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List of works by James P. O'Callaghan

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage of striatal dopaminergic fibers attenuates subsequent astrocyte response to MPTP.

scientific article published in September 1990

2D and 3D assessment of neuropathology in rat brain after prenatal exposure to methylazoxymethanol, a model for developmental neurotoxicity

journal article published in 2005

A logic model of neuronal-glial interaction suggests altered homeostatic regulation in the perpetuation of neuroinflammation

journal article published in 2018

A method for sampling rat cerebrospinal fluid with minimal blood contamination: a critical tool for biomarker studies

chapter published in 2019

A network approach of phosphoprotein signaling to identify mixture interactions ⬇️

abstract published in 2018

A network approach to phosphoprotein signaling in a mouse model of Gulf War Illness using corticosterone and diisopropyl fluorophosphate ⬇️

abstract published in 2019

A novel rat brain atlas for neurotoxicity testing

abstract published in 2006

A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness

journal article published in 2022

A projectile concussive impact model produces neuroinflammation in both mild and moderate-severe traumatic brain injury

journal article published in 2023

A projectile concussive impact model produces neuroinflammation in both mild and moderate-severe traumatic brain injury (dataset) ⬇️

research dataset published in 2023

A review of sleep deprivation studies evaluating the brain transcriptome

journal article published in 2014

A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain

journal article published in 2021

A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes

journal article published in 2007

A threshold neurotoxic exposure to amphetamine disrupts cortical synaptic neuroplasticity ⬇️

abstract published in 2006

AChE-independent phosphoprotein signaling in an acute mouse model of Gulf War Illness ⬇️

abstract published in 2018

AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation

journal article published in 2008

Acetylcholinesterase inhibitor exposures as an initiating factor in the development of Gulf War Illness, a chronic neuroimmune disorder in deployed veterans

journal article published in 2020

Acquisition, steady-state performance, and the effects of trimethyltin on the operant behavior and hippocampal GFAP of Long-Evans and Fischer 244 rats

journal article published in 2003

Acute exposure of the neonatal rat to tributyltin results in decreases in biochemical indicators of synaptogenesis and myelinogenesis ⬇️

scientific article published on 01 July 1988

Acute exposure of the neonatal rat to triethyltin results in persistent changes in neurotypic and gliotypic proteins.

scientific article published in January 1988

Acute postnatal exposure to triethyltin in the rat: effects on specific protein composition of subcellular fractions from developing and adult brain

scientific article published on 01 February 1983

Advancing the role of neuroimmunity and genetic susceptibility in Gulf War Illness

publication published in 2017

Advancing the role of neuroimmunity and genetic susceptibility in Gulf War Illness

publication published in 2022

Age as a susceptibility factor in the striatal dopaminergic neurotoxicity observed in the mouse following substituted amphetamine exposure

journal article published in 2000

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat

journal article published in 2010

Aging, stress and the hippocampus

journal article published in 2005

Alterations in high-order diffusion imaging in veterans with Gulf War Illness is associated with chemical weapons exposure and mild traumatic brain injury

journal article published in 2020

Ampakine CX546 ameliorates Gulf War agents exposure and stress-induced exosomal HMGB1 that causes neurological ailment in experimental Gulf War Illness ⬇️

abstract published in 2020

An Aluminum-Induced Increase in GFAP Is Attenuated by Some Chelators ⬇️

scientific article published on January 1, 1998

An enzyme-linked immunosorbent assay for glial fibrillary acidic protein as an indicator of the presence of brain or spinal cord in meat ⬇️

journal article published in 1999

An increase in glial fibrillary acidic protein follows brain hyperthermia in rats

scientific article published on 01 July 1987

Analysis of C57Bl/6 mice at 8 and 16 months after repeated dosing of paraquat and maneb ⬇️

abstract published in 2010

Application of an enzyme-linked immunosorbent assay for glial fibrillary acidic protein as an indicator of the presence of brain or spinal cord in meat

conference abstract published in 2001

Assessment of chemically-induced alterations in brain development using assays of neuron- and glia-localized proteins

scientific article

Associations of cortical astrogliosis with cognitive performance and dementia status ⬇️

journal article published in 2004

Astrocyte-specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity

journal article published in 2019

Astrocytes: key players in mediation or modulation of neurotoxic responses? Commentary on forum position paper ⬇️

scientific article published on February 1, 1998

Astrogliosis in CNS pathologies: is there a role for microglia?

