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List of works by David T. Curiel

9 intracellular single-chain antibodies for gene therapy

scientific article published in January 2000

A Multi Targeting Conditionally Replicating Adenovirus Displays Enhanced Oncolysis while Maintaining Expression of Immunotherapeutic Agents

scientific article published on 21 December 2015

A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models

scientific article published on 8 January 2015

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases ⬇️

scientific article published on October 26, 2010

A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine

scientific article

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels ⬇️

scientific article published on November 30, 2010

A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo

scientific article

A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

scientific article published on 13 July 2016

A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial.

scientific article published on August 2000

A cancer terminator virus eradicates both primary and distant human melanomas

scientific article published on 7 March 2008

A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model

scientific article published in February 2003

A carcinoembryonic antigen polynucleotide vaccine for human clinical use.

scientific article

A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity

scientific article published in January 1995

A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.

scientific article

A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect

scientific article

A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma

scientific article published on March 2004

A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer

scientific article

A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.

scientific article published on February 2005

A genetically retargeted adenoviral vector enhances viral transduction in esophageal carcinoma cell lines and primary cultured esophageal resection specimens

scientific article published on December 2003

A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy

scientific article published on December 2005

A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging ⬇️

scientific article published on November 1, 2001

A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene.

scientific article published in March 2002

A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism

scientific article published in May 2003

A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway

scientific article

A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism

scientific article

A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: the safety profile of ad5/3-Δ24 in advance of a phase I clinical trial in ovarian cancer patients

scientific article

A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector

scientific article published on 17 January 2017

A new targeting approach for breast cancer gene therapy using the heparanase promoter

scientific article published on 3 November 2005

A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration

scientific article published on June 2008

A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets

scientific article published in September 2004

A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity

scientific article

A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow

scientific article published on January 1997

A novel system for mitigation of ectopic transgene expression induced by adenoviral vectors

scientific article published in August 2001

A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancer

scientific article

A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer ⬇️

scientific article published on June 10, 2013

A phase I study of recombinant adenovirus vector-mediated delivery of an anti-erbB-2 single-chain (sFv) antibody gene for previously treated ovarian and extraovarian cancer patients

scientific article

A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients

scientific article published in March 1997

A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration

scientific article published on 14 July 2008

A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate system

scientific article published on 01 May 2005

A strategy for adenovirus vector targeting with a secreted single chain antibody

scientific article

A system for the propagation of adenoviral vectors with genetically modified receptor specificities

scientific article

A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo

scientific article published on December 2000

A three-dimensional assay for measurement of viral-induced oncolysis

scientific article published on 19 January 2007

A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritis

scientific article published in December 2001

A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice

scientific article

Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems

scientific article

Activation of Adenovirus Early Promoters and Lytic Phase in Differentiated Strata of Organotypic Cultures of Human Keratinocytes ⬇️

scientific article published on June 1, 2003

Addition of a short peptide ligand to the adenovirus fiber protein.

scientific article published in November 1995

Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production

scientific article published on December 2002

Adeno-associated virus for cancer gene therapy.

scientific article

Adeno-associated virus type 2-mediated transduction of human monocyte-derived dendritic cells: implications for ex vivo immunotherapy

scientific article

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

scientific article published on 6 January 2016

Adenoviral Vector Infection of the Human Exocrine Pancreas ⬇️

scientific article published on September 1, 1997

Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors

scientific article published in August 2002

Adenoviral protein V promotes a process of viral assembly through nucleophosmin 1.

scientific article

Adenoviral targeting using genetically incorporated camelid single variable domains

scientific article

Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells

scientific article published in March 2004

Adenoviral vectors targeted to CD40 enhance the efficacy of dendritic cell-based vaccination against human papillomavirus 16-induced tumor cells in a murine model

scientific article published in October 2000

Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo.

