List of works - Peter I Croucher

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

scientific article published in October 2017

A computerised technique for the quantitative assessment of resorption cavities in trabecular bone.

scientific article published in January 1990

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to aCol2a1mutation

article

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation

scientific article

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis

scientific article

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

scientific article published on 25 April 2019

Accelerating functional gene discovery in osteoarthritis

scientific article published on 20 January 2021

Age-related changes in resorption cavity characteristics in human trabecular bone.

scientific article published in September 1991

Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment.

scientific article published on 22 February 2007

An -Ethyl--Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

article published in 2018

An Atlas of Human and Murine Genetic Influences on Osteoporosis

An Essential Physiological Role for MCT8 in Bone in Male Mice

scientific article published on 15 June 2017

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

scientific article

An atlas of genetic influences on osteoporosis in humans and mice

scientific article published on 31 December 2018

Apomine™, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo

scientific article published on 01 April 2007

Assessment of cancellous bone structure: comparison of strut analysis, trabecular bone pattern factor, and marrow space star volume.

scientific article published in July 1996

Assessment of resorption cavity characteristics in trabecular bone: changes in primary and secondary osteoporosis

scientific article published on 01 May 1993

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice

scientific article published on 01 May 2019

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.

scientific article

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

scientific article published on September 1997

Bisphosphonates--mechanisms of action in multiple myeloma

scientific article published on 01 January 2000

Bone Mineral Content and Density

scientific article published on December 2012

Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease?

scientific article published on 11 November 2014

Bone disease in multiple myeloma

scientific article published on 01 December 1998

Bone metastasis: the importance of the neighbourhood.

scientific article published on May 2016

Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

scientific article

Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-?B ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

scientific article published on 01 December 2006

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.

scientific article

Characteristics of trabecular bone resorption cavities in patients with chronic renal failure

scientific article published on 01 February 1992

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo

scientific article published on 24 June 2019

Cloning of a novel membrane-linked metalloproteinase from human myeloma cells

scientific article

Comparison between the lengths of individual osteoid seams and resorption cavities in human iliac crest cancellous bone

scientific article published on 01 October 1993

Corrigendum to "Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells" [Bone 122 (May 2019) 82-92]

scientific article published on 02 May 2019

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment.

scientific article published on 26 October 2017

Effect of diet-induced weight loss on total body bone mass

scientific article published on April 1, 1992

Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women.

scientific article published in July 1996

Elevated serum intact parathyroid hormone levels in elderly patients with hip fracture

scientific article published on 01 December 1989

Evidence for interrupted bone resorption in human iliac cancellous bone

scientific article published on 01 October 1995

Evidence of a role for RANKL in the development of myeloma bone disease.

scientific article published in August 2004

Expression of interleukin-1beta and tumour necrosis factor-alpha in plasma cells from patients with multiple myeloma

scientific article published on 01 February 1999

Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes

scientific article

Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.

scientific article published on June 1997

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

scientific article published in September 2018

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease.

scientific article published on 16 October 2008

Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage.

scientific article published on April 2011

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1.

scientific article published on 30 August 2017

Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.

scientific article

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

scientific article published on 6 November 2017

Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts

scientific article published on 01 February 2000

Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor.

scientific article

Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines

scientific article published on December 1, 1992

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.

scientific article published on 4 September 2017

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

scientific article

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma

scientific article

Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma

scientific article published on 10 May 2007

Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance.

scientific article published in May 1998

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization

scientific article published on 25 June 2019

Low prevalence of osteomalacia in elderly patients with hip fracture

scientific article published on 01 March 1991

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

scientific article published on 10 July 2017

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

scientific article published in Nature Communications

Metastasis and bone loss: advancing treatment and prevention.

scientific article

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function

scientific article published on 16 May 2012

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway

scientific article

Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer.

scientific article published on 17 April 2015

Myeloma bone disease and proteasome inhibition therapies.

scientific article published on 9 May 2007

Myeloma impairs mature osteoblast function but causes early expansion of osteo-progenitors: temporal changes in bone physiology and gene expression in the KMS12BM model.

scientific article

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

scientific article

Next generation mapping reveals novel large genomic rearrangements in prostate cancer

scientific article

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone.

scientific article published on 2 February 2015

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.

scientific article

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

scientific article published on 25 February 2021

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

scientific article published on 05 May 2021

Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.

