List of works - Henning Walczak

A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation ⬇️

scientific article published on 01 August 1998

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

scientific article published in November 2017

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes ⬇️

scientific article published on April 1, 2003

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

scientific article

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

scientific article published on June 2009

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis

scientific article

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

scientific article

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria ⬇️

scientific article published on 02 February 2011

Caspases target only two architectural components within the core structure of the nuclear pore complex

scientific article

Cell nucleus and DNA fragmentation are not required for apoptosis ⬇️

scientific article published on October 1, 1994

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

scientific article

Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS

scientific article published on 16 February 2022

Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma

scientific article

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.

scientific article

Death receptor-ligand systems in cancer, cell death, and inflammation

scientific article

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing ⬇️

scientific article published on July 11, 2013

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis

scientific article

Generation and physiological roles of linear ubiquitin chains

scientific article

Getting TRAIL back on track for cancer therapy

scientific article

In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas

scientific article (publication date: June 2003)

Linear ubiquitination at a glance

scientific article published on 18 January 2019

Linear ubiquitination in immunity

scientific article

Linear ubiquitination prevents inflammation and regulates immune signalling

scientific article

Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis

scientific article (publication date: October 2000)

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

scientific article published in 2024

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

No one can whistle a symphony alone – how different ubiquitin linkages cooperate to orchestrate NF-κB activity ⬇️

scientific article published on February 1, 2012

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

scientific article

Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells

scientific article

Onto better TRAILs for cancer treatment

scientific article

Poly-ubiquitination in TNFR1-mediated necroptosis

scientific article

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

scientific article published on 15 April 2019

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

scientific article

Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

scientific article

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma

scientific article published on 3 March 2009

T cells require TRAIL for optimal graft-versus-tumor activity

scientific article

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

scientific article published on 12 November 2018

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer ⬇️

scientific article published on November 1, 2011

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

scientific article

TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes

scientific article

TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells

scientific article published in April 2002

TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

scientific article

TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells

scientific article

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

scientific article published on 01 October 2008

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

scientific article

The Emerging Role of Linear Ubiquitination in Cell Signaling ⬇️

scientific article published on December 20, 2011

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

scientific article (publication date: September 1992)

The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death

scientific article

We aim to refresh science, not to rebel ⬇️

scientific article published on May 21, 1998

List of works by Henning Walczak

A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation ⬇️

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes ⬇️

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria ⬇️

Caspases target only two architectural components within the core structure of the nuclear pore complex

Cell nucleus and DNA fragmentation are not required for apoptosis ⬇️

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS

Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.

Death receptor-ligand systems in cancer, cell death, and inflammation

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing ⬇️

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis

Generation and physiological roles of linear ubiquitin chains

Getting TRAIL back on track for cancer therapy

In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas

Linear ubiquitination at a glance

Linear ubiquitination in immunity

Linear ubiquitination prevents inflammation and regulates immune signalling

Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

No one can whistle a symphony alone – how different ubiquitin linkages cooperate to orchestrate NF-κB activity ⬇️

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells

Onto better TRAILs for cancer treatment

Poly-ubiquitination in TNFR1-mediated necroptosis

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma

T cells require TRAIL for optimal graft-versus-tumor activity

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer ⬇️

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes

TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells

TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

The Emerging Role of Linear Ubiquitination in Cell Signaling ⬇️

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death

We aim to refresh science, not to rebel ⬇️