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List of works by Katherine Leach

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands

scientific article published on 7 March 2018

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

scientific article published on 13 July 2007

Allosteric Modulation of G Protein–Coupled Receptors

scientific article published on 01 January 2007

Analysis of second messenger pathways stimulated by different chemokines acting at the chemokine receptor CCR5.

scientific article published on 20 June 2007

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

scientific article published on 4 June 2015

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

article

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

scientific article

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells.

scientific article

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.

scientific article published in May 2018

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

scientific article published on March 2014

Identification of global and ligand-specific calcium sensing receptor activation mechanisms

scientific article published on 10 April 2018

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.

scientific article

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

scientific article published on 14 April 2019

Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.

scientific article

Induced Pluripotent Stem Cell–Derived Podocyte-Like Cells as Models for Assessing Mechanisms Underlying Heritable Disease Phenotype: Initial Studies Using Two Alport Syndrome Patient Lines Indicate Impaired Potassium Channel Activity

scientific article published on 13 August 2018

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

scientific article published on 11 February 2019

L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells

scientific article published on 01 July 2019

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

scientific article published on April 2015

Metabotropic glutamate receptor 5 (mGlu5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons

scientific article published on 26 August 2019

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.

scientific article published on 10 December 2016

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

scientific article published on 19 January 2016

Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain

scientific article published on 12 February 2020

Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.

scientific article published on 11 November 2016

Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.

scientific article

Quantification of allosteric interactions at G protein-coupled receptors using radioligand binding assays

scientific article published on 01 March 2011

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

scientific article published on 21 January 2015

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor

scientific article published on 28 July 2014

Structure–Function Studies of Muscarinic Acetylcholine Receptors ⬇️

scientific article published on January 1, 2012

The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor.

scientific article published on 7 February 2011

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

scientific article published on 22 March 2016

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias

scientific article published on 09 March 2015

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