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List of works by Zeev Estrov

A case of lymphocytic variant hypereosinophilic syndrome with sub-diagnostic systemic mastocytosis

scientific article published on 27 March 2017

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia

scientific article

A phase 1-2 study of a farnesyltransferase inhibitor, tipifarnib, combined with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndrome

scientific article

A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis

scientific article published on 05 September 2018

A phase I/II randomized trial of clofarabine or fludarabine added to idarubicin and cytarabine for adults with relapsed or refractory acute myeloid leukemia

scientific article published on 18 July 2017

A phase II study of lenalidomide alone in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes with chromosome 5 abnormalities

scientific article

A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents

scientific article published on 15 November 2018

A phase II trial of ruxolitinib in combination with azacytidine in myelodysplastic syndrome/myeloproliferative neoplasms.

scientific article

A prognostic model of therapy-related myelodysplastic syndrome for predicting survival and transformation to acute myeloid leukemia

scientific article

A prospective analysis of symptom burden for patients with chronic myeloid leukemia in chronic phase treated with frontline second- and third-generation tyrosine kinase inhibitors

scientific article published on 14 October 2018

A randomized phase 2 study of idarubicin and cytarabine with clofarabine or fludarabine in patients with newly diagnosed acute myeloid leukemia

scientific article

A randomized phase II study of low-dose decitabine versus low-dose azacitidine in lower risk MDS and MDS/MPN.

scientific article

A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome

scientific article

A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome

scientific article

AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells

scientific article

Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

scientific article published on 2 March 2015

Acquisition of cytogenetic abnormalities in patients with IPSS defined lower‐risk myelodysplastic syndrome is associated with poor prognosis and transformation to acute myelogenous leukemia ⬇️

scientific article published on July 23, 2013

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

scientific article published on 3 January 2007

Activation of the B-cell receptor successively activates NF-κB and STAT3 in chronic lymphocytic leukemia cells

scientific article

Acute lymphoblastic leukemia arising in post-polycythemic myelofibrosis: a rare entity

scientific article published on 13 March 2012

Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation

scientific article published on 25 June 2015

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

scientific article published on 15 November 2005

Addition of eltrombopag to immunosuppressive therapy in patients with newly diagnosed aplastic anemia

scientific article published on 11 October 2018

Adult stem cells for tissue repair - a new therapeutic concept?

scientific article

An accurate, simple prognostic model consisting of age, JAK2, CALR, and MPL mutation status for patients with primary myelofibrosis

scientific article published on 29 September 2016

An exploratory clinical trial of bortezomib in patients with lower risk myelodysplastic syndromes

scientific article published on 31 March 2017

Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs

Association of bone marrow fibrosis with inferior survival outcomes in chronic myelomonocytic leukemia.

scientific article published on 20 March 2018

Association of gene mutations with time-to-first treatment in 384 treatment-naive chronic lymphocytic leukaemia patients

scientific article published on 26 June 2019

Association of lymphoid malignancies and Philadelphia-chromosome negative myeloproliferative neoplasms: Clinical characteristics, therapy and outcome

scientific article

At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells

scientific article published on 13 April 2016

Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells

scientific article published on 7 July 2006

Atypical chronic lymphocytic leukemia with polyglandular autoimmune endocrinopathy type II: a complex profile

scientific article

Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib

scientific article published on 24 March 2016

Azacitidine in fludarabine-refractory chronic lymphocytic leukemia: a phase II study

scientific article

Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study

scientific article published on April 2007

Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor

scientific article published on 21 April 2011

CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma

scientific article published on 22 June 2013

CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia

scientific article

Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia

scientific article published on 27 July 2017

Cellular signalling pathways: new targets in leukaemia therapy

scientific article

Central nervous system Richter's transformation and parvovirus B19 infection

scientific article

Chronic lymphocytic leukemia and myeloproliferative neoplasms concurrently diagnosed: clinical and biological characteristics

scientific article published on 24 September 2015

Chronic lymphocytic leukemia with central nervous system involvement: a high-risk disease?

