List of works - Yukio Ago

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

scientific article published on 01 October 2019

A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.

scientific article published on 5 June 2008

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

scientific article published on 13 April 2011

An enriched environment ameliorates memory impairments in PACAP-deficient mice

scientific article

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. ⬇️

scientific article published on 17 December 2016

Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression.

scientific article

Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.

scientific article published on 31 May 2007

Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.

scientific article

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

scientific article

Atomoxetine-induced increases in monoamine release in the prefrontal cortex are similar in spontaneously hypertensive rats and Wistar-Kyoto rats

scientific article published on 15 March 2014

Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice.

scientific article

Autism-associated protein kinase D2 regulates embryonic cortical neuron development

scientific article published on 18 September 2019

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid ⬇️

scientific article published on November 18, 2011

Behavioral characterization of mice overexpressing human dysbindin-1.

scientific article

Beneficial Effect of Galantamine on Sensory Information-processing Deficits ⬇️

scientific article published on October 1, 2010

Brain microdialysis of isolation-reared mice under freely-moving conditions

scientific article published in August 2003

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

scientific article published on 16 February 2015

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

scientific article published on 18 September 2014

Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.

scientific article published on 5 June 2015

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

scientific article published on 7 August 2016

Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses.

scientific article

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.

scientific article

Effect of prenatal valproic acid exposure on cortical morphology in female mice.

scientific article published on 22 March 2012

Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum

scientific article published on 20 February 2014

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

scientific article

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice.

scientific article published on 6 February 2010

Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and σ(1) receptor activation

scientific article published on 13 April 2011

Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.

scientific article published on 3 October 2007

Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice

scientific article

Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice ⬇️

scientific article published on August 30, 2012

Galantamine promotes adult hippocampal neurogenesis via M₁ muscarinic and α7 nicotinic receptors in mice

scientific article published on 12 May 2014

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

scientific article

High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.

scientific article

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

scientific article published on 23 January 2015

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

scientific article

Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism

scientific article published on 30 December 2015

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

scientific article published on 21 October 2010

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

scientific article published on 23 June 2016

Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.

scientific article published in December 2001

Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation.

scientific article

Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice.

scientific article published on 9 January 2014

Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice.

scientific article published on 29 December 2012

Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain.

scientific article

Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice

scientific article published on 30 November 2018

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

scientific article published on 25 January 2018

LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth

scientific article published on 01 January 2018

Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex.

scientific article published on 28 November 2006

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

scientific article published on 08 October 2020

Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release.

scientific article published on 12 October 2011

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.

scientific article published on 25 September 2012

Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder, through α2-adrenoceptor activation.

scientific article published in August 2013

Neuronal nitric oxide synthase inhibition attenuates the development of L-DOPA-induced dyskinesia in hemi-Parkinsonian rats.

scientific article published on 16 March 2012

Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger

scientific article published on 01 October 2007

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism.

scientific article

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

scientific article published on 26 February 2020

Pathophysiological implication of the VPAC2 receptor in psychiatric disorders

scientific article published on 01 January 2018

Pharmacological aspects of the acetylcholinesterase inhibitor galantamine.

scientific article published on 16 April 2011

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.

scientific article

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

scientific article published on 18 March 2019

Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.

scientific article

Potential role of serotonin1A receptors in post-weaning social isolation-induced abnormal behaviors in rodents.

scientific article

Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation.

scientific article published on 14 June 2016

Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

scientific article

Preventive effects of an enriched environment on rodent psychiatric disorder models.

scientific article published on September 2011

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.

scientific article published on 29 July 2016

Protective effect of T-588 on toxic damage by serum deprivation and amyloid-beta protein in cultured neurons.

scientific article published in June 2003

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

scientific article published on 19 June 2019

Psychopharmacology of combined activation of the serotonin1A and σ1 receptors

scientific article

Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice

scientific article published on 01 May 2006

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

scientific article

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist.

scientific article

Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex ⬇️

scientific article published on December 1, 2003

Regulation of emotional behaviors by juvenile environmental factors.

