List of works by Kunio Matsumoto

A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.

scientific article published on 16 July 2015

A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats

scientific article published on 01 July 2001

A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury

scientific article published on 09 November 2011

Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors.

scientific article

Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy.

scientific article

Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy.

scientific article

Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1.

scientific article published in March 2003

Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association.

scientific article published on 24 June 2009

Artificial human Met agonists based on macrocycle scaffolds

scientific article

Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.

scientific article published on 5 December 2012

Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.

scientific article published on 9 April 2004

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist

scientific article published in Scientific Reports

Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer.

scientific article published on 11 March 2009

Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production

scientific article published on 01 February 2003

Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer.

scientific article

Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase

scientific journal article

Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.

scientific article published on 26 September 2017

Cyclic Peptide-Based Biologics Regulating HGF-MET

scientific article published on 27 October 2020

De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

scientific article published on 16 October 2021

Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle.

scientific article

Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor.

scientific article

Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach

scientific article published on 17 June 2019

Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer.

scientific article

Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene.

scientific article published on 5 February 2003

Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation.

scientific article published in May 2006

Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus.

scientific article published on 30 December 2003

Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits.

scientific article

Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model.

scientific article published on June 2004

Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.

scientific article published on 16 April 2010

Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons.

scientific article

Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer.

scientific article published on January 2002

Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T lymphocyte activation.

scientific article

Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model.

scientific article

Gene transfer of human hepatocyte growth factor into rat skin wounds mediated by liposomes coated with the sendai virus (hemagglutinating virus of Japan).

scientific article published on November 2002

Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice

scientific article published on 14 November 2007

Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis.

scientific article

HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis.

scientific article published on 21 January 2005

HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.

scientific article published on 6 December 2002

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.

scientific article published on August 2008

Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions.

scientific article published in August 2006

Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels.

scientific article published on 14 September 2006

Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors.

scientific article published on 20 June 2005

Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway.

scientific article published in September 2003

Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis.

scientific article published in July 2005

Hepatocyte growth factor improved learning and memory dysfunction of microsphere-embolized rats

scientific article published in November 2004

Hepatocyte growth factor improves synaptic localization of the NMDA receptor and intracellular signaling after excitotoxic injury in cultured hippocampal neurons.

scientific article published on 13 October 2007

Hepatocyte growth factor in physiology and infectious diseases.

scientific article published on 13 January 2017

Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.

scientific article

Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.

scientific article

Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor.

scientific article published in October 2004

Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1-dependent mechanism

scientific article published on 24 January 2009

Hepatocyte growth factor prevents pulmonary ischemia-reperfusion injury in mice

scientific article published on 01 September 2007

Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts.

scientific article published in May 2005

Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons

scientific article published on 26 June 2007

Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.

scientific article

Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.

scientific article published on 15 December 2009

Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats.

scientific article published in June 2001

Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy

scientific article published on 01 April 2001

Hepatocyte growth factor/MET in cancer progression and biomarker discovery

scientific article published on 08 January 2017

Hsp90 Inhibition Overcomes HGF-Triggering Resistance to EGFR-TKIs in EGFR-Mutant Lung Cancer by Decreasing Client Protein Expression and Angiogenesis

scientific article published on 01 July 2012

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.

scientific article published on 17 September 2009

Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non–Small Cell Lung Adenocarcinoma ⬇️

scientific article published on August 2, 2010

Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer

scientific article published on 13 August 2019

In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade.

scientific article

Induction of Donor-Specific Tolerance Using Superagonistic CD28 Antibody in Rat Renal Allografts: Regulatory T-Cell Expansion Before Engraftment May Be Important ⬇️

scientific article published on December 27, 2010

Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons.

scientific article published on 31 August 2005

Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model.

scientific article published in August 2001

Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.

scientific article published on 26 April 2014

Interruption of the HGF paracrine loop by NK4, an HGF antagonist, reduces VEGF expression of CT26 cells.

scientific article published on 29 May 2013

Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice.

