List of works by Krzysztof Palczewski

3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy

scientific article

A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins

scientific article (publication date: 10 January 2017)

A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation

scientific article

A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

scientific article published on 01 April 2019

A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness

scientific article published on 05 May 2018

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

scientific article published on 27 February 2004

A critical role of CaBP4 in the cone synapse

scientific article

A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1

scientific article

A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).

scientific article published on February 2013

A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids

scientific article

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress

scientific article

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor

scientific article

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

scientific article

A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy

scientific article published on 16 September 2008

A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration

scientific article

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

scientific article

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

scientific article

A therapeutic combination of GPCR modulators that protects photoreceptors from degeneration

scientific article published on 21 November 2017

ABCA4 disease progression and a proposed strategy for gene therapy

scientific article published on 12 December 2008

Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

scientific article

Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

scientific article

Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.

scientific article

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

scientific article published on 09 September 2014

Activation of retinoic acid receptors by dihydroretinoids

scientific article published on 21 September 2009

Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability

scientific article published on 9 February 2015

Advances in understanding the molecular basis of the first steps in color vision

scientific article

Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes

scientific article published in August 2003

Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans

scientific article

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

scientific article published on 01 January 2018

An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase

scientific article

An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device

scientific article published on 3 February 2016

Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)

scientific article

Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration

scientific journal article

Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State

scientific article published on 20 November 2018

Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina

scientific article

Arrestin interaction with rhodopsin: conceptual models.

scientific article published in January 2006

Asymmetry of the rhodopsin dimer in complex with transducin

scientific article published on 9 January 2013

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

scientific article published on 10 December 2012

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene

scientific article

Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner

scientific article

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

scientific article

Biochemistry. As good as chocolate

scientific article published on May 2013

Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle ⬇️

scientific article published on November 1, 2010

Ca2+ -dependent regulation of phototransduction

scientific article published on 12 March 2008

Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma

scientific article

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

scientific article

Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme.

scientific article

Capturing a rhodopsin receptor signalling cascade across a native membrane

scientific article published on 06 April 2022

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

scientific article

Catalytic synthesis of 9-cis-retinoids: mechanistic insights

scientific article published on 01 July 2019

Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates

scientific article published on 10 September 2013

Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme

scientific article published on 29 May 2013

Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man.

scientific article

Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses ⬇️

scientific article published on September 8, 2010

Chemistry and biology of the initial steps in vision: the Friedenwald lecture.

scientific article

Chemistry and biology of vision

scientific article published on 10 November 2011

Chemistry of the retinoid (visual) cycle

scientific article

Chemokine receptors and other G protein-coupled receptors

scientific article published on March 2009

Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton

scientific article

Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity

scientific article published on 07 July 2020

Comparative analysis of GPCR crystal structures

scientific article published on 19 January 2009

Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue

scientific article published on 9 May 2017

Complexes between photoactivated rhodopsin and transducin: progress and questions

scientific article

Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice

scientific article

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

scientific article published on 15 January 2019

Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

scientific article published on 18 April 2016

Conformational Changes in the G Protein-Coupled Receptor Rhodopsin Revealed by Histidine Hydrogen−Deuterium Exchange ⬇️

scientific article published on October 15, 2010

Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation

scientific article

Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein

scientific article

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

scholarly article

Context-dependent compensation among phosphatidylserine-recognition receptors

scientific article published on 7 November 2017

Crowd sourcing difficult problems in protein science

scientific article

Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

scientific article published on 27 February 2019

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

scientific article published on 09 August 2019

Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti.

scientific article published on 5 January 2002

Crystal packing analysis of Rhodopsin crystals

scientific article

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

scientific article

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle

scientific article

Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration

scientific article

Crystallization of G protein-coupled receptors

scientific article published on January 2013

Crystallization of proteins from crude bovine rod outer segments

scientific article published on 17 March 2015

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

scientific article

Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration

scientific article

Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo

scientific article

Delivery of retinoid-based therapies to target tissues

scientific article published on 23 March 2007

Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. ⬇️

scientific article published on 23 October 2017

Designing Safer Analgesics via μ-Opioid Receptor Pathways

scientific article published on 18 September 2017

Detecting molecular interactions that stabilize native bovine rhodopsin

scientific article published on 20 February 2006

Detergents stabilize the conformation of phosphodiesterase 6.