scientific article published on March 2002

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

scientific article published on 01 December 2001

Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells

scientific article published on 01 March 2003

PYY is a negative regulator of bone mass and strength

scientific article published on 12 July 2019

Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

scientific article published on 26 September 2018

Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.

scientific article published on 29 January 2016

Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models

scientific article

Quantitative analysis of trabecular bone structure

scientific article published on 01 May 1993

Rapid phenotyping of knockout mice to identify genetic determinants of bone strength

scientific article

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength

scientific article

Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer

scientific article

Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma

scientific article published on 01 January 2003

Reduced bone formation in patients with osteoporosis associated with inflammatory bowel disease

scientific article published on 01 September 1993

Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation

scientific article published on 01 October 2006

Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer.

scientific article published in May 2004

Signaling between tumor cells and the host bone marrow microenvironment.

scientific article

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging

scientific article

Single Cell RNA Sequencing of Rare Immune Cell Populations

scientific article published on 04 July 2018

Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength

scientific article published on 19 March 2019

Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells

scientific article published on 15 February 2019

Structural mechanisms of trabecular bone loss in primary osteoporosis: specific disease mechanism or early ageing?

scientific article published in May 1994

Targeting tumour-initiating cells with TRAIL based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo

scientific article

The 5T2MM murine model of multiple myeloma: maintenance and analysis

scientific article published on 01 January 2005

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest

scientific article published on 2 June 2015

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

scientific article published on 01 December 1998

The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: defining the stromal defect in myeloma

scientific article published on 31 July 2014

The dormant cancer cell life cycle

scientific article published on 02 June 2020

The effects of gonadotrophin-releasing hormone agonists on iliac crest cancellous bone structure in women with endometriosis

scientific article published on 01 February 1995

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

scientific article

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

scientific article published on 01 October 2000

The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume

scientific article published on 01 March 1990

The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume

scientific article published on 01 January 1990

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis

scientific article published on 29 April 2017

Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.

scientific article

Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development

scientific article

Tracking gene expression during zebrafish osteoblast differentiation.

scientific article

Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo

scientific article

Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival.

scientific article published in March 2003

List of works by Peter I Croucher

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

A computerised technique for the quantitative assessment of resorption cavities in trabecular bone.

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to aCol2a1mutation

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Accelerating functional gene discovery in osteoarthritis

Age-related changes in resorption cavity characteristics in human trabecular bone.

Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment.

An -Ethyl--Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

An Atlas of Human and Murine Genetic Influences on Osteoporosis

An Essential Physiological Role for MCT8 in Bone in Male Mice

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

An atlas of genetic influences on osteoporosis in humans and mice

Apomine™, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo

Assessment of cancellous bone structure: comparison of strut analysis, trabecular bone pattern factor, and marrow space star volume.

Assessment of resorption cavity characteristics in trabecular bone: changes in primary and secondary osteoporosis

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

Bisphosphonates--mechanisms of action in multiple myeloma

Bone Mineral Content and Density

Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease?

Bone disease in multiple myeloma

Bone metastasis: the importance of the neighbourhood.

Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-?B ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.

Characteristics of trabecular bone resorption cavities in patients with chronic renal failure

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo

Cloning of a novel membrane-linked metalloproteinase from human myeloma cells

Comparison between the lengths of individual osteoid seams and resorption cavities in human iliac crest cancellous bone

Corrigendum to "Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells" [Bone 122 (May 2019) 82-92]

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment.

Effect of diet-induced weight loss on total body bone mass

Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women.

Elevated serum intact parathyroid hormone levels in elderly patients with hip fracture

Evidence for interrupted bone resorption in human iliac cancellous bone

Evidence of a role for RANKL in the development of myeloma bone disease.

Expression of interleukin-1beta and tumour necrosis factor-alpha in plasma cells from patients with multiple myeloma

Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes

Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease.

Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage.

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1.

Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts

Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor.

Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma

Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma

Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance.

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization

Low prevalence of osteomalacia in elderly patients with hip fracture

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Metastasis and bone loss: advancing treatment and prevention.

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway

Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer.

Myeloma bone disease and proteasome inhibition therapies.

Myeloma impairs mature osteoblast function but causes early expansion of osteo-progenitors: temporal changes in bone physiology and gene expression in the KMS12BM model.

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Next generation mapping reveals novel large genomic rearrangements in prostate cancer

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone.

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells

PYY is a negative regulator of bone mass and strength

Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.