scientific article

Chronic myeloid leukemia among patients with a history of prior malignancies: A tale of dual survivorship

scientific article published on 20 October 2016

Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia

scientific article

Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia

scientific article published on 12 August 2009

Circulating endothelial progenitor cells and coronary collaterals in patients with non-ST segment elevation myocardial infarction

scientific article published on 8 August 2005

Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

scientific article

Cladribine and low-dose cytarabine alternating with decitabine as front-line therapy for elderly patients with acute myeloid leukaemia: a phase 2 single-arm trial

scientific article published on 13 August 2018

Clinical Outcomes and Influence of Mutation Clonal Dominance in Oligomonocytic and Classical Chronic Myelomonocytic Leukemia

scientific article published on 06 November 2020

Clinical and molecular characteristics of XPO1 mutations in patients with chronic lymphocytic leukemia

scientific article published on 28 July 2016

Clinical characteristics and outcomes of previously untreated patients with adult onset T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma with hyper-CVAD based regimens

scientific article published on 24 June 2017

Clinical correlation of circulating heat shock protein 70 in acute leukemia

scientific article

Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents

scientific article published on 09 February 2016

Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide

scientific article

Clinical significance of microcytosis in patients with primary myelofibrosis

scientific article

Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients

scientific article published on 24 November 2015

Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older

scientific article published on 10 January 2006

Clofarabine combinations as acute myeloid leukemia salvage therapy

scientific article published on October 2008

Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients ≤60 years with newly diagnosed acute myeloid leukemia

scientific article

Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study

scientific article published on 29 September 2015

Commentary: effect of flavonoids on normal and leukemic cells

scientific article published on June 2003

Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens

scientific article published on 20 July 2015

Congenital Amegakaryocytic Thrombocytopenia

Consolidation treatment with lenalidomide following front-line or salvage chemoimmunotherapy in chronic lymphocytic leukemia

scientific article published on 10 August 2017

Constitutive Phosphorylation of STAT3 by the CK2-BLNK-CD5 Complex

scientific article published on 27 January 2017

Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia

scientific article

Cross-talk between chronic lymphocytic leukemia cells and bone marrow endothelial cells: role of signal transducer and activator of transcription 3 ⬇️

scientific article published on July 5, 2011

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

scientific article

Cytogenetic abnormalities in essential thrombocythemia at presentation and transformation

scientific article

DNMT3A, TET2, and JAK2 mutations in polycythemia vera following long-term remission of secondary acute myeloid leukemia

scientific article published on 24 December 2015

Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice

scientific article

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

scientific article published on 15 June 2016

Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy

scientific article published on 08 July 2013

Detection of dormant chronic myeloid leukemia clones in the bone marrow of patients in complete molecular remission

scientific article

Disseminated histoplasmosis as pseudo Richter's transformation in a patient with chronic lymphocytic leukemia

scientific article published on August 2015

Distinct biological impact of dephosphorylation vs. downregulation of p210Bcr-Abl: implications for imatinib mesylate response and resistance

scientific article published on August 2006

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

scientific article published on 17 September 2009

Durable remission with rituximab in a patient with an unusual variant of Castleman's disease with myelofibrosis-TAFRO syndrome

scientific article published on 23 March 2015

Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy.

scientific article published on 15 January 2018

Early results of lower dose dasatinib (50 mg daily) as frontline therapy for newly diagnosed chronic-phase chronic myeloid leukemia.

scientific article

Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin

scientific article published on 15 December 2008

Efficacy and predictors of response of lenalidomide and rituximab in patients with treatment-naive and relapsed CLL

scientific article published on 01 May 2019

Efficacy and safety of generic imatinib after switching from original imatinib in patients treated for chronic myeloid leukemia in the United States

scientific article published on 10 September 2019

Enzymatic activity of circulating proteasomes correlates with clinical behavior in patients with chronic lymphocytic leukemia

scientific article published in March 2008

Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival

scientific article

Epstein-Barr virus-induced CD30-positive diffuse large B-cell lymphoma in a patient with mixed-phenotypic leukemia treated with clofarabine

scientific article published on 14 December 2012

Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL.