scientific article published on 14 October 2011

Determinants shaping the nanoscale architecture of the mouse rod outer segment

scientific article published on 21 December 2021

Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases

scientific article published on 18 July 2020

Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium

scientific article

Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis

scientific article

Different properties of the native and reconstituted heterotrimeric G protein transducin

scientific article

Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1

scientific article

Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

scientific article published on January 2007

Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface

scientific article

Diversifying the repertoire of G protein-coupled receptors through oligomerization.

scientific article

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes).

scientific article

Dominant and recessive mutations in rhodopsin activate different cell death pathways.

scientific article

Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina

scientific article

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance

scientific article

Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice

scientific article published on 15 August 2008

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

scientific article

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

scientific article

Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane

scientific article

Endogenous fluorophores enable two-photon imaging of the primate eye.

scientific article

Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors

scientific article

Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser

scientific article published on March 2017

Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model

scientific article published on 21 July 2020

Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function

scientific article

Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice

scientific article

Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance

scientific article published on 03 June 2009

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

scientific article

Evidence for RPE65-independent vision in the cone-dominated zebrafish retina

scientific article published on 14 September 2007

Evolutionarily conserved long intergenic non-coding RNAs in the eye

scientific article published on 04 April 2013

Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer

scientific article published on November 2003

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration

scientific article

Exploring a new ligand binding site of G protein-coupled receptors

Exploring the Thermodynamics of Activation Pathways of Bovine Rhodopsin with Fast Molecular Dynamics Simulations

Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis

scientific article published on November 2005

Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans

scientific article

Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains

scientific article

Eyes on systems pharmacology

scientific article published on 05 October 2016

Focus on molecules: guanylate cyclase-activating proteins (GCAPs).

scientific article published on 8 January 2009

Focus on vision: 3 decades of remarkable contributions to biology and medicine

scientific article published on February 2011

Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy

scientific article published on January 2017

Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model

scientific article published on 20 December 2020

From atomic structures to neuronal functions of g protein-coupled receptors

scientific article

Function of mammalian M-cones depends on the level of CRALBP in Müller cells

scientific article published on 01 January 2021

Functional and structural characterization of rhodopsin oligomers

scientific article

Functional characterization of rhodopsin monomers and dimers in detergents

scientific article

G protein-coupled receptor rhodopsin

scientific article

G protein-coupled receptor rhodopsin: a prospectus

scientific article

G protein-coupled receptors--recent advances

scientific article

GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice

scientific article

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

scientific article

Guanylate cyclase-activating proteins: structure, function, and diversity

scientific journal article

HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors

scientific article

Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism

scientific article

Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina

scientific article

Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans

scientific article published on 16 November 2011

Heterologous expression of the adenosine A1 receptor in transgenic mouse retina

scientific article

High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules

scientific article

Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling

scientific journal article

Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease

scientific article published on 22 September 2020

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

scientific article

Human aging and disease: Lessons from age-related macular degeneration.

scientific article published on 26 February 2018

Human cone photoreceptor dependence on RPE65 isomerase

scientific article

Human infrared vision is triggered by two-photon chromophore isomerization

scientific article

Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates

scientific article published on 04 April 2019

Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors

scientific article published on 12 April 2017

ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production

scientific article

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase

scientific article

Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels

scientific article

Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase

scientific article

Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475.

scientific article

Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization

scientific article published on 11 November 2021

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success

scientific article

Image registration and averaging of low laser power two-photon fluorescence images of mouse retina

scientific article published on 20 June 2016

Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy

scientific article

Imaging G protein-coupled receptor islands.

scientific article

Imaging of protein crystals with two-photon microscopy

scientific article published on 16 February 2012

Immuno-TEM/STEM in Retinal Research

scientific article published on 01 January 2019

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization

scientific article published on 23 August 2008

Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis

scientific article published on April 2004

Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity

scientific article

Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal

scientific article published on October 2006

Improvement in vision: a new goal for treatment of hereditary retinal degenerations

scientific article published on May 2015

Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals

article by David Salom et al published December 2006 in Journal of Structural Biology

