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List of works by Klaus-Peter Lesch

'Shine bright like a diamond!': is research on high-functioning ADHD at last entering the mainstream?

scientific article published in March 2018

22q11.2 deletion syndrome as a natural model for COMT haploinsufficiency-related dopaminergic dysfunction in ADHD.

scientific article published on 19 July 2006

3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid decreases NMDA receptor mRNA.

scientific article published in September 1992

5-HT1A Receptor Function in Normal Subjects on Clinical Doses of Fluoxetine Blunted Temperature and Hormone Responses to Ipsapirone Challenge

article

5-HT1A receptor function in depression: effect of chronic amitriptyline treatment

scientific article published on 01 January 1990

5-HT1A receptor responsivity in anxiety disorders and depression ⬇️

scientific article published on January 1, 1991

5-HT1A receptor responsivity in unipolar depression. Evaluation of ipsapirone-induced ACTH and cortisol secretion in patients and controls.

scientific article published on October 1990

5-HT1A receptor-effector system responsivity in panic disorder

scientific article published on January 1, 1992

5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze

scientific article

5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

scientific article

A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder.

scientific article published on 21 June 2005

A Promoter-Associated Polymorphic Repeat ModulatesPAX-6Expression in Human Brain ⬇️

scientific article published on July 20, 1998

A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD.

scientific article

A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter.

scientific article published on January 1998

A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity

scientific article published on 30 June 2010

A functional NPSR1 gene variant and environment shape personality and impulsive action: A longitudinal study

article

A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders.

scientific article

A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia

scientific article published in February 2011

A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder.

scientific article published on 6 November 2009

A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception

scientific article

A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine.

scientific article published in February 2005

A lifetime of attention-deficit/hyperactivity disorder: diagnostic challenges, treatment and neurobiological mechanisms.

scientific article published on October 2011

A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function.

scientific article

A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques

scientific article

A novel approach to probabilistic biomarker-based classification using functional near-infrared spectroscopy

scientific article published on 16 January 2012

A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.

scientific article published on 22 August 2007

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity

scientific article

A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients

scientific article published on 27 August 2014

A second large family with catatonic schizophrenia supports the region distally of CHRNA7 on chromosome 15q14-15.

scientific article published in March 2003

A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system.

scientific article published in January 2002

Aberrant accumulation of serotonin in dopaminergic neurons.

scientific article published on 25 April 2006

Abnormal affective responsiveness in attention-deficit/hyperactivity disorder: subtype differences

scientific article

Abnormal responsiveness of growth hormone to human corticotropin-releasing hormone in major depressive disorder

scientific article published on 01 May 1988

Absence of thermal hyperalgesia in serotonin transporter-deficient mice.

scientific article published in January 2003

Acetylcholine-metabolizing butyrylcholinesterase (BCHE) copy number and single nucleotide polymorphisms and their role in attention-deficit/hyperactivity syndrome

scientific article published on 30 August 2013

Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP.

scientific article published in February 2004

Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing

scientific article published on 26 June 2006

Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency

scientific article

Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

scientific article published on 14 January 2011

Affect-modulated startle reflex and dopamine D4 receptor gene variation

scientific article published on 8 October 2009

Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimerʼs disease

article

Allelic variants of SNAP25 in a family-based sample of ADHD.

scientific article published on 4 February 2008

Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits.

scientific article

Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential.

scientific article published in April 2003

Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease.

scientific article published in May 2001

Allelic variation of serotonin transporter function modulates the brain electrical response for error processing

scientific article

Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene

scientific article published on 27 October 2020

Altered expression and functions of serotonin 5-HT1Aand 5-HT1Breceptors in knock-out mice lacking the 5-HT transporter

scientific article published on 01 July 2000

Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety

scientific article published on 15 June 2011

Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome

scientific article published in December 2004

Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study.

scientific article published on 11 August 2006

Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter

scientific article published on 23 September 2005

Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins. ⬇️

scientific article published in December 2009

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.

scientific article

An adenosine A2A receptor gene haplotype is associated with migraine with aura.

scientific article published in February 2007

An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples.

scientific article published in August 2012

An international multicenter association study of the serotonin transporter gene in persistent ADHD.

scientific article published on 25 January 2010

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis.

scientific article published in July 2008

Androgen receptor binding activity in meningiomas

scientific article published on 01 September 1987

Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions

scientific article

Annual research review: The (epi)genetics of neurodevelopmental disorders in the era of whole-genome sequencing--unveiling the dark matter.

scientific article

Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade

scientific article published in 2011

Antidepressants and gene expression profiling: how to SNARE novel drug targets

article

Anxiety-related traits in mice with modified genes of the serotonergic pathway.

scientific article published on November 2003

Association analysis of a PAX-6 gene promoter-associated polymorphic repeat with alcohol dependence

scientific article

Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy

article

Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.

scientific article published in March 2001

Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders.

scientific article published in March 2004

Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype.

scientific article published on 15 September 2010

Association of a NOS1 promoter repeat with Alzheimer's disease

scientific article

Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia

scientific article published on 25 February 2004

Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness

scientific article published in November 2012

Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism

article

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

scientific article

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women

scientific article published on 5 March 2004

Attenuated growth hormone response to growth hormone-releasing hormone in major depressive disorder

scientific article published on 01 December 1987

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. ⬇️

scientific article

Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment.

scientific article published in February 2015

Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice.

scientific article

Autonomic hypoactivity in boys with attention-deficit/hyperactivity disorder and the influence of methylphenidate

scientific article

Away game or home match: The influence of venue and serotonin transporter genotype on the display of offensive aggression

scientific article published on 22 January 2011

BDNF val(66)met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children

scientific article

Benefits of a "vulnerability gene"? A study in serotonin transporter knockout mice

scientific article published on 25 January 2015

Benefits of adversity?! How life history affects the behavioral profile of mice varying in serotonin transporter genotype.

scientific article

Beta-Endorphin-, Leucine Enkephalin- and Methionine Enkephalin-Like Immunoreactivity in Human Cerebrospinal Fluid

scientific article published on 01 January 1984

Beta/A4 domain of APP: antigenic differences between cell lines.

scientific article published on October 1992

Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task

scientific article

Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

scientific article published on 24 April 2019

Brain serotonin deficiency affects female aggression

scientific article published in Scientific Reports

Brain-Derived Neurotrophic Factor (Val66Met) and Serotonin Transporter (5-HTTLPR) Polymorphisms Modulate Plasticity in Inhibitory Control Performance Over Time but Independent of Inhibitory Control Training

scientific article published on 29 July 2016

Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder

scientific article published on 10 January 2005

Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life.

scientific article published on 3 July 2010

CO2 exposure as translational cross-species experimental model for panic

scientific article

COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control.

scientific article published on 22 May 2012

Cadherin 13: human cis-regulation and selectively-altered addiction phenotypes and cerebral cortical dopamine in knockout mice

scientific article

Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain.

scientific article published on 26 September 2017

Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition

scientific article published on 13 October 2015

Candidate system analysis in ADHD: Evaluation of nine genes involved in dopaminergic neurotransmission identifies association withDRD1

article

Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder ⬇️

scientific article published on August 5, 2010

Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder

scientific article

Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder

scientific article published on 5 September 2009

Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processing

scientific article published in June 2009

Cellular effects and clinical implications of SLC2A3 copy number variation

scientific article published on 05 May 2020

Cellular localization and expression of the serotonin transporter in mouse brain.

scientific article published in December 1997

Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT.

scientific article published on 11 September 2015

Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression

article

Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm.

scientific article published on 12 December 2011

Clinical and Biochemical Effects of the Selective Phosphodiesterase Inhibitor Rolipram in Depressed Inpatients Controlled by Determination of Plasma Level

scientific article published on 01 November 1988

Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity.

scientific article published in September 2005

Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center

scientific article published in April 2007

Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.

scientific article published in January 2002

Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

scientific article

Coincidence of Huntington chorea and epilepsy

scientific article published in March 1997

Common brain disorders are associated with heritable patterns of apparent aging of the brain

scientific article published on 24 September 2019

Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.

scientific article published on 26 March 2013

Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations

scientific article published in July 2010

Comparison of GH responses after human GHRH-44 amide administration and TRH-induced TSH release in depressed patients

article

Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.

scientific article published on 02 August 2013

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure

scientific article published on 18 May 2020

Correction: Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene × Environment Interactions.

scientific article published on 5 October 2011

Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.

scientific article

Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2

scientific article published on 01 February 2019

Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand

scientific article published on 01 February 2020

DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders

scientific article

DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

scientific article published in January 2025

Dances with black widow spiders: Dysregulation of glutamate signalling enters centre stage in ADHD

scientific article

Decreased anxiety in mice lacking the organic cation transporter 3.

scientific article published on 11 March 2009

Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems.

scientific article published on 24 August 2013

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

scientific article published on 30 July 2008

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity ⬇️

scientific article published on October 31, 2012

Deuterium content of water increases depression susceptibility: the potential role of a serotonin-related mechanism

scientific article

Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice.

scientific article published on 13 April 2014

Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae

scientific article published on 26 April 2016

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

scientific article

Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics

scientific article published in January 2000

Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment

scientific article published on 23 August 2018

Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour

scientific article published in August 2004

Differential effects of prenatal stress in female 5-HTT-deficient mice: towards molecular mechanisms of resilience

scientific article

Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior.

scientific article published on 30 December 2005

Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1.

scientific article published on 13 November 2010

Differential regulation of adenosine A1 and A2A receptors in serotonin transporter and monoamine oxidase A-deficient mice

scientific article published on 01 December 2000

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

scholarly article published 3 June 2017

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

scientific article published on 26 November 2018

Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation

scientific article published on 06 March 2019

Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia

scientific article published on 01 January 1998

Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3.

scientific article published in October 2004

Dopamine D4 receptor gene variation impacts self-reported altruism

article

Dopamine and cognitive control: the influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility.

scientific article

Dopamine and cognitive control: the influence of spontaneous eyeblink rate, DRD4 exon III polymorphism and gender on flexibility in set-shifting

scientific article published on 6 December 2006

Dopamine and cognitive control: the prospect of monetary gains influences the balance between flexibility and stability in a set-shifting paradigm

scientific article

Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD

scientific article

Duplication 15q14 --> pter: a rare chromosomal abnormality underlying bipolar affective disorder.

scientific article

Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults

scientific article published in August 2010

Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction

scientific article

Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter.

scientific article published in May 2006

Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice

scientific article published on 28 August 2018

Editorial: Attention-deficit/hyperactivity disorder: a continuing challenge to researchers, practitioners and carers.

scientific article

Editorial: Can dysregulated myelination be linked to ADHD pathogenesis and persistence?

scientific article published on 01 March 2019

Editorial: Illuminating the dark matter of developmental neuropsychiatric genetics - strategic focus for future research in child psychology and psychiatry

scientific article published in March 2014

Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells.

scientific article published on June 2000

Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice

scientific article

Effect of aging and Alzheimer's disease-like pathology on brain monoamines in mice.

scientific article

Effects and mechanisms of psychotherapy in the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults

scientific article

Effects of glucocorticoids on the regulation of the hypothalamic-pituitary-somatotropic system in depression

article published in 1989

Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice

scientific article published on 15 July 2019

Elucidating the functions of brain GSK3α: Possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour.

scientific article published on 10 August 2017

Encephalopathy and myoclonus triggered by valproic acid.

scientific article published in September 2004

Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans

article

Endocrine responses to growth hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone in depression

article

Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: a reciprocal risk factor for depression and insulin resistance?

scientific article published on 09 May 2014

Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6 ⬇️

scientific article published on September 1, 1998

Environmental risk factors and attention-deficit/hyperactivity disorder symptoms.

scientific article published in March 2008

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders.

scientific article published on 06 September 2011

Epigenetically regulated microRNAs in Alzheimer's disease.

scientific article published on 18 October 2013

Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality

scientific article published on 12 October 2010

Establishing a learned-helplessness effect paradigm in C57BL/6 mice: behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se.

scientific article

Establishing a probabilistic reversal learning test in mice: Evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin ⬇️

scientific article published on July 21, 2012

Estrogen receptor 1 gene (ESR1) variants in panic disorder

article

Estrogen receptor immunoreactivity in meningiomas

scientific article published on 01 August 1987

Estrophilin immunoreactivity versus estrogen receptor binding activity in meningiomas: Evidence for multiple estrogen binding sites

article

Evolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in females.