scientific article published on July 1997

Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma

scientific article published in August 1996

Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir

scientific article published on December 1995

Adenoviral-mediated suicide gene therapy for ovarian cancer

scientific article published on November 2000

Adenoviral/retroviral vector chimeras: a novel strategy to achieve high‐efficiency stable transduction in vivo ⬇️

scientific article published on July 1, 1997

Adenovirally Mediated Gene Transfer of Functional Human Tissue–type Plasminogen Activator to Murine Lungs ⬇️

scientific article published on March 1, 1998

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery ⬇️

scientific article published on October 1, 1991

Adenovirus facilitation of molecular conjugate-mediated gene transfer

article

Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer

scientific article published on 21 December 2017

Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors

scientific article published in May 2004

Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter

scientific article published on June 2007

Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells

scientific article published on May 1997

Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157:H7 against fatal systemic intoxication

scientific article

Adenovirus-mediated delivery of p16 to p16-deficient human bladder cancer cells confers chemoresistance to cisplatin and paclitaxel.

scientific article

Adenovirus-mediated gene delivery to dendritic cells.

scientific article published on January 2004

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene

scientific article

Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells

scientific article published on July 3, 1998

Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma

scientific article

Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells

scientific article published in February 2000

Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinoma.

scientific article

Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells

scientific article published in August 2002

Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery

scientific article published in February 2005

Administration of a conditionally replicative oncolytic canine adenovirus in normal dogs

article

Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity

scientific article

Advanced generation adenoviral virotherapy agents embody enhanced potency based upon CAR-independent tropism

scientific article

Advancements in adenoviral based virotherapy for ovarian cancer

scientific article published on 05 May 2009

An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles

scientific article published on February 2008

An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations ⬇️

scientific article published on September 9, 2010

An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer

scientific article published in June 2000

An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma

scientific article published in March 2003

An adenovirus serotype 5 vector with fibers derived from ovine atadenovirus demonstrates CAR-independent tropism and unique biodistribution in mice

scientific article published on 3 March 2006

An adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer

scientific article

An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism

scientific article published on June 2004

An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery

scientific article published on January 2006

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

scientific article

An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

scientific article

An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches

scientific article published in August 1999

An allogeneic hybrid-cell fusion vaccine against canine mammary cancer

scientific article

An ex vivo human model system to evaluate specificity of replicating and non-replicating gene therapy agents

scientific article

An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2.

scientific article published on April 1997

Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypic cultures.

scientific article published on April 2004

Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium

scientific article

Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor

scientific article published on January 2005

Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice

scientific article published on March 2000

Antineoplastic effect of anti-erbB-2 intrabody is not correlated with scFv affinity for its target

scientific article published on September 2000

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity ⬇️

scientific article published on May 9, 2011

Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression ⬇️

scientific article published on March 1, 1998

Approaches to enhance cancer radiotherapy employing gene transfer methods

scientific article

Approaches to utilize mesenchymal progenitor cells as cellular vehicles

scientific article published in January 2003

Artificial Extension of the Adenovirus Fiber Shaft Inhibits Infectivity in Coxsackievirus and Adenovirus Receptor-Positive Cell Lines ⬇️

scientific article published on February 1, 2002

Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor

scientific article published on 9 August 2013

Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor

scientific article published in March 2015

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)

scientific article published on September 2011

Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer ⬇️

scientific article published on October 1, 1998

Bax-induced apoptosis as a novel gene therapy approach for carcinoma of the cervix

scientific article

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB.

scientific article

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway

scientific article published in April 1993

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity ⬇️

scientific article published on April 21, 2003

Blood clearance rates of adenovirus type 5 in mice

scientific article published in November 2000

Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension

scientific article published on 2 February 2007

CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

scientific article

CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses

scientific article published in February 2003

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation ⬇️

scientific article published on October 6, 2003

CD40‐targeted adenoviral cancer vaccines: the long and winding road to the clinic ⬇️

scientific article published on June 1, 2012

COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

scientific article published on 17 January 2017

CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter

scientific article

Cancer gene therapy and immunotherapy.

scientific article published in January 2003

Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control

scientific article

Capsid-incorporation strategy to display antigens for an alternative adenoviral vector vaccine approach

scientific article published on 06 November 2018

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

scientific article published on February 2008

Cell cycle arrest and apoptosis induced by SART-1 gene transduction

scientific article

Cell vehicle targeting strategies

scientific article published on 27 March 2008

Cellular vehicles for cancer gene therapy: current status and future potential

scientific article

Chapter two--Adenovirus strategies for tissue-specific targeting

scientific article

Characterization of a messenger RNA polynucleotide vaccine vector.