In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones

scientific article published on February 2016

In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope

In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope

scientific article published in June 2023

In vivo two-photon imaging of the mouse retina

scientific article

Increased adiposity in the retinol saturase-knockout mouse

scientific article

Increasing the Stability of Recombinant Human Green Cone Pigment.

scientific article published on 10 January 2018

Inflammatory priming predisposes mice to age-related retinal degeneration

scientific article

Inherent instability of the retinitis pigmentosa P23H mutant opsin

scientific article published on 10 February 2014

Inner retinal photoreception independent of the visual retinoid cycle.

scientific article

Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase

scientific article

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

scientific article published on 12 April 2018

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

scientific article published on March 2007

Involvement of all-trans-retinal in acute light-induced retinopathy of mice

scientific article published on 20 March 2009

Is rhodopsin dimeric in native retinal rods?

scientific article published in Nature

Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin

scientific article published on 30 September 2008

Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans

scientific article

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase

scientific article published on 24 July 2016

Key enzymes of the retinoid (visual) cycle in vertebrate retina

scientific article

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3

scientific article

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.

scientific article

Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle

scientific article published on 16 May 2016

Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein

scientific article

Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

scientific article published on 10 October 2005

Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness

scientific article (publication date: June 2006)

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

scientific article

Light Inhibition of Bovine Retinal Rod Guanylyl Cyclase Mediated by βγ-Transducin†

scientific article published in 1999

Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1.

scientific article

Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors

scientific journal article

Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans

scientific article published on 16 November 2011

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

scientific article published on 24 June 2009

Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness

scientific article published on 14 October 2005

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

scientific article published on April 2009

Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments

scientific article published in July 2015

Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function

scientific article published on February 2008

Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration

scientific article published on 19 December 2011

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

scientific article published on 31 May 2016

Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation

scientific article published on 01 April 2020

Melanopsin is highly resistant to light and chemical bleaching in vivo.

scientific article

Membrane-binding and enzymatic properties of RPE65

scientific article

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

scientific journal article

Metabolism and transactivation activity of 13,14-dihydroretinoic acid

scientific article

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice

scientific article

Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging

scientific article

Modulation of molecular interactions and function by rhodopsin palmitylation

scientific article published on May 2009

Molecular biology and analytical chemistry methods used to probe the retinoid cycle

scientific article

Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter

scientific article published on 4 April 2013

Molecular pharmacodynamics of emixustat in protection against retinal degeneration

scientific article

Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice

scientific article

Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser

scientific article published on 26 October 2017

Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice

scientific article

Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease

scientific article published on 21 November 2018

New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.

scientific article published on 24 January 2018

Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles

scientific article published on 12 September 2019

Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium

scientific article published on 01 January 2019

Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes

scientific article

Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye

scientific article

Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.

scientific article

Noninvasive two-photon optical biopsy of retinal fluorophores

scientific article published on 26 August 2020

Nonvisual photoreception in the chick iris

scientific article published on 01 October 2004

Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations

scientific article

Novel targeting strategy for generating mouse models with defects in the retinoid cycle ⬇️

scientific article published on December 1, 2003

Oligomeric forms of G protein-coupled receptors (GPCRs).

scientific article published on 9 June 2010

Oligomerization of G protein-coupled receptors: past, present, and future

scientific article published on December 2004

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

scientific article

P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis

scientific article

PAR4 activation involves extracellular loop-3 and transmembrane residue Thr153

scientific article published on 23 June 2020

PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation

scientific article published on 20 April 2020

Palmitoylation stabilizes unliganded rod opsin

scientific article

Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation

scientific article published on 18 July 2005

Pathways and disease-causing alterations in visual chromophore production for vertebrate vision

scientific article published on 13 November 2020

Periscope for noninvasive two-photon imaging of murine retina in vivo.

scientific article published on 13 August 2015

Phagocytosis of retinal rod and cone photoreceptors

scientific article

Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis.

scientific article

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

scientific article

Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex

scientific article published on June 2009

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

scientific article published on 06 November 2019

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

scientific article published on 13 March 2017

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes

scientific article published on August 2016

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

scientific article published on 25 September 2013

Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes

scientific article published on 28 July 2017

Photoreceptor guanylate cyclase variants: cGMP production under control.

