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List of works by Anna Kanerva

A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model

scientific article published in February 2003

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer ⬇️

scientific article published on August 7, 2012

Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

scientific article published on 30 June 2016

Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo

scientific article published on 9 September 2010

Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors

scientific article published in August 2002

Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy

scientific article published on 14 June 2017

Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy

scholarly article by João Manuel Santos published in September 2018

Adenoviruses for treatment of cancer

scientific article

Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases

scientific article

An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance

scientific article

Analysis of predictive and prognostic factors in 290 patients treated with oncolytic adenoviruses.

scientific article published on 4 November 2015

Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus

scientific article

Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues

scientific article published on 9 July 2015

CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses

scientific article published in February 2003

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

scholarly article by Sadia Zafar et al published 2018 in OncoImmunology

Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.

scientific article

Case-control estimation of the impact of oncolytic adenovirus on the survival of patients with refractory solid tumors

scientific article published on 10 November 2014

Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity

scientific article published in January 2007

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

scientific article published on 27 August 2015

Correction: Familial risks of ovarian cancer by age at diagnosis, proband type and histology

scientific article published in PLoS ONE

Corrigendum to "Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma".

scientific article published in November 2016

Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus

scientific article

Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer

scientific article

Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism ⬇️

scientific article published on September 1, 2003

Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

scientific article published in September 2003

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

scientific article published in August 2004

Familial Ovarian Cancer Clusters with Other Cancers

scientific article published in Scientific Reports

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors

scientific article published on 24 June 2015

Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment

scientific article published on 21 August 2013

GMCSF-armed vaccinia virus induces an antitumor immune response

scientific article published on 10 July 2014

Gene therapy of gynaecological diseases

scientific article published on September 2007

Gene transfer approaches for gynecological diseases

scientific article published on 2 May 2006

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

scientific article

Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir

scientific article

Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors

scientific article published in July 2007

Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus

scientific article

Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy ⬇️

scientific article

Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus

scientific article

In vivo and in vitro distribution of type 5 and fiber-modified oncolytic adenoviruses in human blood compartments

scientific article published on 25 January 2011

Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus ⬇️

scientific article published on July 26, 2011

Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

scientific article published in May 2006

Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

scientific article published on 8 August 2011

Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy

scientific article

Interleukin 8 activity influences the efficacy of adenoviral oncolytic immunotherapy in cancer patients

scientific article published on 5 January 2018

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

scientific article published on 7 December 2016

Modified adenoviruses for cancer gene therapy

scientific article published on July 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

scientific article published in February 2003

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

scientific article

Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism

scientific article

Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer

scientific article published in October 2006

Oncograms Visualize Factors Influencing Long-Term Survival of Cancer Patients Treated with Adenoviral Oncolytic Immunotherapy.

scientific article published on 22 April 2018

Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

scientific article published on 25 July 2016

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients ⬇️

scientific article published on 02 April 2013

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

scientific article published on 31 December 2016

Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer

scientific article published on 22 October 2007

Oncolytic adenovirus ICOVIR-7 in patients with advanced and refractory solid tumors

scientific article published on 25 May 2010

Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

scientific article

Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients

scientific article

Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

scientific article

Oncolytic adenoviruses kill breast cancer initiating CD44+CD24-/low cells

scientific article

Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients

scientific article published on 9 February 2012

Oncolytic virotherapy for treatment of breast cancer, including triple-negative breast cancer

scientific article published on 27 August 2015

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy

scientific article

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy

scientific article published on 7 January 2015

Predictive and Prognostic Clinical Variables in Cancer Patients Treated With Adenoviral Oncolytic Immunotherapy

scientific article published on 4 April 2016

Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids ⬇️

scientific article published on May 1, 2003

SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I

scientific article

Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles

scientific article published on 10 December 2014

Safety of glucocorticoids in cancer patients treated with oncolytic adenoviruses

scientific article published on 8 November 2010

Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver

scientific article

Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans

scientific article

Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy

scientific article published on March 2015

Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients

scientific article published in May 2011

Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting

scientific article published on 18 February 2016

Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells

scientific article

Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer

scientific article published on July 2007

Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses ⬇️

scientific article

T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma

scientific article published on November 2016

Targeted chemotherapy for head and neck cancer with a chimeric oncolytic adenovirus coding for bifunctional suicide protein FCU1.

scientific article published on 13 April 2010

Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

scientific article

The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity

scientific article

The flt-1 promoter for transcriptional targeting of teratocarcinoma.

scientific article

The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy ⬇️

scientific article published on April 1, 2003

Tissue-specific promoters active in CD44+CD24-/low breast cancer cells

scientific article

Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.

scientific article

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro, in rodents and in humans

scientific article

Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses

scientific article published in October 2007

Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.

scientific article published in March 2002

Treatment of prostate cancer with Ad5/3Delta24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo

scientific article published in February 2007

Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells

scientific article published on 31 March 2006

Verapamil results in increased blood levels of oncolytic adenovirus in treatment of patients with advanced cancer

scientific article published on November 2011

[Adenoviruses in cancer therapy]

scientific article published on 01 January 2005

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