scientific article published on April 1995

Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob ⬇️

scientific article published on March 1, 1998

Characterization of the canine mda-7 gene, transcripts and expression patterns

scientific article

Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers

scientific article

Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA.

scientific article published on August 2004

Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells

scientific article

Chimeric viral vectors--the best of both worlds?

scientific article

Circumventing recombination events encountered with production of a clinical-grade adenoviral vector with a double-expression cassette

scientific article published on 8 August 2006

Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells

scientific article

Combination of conditionally replicative adenovirus and standard chemotherapies shows synergistic antitumor effect in pancreatic cancer

scientific article

Combination therapy with conditionally replicating adenovirus and replication defective adenovirus

scientific article published on September 2004

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer

scientific article published on 27 June 2016

Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells

scientific article published in May 1998

Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.

scientific article

Combined transcriptional and transductional targeting improves the specificity and efficacy of adenoviral gene delivery to ovarian carcinoma

scientific article published in July 2003

Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo

scientific article

Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors

scientific article

Combining chemotherapy with virotherapy: a novel treatment strategy for malignant pleural mesothelioma

scientific article published on 3 February 2006

Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer

scientific article published on February 2007

Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells

scientific article published in December 2004

Complementation of a human adenovirus early region 4 deletion mutant in 293 cells using adenovirus-polylysine-DNA complexes.

scientific article published on June 1995

Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectors.

scientific article published on May 2005

Conditionally replicative adenoviral vectors for cancer gene therapy

scientific article

Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo

scientific article

Conditionally replicative adenoviruses for cancer therapy

scientific article published in August 1997

Conditionally replicative adenoviruses for ovarian cancer therapy

scientific article

Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon

scientific article

Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein

scientific article published in November 2002

Construction and radiolabeling of adenovirus variants that incorporate human metallothionein into protein IX for analysis of biodistribution

scientific article

Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system

scientific article published on February 1999

Construction of adenovirus vectors for transcriptional targeting.

scientific article

Construction of adenovirus vectors with RGD-modified fiber for transductional targeting

scientific article published in May 2009

Contrasting effects of human, canine, and hybrid adenovirus vectors on the phenotypical and functional maturation of human dendritic cells: implications for clinical efficacy

scientific article published on 17 January 2007

Core labeling of adenovirus with EGFP.

scientific article published on 6 May 2006

Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2.

scientific article

Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy

scientific article published in April 2006

Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells

scientific article

CryoEM visualization of an adenovirus capsid-incorporated HIV antigen

scientific article

Crystallographic Structure of Porcine Adenovirus Type 4 Fiber Head and Galectin Domains

scientific article

Current developments in adenovirus-based cancer gene therapy

scientific article

Current issues and future directions of oncolytic adenoviruses

scientific article

Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma

scientific article published in June 2003

Cytoprotection of pancreatic islets before and early after transplantation using gene therapy

scientific article

Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene

scientific article published in April 2001

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

scientific article published on 15 February 2019

Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine

scientific article

Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan

scientific article published in January 2006

Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector

scientific article

Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation

scientific article

Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX.

scientific article

Derivation of a triple mosaic adenovirus for cancer gene therapy

scientific article

Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement

scientific article published in March 2003

Development of an adenovirus vector vaccine platform for targeting dendritic cells

scientific article

Development of an optimized conditionally replicative adenoviral agent for ovarian cancer

scientific article

Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer

scientific article published in December 1998

Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob

scientific article

Directing adenovirus across the blood-brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model

scientific article published on 30 November 2006

Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets

scientific article

Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency

scientific article published in September 2002

Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cells

scientific article

Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling

scientific article published on February 2006

E1A RNA transcripts amplify adenovirus-mediated tumor reduction.

scientific article published in November 1996

Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells

scientific article

Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds

scientific article published on 12 January 2007

Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv

scientific article

Efficient Gene Transfer to Dispersed Human Pancreatic Islet Cells In Vitro Using Adenovirus-Polylysine/DNA Complexes or Polycationic Liposomes

article

Efficient Gene Transfer to Human Endothelial Cells Using DNA Complexed to Adenovirus Particles ⬇️

scientific article published on August 1, 1998

Efficient delivery of triplex forming oligonucleotides to tumor cells by adenovirus-polylysine complexes

scientific article

Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells

scientific article published in February 1994

Efficient gene delivery into epstein-barr virus (EBV)-transformed human B cells mediated by replication-defective herpes simplex virus-1 (HSV-1): A gene therapy model for EBV-related B cell malignancy

scientific article published on November 1998

Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells

scientific article

Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors

scientific article published in February 2001

Efficient transfection of primary cells in a canine hemophilia B model using adenovirus-polylysine-DNA complexes

scientific article published on March 1994

Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents

scientific article published in June 2006

Employment of microarray analysis to characterize biologic differences associated with tropism-modified adenoviral vectors: utilization of non-native cellular entry pathways

scientific article published on February 2005

Endothelial cell vehicles for delivery of cytotoxic genes as a gene therapy approach for carcinoma of the ovary ⬇️

scientific article published on February 1, 1998

Engineering of adenovirus vectors containing heterologous peptide sequences in the C terminus of capsid protein IX.

scientific article

Engineering regulatory elements for conditionally-replicative adeno-viruses

scientific article

Engineering targeted viral vectors for gene therapy

scientific article published on 3 July 2007

Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism ⬇️

scientific article published on September 1, 2003

Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

Enhanced Gene Delivery to Human Primary Endothelial Cells Using Tropism-Modified Adenovirus Vectors

scientific article published on January 2008

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

scientific article

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells

scientific article published on May 2012

Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter molecule

scientific article published on May 2004

Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV) ⬇️

scientific article published on January 1, 2014

Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

scientific article published in September 2003

Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus

scientific article published in September 2006

Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession

scientific article published on 10 June 2008

Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene

scientific article published on July 1996

Enhancing Adenoviral-Mediated Gene Transfer and Expression to Endometrial Cells

scientific article

Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

scientific article

Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma

scientific article published on September 2002

Epidermal growth factor receptor targeting of replication competent adenovirus enhances cytotoxicity in bladder cancer

scientific article published in July 2002

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus

scientific article published on June 2007

Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach

scientific article

Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology

scientific article published on 4 May 2016

Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor

scientific article published on February 2007

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

scientific article published in August 2004

Evaluation of adenovirus capsid labeling versus transgene expression

scientific article

Evaluation of tissue-specific promoters in carcinomas of the cervix uteri

scientific article published on November 2004

Evaluation of tumor-specific promoter activities in melanoma.

scientific article published on February 2005

Evolving gene therapy approaches for osteosarcoma using viral vectors: review

scientific article published on 26 December 2006

Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus

scientific article

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

scientific article published on 7 December 2007

Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells

scientific article published on April 2001

Fiber shaft extension in combination with HI loop ligands augments infectivity for CAR-negative tumor targets but does not enhance hepatotropism in vivo

scientific article

Fiber-modified adenoviruses for targeted gene therapy

scientific article

Fiber-mosaic adenovirus as a novel approach to design genetically modified adenoviral vectors

scientific article published on September 2004

Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice

scientific article published on June 1999

Fluorescently labeled adenovirus with pIX-EGFP for vector detection

scientific article published on April 2004

Fluorescently tagged canine adenovirus via modification with protein IX-enhanced green fluorescent protein

scientific article published on December 2005

Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models

scientific article published in June 2000

From gene therapy to virotherapy for ovarian cancer.

scientific article

Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome

scientific article

Functional Knock-Out of c-myb by an Intracellular Anti-c-Myb Single-Chain Antibody ⬇️

scientific article published on October 9, 1998

Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice

scientific article

Gene Therapy:Ovarian Carcinoma as the Paradigm ⬇️

scientific article published on April 1, 1998

Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo versus in vitro models

scientific article published on 23 May 2007

Gene therapy and ovarian cancer: a review

scientific article

Gene therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria toxin gene delivered by a novel adenovirus-polylysine conjugate

scientific article published on January 1994

Gene therapy for cancer

scientific article

Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses

scientific article

Gene therapy for meningioma: improved gene delivery with targeted adenoviruses

scientific article published in August 2002

Gene therapy for ovarian cancer: progress and potential

scientific article

Gene therapy for ovarian carcinoma

scientific article published on June 1, 1998

Gene therapy for renal cancer

scientific article published in January 2008

Gene therapy for the treatment of cancer

scientific article

Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

scientific article published in November 2000

Gene therapy strategies for AIDS-related malignancies ⬇️

scientific article published on December 1, 1997

Gene therapy strategies for carcinoma of the breast ⬇️

scientific article published on June 1, 1997

Gene therapy strategies for novel cancer therapeutics

scientific article published on January 1996

Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts

scientific article published in May 2000

Gene therapy: human germline genetic modifications--assessing the scientific, socioethical, and religious issues

scientific article published in January 2007

Gene therapy: science fiction or reality?

scientific article published on January 2007

Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement

scientific article published in August 2001

Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system

scientific article published on 8 November 2005

Gene transfer to cervical cancer with fiber-modified adenoviruses

scientific article published in September 2004

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

scientific article

Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway

scientific article published on March 1992

Generation and selection of targeted adenoviruses embodying optimized vector properties

scientific article published on 15 November 2005

Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob

scientific article published in February 2003

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism.

scientific article published in October 1996

Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene

scientific article published in February 1999

Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion

scientific article

Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virion

scientific article published on October 2006

Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging

scientific article (publication date: 9 February 2011)

Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation

scientific article published in March 1999

Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapy

scientific article published on May 2004

Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin

scientific article published on May 2001

Genetic targeting strategies for adenovirus

scientific article

Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model

scientific article published in January 2000

Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets

scientific article published in March 2002

Genetically targeted adenovirus vector directed to CD40-expressing cells

scientific article published on November 2003

HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach ⬇️

scientific article published on July 27, 2010

HSV-1 virions engineered for specific binding to cell surface receptors

scientific article published on March 2004

Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus ⬇️

scientific article published on December 1, 2001

Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver

scientific article published on June 2002

High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN.

scientific article published on 20 March 2005

High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector

scientific article published in November 1998

High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes

scientific article published on March 1994

High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes

scientific article published on April 1992

High-efficiency gene transfer mediated by adenovirus-polylysine-DNA complexes

scientific article published on May 1994

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.

scientific article published on 08 March 2009

Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation Is Compatible with Adenovirus Replication and Facilitates Efficient Dispersion of Viral Gene Products andDe Novo-Synthesized Virus Particles ⬇️

scientific article published on December 10, 2001

Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment

scientific article published on 18 October 2006

Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes

scientific article published on August 2001

Humoral and cellular immune responses of dogs immunized with a nucleic acid vaccine encoding human carcinoembryonic antigen

scientific article published in July 1998

Icodextrin enhances survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy

scientific article published on 20 July 2006

Identification of sites in adenovirus hexon for foreign peptide incorporation

scientific article

Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancer.

scientific article

Identifying the safety profile of a novel infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-RGD, in anticipation of a phase I trial for recurrent ovarian cancer

scientific article published on 01 April 2007

Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5) ⬇️

scientific article published on June 1, 1998

Immune response to a carcinoembryonic antigen polynucleotide vaccine.

scientific article published in March 1994

Immunization with a plasmid expressing pneumococcal surface protein A (PspA) can elicit protection against fatal infection with Streptococcus pneumoniae

scientific article

Improved anti-tumor therapy based upon infectivity-enhanced adenoviral delivery of RNA interference in ovarian carcinoma cell lines

scientific article published on 03 December 2007

Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors

scientific article

In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer

scientific article

In vitro dynamic visualization analysis of fluorescently labeled minor capsid protein IX and core protein V by simultaneous detection

scientific article published on 21 October 2009

In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin

scientific article published in June 2006

In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacy

scientific article

In vivo gene transfer to the human biliary tract

scientific article

In vivo imaging of adenovirus transduction and enhanced therapeutic efficacy of combination therapy with conditionally replicating adenovirus and adenovirus-p27.

scientific article published on January 2006

In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector

scientific article published on February 1999

In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus

scientific article

Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo.

