sensory neurons into ganglia-like microtissues

scientific article published on 6 September 2005

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

scientific article published on 28 March 2010

Semi-synthetic mammalian gene regulatory networks

scientific article published on July 2005

Sensing and responding to allergic response cytokines through a genetically encoded circuit

scientific article

Smart medication through combination of synthetic biology and cell microencapsulation ⬇️

scientific article published on June 24, 2011

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

scientific article published on 07 June 2021

Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice.

scientific article

Stabilized Autologous Fibrin-Chondrocyte Constructs for Cartilage Repair in Vivo ⬇️

scientific article published on November 1, 2003

Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice

scientific article

Survival factor-like activity of small peptides in hybridoma and CHO cells cultures

scientific article published in January 2005

Synchronized bacterial clocks

scientific article published in Nature

Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine

scientific article

Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels

scientific article published on 31 May 2012

Synthetic Biology--Toward Therapeutic Solutions

scientific article published on 31 August 2015

Synthetic Biology-The Synthesis of Biology

scientific article published on 11 December 2016

Synthetic Biology: Engineering Mammalian Cells To Control Cell-to-Cell Communication at Will

scientific article published on 21 March 2019

Synthetic RNA-based switches for mammalian gene expression control

scientific article published on 4 April 2017

Synthetic biology

scholarly article by Adam Arkin & Martin Fussenegger published December 2013 in Current Opinion in Chemical Biology

Synthetic biology advancing clinical applications ⬇️

scientific article published on July 21, 2012

Synthetic biology-application-oriented cell engineering

scientific article published on 29 April 2016

Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer

scientific article published on 01 April 2018

Synthetic biology-inspired therapies for metabolic diseases

scientific article

Synthetic biology. Dynamic genome engineering in living cells

scientific article

Synthetic biology: How best to build a cell

scientific article published in May 2014

Synthetic biology: Toehold gene switches make big footprints.

scientific article

Synthetic biology: applying biological circuits beyond novel therapies

scientific article published on 24 December 2015

Synthetic ecosystems based on airborne inter- and intrakingdom communication

scholarly article

Synthetic gene circuits for the detection, elimination and prevention of disease

scientific article published on 11 June 2018

Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves' disease

scientific article published on 19 January 2016

Synthetic gene networks in mammalian cells

scientific article published on 04 August 2010

Synthetic immunology: modulating the human immune system

scientific article

Synthetic mammalian gene circuits for biomedical applications

scientific article published on December 2013

Synthetic mammalian trigger-controlled bipartite transcription factors ⬇️

scientific article published on May 17, 2013

Synthetic therapeutic gene circuits in mammalian cells

scientific article

Synthetic two-way communication between mammalian cells

scientific article published on 16 September 2012

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

scientific journal article

The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology

scientific article published on 07 October 2019

The best of both worlds: reaping the benefits from mammalian and bacterial therapeutic circuits

scientific article published on 26 May 2016

The food additive vanillic acid controls transgene expression in mammalian cells and mice

scientific article published on 19 December 2011

The impact of synthetic biology on drug discovery

scientific article published on 04 July 2009

The use of light for engineered control and reprogramming of cellular functions ⬇️

scientific article published on December 26, 2011

The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells

scientific article

Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles

scientific article

Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats

scientific article published in September 2006

Tobacco smoke as inducer for gas phase-controlled transgene expression in mammalian cells and mice

scientific article

Toward a world of theranostic medication: Programming biological sentinel systems for therapeutic intervention

scientific article published on 14 May 2016

Toward construction of a self-sustained clock-like expression system based on the mammalian circadian clock

scientific article published on July 2004

Toward higher order control modalities in mammalian cells-independent adjustment of two different gene activities

scientific article

Transgene control engineering in mammalian cells

scientific article published in January 2005

Treatment of chronic pain by designer cells controlled by spearmint aromatherapy

scientific article published on 06 February 2018

Tricalcium phosphate nanoparticles enable rapid purification, increase transduction kinetics, and modify the tropism of mammalian viruses

scientific article

VEGF profiling and angiogenesis in human microtissues

scientific article published in August 2005

Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering

scientific article published in December 2002

Vitamin H-regulated transgene expression in mammalian cells

scientific article

Watch the clock-engineering biological systems to be on time

scientific article published on 08 October 2010

Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells

scientific article

mRNA transfection-based, feeder-free, induced pluripotent stem cells derived from adipose tissue of a 50-year-old patient ⬇️

scientific article published on March 28, 2013

p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media

scientific article published on September 2002

β-cell-mimetic designer cells provide closed-loop glycemic control

scientific article

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