List of works - Jorge A. R. Salvador

16α,17α-Epoxy-5α-hydroxy-6β-nitrooxy-20-oxopregnan-3β-yl acetate ⬇️

scientific article published on May 14, 2009

19β,28-Ep-oxy-18α-olean-3β-ol.

scientific article published on 8 August 2009

3-Oxo-18α-olean-28,13β-olide

scientific article published on 31 July 2010

3-Oxoandrost-4-en-17β-yl 1H-imidazole-1-carboxylate

3β-Acetoxy-lup-20(29)-en-28-yl 1H-1,2,4-triazole-1-carboxylate ⬇️

scientific article published on October 31, 2010

3β-Hy-droxy-lup-20(29)-en-28-yl 1H-imidazole-1-carboxyl-ate.

scientific article published on 30 June 2010

5Beta,6beta-epoxy-17-oxoandrostan-3beta-yl acetate and 5beta,6beta-epoxy-20-oxopregnan-3beta-yl acetate.

scientific article published on 19 April 2008

6beta-Azido-7alpha-hydroxy-17-oxo-5alpha-androstan-3beta-yl acetate.

scientific article published on 11 August 2004

6beta-Hydroxy-5beta-methyl-20-oxo-19-norpregn-9(10)-en-3beta-yl acetate.

scientific article published on 10 April 2009

6β-Acetamido-5α-hydroxy-cholestan-3β-yl acetate.

scientific article published on 8 November 2008

Anticancer steroids: linking natural and semi-synthetic compounds ⬇️

scientific article published on February 1, 2013

Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine

scientific article (publication date: 2014)

Bismuth compounds in medicinal chemistry.

scientific article published on July 2012

Bismuth(III) reagents in steroid and terpene chemistry.

scientific article published on 04 April 2011

Bismuth(III) salt-catalyzed Westphalen and “backbone” rearrangements of 5β,6β-epoxysteroids

scientific article published on 18 January 2008

Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain.

scientific article published in November 2009

CYP17 inhibitors for prostate cancer treatment--an update.

scientific article published on January 2008

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity

scientific article published on 03 October 2019

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design

scientific article published on 25 October 2019

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

scientific article published on 01 April 2020

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview

scientific article

Corrigendum to "Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells" [Eur. J. Med. Chem. 123 (2016) 317-331].

scientific article published on 23 October 2016

Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds.

scientific article

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives ⬇️

scientific article published on January 30, 2012

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

scientific article

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

scientific article published on 25 July 2019

New applications for bismuth(III) salts in organic synthesis: from bulk chemicals to steroid and terpene chemistry

scientific article published on 01 January 2012

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.

scientific article

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation

scientific article

Novel oleanolic vinyl boronates: synthesis and antitumor activity.

scientific article published on 9 February 2013

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.

scientific article

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

scientific article published on 14 July 2017

One-pot, high yield synthesis of alpha-ketols from Delta5-steroids

scientific article published on 20 December 2005

Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c‐FLIP in Cancer Cells ⬇️

scientific article published on July 16, 2012

Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.

scientific article published on 18 May 2013

Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition

scientific article published on 29 July 2019

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

scientific article published on 14 August 2019

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

scientific article published on 20 February 2019

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

scientific article published on 28 September 2018

Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives.

scientific article published on 11 March 2016

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

scientific article published on 22 July 2016

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.

scientific article published on 15 August 2007

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid.

scientific article

Synthesis of chiral hexacyclic steroids via [8π + 2π] cycloaddition of diazafulvenium methides

scientific article published on 30 July 2015

Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells

scientific article published on 01 February 2013

Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.

scientific article published on 16 August 2012

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3β-yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes

scientific article published on 23 February 2011

List of works by Jorge A. R. Salvador

16α,17α-Epoxy-5α-hydroxy-6β-nitrooxy-20-oxopregnan-3β-yl acetate ⬇️

19β,28-Ep-oxy-18α-olean-3β-ol.

3-Oxo-18α-olean-28,13β-olide

3-Oxoandrost-4-en-17β-yl 1H-imidazole-1-carboxylate

3β-Acetoxy-lup-20(29)-en-28-yl 1H-1,2,4-triazole-1-carboxylate ⬇️

3β-Hy-droxy-lup-20(29)-en-28-yl 1H-imidazole-1-carboxyl-ate.

5Beta,6beta-epoxy-17-oxoandrostan-3beta-yl acetate and 5beta,6beta-epoxy-20-oxopregnan-3beta-yl acetate.

6beta-Azido-7alpha-hydroxy-17-oxo-5alpha-androstan-3beta-yl acetate.

6beta-Hydroxy-5beta-methyl-20-oxo-19-norpregn-9(10)-en-3beta-yl acetate.

6β-Acetamido-5α-hydroxy-cholestan-3β-yl acetate.

Anticancer steroids: linking natural and semi-synthetic compounds ⬇️

Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine

Bismuth compounds in medicinal chemistry.

Bismuth(III) reagents in steroid and terpene chemistry.

Bismuth(III) salt-catalyzed Westphalen and “backbone” rearrangements of 5β,6β-epoxysteroids

Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain.

CYP17 inhibitors for prostate cancer treatment--an update.

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview

Corrigendum to "Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells" [Eur. J. Med. Chem. 123 (2016) 317-331].

Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds.

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives ⬇️

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

New applications for bismuth(III) salts in organic synthesis: from bulk chemicals to steroid and terpene chemistry

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation

Novel oleanolic vinyl boronates: synthesis and antitumor activity.

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

One-pot, high yield synthesis of alpha-ketols from Delta5-steroids

Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c‐FLIP in Cancer Cells ⬇️

Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.

Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives.

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid.

Synthesis of chiral hexacyclic steroids via [8π + 2π] cycloaddition of diazafulvenium methides

Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells

Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3β-yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes