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List of works by Darius Lane

A rapid and specific microplate assay for the determination of intra- and extracellular ascorbate in cultured cells.

scientific article published on 11 April 2014

A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane.

scientific article published on 13 May 2010

Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool

scientific article published on 26 August 2013

Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia.

scientific article published on August 2013

Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly.

scientific article published on 16 May 2016

Can we target the α2-macroglobulin-hepcidin interaction to treat pathologic hypoferremia?

scientific article published on January 2014

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

scientific article

Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

scientific article published on 01 August 2014

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

scientific article published on 23 June 2016

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes

scientific article published on 16 May 2018

Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

scientific article published on 31 March 2015

Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.

scientific article published on 25 January 2014

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

scientific article

Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxia

scientific article published on April 2014

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

scientific article published on June 2016

Frataxin, a molecule of mystery: trading stability for function in its iron-binding site

scientific article published on 09 February 2010

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.

scientific article published on 24 November 2015

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

scientific article published on 15 July 2014

Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression.

scientific article published in June 2013

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

scientific article published on 01 January 2018

Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

scientific article published on 16 November 2016

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

scientific article published on 18 April 2016

Making a case for albumin – a highly promising drug-delivery system.

scientific article published in January 2015

Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action ⬇️

scientific article published on January 15, 2013

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

scientific article published on 05 April 2016

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

scientific article

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.

scientific article

Nitrogen monoxide (NO) storage and transport by dinitrosyl-dithiol-iron complexes: long-lived NO that is trafficked by interacting proteins

scientific article published on 19 January 2012

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

scientific article published on 8 December 2015

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

scientific article published in April 2015

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

scientific article published on February 2016

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

scientific article

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

scientific article published on 5 May 2016

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

scientific article

The active role of vitamin C in mammalian iron metabolism: much more than just enhanced iron absorption!

scientific article

The glutamate aspartate transporter (GLAST) mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes.

scientific article

The lure of a LYR: The logistics of iron sulfur cluster delivery

scientific article published on 01 March 2014

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

scientific article published on 15 February 2014

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

scientific article published on 3 November 2015

The old and new biochemistry of polyamines

scientific article published on 08 June 2018

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

scientific article published in April 2015

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

scientific article published on 26 August 2015

Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by the chelator, Dp44mT.

scientific article published on 12 October 2017

Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.

scientific article published on 26 February 2013

Transplasma membrane electron transport comes in two flavors.

scientific article published on January 2008

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

scientific article published on 5 January 2018

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance.

scientific article published on 3 May 2016

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.

scientific article published on November 2010

Voltage-dependent anion-selective channel (VDAC) in the plasma membrane

scientific article

Voltage-dependent anion-selective channel 1 (VDAC1)--a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane.

scientific article

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