List of works - Colin W Levy

A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase

scientific article

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

scientific article published on 24 July 2019

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

scientific article published on 3 January 2016

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

scientific article published on 23 July 2019

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

scientific article published on 27 May 2019

Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics

scientific article published on 21 November 2017

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

scientific article published on 5 December 2016

Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.

scientific article published on 21 January 2016

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

scientific article published on 10 April 2015

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

scientific article published on 22 March 2016

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

scientific article published on 22 October 2019

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

scientific article

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

scientific article published on 29 November 2017

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

scientific article published in Scientific Reports

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

scientific article

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

scientific article published on 30 May 2017

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

scientific article published on 03 August 2018

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

scientific article published on 23 October 2019

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

scientific article published on 01 February 2019

Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase

scientific article published on 28 June 2018

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

scientific article

Structure and mechanism of imidazoleglycerol-phosphate dehydratase

scientific article

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

scientific article published on 31 October 2019

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

scientific article published on 21 June 2019

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

scholarly article by Michele Tavanti published in July 2018

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

scientific article published on 13 May 2017

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

article

The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.

scientific article

List of works by Colin W Levy

A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

Structure and mechanism of imidazoleglycerol-phosphate dehydratase

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.