scientific article

Eradication of leukemia stem cells as a new goal of therapy in leukemia

scientific article

Evaluating the serial use of the Myelofibrosis Symptom Assessment Form for measuring symptomatic improvement: performance in 87 myelofibrosis patients on a JAK1 and JAK2 inhibitor (INCB018424) clinical trial

scientific article

Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia

scientific article published on February 2004

FCR and bevacizumab treatment in patients with relapsed chronic lymphocytic leukemia

scientific article

Factors associated with risk of central nervous system relapse in patients with non-core binding factor acute myeloid leukemia

scientific article published on 27 May 2017

Final results of a phase 2, open-label study of indisulam, idarubicin, and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome.

scientific article published on 16 April 2018

Final results of the phase II study of rabbit anti‐thymocyte globulin, ciclosporin, methylprednisone, and granulocyte colony‐stimulating factor in patients with aplastic anaemia and myelodysplastic syndrome ⬇️

scientific article published on February 24, 2012

Fludarabine, cyclophosphamide, and multiple-dose rituximab as frontline therapy for chronic lymphocytic leukemia

scientific article

Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia ⬇️

scientific article published on July 12, 2011

Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia

scientific article published on 17 August 2016

Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact

scientific article published on 16 August 2010

Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia

scientific article published on 27 March 2003

Hematopoietic recovery following induction therapy of acute leukemias: prognostic implications and a new look at the definition of remission.

scientific article

Hemophagocytic lymphohistiocytosis in adults: An under recognized entity

scientific article published on 20 December 2016

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

scientific article published on September 2012

High fluorescence in situ hybridization percentage of deletion 11q in patients with chronic lymphocytic leukemia is an independent predictor of adverse outcome

scientific article published on 30 March 2015

Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.

scientific article

Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia

scientific article published on 11 January 2017

Ibrutinib inhibits free fatty acid metabolism in chronic lymphocytic leukemia

scientific article published on 21 February 2018

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study

scientific article published on 07 August 2019

Impact of BCR-ABL transcript type on outcome in patients with chronic-phase CML treated with tyrosine kinase inhibitors

scientific article published on 4 January 2016

Impact of achievement of complete cytogenetic response on outcome in patients with myelodysplastic syndromes treated with hypomethylating agents

scientific article published on 11 January 2017

Impact of p210(Bcr-Abl) on ultraviolet C wavelength-induced DNA damage and repair ⬇️

scientific article published on September 1, 2003

Impact of the number of mutations in survival and response outcomes to hypomethylating agents in patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms

scientific article published on 3 January 2018

Implications of discrepancy in morphologic diagnosis of myelodysplastic syndrome between referral and tertiary care centers ⬇️

scientific article published on August 25, 2011

Incidence of and risk factors for involvement of the central nervous system in acute myeloid leukemia

scientific article published on 3 November 2014

Incidence of extramedullary disease in patients with acute promyelocytic leukemia: a single-institution experience

scientific article

Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome

scientific article published in May 2003

Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor

scientific article published on 24 July 2003

Initial Report of a Phase I Study of LY2510924, Idarubicin, and Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia ⬇️

Interaction between myelomonocytic and lymphoid cells in a patient with acute myelomonocytic leukemia and chronic lymphocytic leukemia

scientific article published on 28 January 2014

Interleukin-7 receptor-α gene mutations are not detected in adult T-cell acute lymphoblastic leukemia

scientific article

Is acute myeloid leukemia a liquid tumor? ⬇️

scientific article published on 04 February 2013

Isolated mesenteric CD20-positive myeloid sarcoma

scientific article published on 26 June 2014

Kit inhibitor APcK110 extends survival in an AML xenograft mouse model

scientific article

Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells

scientific article published on 21 April 2009

Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?

scholarly article by Musa Yilmaz et al published 16 January 2019 in Blood Cancer Journal

Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia

scientific article

Long-term Follow-up of Treatment with Ibrutinib and Rituximab in Patients with High-Risk Chronic Lymphocytic Leukemia.

