List of works - Jean Marc Pascussi

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

scientific article published on June 2009

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

scientific article published on 11 May 2016

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

scientific article published on 10 August 2015

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.

scientific article published on 4 May 2016

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site

scientific article

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

scientific article

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

scientific article published on September 2011

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor

scientific article

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

scientific article

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

scientific article

Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification

scientific article published in June 2005

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

scientific article published on December 2001

Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.

scientific article published on 12 October 2011

Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression

scientific article

Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

scientific article

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

scientific article

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.

scientific article published on 10 November 2017

Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).

scientific article published on 25 February 2010

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

scientific article published on 24 March 2006

Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.

scientific article published on 15 October 2010

Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.

scientific article

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

scientific article

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

scientific article

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.

scientific article published on 27 May 2016

Mechanisms of resistance of cancer stem cells to chemotherapy

scientific article published on 21 November 2017

Metabonomic studies on human hepatocyte in primary culture.

scientific article published on January 2010

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

scientific article published on 3 December 2007

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

scientific article

Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.

scientific article published in March 2007

Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.

scientific article published on 11 August 2011

Pathophysiological factors affecting CAR gene expression.

scientific article published on November 2003

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

scientific article

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.

scientific article published on 22 July 2017

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

scientific article published on 18 July 2016

Response to Zhou et al. Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital.

scientific article published in October 2006

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

scientific article

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

scientific article published on 09 June 2017

The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

scientific article published on 28 September 2016

The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes.

scientific article published on 16 December 2011

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

scientific article

The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.

scientific article

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

scientific article

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

scientific article published on January 2008

Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells.

scientific article published on 6 March 2018

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

scientific article published on 28 April 2008

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

scientific article

Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3

scientific article published on 01 June 2006

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

scientific article published on 27 December 2007

List of works by Jean Marc Pascussi

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.

Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression

Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.

Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.

Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.

Mechanisms of resistance of cancer stem cells to chemotherapy

Metabonomic studies on human hepatocyte in primary culture.

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.

Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.

Pathophysiological factors affecting CAR gene expression.

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Response to Zhou et al. Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital.

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes.

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells.

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.