List of works - Michael F Freeman

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

scientific article published on 24 August 2018

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

scientific article published on 14 April 2020

An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.

scientific article

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

scientific article

Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

scientific article

Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression.

scientific article

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

scientific article published on 09 September 2021

Distinct Autocatalytic α- N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products

scientific article published on 05 June 2019

Diverse Protein Architectures and α-<i>N</i>-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters

scientific article published on 17 March 2022

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

scientific article

Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.

scientific article

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

scientific article

Genome mining- and synthetic biology-enabled production of hypermodified peptides ⬇️

scientific article published on 09 September 2019

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

scientific article

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

scientific article published on 09 January 2019

Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.

scientific article published in June 2013

Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics

scientific article

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria

scientific article

Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products

scientific article published on 18 June 2014

RiPPing apart the rules for peptide natural products.

scientific article

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

scientific article published on 28 November 2016

List of works by Michael F Freeman

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression.

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Distinct Autocatalytic α- N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products

Diverse Protein Architectures and α-<i>N</i>-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

Genome mining- and synthetic biology-enabled production of hypermodified peptides ⬇️

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.

Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria

Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products

RiPPing apart the rules for peptide natural products.

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium