List of works - Heather N Tinsley

A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

scientific article published on November 2010

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

scientific article published on 26 May 2009

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity

scientific article published on 3 May 2012

Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice.

scientific article

Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition ⬇️

scientific article published on September 28, 2010

Cyclic GMP signaling during human lactation and breast cancer: Implications for breast cancer prevention

scientific article published on 20 May 2019

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

scientific article

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

scientific article published on 22 December 2010

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

scientific article published on 20 September 2009

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

scientific article published on 29 September 2012

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/β-Catenin–Mediated Transcription in Human Breast Tumor Cells ⬇️

scientific article published on April 19, 2011

Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

scientific article published on January 2013

NSAIDs: Old Drugs Reveal New Anticancer Targets.

scientific article

New NSAID targets and derivatives for colorectal cancer chemoprevention.

scientific article published on January 2013

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases ⬇️

scientific article published on December 1, 2012

Ripped from the Headlines: Using Current Events and Deliberative Democracy to Improve Student Performance in and Perceptions of Nonmajors Biology Courses

scientific article published on 02 December 2016

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

scientific article

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation

scientific article

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

scientific article published on 28 December 2010

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors.

scientific article published on 23 February 2011

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

scientific article published on April 2010

The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment

scientific article published on 26 February 2014

cGMP signaling as a target for the prevention and treatment of breast cancer

scientific article published on 24 June 2014

List of works by Heather N Tinsley

A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity

Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice.

Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition ⬇️

Cyclic GMP signaling during human lactation and breast cancer: Implications for breast cancer prevention

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/β-Catenin–Mediated Transcription in Human Breast Tumor Cells ⬇️

Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

NSAIDs: Old Drugs Reveal New Anticancer Targets.

New NSAID targets and derivatives for colorectal cancer chemoprevention.

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases ⬇️

Ripped from the Headlines: Using Current Events and Deliberative Democracy to Improve Student Performance in and Perceptions of Nonmajors Biology Courses

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors.

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment

cGMP signaling as a target for the prevention and treatment of breast cancer