scientific article

Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article

Long-term follow-up of lower dose dasatinib (50 mg daily) as frontline therapy in newly diagnosed chronic-phase chronic myeloid leukemia

scientific article published on 25 September 2019

Long-term follow-up of patients receiving allogeneic stem cell transplant for chronic lymphocytic leukaemia: mixed T-cell chimerism is associated with high relapse risk and inferior survival

scientific article published on 14 March 2017

Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab

scientific article published on 21 December 2016

Long-term outcomes for patients with chronic lymphocytic leukemia who discontinue ibrutinib

scientific article

Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls

scientific article

Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia

scientific article published on 30 January 2020

Long-term results of frontline dasatinib in chronic myeloid leukemia

scientific article published on 30 January 2020

MYC protein expression is an important prognostic factor in acute myeloid leukemia

scientific article published on 09 May 2018

Measurement of Residual Leukemia during Remission in Childhood Acute Lymphoblastic Leukemia

article

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

scientific article

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

scientific article

Meir Wetzler, MD.

scientific article published in April 2015

Metabolism pathways in chronic lymphocytic leukemia

scientific article published on 8 December 2015

Metastasis--an alternative hypothesis

scientific article

Minimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia

scientific article published on 22 October 2015

Modulation of cellular signaling pathways: prospects for targeted therapy in hematological malignancies.

scientific article

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

scientific article published on 19 June 2013

Morphologic and Molecular Characteristics of De Novo AML With JAK2 V617F Mutation

scientific article published in June 2017

Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

scientific article

Myelofibrosis osteoclasts are clonal and functionally impaired

scientific article published on 11 February 2019

Myeloid neoplasms after breast cancer: "therapy-related" not an independent poor prognostic factor

scientific article

N-(4-Hydroxylphenyl)retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL).

scientific article published on March 2003

Natural history of chronic myelomonocytic leukemia treated with hypomethylating agents

scientific article published on 26 May 2017

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia ⬇️

scientific article published on January 1, 2002

Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

scientific article published on 18 December 2003

OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action

scientific article published on December 2005

Ocular granulocytic sarcoma: a case report and literature review of ocular extramedullary acute myeloid leukemia

scientific article

Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome

scientific article published on 26 April 2010

Outcomes of Patients With Chronic Lymphocytic Leukemia and Richter's Transformation After Transplantation Failure

scientific article published on 6 April 2015

Outcomes of adults with relapsed or refractory Burkitt and high-grade B-cell leukemia/lymphoma

scientific article published on 15 March 2017

Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib

scientific article published on 8 January 2015

PET-positive lymphadenopathy in CLL-Not always Richter transformation

scientific article published on 27 September 2016

Patient characteristics and outcomes in adolescents and young adults with classical Philadelphia chromosome-negative myeloproliferative neoplasms

scientific article published on 15 November 2017

Pegylated interferon alfa-2a in patients with essential thrombocythaemia or polycythaemia vera: a post-hoc, median 83 month follow-up of an open-label, phase 2 trial

scientific article

Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera

scientific article published on 13 October 2009

Pentraxin-3 plasma levels correlate with tumour burden and overall survival in patients with primary myelofibrosis

scientific article published on 03 August 2018

Persistence of cytogenetic abnormalities at complete remission after induction in patients with acute myeloid leukemia: prognostic significance and the potential role of allogeneic stem-cell transplantation

scientific article published on 09 May 2011

Persistence of minimal residual disease assessed by multiparameter flow cytometry is highly prognostic in younger patients with acute myeloid leukemia

scientific article published on 22 September 2016

Personalized medicine in CLL: Current status and future perspectives ⬇️

scientific article published on July 20, 2013

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

scientific article published on 17 November 2005

Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies

scientific article

Phase 1 study of XL119, a rebeccamycin analog, in patients with refractory hematologic malignancies

scientific article

Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

scientific article

Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

scientific article published in August 2006

Phase 2 Study of Hyper-CMAD with Liposomal Vincristine for Patients with Newly Diagnosed Acute Lymphoblastic Leukemia