scientific article published on October 2002

Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor beta1.

scientific article published on 13 December 2005

Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland

scientific article

Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.

scientific article

Liver organogenesis promoted by endothelial cells prior to vascular function.

scientific article published on 27 September 2001

Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression

scientific article published on 01 September 2006

Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model

scientific article published on 25 October 2013

MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner

article

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor

scientific article published on 17 May 2019

Mechanisms and significance of bifunctional NK4 in cancer treatment.

scientific article

Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.

scientific article published on 8 February 2012

Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes.

scientific article

N-glycosylation regulates MET processing and signaling

scientific article published on 13 February 2022

NK4 gene therapy targeting HGF-Met and angiogenesis.

scientific article published on January 2008

NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor.

scientific article published on April 2007

No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice.

scientific article published on February 2004

Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases

scientific article published on 30 December 2015

Novel long-acting prostacyclin agonist (ONO-1301) with an angiogenic effect: promoting synthesis of hepatocyte growth factor and increasing cyclic AMP concentration via IP-receptor signaling.

scientific article published on 30 November 2013

Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer.

scientific article published on 13 November 2013

Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells.

scientific article published on 2 May 2012

Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans.

scientific article published on 9 October 2012

Pharmacokinetics and pharmacodynamics following intravenous administration of recombinant human hepatocyte growth factor in rats with renal injury

scientific article published on 31 October 2014

Possible effects of hepatocyte growth factor for the prevention of peritoneal fibrosis

scientific article published on 19 January 2005

Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis ⬇️

scientific article published on July 1, 1997

Promotion of rabbit ligament healing by local delivery of hepatocyte growth factor

scientific article published on 25 May 2011

Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion

scientific article published on 07 October 2020

Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells.

scientific article published in May 2003

Recombinant human hepatocyte growth factor (HGF), but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism.

scientific article published in March 2011

Reduced HGF expression in subcutaneous CT26 tumor genetically modified to secrete NK4 and its possible relation with antitumor effects.

scientific article published on April 2004

Reduction of fibrosis in a rat model of non-alcoholic steatohepatitis cirrhosis by human HGF gene transfection using electroporation.

scientific article published on 30 August 2007

Regulation of cell migration and cytokine production by HGF-like protein (HLP) / macrophage stimulating protein (MSP) in primary microglia.

scientific article

Renotropic role and therapeutic potential of HGF in the kidney

scientific article published on 01 January 2002

Repair of segmental bone defects in rabbit tibia promoted by a complex of β-tricalcium phosphate and hepatocyte growth factor

scientific article published on 05 July 2012

Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor ⬇️

scientific article published on 01 September 1997

Stimulation of hepatocyte growth factor production by heparin-derived oligosaccharides.

scientific article published on 22 February 2007

Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy

scientific article published on 13 September 2004

Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression.

scientific article published on 8 December 2011

Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice

scientific article published on 01 October 2005

Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres.

scientific article published in July 2004

Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin.

scientific article published in August 2004

Sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model

scientific article published on 14 March 2012

Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells.

scientific article published on 10 August 2007

Targeting the hepatocyte growth factor/Met pathway in cancer.

scientific article published on 3 July 2017

The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo.

scientific article published in September 2003

The novel phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor.

scientific article published on 12 February 2013

The protective effect of hepatocyte growth factor against cell death in the hippocampus after transient forebrain ischemia is related to the improvement of apurinic/apyrimidinic endonuclease/redox factor-1 level and inhibition of NADPH oxidase activ

scientific article published on 14 September 2006

Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer

scientific article published on 14 September 2020

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

scientific article published on 10 January 2011

Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle.

scientific article

Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas.

scientific article published on August 2002

Tumor suppression induced by intratumor administration of adenovirus vector expressing NK4, a 4-kringle antagonist of hepatocyte growth factor, and naive dendritic cells.

scientific article published on 25 July 2002

Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy.

scientific article

hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells.

scientific article

mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF.

scientific article

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