scientific article published in January 2017

Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety.

scientific article published on 11 July 2018

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

scientific article

Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice.

scientific article published in September 2007

Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice.

scientific article published on 31 October 2015

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.

scientific article

Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex.

scientific article

Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice.

scientific article published in November 2006

Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice.

scientific article published on 20 February 2013

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice.

scientific article

SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease ⬇️

scientific article published on September 2, 2011

SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia

scientific article published on March 2005

Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice

scientific article

Simultaneous neuron- and astrocyte-specific fluorescent marking.

scientific article published on 24 February 2015

Social crowding in the night-time reduces an anxiety-like behavior and increases social interaction in adolescent mice

scientific article published on 4 May 2014

Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test

scientific article published on August 2010

Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.

scientific article published in January 2005

T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons.

scientific article

The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze.

scientific article

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

scientific article published on 29 May 2015

The Na+/Ca2+ exchanger-mediated Ca2+ influx triggers nitric oxide-induced cytotoxicity in cultured astrocytes

scientific journal article

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation

scientific article published on 02 January 2019

The glial sodium-calcium exchanger: a new target for nitric oxide-mediated cellular toxicity.

scientific article published on February 2013

The novel method female encounter test

scientific article published in January 2016

The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release

scientific article

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice

scientific article published on 27 January 2012

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide.

scientific article published in February 2013

The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells.

scientific article published on 6 June 2011

Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells

scientific article published on 24 August 2018

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

scientific article published on 08 April 2019

[Depression and corticosteroid receptors]

scientific article published on 01 December 2009

[Haploinsufficiency of the T-box transcription factor Tbr1]

scientific article published on 01 September 2014

[Mitochondrial dysfunction and neuronal apoptosis: new molecular approach to prevent Alzheimer's disease].

scientific article published in October 2009

[Transitive inference task in mice using a touchscreen assay]

scientific article published on 01 July 2014

mGlu2/3 and mGlu5 receptors: potential targets for novel antidepressants

scientific article published on 26 May 2012

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

scientific article published on 09 November 2018

p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice

scientific journal article

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

scientific article

List of works by Yukio Ago

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

An enriched environment ameliorates memory impairments in PACAP-deficient mice

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. ⬇️

Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression.

Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.

Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

Atomoxetine-induced increases in monoamine release in the prefrontal cortex are similar in spontaneously hypertensive rats and Wistar-Kyoto rats

Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice.

Autism-associated protein kinase D2 regulates embryonic cortical neuron development

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid ⬇️

Behavioral characterization of mice overexpressing human dysbindin-1.

Beneficial Effect of Galantamine on Sensory Information-processing Deficits ⬇️

Brain microdialysis of isolation-reared mice under freely-moving conditions

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses.

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.

Effect of prenatal valproic acid exposure on cortical morphology in female mice.

Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice.

Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and σ(1) receptor activation

Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.

Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice

Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice ⬇️

Galantamine promotes adult hippocampal neurogenesis via M₁ muscarinic and α7 nicotinic receptors in mice

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.

Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation.

Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice.

Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice.

Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain.

Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth

Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex.

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release.

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.

Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder, through α2-adrenoceptor activation.

Neuronal nitric oxide synthase inhibition attenuates the development of L-DOPA-induced dyskinesia in hemi-Parkinsonian rats.

Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism.

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

Pathophysiological implication of the VPAC2 receptor in psychiatric disorders

Pharmacological aspects of the acetylcholinesterase inhibitor galantamine.

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.

Potential role of serotonin1A receptors in post-weaning social isolation-induced abnormal behaviors in rodents.

Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation.

Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

Preventive effects of an enriched environment on rodent psychiatric disorder models.

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.

Protective effect of T-588 on toxic damage by serum deprivation and amyloid-beta protein in cultured neurons.

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

Psychopharmacology of combined activation of the serotonin1A and σ1 receptors

Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist.

Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex ⬇️

Regulation of emotional behaviors by juvenile environmental factors.

Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety.

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice.

Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice.

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.

Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex.