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List of works by Joao F Passos

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

scientific article published in 2022

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

scientific article

CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells

scientific article

Cell Sorting of Young and Senescent Cells

scientific article published on 01 January 2013

Cellular senescence drives age-dependent hepatic steatosis.

scientific article

Cellular senescence mediates fibrotic pulmonary disease

scientific article published on 23 February 2017

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

scientific article

Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery

scientific article published on 29 September 2020

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

scientific article

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

scientific article published on 16 December 2021

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

scientific article

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

scientific article

Demystifying the role of mitochondria in senescence.

scientific article

Depletion of mitochondria in mammalian cells through enforced mitophagy.

scientific article published on 22 December 2016

Detecting senescence: a new method for an old pigment.

scientific article published on 9 February 2017

Feedback between p21 and reactive oxygen production is necessary for cell senescence

scientific article

JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells

scientific article

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

scientific article published on 08 February 2019

Lysosome-mediated processing of chromatin in senescence.

scientific article

Measuring reactive oxygen species in senescent cells.

scientific article

Mechanisms driving the ageing heart

scientific article published on 17 October 2017

Methods for cell sorting of young and senescent cells.

scientific article published on January 2007

Mitochondria and ageing: winning and losing in the numbers game.

scientific article published in September 2007

Mitochondria and cellular senescence: Implications for musculoskeletal ageing

scientific article published on 15 October 2018

Mitochondria are required for pro-ageing features of the senescent phenotype.

scientific article

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.

scientific article

Mitochondria: Are they causal players in cellular senescence?

scientific article published on 28 May 2015

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

scientific article

Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging ⬇️

scientific article published on February 1, 2012

Mitochondrial dysfunction and cell senescence: cause or consequence?

scientific article

Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose.

scientific article

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

scientific article published on 26 July 2018

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy

scientific article published on 12 July 2018

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

scientific article published on 03 January 2019

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

scientific article published on 17 January 2018

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

scientific article published on 28 March 2019

Portugal gets ready to embrace ageing research.

scientific article published on 12 February 2008

Powering senescence: The ugly side of mitochondria

scientific article published on 11 July 2016

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage

scientific article published on 20 August 2007

Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice

scientific article published on 23 November 2018

Reactive Oxygen Species Detection in Senescent Cells

scientific article published on 01 January 2019

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

scientific article

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

scientific article published on 21 October 2019

Stress, cell senescence and organismal ageing

scientific article

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

scientific article published on 20 February 2017

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

scientific article published on 11 March 2008

Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis

scientific article published on April 2016

Telomeres and Cell Senescence - Size Matters Not.

scientific article published on 21 March 2017

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

scientific article

Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

scientific article published on 16 January 2014

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Therapeutic Potential of Senolytics in Cardiovascular Disease

scientific article published on 26 September 2020

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice

scientific article published on 20 January 2021

mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG

scientific article

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