scientific article published on 14 March 2020

Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis

scientific article

Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia

scientific article published on 15 March 2012

Phase I study of ruxolitinib in previously treated patients with low or intermediate-1 risk myelodysplastic syndrome with evidence of NF-kB activation

scientific article published on 14 September 2018

Phase I-II study of bendamustine in patients with acute leukemia and high risk myelodysplastic syndrome

scientific article

Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia

scientific article published in January 2008

Phase I/II Study of Dasatinib in Combination with Decitabine in Patients with Accelerated or Blast Phase Chronic Myeloid Leukemia

scientific article published on 18 July 2020

Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia

scientific article

Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy

scientific article published in January 2007

Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome

scientific article

Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome

scientific article

Phase II study of methotrexate, vincristine, pegylated-asparaginase, and dexamethasone (MOpAD) in patients with relapsed/refractory acute lymphoblastic leukemia

scientific article published on 19 November 2014

Phase II study of the histone deacetylase inhibitor panobinostat (LBH589) in patients with low or intermediate‐1 risk myelodysplastic syndrome ⬇️

scientific article published on November 10, 2011

Phase II trial of CPX-351 in patients with acute myeloid leukemia at high risk for induction mortality

scientific article published on 16 June 2020

Phase II trial of homoharringtonine with imatinib in chronic, accelerated, and blast phase chronic myeloid leukemia

scientific article published on 9 February 2017

Philadelphia-positive dimorphic blasts in mixed-phenotype acute leukemia with TET2 mutation

scientific article published on 21 January 2016

Pilot study of pegylated interferon-alpha 2b in patients with essential thrombocythemia

scientific article

Plasma thrombopoietin compared with immunoglobulin heavy-chain mutation status as a predictor of survival in chronic lymphocytic leukemia

scientific article

Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor

scientific article published on 7 April 2010

Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes

scientific article published on 30 September 2019

Prognostic factors and survival outcomes in patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era: Cohort study of 477 patients

scientific article published on 25 July 2017

Prognostic impact of RAS mutations in patients with myelodysplastic syndrome

scientific article

Prognostic implications and clinical characteristics associated with bone marrow fibrosis in patients with myelofibrosis

scientific article published on 21 February 2013

Prognostic value of blasts in peripheral blood in myelofibrosis in the ruxolitinib era

scientific article published on 22 July 2020

Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia

scientific article published on 02 July 2013

Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome

scientific article

Proteasome enzymatic activities in plasma as risk stratification of patients with acute myeloid leukemia and advanced-stage myelodysplastic syndrome

scientific article

Randomized Open-Label Phase II Study of Decitabine in Patients With Low- or Intermediate-Risk Myelodysplastic Syndromes ⬇️

scientific article published on June 3, 2013

Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia

scientific article

Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells

scientific article published on July 2002

Relapsed Refractory BRAF-Negative, IGHV4-34-Positive Variant of Hairy Cell Leukemia: A Distinct Entity?

scientific article

Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response

scientific article

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias

scientific article published on 14 October 2004

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

scientific article

Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

scientific article published on 10 April 2003

Routine sequencing in CLL has prognostic implications and provides new insight into pathogenesis and targeted treatments

scientific article published on 28 March 2019

Ruxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial

scientific article

STAT-3 Activates NF-κB in Chronic Lymphocytic Leukemia Cells ⬇️

scientific article published on March 1, 2011

STAT3 is constitutively acetylated on lysine 685 residues in chronic lymphocytic leukemia cells

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

scientific article

STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage

scientific article published on 23 October 2019

STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells.