journal article published in 2010

Autoantibodies to nervous system proteins following trimethyl tin (TMT) exposure: a comparison of ELISA and Western-blot analysis ⬇️

abstract published in 2002

Autoantibodies to neurotypic and gliotypic proteins as biomarkers of neurotoxicity: assessment of trimethyltin (TMT)

journal article published in 2008

BAC-TRAP technology in neurotoxicology: assessing the astrocyte response to MPTP-induced damage in the ALDH1L1 BAC-TRAP mouse ⬇️

abstract published in 2014

BAC-TRAP technology in neurotoxicology: the ALDH1L1BAC-TRAP mouse as a tool to assess astrocyte specific responses to neural injury ⬇️

abstract published in 2014

Basic neurotoxicology ⬇️

abstract published in 2004

Behavioral and histological evidence of a neuroimmune basis for Gulf War Illness ⬇️

abstract published in 2019

Biochemical, functional and morphological indicators of neurotoxicity: effects of acute administration of trimethyltin to the developing rat.

scientific article published in December 1984

Biomarkers of Parkinson's disease: present and future

journal article published in 2015

Boston biorepository, recruitment and integrative network (BBRAIN): a resource for the Gulf War Illness scientific community

journal article published in 2021

Brain concentrations of d-MDMA are increased after stress

journal article published in 2004

Brain injury: prolonged induction of transcription factors in brain injury ⬇️

journal article published in 2000

Brain organochlorines and Lewy pathology: The Honolulu‐Asia aging study ⬇️

scientific article published on September 13, 2012

Brain tissue analysis in the Honolulu-Asia aging study (HAAS): pesticides and other persistent chemicals

abstract published in 2004

Breaking the routine: is there room for modern techniques of neuropathology assessment in routine preclinical safety studies? ⬇️

abstract published in 2013

CSF proteome as fluidic biomarkers of neurotoxicity ⬇️

abstract published in 2021

Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+- exposed rats

journal article published in 2005

Cerebellar hypoplasia in the Gunn rat is associated with quantitative changes in neurotypic and gliotypic proteins.

scientific article published in August 1985

Changes in in vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens ⬇️

journal article published in 1985

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: a trimethyltin study

journal article published in 2018

Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

scientific article published in June 1990

Characterization of welding fumes and their potential neurotoxic effects

abstract published in 2006

Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1).

scientific article published in January 2002

Chemically-induced neuroinflammation and "sickness behavior" disorders ⬇️

abstract published in 2017

Chronic corticosterone primes the brain response to select neuroinflammatory agents by overexpression of Toll-like receptor 2 and S100A8: a potential role for microglia ⬇️

abstract published in 2015

Chronic dopaminergic signaling in the basal ganglia: a damage perspective on kinases and fos-related antigens

journal article published in 2000

Chronic exposure to CORT primes the CNS proinflammatory response in MPTP and METH models of neurotoxicity ⬇️

abstract published in 2010

Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine

journal article published in 2012

Chronic forced exercise attenuates kainic acid-induced neurotoxicity independent of changes in plasma or brain levels of insulin-like growth factor-1 ⬇️

abstract published in 2006

Chronic glucocorticoid and nerve agent DFP exposures produce a neuroinflammatory model of Gulf War Illness without neurodegeneration ⬇️

abstract published in 2015

Chronic glucocorticoid exposure primes the neuroinflammatory response to nerve agent sarin ⬇️

abstract published in 2020

Chronic high physiological stressor mimic, corticosterone, primes the neuroinflammatory response in cortex to dermal sulfur mustard exposure: a potential contribution to initiation of Gulf War Illness ⬇️

abstract published in 2024

Chronic treatment with supraphysiological levels of corticosterone enhances d-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse

journal article published in 2002

Circulating biomarkers of neurotoxicity: identifying fluidic endpoints correlating with central nervous system toxicity in a rodent model of neurotoxicity ⬇️

abstract published in 2019

Comparative study of fluoxetine, sibutramine, sertraline, and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry

journal article published in 2000

Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine

journal article published in 2017

Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness

journal article published in 2019

Corticosterone attenuates hippocampal neurotoxicity and reactive gliosis through regulation of the blood-brain barrier in C57BL/6J mice treated with kainic acid ⬇️