scientific article published on July 2005

Incorporation of β-globin untranslated regions into a Sindbis virus vector for augmentation of heterologous mRNA expression ⬇️

scientific article published on June 1, 1997

Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells

scientific article published in November 1998

Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma

scientific article published in August 2004

Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer ⬇️

scientific article published on October 1, 2003

Infectivity enhanced, hTERT promoter-based conditionally replicative adenoviruses are useful for SCLC treatment

scientific article

Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells

scientific article published on March 2006

Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

scientific article published in May 2006

Inhibition of Tumor Necrosis FactorαDecreases Inflammation and Prolongs Adenovirus Gene Expression in Lung and Liver ⬇️

scientific article published on September 1, 1998

Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma

scientific article

Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy

scientific article

Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas

scientific article published on September 2006

Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy.

scientific article

Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosis

scientific article

Intracellular expression of a single-chain antibody directed against human papillomavirus type 16 E7 oncoprotein achieves targeted antineoplastic effects ⬇️

scientific article published on May 1, 1998

Intracellular expression of the anti-erbB-2 sFv N29 fails to accomplish efficient target modulation

scientific article published on September 1998

Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines

scientific article published on September 1, 1994

Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity.

scientific article published in July 2003

Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer

scientific article

Lipid- and adenoviral-mediated gene transfer into AIDS-Kaposi's sarcoma cell lines

scientific article published on May 1, 1998

Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer ⬇️

scientific article published on 01 August 1997

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9

scientific article published on 13 February 2019

Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling

scientific article

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells

scientific article published on 10 August 2004

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

scientific article

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors

scientific article published on 19 March 2008

MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?

scientific article

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism

scientific article

MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo

scientific article published on 15 October 2006

Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector

scientific article published on June 1999

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine

scientific article

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?

scientific article published on May 2007

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma

scientific article published on 23 November 2006

Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress

scientific article

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

scientific article published on November 2007

Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors

scientific article

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology

scientific article published on 3 March 2016

Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses

scientific article published on March 2006

Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma

scientific article published on 13 January 2007

Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy

scientific article

Methods for Gene Transfer Using DNA-Adenovirus Conjugates

scientific article published in January 1997

Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma ⬇️

scientific article published on December 1, 2001

Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor

scientific article published in April 2002

Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors

scientific article

Minting a new class of polo-like-kinase inhibitors

scientific article

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

scientific article published on September 2008

Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo

scientific article published on March 2004

Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7 ⬇️

scientific article published on May 15, 1998

Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein

scientific article

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

scientific article published in February 2003

Modulation of renal glomerular disease using remote delivery of adenoviral‐encoded solubletype II TGF‐β receptor fusion molecule ⬇️

scientific article published on October 1, 2003

Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses

scientific article published on 01 January 2008

Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo ⬇️

scientific article published on October 1, 1997

Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene

scientific article published on February 2004

Monitoring of biodistribution and persistence of conditionally replicative adenovirus in a murine model of ovarian cancer using capsid-incorporated mCherry and expression of human somatostatin receptor subtype 2 gene

scientific article published on January 2014

Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.

scientific article published in May 1995

New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry

scientific article

Nonhuman primate models in type 1 diabetes research

scientific article published in January 2004

Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus

scientific article

Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene

scientific article

Noninvasive monitoring of mRFP1- and mCherry-labeled oncolytic adenoviruses in an orthotopic breast cancer model by spectral imaging

scientific article

Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein

scientific article

Nonreplicating DNA viral vectors for suicide gene therapy: the adenoviral vectors.

scientific article published on January 2004

Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity.

scientific article published in July 1996

Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer

scientific article published on September 2009

Novel oncolytic adenoviruses targeted to melanoma: specific viral replication and cytolysis by expression of E1A mutants from the tyrosinase enhancer/promoter

scientific article published in August 2002

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

scientific article

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells

scientific article published on 08 January 2008

Oncolytic adenoviral therapy in gallbladder carcinoma

scientific article

Oncolytic adenoviruses - selective retargeting to tumor cells

scientific article

Oncolytic adenoviruses targeted to cancer stem cells

scientific article published on 11 August 2009

Oncolytic virotherapy of meningiomas in vitro with replication-competent adenovirus

scientific article

Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach

scientific article published on 21 August 2008

Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model

scientific article

Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy

scientific article published on 12 October 2005

Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv.

scientific article

Overexpression of Adenovirus-Encoded Transgenes from the Cytomegalovirus Immediate Early Promoter in Irradiated Tumor Cells ⬇️

scientific article published on November 20, 1997

PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles.