scientific article published on May 2002

Excess of High Activity Monoamine Oxidase A Gene Promoter Alleles in Female Patients with Panic Disorder

article

Exome chip analyses in adult attention deficit hyperactivity disorder.

scientific article published on 18 October 2016

Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders.

scientific article published on December 2003

Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain

scientific article published on 31 October 2014

Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: a meta-analysis in four European populations

scientific article published on 18 May 2011

Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes

scientific article published on 20 April 2012

Expression of the ADHD candidate gene Diras2 in the brain.

scientific article

Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: Possible molecular basis for species differences in the susceptibility to MPP+

scientific article published on 01 January 1993

F5. Brain Disorders are Associated With Increased Brain Age

Family environment interacts with CRHR1 rs17689918 to predict mental health and behavioral outcomes

article

Family-based association study on functional α-synuclein polymorphisms in attention-deficit/hyperactivity disorder

scientific article published on 29 March 2019

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

scientific article published on 05 June 2019

Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain

scientific article (publication date: October 1992)

Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics.

scientific article

Functional Impact of An ADHD-Associated DIRAS2 Promoter Polymorphism.

scientific article

Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia.

scientific article

Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray's trait "sensitivity to punishment".

scientific article published on 9 June 2010

Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site.

scientific article

Functional characterization of the human PAX3 gene regulatory region.

scientific article

Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs

scientific article published on 10 April 2007

Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene

article

Functional variants ofTSPAN8are associated with bipolar disorder and schizophrenia

scientific article published on 01 June 2010

Further evidence for an association of 5-HTTLPR with intensity dependence of auditory-evoked potentials

scientific article published on 18 January 2006

Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn107Ile) with impulsivity and hyperactivity

scientific article published on 5 March 2015

GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice

scientific article published on 11 October 2012

GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors.

scientific article

Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies

scientific article published in July 2006

Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models

scientific article

Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3.

scientific article published on 13 February 2018

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

scientific article published on 23 September 2020

Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

scientific article published on 18 October 2016

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

scientific article published in May 2022

Genetic contributions to acute autonomic stress responsiveness in children

scientific article published on 28 November 2011

Genetic perspectives on the serotonin transporter ⬇️

scientific article published on November 15, 2001

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels

scientific article published on 16 August 2011

Genetic variation in serotonin function impacts on altruistic punishment in the ultimatum game: A longitudinal approach

scientific article published on 30 May 2018

Genetic variation of serotonin function and cognitive control.

scientific article published in December 2007

Genetic variation of serotonin receptor function affects prepulse inhibition of the startle

scientific article

Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice

scientific article published on 3 October 2017

Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? ⬇️

scientific article published on August 1, 1998

Genetics of brain age suggest an overlap with common brain disorders

article

Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder

scientific article published on 29 March 2016

Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.

scientific article published on February 2012

Genome-wide association study in German patients with attention deficit/hyperactivity disorder

scientific article published on 19 October 2011

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

scientific article

Growth hormone (GH) and prolactin responses after GH-releasing hormone in major depressive disorder: Relationship to somatomedin C levels and dexamethasone suppressibility of cortisol

article

Hallucinations: psychopathology meets functional genomics ⬇️

scientific article published on July 1, 1998

Haplotype co-segregation with attention deficit-hyperactivity disorder in unrelated german multi-generation families

article

High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene ⬇️

scientific article published on June 5, 1998

High loading of polygenic risk for ADHD in children with comorbid aggression

scientific article published on August 2013

Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses.

scientific article published in September 2005

Hope for the best or prepare for the worst? Towards a spatial cognitive bias test for mice

scientific article

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.

scientific article

Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF.

scientific article

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

scientific article published on 13 October 2016

Hypermethylation of FOXP3 Promoter and Premature Aging of the Immune System in Female Patients with Panic Disorder?

scientific article

Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing

article

Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala

scientific article published on 10 May 2019

Identification of serotonin transporter mRNA in rat platelets

scientific article published on 01 January 1996

Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression.

scientific article published on 22 October 2007

Imaging genetics in adult attention-deficit/hyperactivity disorder (ADHD): a way towards pathophysiological understanding?