abstract published in 2009

Corticosterone enhances chlorpyrifos-induced neuroinflammation ⬇️

abstract published in 2014

Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness

journal article published in 2018

Corticosterone pretreatment attenuates neurodegeneration and blood-brain barrier disruption following excitotoxic damage from kainic acid ⬇️

abstract published in 2008

Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness

journal article published in 2015

Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition

journal article published in 2017

Corticosterone primes the neuroinflammatory responses to Gulf War Illness associated exposures: effects of irreversible vs. reversible acetylcholinesterase inhibitors ⬇️

abstract published in 2015

Corticosterone priming of the neuroinflammatory response to AChE inhibitors results in overexpression of Tlr2 and downstream targets, but not activation of the Nlrp3 inflammasome ⬇️

abstract published in 2016

Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus

journal article published in 2006

Corticosterone suppresses the early increase in MCP-1 associated with chemically-induced brain damage but does not suppress accompanying gliosis

conference abstract published in 2000

Corticosterone-primed neuroinflammatory response to AChE inhibitors is not related to brain acetylcholine concentration ⬇️

abstract published in 2017

Cost-effective neurotoxicity testing with high discriminative power: examples in rats after pre- or peri-natal exposure too methylazoxy methanol or methylmercury

journal article published in 2007

Cost-effective optimization of a neuropathology protocol for use in regulatory developmental neurotoxicity studies ⬇️

abstract published in 2006

Cytokine and growth factor gene expression in response to trimethyl tin (TMT)-induced neurotoxicity in the adult rat hippocampus ⬇️

abstract published in 1999

DARPP-32: regulator of the efficacy of dopaminergic neurotransmission

journal article published in 1998

Decreased neuronal damage and glial reactivity in an animal model of stress ⬇️

abstract published in 2010

Defining "neuroinflammation" lessons from MPTP- and methamphetamine-induced neurotoxicity

journal article published in 2008

Defining "neuroinflammation": lessons from MPTP- and METH-induced neurotoxicity

conference abstract published in 2007

Defining "neuroinflammation": lessons from MPTP- and methamphetamine-induced neurotoxicity ⬇️

abstract published in 2008

Depression, cytokines, and glial function

journal article published in 2005

Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation

journal article published in 2006

Developmental neuropathology of methyl mercury chloride ⬇️

abstract published in 2005

Developmental neurotoxicity of methylmercury and methylazoxymethanol: body weight, motor activity and brain damage combined

abstract published in 2006

Developmental neurotoxicity testing with methylmercury and methylazoxymethanol

abstract published in 2004

Diethyldithiocarbamate increases distribution of cadmium to brain but prevents cadmium-induced neurotoxicity

scientific article published in April 1986

Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium

scientific article published in August 1991

Differential activation of microglia and astrocytes following trimethyl tin-induced neurodegeneration

scientific article published on 01 May 1996

Discovery of novel alpha7 nicotinic receptor antagonists

journal article published in 2010

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum

journal article published in 2008

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum

conference abstract published in 2008

Divergent roles for tumor necrosis factor-alpha in the brain

journal article published in 2007

Diverse models of neurotoxicity link induction of astrogliosis to activation of STAT3 ⬇️

abstract published in 2014

Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?

journal article published in 2008

Dopamine levels in the putamen and caudate in incidental Lewy body disease are intermediate between normal and Parkinson's disease brains: the Honolulu-Asia Aging Study ⬇️

abstract published in 2011

Dose-response evaluation of C57Bl/6 mice for motor abnormalities and Parkinson-patterned neuropathology after paraquat and maneb exposure ⬇️

abstract published in 2009

Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity

journal article published in 2014

Early alterations of brain cellular energy homeostasis in Huntington disease models

journal article published in 2012

Effect of oral administration of tri-o-cresyl phosphate on in vitro phosphorylation of membrane and cytosolic proteins from chicken brain

scientific article

Effects of aging and stress on hippocampal structure and function ⬇️

scientific article published on October 1, 2003

Effects of concentrated ambient ultrafine/fine particles in insulin-resistant, obese rats ⬇️

abstract published in 2007

Effects of developmental methylphenidate (MPH) treatment on monoamine neurochemistry of male and female rats

journal article published in 2014

Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain ⬇️

scientific article published on August 1, 1998

Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test

journal article published in 2011

Elevated environmental temperature and methamphetamine neurotoxicity ⬇️

scientific article published on May 1, 2003

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse

scientific article published on 01 August 1994

Epigenetic analysis in a murine genetic model of Gulf War illness

journal article published in 2023

Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness

journal article published in 2018

Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures

journal article published in 2002

Evaluation of C57B1/6 mice for motor abnormalities and Parkinson-patterned neuropathology after Paraquat and Maneb exposure at human-relevant doses

conference abstract published in 2009

Exercise provides neuroprotection against kainic acid toxicity through induction of the chemokine mcp-1 in the hippocampus of C57BL/6J mice ⬇️

abstract published in 2007

Exploration of the Gulf War Illness phenotype in a mouse model challenged with LPS at long term time points ⬇️

abstract published in 2016

Exploring the relationship between neuroinflammation and neurotoxicity ⬇️

abstract published in 2014

Exploring the role of chemokine receptor 6 (Ccr6) in the BXD mouse model of Gulf War Illness

journal article published in 2020

Expression of fos-related antigen-2 in rat hippocampus after middle cerebral arterial occlusion

journal article published in 2000

Extrapulmonary tissue distribution of metals following repeated lung exposures to welding fumes with different elemental profiles ⬇️

abstract published in 2008

Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins

journal article published in 2004

Forced exercise attenuates kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice ⬇️

abstract published in 2005

Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission

journal article published in 2015

Gene expression and cell-signaling events associated with toxicant-induced gliosis ⬇️

abstract published in 2002

Gene expression profiling and pathway analyses reveal molecular signatures and relationships underlying enhanced methamphetamine neurotoxicity caused by protracted corticosterone exposure ⬇️

abstract published in 2012

Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains

journal article published in 2014

Genetic-based, differential susceptibility to exposure to combined organophosphate and increased glucocorticoid in a mouse model of Gulf War Illness ⬇️

abstract published in 2019

Genome-wide transcriptome architecture in a mouse model of Gulf War Illness

journal article published in 2020

Genomic and proteomic profiling in a Parkinsonian model of neurodegeneration ⬇️

abstract published in 2003

Genomic basis for individual differences in susceptibility to the neurotoxic effects of diesel exhaust

journal article published in 2022

Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice ⬇️

scientific article published on June 12, 2011

Glial fibrillary acidic protein (GFAP) and related astroglial proteins as biomarkers of neurotoxicity ⬇️

abstract published in 2018

Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity

journal article published in 2005

Glial reactivity in response to neurotoxins: relevance and methods

chapter published in 2019

Glial signaling, TNF-alpha and dopaminergic neurodegeneration

conference abstract published in 2005

Glucocorticoid exposure primes the neuroinflammatory response to the nerve agent DFP in a model of Gulf War Illness ⬇️

abstract published in 2013

Gold nanoparticles in central nervous system of mice: localization and inflammatory markers ⬇️

abstract published in 2013

Gulf War Illness and the health of Gulf War veterans: research update and recommendations, 2009-2013 -- updated scientific findings and recommendations ⬇️

book published in 2014

Gulf War-relevant organophosphate exposure results in changes in memory and neural plasticity ⬇️

abstract published in 2021

Health assessment of gasoline and fuel oxygenate vapors: neurotoxicity evaluation

journal article published in 2014

Health assessment of gasoline and fuel oxygenate vapors: reproductive toxicity assessment

journal article published in 2014

Health effects of subchronic exposure to diesel-water emulsion emission

journal article published in 2005

Health effects of subchronic exposure to diesel-water-methanol emulsion emission

journal article published in 2006

High physiological levels of the stress hormone, corticosterone (CORT), exacerbate brain inflammatory responses to lipopolysaccharide (LPS) and to the nerve agent, DFP: role in Gulf War Illness? ⬇️

abstract published in 2009

Honolulu-Asia Aging Study (HAAS): relationship of organochlorine levels with Parkinson's disease risk ⬇️

abstract published in 2009

Identification and quantification of neuropeptides in brain tissue by capillary liquid chromatography coupled off-line to MALDI-TOF and MALDI-TOF/TOF-MS

journal article published in 2006

Identification of signaling pathways activating reactive gliosis in multiple models of brain injury: a genomic, proteomic and protein phosphorylation analysis ⬇️

abstract published in 2005

Immunohistochemical localization and quantification of glial fibrillary acidic protein and synaptosomal-associated protein (mol. wt 25 000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine ⬇️

