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List of works by Hiroshi Takeshima

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility.

scientific article published on 14 December 2015

A brain-specific transcript from the 3'-terminal region of the skeletal muscle ryanodine receptor gene.

scientific article published in May 1993

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.

scientific article

A junctophilin-caveolin interaction enables efficient coupling between ryanodine receptors and BKCa channels in the Ca2+ microdomain of vascular smooth muscle

scientific article published on 15 July 2019

A negatively charged region of the skeletal muscle ryanodine receptor is involved in Ca(2+)-dependent regulation of the Ca(2+) release channel.

scientific article

A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle

scientific article published on 01 March 1997

A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene.

scientific article published in January 2003

Aberrant behavioral sensitization by methamphetamine in junctophilin-deficient mice.

scientific article

Abnormal formation of sarcoplasmic reticulum networks and triads during early development of skeletal muscle cells in mitsugumin29-deficient mice

scientific article published on 01 December 2001

Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1 ⬇️

scientific article published on May 8, 2003

Abnormal junctions between surface membrane and sarcoplasmic reticulum in skeletal muscle with a mutation targeted to the ryanodine receptor

scientific article

Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor

scientific article published on 01 October 1996

Acetyl CoA carboxylase inhibitors from the fungus Gongronella butleri ⬇️

scientific article published on 01 May 1985

Brainstem auditory regions in mice: expression of nociceptin/orphanin FQ precursor mRNA in select neurons.

scientific article published in November 2001

Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.

scientific article

Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle ⬇️

scientific article published on September 21, 2010

Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM

scientific article published on 14 May 2019

Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair

scientific article

Ca²⁺ microdomains organized by junctophilins

scientific article published on 25 January 2015

Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells

scientific journal article

Changes in Ca2+ handling in adult MG29-deficient skeletal muscle

scientific journal article

Characterization of human junctophilin subtype genes

scientific article published in July 2000

Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel

scientific article

Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task

scientific article published on 05 January 2007

Co-expression in CHO cells of two muscle proteins involved in excitation-contraction coupling.

scientific article published in October 1995

Coexpression of junctophilin type 3 and type 4 in brain ⬇️

scientific article published on October 21, 2003

Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice

scientific article

Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.

scientific article

Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.

scientific article

Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3

scientific article published on 01 October 1999

Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells

scientific article published on 13 September 2018

Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel

scientific article published on 01 December 1993

Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A

scientific article published on 7 April 2017

Deletion of amino acids 1641–2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel ⬇️

scientific article published on September 1, 1997

Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons

scientific article

Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord

scientific article

Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.

scientific article

Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.

scientific article

Endogenously determined restriction of food intake overcomes excitation–contraction uncoupling in JP45KO mice with aging ⬇️

scientific article published on January 25, 2012

Enhanced activity of multiple TRIC-B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents.

scientific article

Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice ⬇️

scientific article published on January 1, 2013

Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice

scientific journal article

Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.

scientific article

Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice.

scientific article published in February 1998

Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation.

scientific article published on 10 June 2009

Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene

scientific journal article

Existence of distinct sodium channel messenger RNAs in rat brain

scientific journal article

Expression and functional characterization of the cardiac muscle ryanodine receptor Ca(2+) release channel in Chinese hamster ovary cells

scientific article

Expression of Ca(2+)-induced Ca2+ release channel activity from cardiac ryanodine receptor cDNA in Chinese hamster ovary cells ⬇️

scientific article published on October 1, 1992

Expression of functional sodium channels from cloned cDNA.

scientific article published in August 1986

Extraocular muscle function is impaired in ryr3 -/- mice

scientific article published on 13 May 2019

Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels.

scientific article published on 16 April 2013

Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.

scientific article

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

scientific article published in June 1997

Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor

scientific article

Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNA.

scientific article published on December 1989

Generation and characterization of mutant mice lacking ryanodine receptor type 3.

scientific article published in August 1996

Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells.

scientific article published on 29 July 2008

Gm7325 is MyoD-dependently expressed in activated muscle satellite cells

scientific article published in January 2017

Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus.

scientific article

Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins.

scientific article

Immunolocalization of mitsugumin29 in developing skeletal muscle and effects of the protein expressed in amphibian embryonic cells

scientific article published on 01 June 1999

Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice.

scientific article

Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes

scientific article

Impaired cerebellar functions in mutant mice lacking DNER.

scientific article

Important role of junctophilin in nematode motor function.

scientific article published on November 2001

In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated.

scientific article published in June 2001

Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene

scientific article published on 09 November 2000

Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function.

scientific article published in July 2001

Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel

scientific article published on 13 August 2015

Inhibition of liver acetyl-coenzyme-A carboxylase by 2-tetradecanylglutarate

scientific article published on 01 February 1986

Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.

scientific article

Involvement of ryanodine receptor type 3 in dopamine release from the striatum: evidence from mutant mice lacking this receptor

scientific article published on 01 December 1999

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

scientific article

Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells

scientific journal article

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.

scientific article

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

scientific article published on 11 November 2019

Lack of nociceptin receptor alters body temperature during resting period in mice.

scientific article published in April 2004

Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice.

scientific article published on July 1998

Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis.

scientific article

Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45

scholarly article

MG53 constitutes a primary determinant of cardiac ischemic preconditioning

scientific article published on 01 June 2010

MG53 nucleates assembly of cell membrane repair machinery.

scientific article

MG53 regulates membrane budding and exocytosis in muscle cells.

scientific article

Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin

scientific article

Methamphetamine sensitization in nociceptin receptor knockout mice: locomotor and c-fos expression.

scientific article published on 29 December 2004

Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations

scientific journal article

Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

scientific article published on 17 May 2016

Mitsugumin 23 Forms a Massive Bowl-Shaped Assembly and Cation-Conducting Channel ⬇️

scientific article published on March 7, 2011

Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.

scientific article

Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.

scientific article published in April 2015

Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes ⬇️

scientific article published on August 7, 1998

Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle ⬇️

scientific article published on April 1, 1998

Modulation of TRIM72 Alters the Repair Capacity of Lung EpithelialCells.

scientific article published in March 2015

Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor.

scientific article

Molecular architecture of Ca2+signaling control in muscle and heart cells ⬇️

scientific article published on September 1, 2011

Molecular basis of ryanodine receptor-mediated Ca2+ release

scientific article published in December 2007

Molecular characterization of flubendiamide sensitivity in the lepidopterous ryanodine receptor Ca(2+) release channel.

scientific article published on November 2009

Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel.

scientific article

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors

scientific article published on 01 December 1998

Mu opioid receptor: expression and vagotomy-induced depletion of the mRNA in medullary preganglionic neurons.

scientific article published in July 1994

Multiple types of ryanodine receptor/Ca2+ release channels are differentially expressed in rabbit brain

scientific article published on 01 August 1994

Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus.

scientific article published in March 2000

Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy

scientific article

Nano-structural analysis of engrafted human induced pluripotent stem cell-derived cardiomyocytes in mouse hearts using a genetic-probe APEX2

scientific article published on 15 October 2018

Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle.

scientific article published on 14 March 2018

New and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca(2+) release?

scientific article (publication date: August 2015)

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes

scientific article

Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function ⬇️

scientific article published on October 28, 2011

Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism.

scientific article

Nociceptin and nociceptin receptor

scientific article published on July 1, 1998

Nociceptin system does not affect MAC of volatile anaesthetics.

scientific article published in July 2005

Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites.

scientific article published in April 1999

Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice

scientific article published in January 2008

Non-morphogenic effect of Sonic Hedgehog on gastric H+,K+-ATPase activity

scientific article published on 21 August 2019

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.

scientific article

Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor

scientific article published on 01 June 2003

Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.

scientific article published in August 1995

Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene

scientific article published on 01 November 1997

Physiological functions of TRIC channels

scientific article published in November 2009

Positive regulation of the enzymatic activity of gastric H(+),K(+)-ATPase by sialylation of its β-subunit.

scientific article

Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain.

scientific article published in November 1992

Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.

scientific article

Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice.

scientific article

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

scientific article published on 14 November 2008

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair

scientific article

Reduced Expression of Cardiac Ryanodine Receptor Protects against Stress-induced Ventricular Tachyarrhythmia, but Increases the Susceptibility to Cardiac Alternans

scientific article published on 23 November 2017

Requirement of the calcium channel beta subunit for functional conformation

scientific article published on 01 June 1993

RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells.

scientific article published in April 1999

Role of nociceptin systems in learning and memory.

scientific article

Role of sarcoplasmic reticulum junctional proteins in skeletal muscle strength.

scientific article published on 18 August 2014

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

scientific article

Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle

scientific article published on 15 March 2007

Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy.

scientific article published on 10 October 2011

Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.

scientific article published on 20 November 2016

Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum

scientific article published on 19 September 2007

Sarcalumenin is essential for maintaining cardiac function during endurance exercise training

scientific article

Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity

scientific article published on 25 November 2011

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

scientific article published on 05 October 2016

Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells.

scientific article published in February 2002

Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C).

scientific article published on December 1994

Structure and expression of mitsugumin29 gene1 ⬇️

scientific article published on July 17, 1998

Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach

scientific article published on July 2015

Syncytium calcium signaling and macrophage function in the heart.

scientific article

Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle

scientific article

TRIC channels are essential for Ca2+ handling in intracellular stores.

scientific article published in July 2007

TRIC channels supporting efficient Ca2+ release from intracellular stores ⬇️

scientific article published on December 15, 2012

TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle

scientific article published on 06 December 2019

TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance

scientific article published on 01 August 2011

TRIC-B Mutations Causing Osteogenesis Imperfecta.

scientific article published on January 2016

TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.

scientific article

TRIM72 is required for effective repair of alveolar epithelial cell wounding.

scientific article

TRIM72 modulates caveolar endocytosis in repair of lung cells.

scientific article published on 4 December 2015

TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development

scientific article published on 09 April 2019

The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide.

scientific article published in September 2006

The natural flavonoid myricetin inhibits gastric H+, K+-ATPase.

scientific article published on 20 December 2017

The synthesis of compactin (ML-236B) and monacolin K in fungi ⬇️

scientific article published on 01 November 1986

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

scientific article

Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis

scientific article published on February 2014

Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes

scientific article

[Excitation-contraction coupling and junctional membrane structures.]

scientific article published on 01 January 2017

[TRIC (trimeric intracellular cation)-channel functions during Ca(2+) release from the sarco/endoplasmic reticulum]

scientific article published on 01 March 2010

[TRIC channel and hypertension]

scientific article published on 01 April 2013

cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands.

scientific article

cDNA cloning and regional distribution of a novel member of the opioid receptor family.

scientific article published on April 1994

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