scientific article published on 12 May 2014

Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders

scientific article published on 28 June 2006

Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks

scientific article published on 12 July 2012

Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study

scientific article

Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice

scientific article published on 18 August 2017

Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification.

scientific article

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice

scientific article

Impulsivity and Venturesomeness in an Adult ADHD Sample: Relation to Personality, Comorbidity, and Polygenic Risk

scientific article published on 14 December 2020

In Memoriam: Dennis L. Murphy, MD – Neuropsychopharmacologist, Scientific Mentor, and Friend.

scientific article published on 3 January 2018

Increased fear learning, spatial learning as well as neophobia in Rgs2-/- mice.

scientific article published on 28 August 2017

Increased functional coupling of 5-HT1A autoreceptors to GIRK channels in Tph2-/- mice.

scientific article published on 7 November 2017

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders

scientific article published on 14 October 2021

Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test.

scientific article

Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study

scientific article published on 13 January 2011

Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD).

scientific article

Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults

scientific article published on 12 January 2010

Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans

scientific article published in January 2009

Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder

scientific article published on 01 January 1998

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment

scientific article published on 24 April 2018

Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice.

scientific article published on 18 February 2016

Insulin-like growth factor I in depressed patients and controls

scientific article published on 01 December 1988

Integrating neurobiological markers of depression.

scientific article

Intellectual Investment, Dopaminergic Gene Variation, and Life Events: A Critical Examination

scientific article published on 04 July 2018

Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits.

scientific article published on 28 March 2007

Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.

scientific article published in November 2004

Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice

scientific article published on 27 February 2015

Interaction of serotonergic and noradrenergic gene variants in panic disorder.

scientific article published in April 2006

Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response

scientific article

Interaction of the neuropeptide S receptor gene Asn¹⁰⁷Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour

scientific article published on 16 December 2013

Internalizing and externalizing behavior in adult ADHD.

scientific article published on 21 February 2014

Isolation of a cDNA encoding the human brain serotonin transporter

scientific article published on 01 January 1993

KCNIP4 as a candidate gene for personality disorders and adult ADHD.

scientific article published on 14 September 2012

KCNJ6 variants modulate reward-related brain processes and impact executive functions in attention-deficit/hyperactivity disorder

scientific article published on 17 May 2019

Knockout Corner: 5-HT1A receptor inactivation: anxiety or depression as a murine experience

scientific article published on 01 December 1999

Knockout mice in neuropsychopharmacology: present and future.

scientific article

Lack of association between polymorphisms of the dopamine D4 receptor gene and personality

scientific article published in January 2003

Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia

scientific article published on 28 April 2014

Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour.

scientific article published on July 2007

Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan

scholarly article by Barbara Franke et al published October 2018 in European Neuropsychopharmacology

Living in a dangerous world decreases maternal care: a study in serotonin transporter knockout mice

scientific article published on 20 July 2011

Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype.

scientific article

Long story short: the serotonin transporter in emotion regulation and social cognition

scientific article

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

scientific article

Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice

scientific article published in March 2005

Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

scientific article

MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy.

scientific article published on 5 April 2016

MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia.

scientific article published on 8 January 2007

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

Maturing insights into the genetic architecture of neurodevelopmental disorders - from common and rare variant interplay to precision psychiatry.

scientific article published in June 2016

Mental health dished up-the use of iPSC models in neuropsychiatric research

scientific article published on 07 May 2020

Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder ⬇️

scientific article published on August 1, 2010

Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations.

scientific article published in March 2010

Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder

scientific article

Meta-analysis of the DRD5 VNTR in persistent ADHD.

scientific article published on 29 July 2016

Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?

scientific article published on 18 February 2020

Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters

scientific article

Methylphenidate and emotional-motivational processing in attention-deficit/hyperactivity disorder

scientific article published on 6 February 2016

Methylphenidate normalizes emotional processing in adult patients with attention-deficit/hyperactivity disorder: preliminary findings

scientific article published on 6 January 2011

Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

scientific article published in December 2003

MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits

scientific article published on 2 April 2015

Moclobemide response in depressed patients: association study with a functional polymorphism in the monoamine oxidase A promoter

scientific article published in July 2002

Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood

scientific article published on 25 September 2009

Molecular and behavioural abnormalities in the FUS-tg mice mimic frontotemporal lobar degeneration: Effects of old and new anti-inflammatory therapies

scientific article published on 15 July 2020

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

scientific journal article

Molecular heterogeneity of neurotransporters: implications for neurodegeneration ⬇️

scientific article published on January 1, 1997

Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

scientific article

Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys

article

Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression

article

Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD.

scientific article published on 15 October 2014

Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD.

scientific article

Mutational analysis of the connexin 36 gene (CX36) and exclusion of the coding sequence as a candidate region for catatonic schizophrenia in a large pedigree

scientific article published in November 2002

Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment.

scientific article

Neural correlates of epigenesis

scholarly article

Neural hyporesponsiveness and hyperresponsiveness during immediate and delayed reward processing in adult attention-deficit/hyperactivity disorder.

scientific article published on 21 August 2008

Neural response to reward anticipation is modulated by Gray's impulsivity

scientific article published on 25 March 2009

Neural stem cell proliferation is decreased in schizophrenia, but not in depression.

scientific article published in May 2006

Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice

scientific article published on 23 December 2019

Neurobiology of attention-deficit hyperactivity disorder

scientific article published in July 2008

Neurogenesis and schizophrenia: dividing neurons in a divided mind?

scientific article published on August 2007

Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF.

scientific article

Neuropeptide S receptor gene variant and environment: contribution to alcohol use disorders and alcohol consumption

scientific article published on 23 April 2014

Neurovascular Coupling in the Human Visual Cortex Is Modulated by Cyclooxygenase-1 (COX-1) Gene Variant

article

No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking.

scientific article

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families.

scientific article

No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample

article

No missense mutation of WKL1 in a subgroup of probands with schizophrenia.

scientific article published on January 2002

Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals

scientific article

Novel 5′-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder

article

OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency

scientific article published on 10 January 2017

Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene

article

Olfactory and gustatory sensitivity in adults with attention-deficit/hyperactivity disorder

scientific article published on 08 January 2011

Olfactory deficits in deletion syndrome 22q11.2

scientific article published on 01 February 2011

On the role of NOS1 ex1f-VNTR in ADHD-allelic, subgroup, and meta-analysis

scientific article published on 18 June 2015

On the role of serotonin and effort in voluntary attention: evidence of genetic variation in N1 modulation

scientific article

Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice.

scientific article published in March 2003

Organization of the human serotonin transporter gene

article

Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety

scientific article

PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.

scientific article

Panic disorder and a possible treatment approach by means of high-frequency rTMS: a case report.

scientific article published in January 2009

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice

scientific article (publication date: 2016)

Periodic catatonia: A schizophrenic subtype with major gene effect and anticipation

article

Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response.

scientific article published on 10 May 2014

Pharmacogenetic prediction of clozapine response

scientific article published in The Lancet

Pharmacogenetics of the serotonin transporter

scientific article

Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans

scientific article published on 01 January 1990

Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood

scientific article published on 06 May 2012

Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice.

scientific article

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants ⬇️

scientific article

Polymorphic MAO-A and 5-HT-Transporter Genes: Analysis of Interactions in Panic Disorder

article

Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training.

scientific article

Pre- and Postsynaptic Alpha-Adrenergic Effects of Clonidine in Major Depressive Disorder

scientific article published on 01 November 1988

Predicting cortisol stress responses in older individuals: Influence of serotonin receptor 1A gene (HTR1A) and stressful life events

article

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

scientific article published on 13 December 2019

Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system

scientific article published on 27 September 2013

Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT-deficient mice.

scientific article

Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter.

scientific article published in June 1993

Primary structure of the serotonin transporter in unipolar depression and bipolar disorder

scientific article published on 01 February 1995

Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action

scientific article

Protein alterations in olfactory neuroblasts from Alzheimer donors

scientific article published on 01 November 1994

Psychoneuroendocrine research in depression

scientific article published on 01 January 1989

Psychoneuroendocrine research in depression

Psychotropic Effects of Corticotropin-Releasing Hormone Stimulation in Depressive Patients

scientific article published on 01 January 1988

Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain

scientific article published on 01 February 2020

Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice.

scientific article

Randomness of resting-state brain oscillations encodes Gray's personality trait.