scientific article published on July 1, 1998

Impact of the stress hormone corticosterone on hippocampal response to neurotoxic injury in susceptible and resistant mouse strains ⬇️

conference abstract published in 2000

In vivo stress activates JAK-STAT in liver but not brain ⬇️

abstract published in 2002

In vivo stress and chronic glucocorticoid exposure influence the neuroinflammation and dopaminergic neurotoxicity associated with methamphetamine ⬇️

abstract published in 2012

Indirubins deplete striatal monoamines in the intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis

journal article published in 2010

Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration

journal article published in 2004

Inflammation is not a component of the glial response to toxicant-induced injury of the hippocampus ⬇️

abstract published in 2000

Inhalation exposure to white spirit causes region-dependent alterations in the levels of glial fibrillary acidic protein

journal article published in 2000

Inhalation health effects testing of isobutanol gasoline blend: a promising new biofuel ⬇️

abstract published in 2016

Inhalation toxicity of gasoline & fuel oxygenates - reproductive toxicity assessment ⬇️

abstract published in 2004

Inhalation toxicity of gasoline & fuel oxygenates: neurotoxicity ⬇️

abstract published in 2004

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

journal article published in 2020

Investigating the localization and anti-inflammatory effects of gold nanoparticles in the central nervous system of mice ⬇️

abstract published in 2015

Investigation of astrocyte specific responses to MPTP-induced neurotoxicity in the ALDH1L1 BAC-TRAP mouse ⬇️

abstract published in 2014

Iron: key to individual differences in susceptibility to pesticide neurotoxicity?

abstract published in 2013

Leptin-deficient (OB/OB) condition exacerbates neurodegeneration ⬇️

abstract published in 2001

Long-term induction of fos-related antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and trimethyltin-induced brain injury

journal article published in 2000

Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats

journal article published in 2008

MCP-1 is elevated in hippocampus after trimethyl tin (TMT)-induced neuronal damage: biomarker of neural injury? ⬇️

abstract published in 2001

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains

journal article published in 2016

MPTP neurotoxicity is highly concordant between the sexes in BXD recombinant inbred mouse strains ⬇️

abstract published in 2016

Mechanisms of dysregulation of dopamine neurotransmission by cholinesterase-inhibitors: implications for Gulf War Illness ⬇️

abstract published in 2010

Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

journal article published in 2014

Microglia are biosensors of neuroinflammogens and neurotoxicity, whereas astrocytes are linked only to neurotoxicity ⬇️

abstract published in 2016

Microglial activation and responses to vasculature that result from an acute LPS exposure

journal article published in 2020

Microscale sample deposition onto hydrophobic target plates for trace level detection of neuropeptides in brain tissue by MALDI- MS

journal article published in 2005

Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure

journal article published in 2009

Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor- alpha

journal article published in 2006

Modeling chemical sensitivity: prior exposure to stress and pesticide affects neuroinflammatory response to subsequent exposures in mice ⬇️

abstract published in 2024

Modeling neuroimmune interactions in human subjects and animal models to predict subtype-specific multidrug treatments for Gulf War Illness

journal article published in 2021

Modeling the genetic basis of individual differences in susceptibility to Gulf War Illness

journal article published in 2020

Molecular strategies for neurotoxicity screening: moving beyond the one compound, one mechanism approach

conference abstract published in 2001

Multiple histological markers reveal subpopulations of microglia respond differentially to excitotoxicity and corticosteroid treatment ⬇️

conference abstract published in 2008

NIOSH List of Hazardous Drugs in Healthcare Settings, 2024 ⬇️

NIOSH publication published in 2024

NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2014 (superseded by 2016-161) ⬇️

superseded NIOSH publication published in 2014

NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2016. (Supersedes 2014-138) ⬇️

NIOSH publication published in 2016

Nerve agent exposure and physiological stress alter brain microstructure and immune profiles after inflammatory challenge in a long-term rat model of Gulf War Illness

journal article published in 2024

Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain

journal article published in 2010

NeuroAIDS, drug abuse, and inflammation: building collaborative research activities

journal article published in 2006

Neurochemical correlates of cognitive deficits in weanling rats exposed to chlorpyrifos ⬇️

abstract published in 2001

Neuroendocrine aspects of the response to stress

journal article published in 2002

Neuroinflammation and Gulf War Illness: the role of microglia in the response to in-theater toxicant exposure ⬇️

abstract published in 2018

Neuroinflammation disorders exacerbated by environmental stressors

journal article published in 2019

Neuron-specific phosphoproteins as biochemical indicators of neurotoxicity: effects of acute administration of trimethyltin to the adult rat.

