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List of works by Elizabeth C de Lange

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

scientific article published on 28 May 2014

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

scientific article

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

scientific article published on 18 November 2016

A comparison of two semi-mechanistic models for prolactin release and prediction of receptor occupancy following administration of dopamine D2 receptor antagonists in rats

scientific article published on 6 July 2016

A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.

scientific article published on 19 May 2009

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

scientific article

Access to the CNS: Biomarker Strategies for Dopaminergic Treatments

scientific article published on 15 February 2018

Age-associated physiological and pathological changes at the blood-brain barrier: A review.

scientific article published on 11 November 2016

Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate ⬇️

scientific article published on January 4, 2012

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

scientific article

Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities.

scientific article published on 6 September 2017

Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain

scientific article published on 30 November 2012

Biomarkers in epilepsy-A modelling perspective

scientific article

Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

scientific article published on 24 January 2019

Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics.

scientific article published on 8 March 2018

Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

scientific article published on 06 September 2018

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

scientific article

Correction to: Access to the CNS: Biomarker Strategies for DopaminergicTreatments

scientific article published on 19 March 2018

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

scientific article published on 01 October 2018

Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

scientific article

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.

scientific article published on 26 October 2017

Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain

scientific article published on 11 June 2014

Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite.

scientific article

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

scientific article published on 01 February 1997

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

scientific article published on 19 February 2015

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

scientific article published on 01 July 2017

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

scientific article published on 8 February 2012

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling

article

From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action

scientific article published on 26 October 2017

Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier

scientific article

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats.

scientific article published on 14 February 2014

Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model

scientific article published on 08 August 2018

In Vivo Quantitative Understanding of PEGylated Liposome's Influence on Brain Delivery of Diphenhydramine

scientific article published on 08 November 2018

In vitro and in silico analysis of the effects of D receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

scientific article published on 21 September 2018

In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.

scientific article

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

scientific article

Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG.

scientific article published on 30 April 2007

Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.

scientific article

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

scientific article published on 30 August 2019

Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.

scientific article published on 12 July 2012

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

scientific article published on 18 March 2008

Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

scientific article published on 18 June 2019

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

scientific article

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier

scientific article published on 01 September 1997

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

scientific article published on 9 March 2017

Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity

scientific article published on 28 May 2019

Modeling of prolactin response following dopamine D2 receptor antagonists in rats: can it be translated to clinical dosing?

scientific article published in December 2017

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

scientific article published on 18 May 2018

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

scientific article published on 4 September 2017

Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies

scientific article published on 10 September 2018

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

scientific article published on 21 September 2017

Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples.

scientific article published on 26 February 2010

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

scientific article published on 23 August 2018

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

scientific article published in October 2002

Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

scientific article published in April 1998

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics.

scientific article

Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

scientific article published on 24 January 2019

Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.

scientific article published on 17 May 2012

Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.

scientific article published on 30 April 2007

Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.

scientific article

Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.

scientific article published on 04 May 2011

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model

scientific article published on 11 September 2017

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

scientific article

Prediction of methotrexate CNS distribution in different species - influence of disease conditions.

scientific article published on 22 January 2014

Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.

scientific article published on 14 December 2008

Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability

scientific article published on 01 December 1995

Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats

scientific article published on 15 February 2007

Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling

scientific article published on 26 October 2016

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

scientific article published on 14 May 2011

Summary data of potency and parameter information from semi-mechanistic PKPD modeling of prolactin release following administration of the dopamine D2 receptor antagonists risperidone, paliperidone and remoxipride in rats

scientific article

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

scientific article published on 5 January 2012

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.

scientific article published on 8 September 2011

T lymphocytes impair P-glycoprotein function during neuroinflammation.

scientific article published on 2 December 2009

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

scientific article published on 4 December 2017

Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.

scientific article published on 11 November 2016

Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?

scientific article published on 02 April 2019

The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions

scientific article published on 09 July 2020

The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

scientific article published on 17 March 2017

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.

scientific article published on 13 November 2007

The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.

scientific article published on 29 March 2013

The implications of target saturation for the use of drug-target residence time

scientific article published on 01 December 2018

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

scientific article

The need for mathematical modelling of spatial drug distribution within the brain

scientific article published on 16 May 2019

The physiological characteristics and transcytosis mechanisms of the blood-brain barrier (BBB).

scientific article published on September 2012

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

scientific article published on October 1999

The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain

scientific article published on 01 December 1995

The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics.

scientific article

Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.

scientific article

Transport across the blood-brain barrier: stereoselectivity and PET-tracers.

scientific article published in September 2004

Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

scientific article published on 12 July 2016

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

scientific article published on 30 April 2020

Utility of CSF in translational neuroscience.

scientific article published on 12 February 2013

White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.

scientific article

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

scientific article published on 2 July 2012

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

scientific article

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