scientific article published on 26 August 2011

Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder

scientific article published on 5 August 2005

Recovery and aging of serotonergic fibers after single and intermittent MDMA treatment in dark agouti rat

scientific article published on 01 August 2011

Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2.

scientific article

Reduced programmed cell death in brains of serotonin transporter knockout mice

scientific article published in March 2003

Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter

scientific article

Reducing central serotonin in adulthood promotes hippocampal neurogenesis.

scientific article published on 3 February 2016

Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention-deficit/hyperactivity disorder

scientific article published in July 2009

Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants.

scientific article published in January 1993

Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.

scientific article

Regulation of PAX-6 gene transcription: alternate promoter usage in human brain.

scientific article

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity

scientific article published on 26 November 2018

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice

scientific article published on 04 February 2019

Reversible ischaemic neurological deficit associated with short-term methylphenidate medication.

scientific article published on 8 July 2005

Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing

scientific article published on 13 February 2020

Rsk2 Knockout Affects Emotional Behavior in the IntelliCage.

scientific article published on 6 June 2017

SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder

scientific article

SPOCK3, a risk gene for adult ADHD and personality disorders

scientific article published on 29 November 2013

Serotonergic gene expression and depression: implications for developing novel antidepressants.

scientific article

Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei.

scientific article published on 17 April 2012

Serotonergic modulation in executive functioning: linking genetic variations to working memory performance

scientific article published in October 2011

Serotonergic modulation of 'waiting impulsivity' is mediated by the impulsivity phenotype in humans.

scientific article

Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function

scientific article published on 28 February 2020

Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity

scientific article published on 24 April 2019

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice.

scientific article published on 12 September 2017

Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells

scientific article

Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders

scientific article published on October 2012

Serotonin now: Part 1. Neurobiology and developmental genetics

scientific article published on 25 March 2010

Serotonin now: Part 2. Behavioral genetics and psychopathology

scientific article published on 9 March 2010

Serotonin transporter (5-HTT) gene variants associated with autism? ⬇️

scientific article published on December 1, 1997

Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy

scientific article published on 17 March 2011

Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF).

scientific article published in March 2000

Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response

scientific article published on 28 March 2014

Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia

scientific article published on 26 May 2005

Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder ⬇️

scientific article published on June 15, 1998

Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety

scientific article

Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.

scientific article published on 10 October 2006

Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress.

scientific article

Serotonin transporter knockout and repeated social defeat stress: Impact on neuronal morphology and plasticity in limbic brain areas ⬇️

scientific article published on January 14, 2011

Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative.

scientific article published in June 2002

Serotonin-1A Receptor Gene HTR1A Variation Predicts Interferon-Induced Depression in Chronic Hepatitis C

article

Sex hormone‐dependent desensitization of 5‐HT1A autoreceptors in knockout mice deficient in the 5‐HT transporter ⬇️

scientific article published on October 1, 2003

Sex- and Subtype-Related Differences in the Comorbidity of Adult ADHDs

scientific article published on 6 November 2013

Sex- and Subtype-Related Differences of Personality Disorders (Axis II) and Personality Traits in Persistent ADHD.

scientific article published on 7 February 2014

Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques.

scholarly article

Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression.

scientific article published on 28 October 2010

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

scientific article published on 12 April 2020

Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain

scientific article (publication date: October 1992)

Simultaneous estradiol and progesterone receptor analysis in meningiomas

scientific article published on 01 September 1986

Social status and day-to-day behaviour of male serotonin transporter knockout mice

scientific article published on 27 March 2010

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice

scientific article

Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps?

scholarly article by Joan Asarnow et al published July 2018 in The Journal of Child Psychology and Psychiatry

Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15

scientific article

Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans.

scientific article

Stratified medicine for mental disorders

scientific article published on 04 October 2013

Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors

scientific article published on 01 May 2020

Structural and functional characterization of the human PAX7 5'-flanking regulatory region

scientific article (publication date: 10 July 2002)

Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates.

scientific article published in February 2006

Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

scientific article published on 16 June 2020

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.

scientific article published on 16 February 2017

Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene ⬇️

scientific article published on January 1, 1998

Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA).

scientific article published in December 2002

T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation.