scientific article published in December 1984

Neuronal MAPK/ERK1/ERK2 activation is blocked in mouse brain by restraint stress ⬇️

conference abstract published in 2003

Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine

scientific article published on 15 October 2003

Neuroprotective actions of estrogen implications for exposure to estrogenic chemicals ⬇️

abstract published in 1999

Neuroproteomic profiling of the sleep-restricted aged female rat after ischemic stroke using iTRAQ LC-MS/MS ⬇️

abstract published in 2016

Neurotoxic effects of substituted amphetamines in rats and mice ⬇️

book or book chapter published in 2001

Neurotoxic esterase: not so toxic?

journal article published in 2003

Neurotoxicant-induced phosphoprotein profiles in vivo: temporal delineation and potential sites for regulation ⬇️

abstract published in 2000

Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse. Interactions with stress and the adrenal system

scientific article published on October 1996

Neurotoxicity of trimethyl tin (TMT) assessed using autoantibodies to neurotypic and gliotypic proteins ⬇️

abstract published in 2001

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse

scientific article published on 01 August 1994

New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases

journal article published in 2017

New insights into the role microglia play in the etiology of Gulf War Illness ⬇️

abstract published in 2018

Obesity and increased susceptibility to chemically-induced neurodegeneration ⬇️

abstract published in 2006

Obesity as a potential risk factor for dopaminergic neurotoxicity ⬇️

abstract published in 2001

Obesity as a potential risk factor for susceptibility to neurotoxic insult ⬇️

abstract published in 2000

Obesity exacerbates chemically induced neurodegeneration

journal article published in 2002

Obesity exacerbates neurotoxicity

abstract published in 2004

Oligodendrocyte involvement in Gulf War Illness

journal article published in 2019

Organophosphate-induced neuroinflammation, with and without corticosterone pretreatment, is not due to acetylcholinesterase inhibition ⬇️

abstract published in 2016

Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum ⬇️

scientific article published on September 20, 2011

Paraquat toxicogenetics: strain-related reduction of tyrosine hydroxylase staining in substantia nigra in mice

journal article published in 2021

Personalized medicine in major depressive disorder -- opportunities and pitfalls

journal article published in 2013

Phenobarbital and dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms that are independent of thermoregulation ⬇️

scientific article published on November 16, 2001

Phenotype comparisons of ALDH1L1 BAC-TRAP mice under control and neurotoxic (MPTP) conditions ⬇️

abstract published in 2015

Phosphoprotein signaling associated with methamphetamine-induced glial activation ⬇️

abstract published in 2001

Phosphorylation of protein phosphatase inhibitor-1 by Cdk5 ⬇️

journal article published in 2001

Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to alzheimer-type pathology and dementia

journal article published in 2009

Prenatal exposure to methyl mercury or methylazoxy methanol: effects on early postnatal motor activity ⬇️

abstract published in 2005

Preserving in vivo protein phosphorylation by focused microwave irradiation sacrifice is critical for analysis of signaling pathways in the brain

conference abstract published in 2004

Prior exposure to a behaviorally sensitizing regimen of d-methamphetamine does not alter the striatal dopaminergic damage induced by a neurotoxic regimen

journal article published in 2000

Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS

journal article published in 2018

Prior exposure to stress hormone exacerbates the neuroinflammatory response to the nerve agent sarin and pesticide dichlorvos in a mouse model of Gulf War Illness ⬇️

abstract published in 2021

Propranolol as a novel treatment for Gulf War Illness in a preclinical mouse model ⬇️

abstract published in 2019

Protein phosphatase 1 as a potential mediator of aluminum neurotoxicity

book or book chapter published in 2010

Protein phosphorylation cascades associated with methamphetamine-induced glial activation

journal article published in 2000

Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice

journal article published in 2009

Pyridostigmine bromide suppresses neuroinflammation induced by DFP ⬇️

abstract published in 2015

Quantification of GFAP levels in neocortical regions of elderly Japanese-American men with Alzheimer's disease