scientific article published on January 2003

Photoreceptor phagocytosis is mediated by phosphoinositide signaling

scientific article published on 02 August 2013

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal

scientific article published on 9 April 2013

Phototransduction: crystal clear

scientific article

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

scientific article

Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells

scientific article published on 20 December 2011

Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4

scientific article published on 8 July 2011

Primary amines protect against retinal degeneration in mouse models of retinopathies

scientific article

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations

scientific article

Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles

scientific article

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

scientific article published on 17 July 2018

Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations

scientific article published on 24 February 2015

Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

scientific article published on 29 October 2020

Purification, crystallization and structure determination of native GroEL fromEscherichia colilacking bound potassium ions

scientific article

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles

scientific article

Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.

scientific article published on 4 October 2017

R9AP overexpression alters phototransduction kinetics in iCre75 mice.

scientific article published on 06 March 2014

RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome

scientific article published on March 2008

Rational Tuning of Visual Cycle Modulator Pharmacodynamics

scientific article

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

scientific article published on 14 November 2016

Recovery of visual functions in a mouse model of Leber congenital amaurosis

scientific journal article

Redundant and unique roles of retinol dehydrogenases in the mouse retina

scholarly article

Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids

scientific article

Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time

scientific article published on 19 February 2014

Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462]

scientific article published on 01 August 2007

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

scientific article

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

scientific article published on 07 January 2017

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

scientific article published on 19 October 2020

Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention

scientific article published on 17 May 2019

Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage

scientific article published on 9 February 2012

Retinal degeneration in animal models with a defective visual cycle

scientific article

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

scientific article published on 15 October 2013

Retinal-chitosan conjugates effectively deliver active chromophores to retinal photoreceptor cells in blind mice and dogs

scientific article published on 16 February 2018

Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).

scientific article

Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization.

scientific article published on December 2003

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

scientific article published on 2 March 2018

Retinoids and Retinal Diseases

scientific article published on 18 July 2016

Retinoids for treatment of retinal diseases

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Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor

scientific article published on 03 June 2020

Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity

scientific article published on 13 November 2019

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice

scientific article

Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina.

scientific article published on 9 September 2015

Retinopathy in mice induced by disrupted all-trans-retinal clearance

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Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies

scientific article

Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis

scientific journal article

Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina

scientific article

Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues

scientific article

Retinylamine Benefits Early Diabetic Retinopathy in Mice

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Rhodopsin and its kinase

scientific article

Rhodopsin dimers in native disc membranes

scientific article published in Nature

Rhodopsin phosphorylation: 30 years later ⬇️

scientific article published on July 1, 2003

Rhodopsin self-associates in asolectin liposomes

scholarly article

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

scientific article

Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization

scientific article published on 6 September 2011

Rhodopsin: a structural primer for G-protein coupled receptors

scientific article

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration.

scientific article published on 2 October 2014

Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man.

scientific article published on September 2000

Role of bulk water in hydrolysis of the rhodopsin chromophore

scientific article

Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

scientific article

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

scientific article

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

scholarly article

STRA6 is critical for cellular vitamin A uptake and homeostasis

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Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans

scientific article

Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells

scientific article published on 13 August 2015

Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas

scientific article

Sensitivity of Mammalian Cone Photoreceptors to Infrared Light

scientific article published on 07 August 2019

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

scientific article

Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo

scientific article published on 10 November 2006

Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes.

scientific article

Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology

scientific article

Serum levels of lipid metabolites in age-related macular degeneration

scientific article

Shedding new light on the generation of the visual chromophore

scientific article published on 05 August 2020

Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II

scientific article

Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody

scientific article published on 28 August 2020

Skunkworks project for Big Pharma

scientific article published on 28 March 2017

Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators

scientific article

Specificity of the chromophore-binding site in human cone opsins

scientific article published on 15 February 2019

Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol

scientific article published on 25 January 2007

Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina

scientific article

Stabilizing Function for Myristoyl Group Revealed by the Crystal Structure of a Neuronal Calcium Sensor, Guanylate Cyclase-Activating Protein 1

scientific article

Stabilizing effect of Zn2+ in native bovine rhodopsin

scientific article

Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium

scientific article published on 03 April 2020

Stereospecific modulation of dimeric rhodopsin

scientific article published on 23 May 2019

Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids

scientific article published on 8 January 2008

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

scientific article

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

scientific article

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family

scientific article

Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels

scientific article

Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells

scientific article

Structural approaches to understanding retinal proteins needed for vision

scientific article (publication date: April 2014)