scientific article

STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis

scientific article

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

scientific article

Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini-Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Phase 2 Clinical Trial

scientific article

Salvage therapy using FLT3 inhibitors may improve long-term outcome of relapsed or refractory AML in patients with FLT3-ITD

scientific article

Second cancers in patients with chronic lymphocytic leukemia who received frontline fludarabine, cyclophosphamide and rituximab therapy: distribution and clinical outcomes

scientific article published on 19 November 2014

Secondary solid tumors and lymphoma in patients with essential thrombocythemia and polycythemia vera - single center experience

scientific article

Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells

scientific article published on June 2013

Signal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia

scientific article

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

scientific article published on April 2006

Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia ⬇️

scientific article published on January 1, 2013

Sorafenib Combined with 5-azacytidine in Older Patients with Untreated FLT3-ITD Mutated Acute Myeloid Leukemia

scientific article published on 31 August 2018

Spontaneous remission of chemo-immunotherapy related, non-transplant Epstein-Barr virus-associated lymphoproliferative disorder in a patient with chronic lymphocytic leukemia

scientific article published on 8 March 2013

Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells ⬇️

scientific article published on July 29, 2010

Statin and aspirin use is associated with improved outcome of FCR therapy in relapsed/refractory chronic lymphocytic leukemia

scientific article published on February 2014

Stem cells and somatic cells: reprogramming and plasticity

scientific article published on January 2009

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

scientific article

Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells".

scientific article

Survival outcomes for clonal evolution in chronic myeloid leukemia patients on second generation tyrosine kinase inhibitor therapy

scientific article published on June 2010

Synchronous del5q myelodysplastic syndrome (del5qMDS) and adult B-cell acute lymphoblastic leukemia (B-ALL) with TET2 and TP53 mutations

scientific article published on 6 October 2015

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

scientific article published in May 2002

TP53 mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper-CVAD-based regimens

scientific article

TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes

scientific article published on 26 July 2016

Targeting inflammatory pathways in chronic lymphocytic leukemia ⬇️

scientific article published on August 12, 2013

The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

scientific article published in January 2017

The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation

scientific article

The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells

scientific article

The absolute percent deviation of IGHV mutation rather than a 98% cut-off predicts survival of chronic lymphocytic leukaemia patients treated with fludarabine, cyclophosphamide and rituximab

scientific article published on 21 November 2017

The addition of CD20 monoclonal antibodies to lenalidomide improves response rates and survival in relapsed/refractory patients with chronic lymphocytic leukaemia relative to lenalidomide monotherapy - the MD Anderson Cancer Center experience

scientific article published on 30 March 2015

The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

scientific article

The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia-negative B-cell acute lymphoblastic leukemia is a strong predictor for survival

scientific article published on 19 November 2019

The landscape of genetic mutations in patients with chronic lymphocytic leukaemia and complex karyotype

scientific article published on 25 July 2019

The leukemia stem cell

scientific article published on January 2010

The significance of spliceosome mutations in chronic lymphocytic leukemia

scientific article

The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells

scientific article

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

scientific article

The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-up

scientific article published on 03 September 2009

Therapeutic effects of ruxolitinib in patients with myelofibrosis without clinically significant splenomegaly

scientific article published on September 2012

Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis

scientific article

Therapy-related myelofibrosis does not appear to exist

scientific article published on 26 May 2017

Transformation of human mesenchymal cells and skin fibroblasts into hematopoietic cells

scientific article

Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia - a distinct subtype with favorable prognosis

scientific article published on 21 September 2020

Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis

scientific article published on 19 July 2017

Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations

scientific article

Treatment with a 5-day versus a 10-day schedule of decitabine in older patients with newly diagnosed acute myeloid leukaemia: a randomised phase 2 trial

scientific article published on 10 December 2018

Treatment with lenalidomide modulates T‐cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia ⬇️

scientific article published on February 24, 2011

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

scientific article published on 23 March 2006

Ubiquitin–proteasome system profiling in acute leukemias and its clinical relevance ⬇️

scientific article published on October 15, 2010

Very high levels of lactate dehydrogenase at diagnosis predict central nervous system relapse in acute promyelocytic leukaemia

scientific article published on 21 November 2014

WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML).

scientific article published on May 2005

WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells

scientific article published in December 2007

WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation

scientific article

Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma

scientific article published on 3 October 2005

β2 -microglobulin normalization within 6 months of ibrutinib-based treatment is associated with superior progression-free survival in patients with chronic lymphocytic leukemia

scientific article published on 20 November 2015

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