scientific article published on May 2005

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

scientific article published on 17 January 2008

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

scientific article published on 13 February 2008

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells

scientific article

PI3K: A rational target for ovarian cancer therapy?

scientific article

Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene

scientific article published in May 1997

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate ⬇️

scientific article published on July 21, 1998

Phage display of adenovirus type 5 fiber knob as a tool for specific ligand selection and validation

scientific article

Phenotypic knock-out of the latent membrane protein 1 of Epstein-Barr virus by an intracellular single-chain antibody

scientific article published on September 1998

Polynucleotide immunization of nonhuman primates against carcinoembryonic antigen.

scientific article published in November 1998

Polynucleotide-mediated immunization therapy of cancer.

scientific article published on February 1996

Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine

scientific article published on 11 July 2011

Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.

scientific article published in October 2002

Preclinical Characterization of the Antiglioma Activity of a Tropism-Enhanced Adenovirus Targeted to the Retinoblastoma Pathway ⬇️

scientific article published on May 7, 2003

Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy

scientific article published in May 2004

Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system

scientific article

Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation

scientific article

Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer

scientific article published in March 2000

Production of an EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potential

scientific article published in August 2003

Productive replication of human adenovirus type 5 in canine cells.

scientific article

Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors

scientific article published on 01 November 2002

Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein

scientific article

Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer.

scientific article published on January 2005

Promotion of incisional wound repair by human mesenchymal stem cell transplantation

scientific article published on 18 September 2008

Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels

scientific article published on 30 January 2016

RETRACTED: Insulin-like Growth Factor-binding Protein-7 (IGFBP7); A Promising Gene Therapeutic for Hepatocellular Carcinoma (HCC) ⬇️

scientific article published on January 15, 2013

Radiation-induced cell signaling: inside-out and outside-in

scientific article published on March 2007

Rational design of viral vectors based on rigorous analysis of capsid structures

scientific article published in January 2000

Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression ⬇️

scientific article published on June 18, 1998

Receptor-mediated gene transfer to airway epithelial cells in primary culture

scientific article published on October 1993

Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection ⬇️

scientific article published on 01 December 2001

Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus

scientific article published in May 2001

Recombinant adenovirus-mediated gene transfer to genitourinary epithelium in vitro and in vivo

scientific article published on June 1995

Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene

scientific article published in August 1999

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

scientific article

Reovirus sigma1 fiber incorporated into adenovirus serotype 5 enhances infectivity via a CAR-independent pathway

scientific article

Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids ⬇️

scientific article published on May 1, 2003

Replicative adenoviruses for cancer therapy

scientific article

Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins ⬇️

scientific article published on April 1, 2011

Retargeted oncolytic adenovirus displaying a single variable domain of camelid heavy-chain-only antibody in a fiber protein

scientific article published on 18 February 2015

Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single‐chain diabody (scDb) adapter that binds to fiber knob and HMWMAA ⬇️

scientific article published on January 1, 2004

Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin

scientific article published in September 2000

Retargeting of gene expression using endothelium specific hexon modified adenoviral vector

scientific article published on 15 October 2013

Retargeting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma

scientific article published in August 1999

SEREX analysis for tumor antigen identification in a mouse model of adenocarcinoma

scientific article published in March 2000

Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients.

scientific article published in September 2002

Scavenger receptor A: a new route for adenovirus 5.

scientific article published in March 2009

Searching for a cure: gene therapy for glioblastoma

scientific article published on 02 September 2008

Selected strategies to augment polynucleotide immunization

scientific article

Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector

scientific article published in September 1999

Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors

scientific article published on May 2001

Selective transduction of mature DC in human skin and lymph nodes by CD80/CD86-targeted fiber-modified adenovirus-5/3.

scientific article published in November 2009

Selective transduction of murine myelomonocytic leukemia cells (WEHI-3B) with regular and RGD-adenoviral vectors

scientific article

Selectivity of TAG-72-targeted adenovirus gene transfer to primary ovarian carcinoma cells versus autologous mesothelial cells in vitro.

scientific article published in November 2000

Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy

scientific article

Serum and ascites neutralizing antibodies in ovarian cancer patients treated with intraperitoneal adenoviral gene therapy

scientific article published in August 2002

Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells

scientific article published on 29 November 2007

Single-chain antibodies: A therapeutic modality for cancer gene therapy (review).