Structural basis of carotenoid cleavage: from bacteria to mammals

scientific article

Structural biology of 11-retinaldehyde production in the classical visual cycle

article

Structural characterization of the rod cGMP phosphodiesterase 6.

scientific article

Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1.

scientific article

Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4)

scientific article

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.

scientific article

Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center

scientific article published on 11 May 2017

Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis

scientific article

Structure of cone photoreceptors

scientific article

Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors

scientific article

Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation

scientific article

Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).

scientific article

Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration

scientific article published on 26 July 2016

Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration

scientific article

Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders

scientific article

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

scientific article published on 15 November 2013

Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis

scientific article published on 28 February 2017

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

scientific article

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

scientific article

The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease

scientific article

The Biochemical Basis of Vitamin A3 Production in Arthropod Vision

scientific article published on 26 January 2016

The G protein-coupled receptor rhodopsin in the native membrane

scientific article

The G protein-coupled receptor rhodopsin: a historical perspective

scientific article

The Molecular Mechanism of P2Y1 Receptor Activation

scientific article published on 27 July 2016

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

scientific article

The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies

scientific article

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

scientific article

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors

scientific journal article

The impact of microRNA gene regulation on the survival and function of mature cell types in the eye

scientific article

The loss of infrared-light sensitivity of photoreceptor cells measured with two-photon excitation as an indicator of diabetic retinopathy: A pilot study

scientific article published on 10 December 2020

The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements

scientific article

The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors.

scientific article published on 12 May 2015

The molecular basis of retinoid absorption: a genetic dissection

scientific article published on 17 March 2008

The physiological impact of microRNA gene regulation in the retina

scientific article

The retinoid cycle and retina disease ⬇️

scientific article published on December 1, 2003

The rhodopsin-transducin complex houses two distinct rhodopsin molecules

scientific article published on 28 February 2013

The role of retinol dehydrogenase 10 in the cone visual cycle

scientific article published on 24 May 2017

The role of the 11-cis-retinal ring methyl substituents in visual pigment formation

scientific article published on 01 November 2006

The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration

scientific article published on 09 May 2019

The significance of G protein-coupled receptor crystallography for drug discovery

scientific article

The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes

scientific article

Thematic minireview series on focus on vision

scientific article

Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography

scientific article

Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes

scientific article

Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium

scientific article published on 15 October 2019

Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice

scientific article

Topology and membrane association of lecithin: retinol acyltransferase.

scientific article

Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors

scientific article published on 22 October 2008

Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness

scientific article

Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal

scientific article published on April 2008

Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas

scientific article

Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa

scientific article published on 9 November 2016

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

scientific article published on 01 April 2019

Two carotenoid oxygenases contribute to mammalian provitamin A metabolism

scientific article published on 08 October 2013

Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye.

scientific article published on February 2016

Two-photon imaging of the mammalian retina with ultrafast pulsing laser

scientific article published on 06 September 2018

Two-photon microperimetry with picosecond pulses

Two-photon microperimetry: sensitivity of human photoreceptors to infrared light

scientific article published on 09 August 2019

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

scientific article published on 24 March 2014

Use of thallium to identify monovalent cation binding sites in GroEL

scientific article

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation

scientific article

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases

scientific article

Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice

scientific article

Vertebrate membrane proteins: structure, function, and insights from biophysical approaches

scientific article published on 05 March 2008

Visual rhodopsin sees the light: structure and mechanism of G protein signaling

scientific article published on 8 February 2007

Visualization of retinoid storage and trafficking by two-photon microscopy

scientific article

Visualizing water molecules in transmembrane proteins using radiolytic labeling methods.

scientific article

Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis

scientific article

WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration

retracted scientific article published on 13 August 2009

Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis

scientific article published on 28 August 2019

[24] Short-chain dehydrogenases/reductases in retina

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