List of works - Saskia van Mil

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.

scientific article published on 22 April 2011

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

scientific article published on 20 July 2012

Characterization of mutations in ATP8B1 associated with hereditary cholestasis

scientific article

Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.

scientific article published on 9 December 2016

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

scientific article published in April 2009

Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool

scientific article published on 24 June 2019

Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy.

scientific article published on October 2010

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.

scientific article published on 24 January 2017

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

scientific journal article

Farnesoid X receptor: A "homeostat" for hepatic nutrient metabolism

scientific article

Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease

scientific article published on September 2016

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

scientific article published on 27 July 2015

Identification of FDA-approved drugs targeting the Farnesoid X Receptor

scientific article published on 18 February 2019

Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid

scientific article

Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor.

scientific article published on 8 January 2013

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

scientific article

Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery

scientific article published on 01 June 2018

Progress and challenges of selective Farnesoid X Receptor modulation

scientific article published on 20 June 2018

Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation

scientific article published on 01 September 2003

Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry

scientific article published on 29 March 2018

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation.

scientific article

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function.

scientific article published on October 2010

Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy

scientific article published in October 2008

Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis.

scientific article published on 7 November 2015

Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

scientific article published on 3 February 2016

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.

scientific article published on 15 September 2015

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr.

scientific article

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

scientific article published on 7 November 2013

List of works by Saskia van Mil

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

Characterization of mutations in ATP8B1 associated with hereditary cholestasis

Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool

Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy.

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

Farnesoid X receptor: A "homeostat" for hepatic nutrient metabolism

Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

Identification of FDA-approved drugs targeting the Farnesoid X Receptor

Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid

Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor.

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery

Progress and challenges of selective Farnesoid X Receptor modulation

Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation

Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation.

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function.

Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy

Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis.

Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr.

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates