List of works - Paola Rognoni

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

scientific article

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum.

scientific article published on 4 January 2011

A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli

scientific article

Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy ⬇️

scientific article published on October 14, 2010

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

scientific article published on 28 January 2017

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

scientific article published in December 2017

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

scientific article published on 20 March 2019

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

scientific article published in 2024

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

scientific article published on 04 July 2016

In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.

scientific article

Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: A lesson from C. elegans

scientific article published on July 2014

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

scientific article published on 20 September 2020

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis.

scientific article published on 28 July 2015

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

scientific article

Regulated expression of amyloidogenic immunoglobulin light chains in mice

SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase.

scientific article

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

scientific article

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity.

scientific article

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.

scientific article published on 8 November 2011

List of works by Paola Rognoni

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum.

A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli

Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy ⬇️

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.

Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: A lesson from C. elegans

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis.

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

Regulated expression of amyloidogenic immunoglobulin light chains in mice

SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase.

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity.

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.