conference abstract published in 2000

Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease ⬇️

scientific article published on May 1, 2003

Quantitative immunoblots of proteins resolved from brain homogenates: underestimation of specific protein concentration and of treatment effects

journal article published in 1999

Reactive astrocyte nomenclature, definitions, and future directions

journal article published in 2021

Reactive gliosis in neurotoxic and mechanical injury models ⬇️

abstract published in 2005

Reactive gliosis is modulated by gp - 130 cytokines and microglial chemokines in ex - vivo brain slices

conference abstract published in 2004

Recapitulation of cell signaling events associated with astrogliosis using the brain slice preparation

journal article published in 2007

Recent research on Gulf War Illness and other health problems in veterans of the 1991 Gulf War: effects of toxicant exposures during deployment

journal article published in 2016

Regional neuropathology following kainic acid intoxication in C57BL/6J mice ⬇️

conference abstract published in 2003

Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice

journal article published in 2006

Regional profile and time course of neuropathology following kainic acid intoxication in FVB mice

conference abstract published in 2004

Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives

journal article published in 2005

Repeated exposure results in the loss of the neuroprotective properties of restraint-induced hypothermia in the substituted amphetamine model of striatal dopaminergic neurotoxicity ⬇️

abstract published in 1999

Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice

journal article published in 2000

Resetting homeostasis in Gulf War Illness, a computational biology hypothesis tested in a translational mouse model ⬇️

abstract published in 2017

Restraint stress activates STAT3 via adrenoceptor stimulation and IL-6 production in mouse liver ⬇️

abstract published in 2004

Restraint stress causes phosphorylation of STAT3 in liver of C57BL/6J mice through activation of adrenergic receptors ⬇️

abstract published in 2007

Role of proinflamatory cytokines in chemically-induced dopaminergic neurodegeration ⬇️

abstract published in 2005

Role of proinflammatory cytokines in chemically-induced D opaminergic neurodegeneration

abstract published in 2004

Roles of glia in developmental neurotoxicity: session VI summary and research needs

journal article published in 2001

SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation

journal article published in 2014

Sample-dependent effects on the neuropeptidome detected in rat brain tissue preparations by capillary liquid chromatography with tandem mass spectrometry

journal article published in 2005

Screening the activation state of multiple phosphoproteins reveals the in vivo impact of stressors on brain signaling pathways controlling cellular structure ⬇️

abstract published in 2008

Selective changes in gene expression in cortical regions sensitive to amphetamine during the neurodegenerative process

journal article published in 2004

Sensitive indicators of injury reveal hippocampal damage in C57BL/6J mice treated with kainic acid in the absence of tonic-clonic seizures

journal article published in 2004

Signaling pathways associated with gliosis can be studied using a brain slice preparation ⬇️

abstract published in 2004

Spatiotemporal phosphoprotein signaling in a mouse model using corticosterone and relevant organophosphates ⬇️

abstract published in 2020

Spinal glia and chronic pain ⬇️

scientific article published on October 1, 2010

Stat3 activation in MPTP-induced reactive gliosis: temporal delineation and pharmacological manipulation ⬇️

conference abstract published in 2000

Stress-induced changes in brain signaling pathways: implications for plastic brain changes caused by drugs of abuse

conference abstract published in 2007

Striatal dopaminergic neurotoxicity and neuroinflammation caused by methamphetamine are differentially affected by in vivo stressors versus corticosterone treatment ⬇️

abstract published in 2014

Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology

journal article published in 2008

Supporting a neuroimmune basis of Gulf War Illness

publication published in 2016

Supraphysiological levels of the stress hormone corticosterone attenuate blood-brain barrier disruption and microglial activation in hippocampus of C57BL/6J mice treated with kainic acid ⬇️

abstract published in 2004

Systems analysis of genetic variation in MPTP neurotoxicity in mice

journal article published in 2013

Systems genetics analysis of MPTP neurotoxicity ⬇️

abstract published in 2015

Systems genetics and systems biology analysis of paraquat neurotoxicity in BXD recombinant inbred mice

journal article published in 2020

TIMP1 mRNA expression is a biomarker of astrogliosis: evidence from multiple neurotoxicants and BAC-TRAP technology ⬇️

abstract published in 2015

TLR4 and inflammatory response to neuronal degeneration

journal article published in 2007

The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness

journal article published in 2021

The Detection of Central Nervous System Tissue on Beef Carcasses and in Comminuted Beef ⬇️

