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List of works by Vijay Chudasama

A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

scientific article

A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics

scientific article published on 02 March 2020

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

scientific article published on 01 October 2018

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.

scientific article published in March 2015

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

scientific article published on July 2013

A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.

scientific article published on 18 June 2013

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

scientific article published on 4 March 2015

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

scientific article published on 25 June 2015

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

scientific article

A rapid, site-selective and efficient route to the dual modification of DARPins.

scientific article

A versatile synthesis of 2,4-substituted oxazoles.

scientific article published on 16 June 2008

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

scientific article published on September 2013

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.

scientific article published on 29 November 2013

Advances in targeting the folate receptor in the treatment/imaging of cancers.

scientific article

Aerobically-initiated C(sp3)-H bond amination through the use of activated azodicarboxylates

scientific article published on 06 August 2020

An overview of the synthesis of acyl hydrazides from aldehydes and reactions of the products thereof.

scientific article

Antibody - Drug conjugates (ADC) - Drug discovery today: Technologies

scientific article published on 01 December 2018

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

scientific article

Assembly of High-Potency Photosensitizer-Antibody Conjugates through Application of Dendron Multiplier Technology.

scientific article

Bromomaleimide-linked bioconjugates are cleavable in mammalian cells

scientific article published on 18 November 2011

Cysteine-to-lysine transfer antibody fragment conjugation

scientific article published on 11 October 2019

Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water

scientific article published on 13 November 2009

Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions

scientific article published on 18 March 2019

Dual modification of biomolecules.

scientific article

E- and Z-stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates

scientific article published on 29 November 2011

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

scientific article

Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker)

scientific article published on 01 January 2020

Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides

scientific article published on 17 December 2019

Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments.

scientific article published on 14 August 2017

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

scientific article published on 05 June 2015

Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water

scientific article published on 01 February 2011

Functionalised thermally induced phase separation (TIPS) microparticles enabled for "click" chemistry

scientific article published on 01 March 2020

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.

scientific article

Homogeneous antibody-drug conjugates via site-selective disulfide bridging

scientific article published on 12 October 2018

Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation

scientific article published on 06 June 2010

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

scientific article published on 01 March 2016

Metal-free, hydroacylation of C=C and N=N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof

scientific article published on 01 November 2013

Minireview: Addressing the retro-Michael instability of maleimide bioconjugates

scientific article published on 29 July 2018

Motional timescale predictions by molecular dynamics simulations: case study using proline and hydroxyproline sidechain dynamics.

scientific article published on 17 September 2013

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

scientific article published on October 2014

Next-generation disulfide stapling: reduction and functional re-bridging all in one.

scientific article published on 15 September 2015

Optical control of trimeric P2X receptors and acid-sensing ion channels

scientific article published on 23 December 2013

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

scientific article published on 14 March 2017

Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers

scientific article published on 01 August 2019

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

scientific article published on 01 June 2019

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines

scientific article published on 01 January 2016

Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range

scientific article published on 7 December 2017

Recent advances in metal-free aerobic C-H activation

scientific article published on 01 March 2019

Recent advances in the construction of antibody-drug conjugates

scientific article published on 04 January 2016

Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells

scientific article published on 21 May 2020

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment

scientific article published on 7 March 2014

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.

scientific article published on 4 September 2015

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation

scientific article published on 23 January 2020

Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation.

scientific article

Synthesis of novel and potent vorapaxar analogues.

scientific article published in March 2016

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

scientific article

Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.

scientific article published on 21 November 2013

Tyrosine bioconjugation - an emergent alternative

scientific article published on 03 November 2020

Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation

scientific article published on 01 December 2019