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List of works by Nicole A Seebacher

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.

scientific article published on December 2016

Advances in sarcoma gene mutations and therapeutic targets.

scientific article published on 11 November 2017

Application of liquid biopsy in bone and soft tissue sarcomas: Present and future

scientific article published on 14 September 2018

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

scientific article

Global Interest in Gender Affirmation Surgery: A Google Trends Analysis

scientific article published on 01 January 2019

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.

scientific article published on 24 November 2015

Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics.

scientific article published on 17 March 2015

Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma.

scientific article published on 18 April 2018

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

scientific article published on 18 April 2016

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

scientific article

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer.

scientific article published on 12 July 2017

Regulation of microRNAs function by circular RNAs in human cancer

scientific article published on 4 August 2017

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

scientific article published on 26 August 2015

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance.

scientific article published on 3 May 2016

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