scientific article published on December 1, 2001

The Effect of Age and Testosterone on the Expression of Glial Fibrillary Acidic Protein in the Rat Cerebellum ⬇️

scientific article published on June 1, 1998

The MAP kinase cascade is activated prior to the induction of gliosis in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of dopaminergic neurotoxicity

journal article published in 1998

The astrocyte response to neural injury: a review and reconsideration of key features

book or book chapter published in 2002

The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity

journal article published in 2017

The impact of gender and estrogen on striatal dopaminergic neurotoxicity

journal article published in 1998

The interactions of MK-801 with the amphetamine analogues D-methamphetamine (D-METH), 3,4-methylenedioxymethamphetamine (D-MDMA) or D-fenfluramine (D-FEN): neural damage and neural protection

scientific article published in May 1993

The multiple hit hypothesis for Gulf War Illness: self-reported chemical/biological weapons exposure and mild traumatic brain injury

journal article published in 2018

The neuroinflammatory phenotype in a mouse model of Gulf War Illness is unrelated to brain regional levels of acetylcholine as measured by quantitative HILIC-UPLC-MS/MS

journal article published in 2018

The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) alters immune function when given in combination with diethyldithiocarbamate (DDC)

scientific article published on May 11, 1992

The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: evidence for glial response to injury

scientific article published on 01 December 1988

The pharmacology of wakefulness

journal article published in 2006

The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine

scientific article published on August 1995

The role of the alpha, adrenergic receptor in the restraint-induced phosphorylation of stat3 ⬇️

abstract published in 2003

The trimethyltin model of hippocampal injury: gene array analysis reveals early and diverse changes in gene expression associated with neuronal injury and glial activation ⬇️

abstract published in 2004

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

journal article published in 2002

Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines ⬇️

scientific article published on October 21, 2011

Toxicant-induced reactive gliosis in the developing nervous system ⬇️

abstract published in 2000

Toxicological assessment of diesel-methanol-water emulsion [Purinox (all weather) generation 2 fuel] exhaust emissions ⬇️

abstract published in 2004

Toxicological assessment of diesel-water emulsion [Purinox (summer fuel blend)] exhaust emissions ⬇️

abstract published in 2004

Translational biomarkers of neurotoxicity: a Health and Environmental Sciences Institute perspective on the way forward

journal article published in 2015

Treatment with corticosterone suppresses the early induction of MCP-1 after neuronal injury but does not prevent gliosis ⬇️

conference abstract published in 2000

Trimehtyltin and LPS induce distinct patterns of cytokine and chemokine expression in rat hippocampus: lack of an association in injury ⬇️

abstract published in 2000

Trimethyltin-induced neurotoxicity: Gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis ⬇️

scientific article published on November 12, 2011

Upregulation of NF-kappaB p50 during neuronal adaptation after chemotoxic injury to the hippocampus ⬇️

conference abstract published in 2000

Upregulation of phosphorylated Stat3 precedes glial induction in MPTP-mediated neurotoxicity ⬇️

abstract published in 2000

Use of non-biased stereology to estimate the number of TH+ neurons in the substantia nigra of 8 and 16 month old male and female C57BL/6 mice repeatedly exposed to paraquat and maneb ⬇️

abstract published in 2011

Using RNA-Seq to evaluate the aged female Sprague-Dawley rat cortex transcriptome after repeated bouts of sleep deprivation induced by the gentle-handling method ⬇️

abstract published in 2012

Using global gene expression profiling and pathway analysis to investigate kainic acid neurotoxicity and corticosterone neuroprotection in the C57BL/6J mouse hippocampus ⬇️

abstract published in 2012

Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2

journal article published in 2007

Variability in neurotoxicity: who is susceptible and why ⬇️

abstract published in 2014

Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

journal article published in 2016

Vitamin E deficiency increases susceptibility of the BALB/c mouse to MDMA-induced dopaminergic neurotoxicity ⬇️

abstract published in 2000

Whole genome transcriptome analysis in a genetic model of Gulf War Illness ⬇️

abstract published in 2020

Work, obesity, and occupational safety and health

journal article published in 2007

cDNA array analysis of the changes in gene expression specifically produced by neurotoxic doses of amphetamine: not quite mission impossible

abstract published in 2004

d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity

journal article published in 2002

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