scientific article published on April 2004

Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes

scientific article

Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors

scientific article published in May 1999

Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector ⬇️

scientific article published on September 1, 1997

Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications

scientific article

Strategies to accomplish targeted gene delivery to muscle cells employing tropism-modified adenoviral vectors ⬇️

scientific article published on July 1, 1997

Strategies to adapt adenoviral vectors for targeted delivery

scientific article

Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds

scientific article

Strategy for achieving selective killing of carcinomas

scientific article published on January 1, 1994

Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas

scholarly article

Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy

scientific article

Substitution of the adenovirus serotype 5 knob with a serotype 3 knob enhances multiple steps in virus replication.

scientific article published in March 2003

Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells

scientific article

Surfactant protein A-directed toxin gene kills lung cancer cells in vitro

scientific article published on January 1994

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs

scientific article published on March 2017

Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma.

scientific article published on November 2006

Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma

scientific article

Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy

scientific article published on 22 April 2009

Targeted adenoviral vectors for cancer gene therapy.

scientific article

Targeted and shielded adenovectors for cancer therapy

scientific article

Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors

scientific article

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva

scientific article published on June 2008

Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody

scientific article

Targeted gene delivery by tropism-modified adenoviral vectors ⬇️

scientific article published on November 1, 1996

Targeted gene therapy for ovarian cancer

scientific article

Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9.

scientific article published on 27 March 2018

Targeted tumor killing via an intracellular antibody against erbB-2.

scientific article published on December 1995

Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus

scientific article

Targeting Mcl-1 for the therapy of cancer

scientific article

Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas

scientific article published on 02 July 2013

Targeting adenovirus to CD80 and CD86 receptors increases gene transfer efficiency to malignant glioma cells

scientific article published in September 2007

Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

scientific article

Targeting lung cancer using an infectivity enhanced CXCR4-CRAd

scientific article published on 17 November 2006

Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenoviruses

scientific article

Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neck

scientific article

Targeting of adenoviral vectors through a bispecific single-chain antibody

scientific article published in June 2000

Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody

scientific article published on 13 March 2009

Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge

scientific article

Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor

scientific article

Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule

scientific article

Targeting strategies for cancer radiotherapy

scientific article

Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562.

scientific article

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

scientific article

The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context

scientific article published on February 2006

The development of MDA-7/IL-24 as a cancer therapeutic ⬇️

scientific article published on August 21, 2010

The development of conditionally replicative adenoviruses for cancer therapy.

scientific article

The flt-1 promoter for transcriptional targeting of teratocarcinoma.

scientific article

The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma

scientific article published on April 2006

The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv ⬇️

scientific article published on May 1, 1998

The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting

scientific article

The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

scientific article published on November 2005

The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro

scientific article published in November 2002

The potential of virus-based gene therapies for treatment of metastatic kidney cancer ⬇️

scientific article published on June 1, 2011

The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses.

scientific article published in November 2002

The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy ⬇️

scientific article published on April 1, 2003

The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells

scientific article published in September 2002

The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses

scientific article

Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer

scientific article published on 12 September 2014

Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer

scientific article published on August 1999

Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor

scientific article

Three-dimensional structure of canine adenovirus serotype 2 capsid

scientific article published on 23 January 2008

Toward a new generation of conditionally replicating adenoviruses: pairing tumor selectivity with maximal oncolysis

scientific article

Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells

scientific article

Toward gene therapy of uterine fibroids: targeting modified adenovirus to human leiomyoma cells

scientific article published on 8 January 2008

Towards a double controlled conditionally replicative adenovirus for potent and specific melanoma cell kill.

scientific article

Towards the optimal vector for prostate cancer gene therapy; a caPCURE meeting report

scientific article published in December 2000

Towards the use of replicative adenoviral vectors for cancer gene therapy.

scientific article

Trans complementation of an E1A-deleted adenovirus with codelivered E1A sequences to make recombinant adenoviral producer cells

scientific article published on 01 November 1994

Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with e1 deleted

scientific article

Transcriptional blocks limit adenoviral replication in primary ovarian tumor

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Transcriptional targeting for ovarian cancer gene therapy

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