scientific article published on 6 April 2017

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour

scientific article

The 5-HT receptor ? G-protein ? effector system complex in depression I. Effect of glucocorticoids

scientific article published on 01 January 1991

The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.

scientific article published on 17 April 2012

The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice

scientific article published on 12 February 2011

The Corticotropin-Releasing Factor (CRF)-system and monoaminergic afferents in the central amygdala: Investigations in different mouse strains and comparison with the rat

scientific article published on 01 January 2005

The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study

scientific article published on 21 November 2019

The Unexpected Effects of Beneficial and Adverse Social Experiences during Adolescence on Anxiety and Aggression and Their Modulation by Genotype

scientific article published on 26 May 2016

The Wuerzburg Research Initiative on Adult Attention-Deficit/Hyperactivity Disorder (WURIN-AADHD): multi-layered evaluation of long-term course.

scientific article published in September 2006

The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells.

scientific article published on September 1998

The brain acid-base homeostasis and serotonin: A perspective on the use of carbon dioxide as human and rodent experimental model of panic

scientific article published on 27 April 2015

The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain.

scientific article published in December 2003

The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity

scientific article published on 26 February 2010

The epigenome and postnatal environmental influences in psychotic disorders.

scientific article published on 19 February 2014

The expression of the transcription factor FEV in adult human brain and its association with affective disorders

scientific article published on 18 May 2010

The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia

scientific article published on 01 June 2008

The genetic architecture of human brainstem structures and their involvement in common brain disorders

scientific article published on 11 August 2020

The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia: further evidence and meta-analysis

scientific article

The genetics of attention deficit/hyperactivity disorder in adults, a review

scientific article

The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits

scientific article

The genomic organization of the murine Mlc1 (Wkl1, KIAA0027) gene.

scientific article published in April 2003

The human serotonin transporter gene polymorphism-basic research and clinical implications

article

The influence of dexamethasone on growth hormone (GH). Response to GH-releasing hormone in normal men

scientific article published on 01 January 1990

The influence of human corticotropin-releasing hormone on somatostatin secretion in depressed patients and controls

scientific article published on 01 January 1989

The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis

article

The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits

scientific article

The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes.

scientific article published on July 1996

The role of the serotonin transporter polymorphism for the endocrine stress response in newborns

scientific article published on 3 August 2009

The tricks of the trait: neural implementation of personality varies with genotype-dependent serotonin levels.

scientific article published on 16 May 2013

The winner and loser effect, serotonin transporter genotype, and the display of offensive aggression

scientific article published on 28 April 2011

Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice.

scientific article

Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet.

scientific article published on 21 February 2015

To attack, or not to attack? The role of serotonin transporter genotype in the display of maternal aggression.

scientific article published on 3 January 2013

Toward a molecular architecture of personality.

scientific article

Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals.

scientific article published on 22 April 2008

Transcriptome profiling in adult attention-deficit hyperactivity disorder

scientific article published on 18 November 2020

Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive—compulsive disorder

article

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder

scientific article

Triplet repeats in clinical subtypes of schizophrenia: variation at the DRPLA (B37 CAG repeat) locus is not associated with periodic catatonia

scientific article published on 01 January 1994

Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective.

scientific article published on 22 January 2011

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

scientific article

Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats.

scientific article published on 29 March 2016

Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat

scientific article published on 30 October 2010

Unaltered susceptibility to scrapie in serotonin transporter deficient mice.

scientific article published on 30 May 2006

Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype

scientific article

Variability in the effect of 5-HTTLPR on depression in a large European population: the role of age, symptom profile, type and intensity of life stressors

scientific article

Variation in genes involved in dopamine clearance influence the startle response in older adults

scientific article published on 29 March 2011

Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention.

scientific article published on 20 December 2012

Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs ⬇️

scientific article published on December 1, 2001

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

scientific article published on 26 August 2020

Vulnerability versus resilience to prenatal stress in male and female rats; implications from gene expression profiles in the hippocampus and frontal cortex.

scientific article published on 28 November 2012

Weird world inside the brain

scientific article published in The Lancet

When cells become depressed: focus on neural stem cells in novel treatment strategies against depression.

scientific article

Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder

article

hKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia

article

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