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List of works by Alexander Dalpke

2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

scientific article published on 20 March 2015

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms

scientific article published on 24 April 2019

A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae

scientific article published on 4 January 2017

A modified dinucleotide motif specifies tRNA recognition by TLR7.

scientific article published on 22 July 2014

Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients

scientific article published on 17 January 2017

Activation of toll-like receptor 9 by DNA from different bacterial species

scientific article

Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment

scientific article

Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries

scientific article published on 31 July 2019

Antineoplastic effect of immunostimulatory DNA (CpG-ODN) in a murine C57-BL6/MB-49 transitional cell carcinoma model.

scientific article published on July 2004

Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B ⬇️

scientific article published on May 25, 2012

Bacterial RNA is recognized by different sets of immunoreceptors

scientific article

Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses

scientific article

Bacterial biofilm composition in healthy subjects with and without caries experience

scientific article published on 26 June 2019

Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.

scientific article published on 24 March 2017

Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells ⬇️

scientific article published on January 12, 2011

Bronchial epithelial cells induce alternatively activated dendritic cells dependent on glucocorticoid receptor signaling

scientific article published on 25 June 2014

Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii ⬇️

scientific article published on August 27, 2011

Cell-contact dependent inhibition of monocytes by airway epithelial cells and reversion by infection with Respiratory Syncytial Virus

scientific article published on 27 June 2015

Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity

scientific article published on 23 October 2007

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis.

scientific article published on 5 October 2017

Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study

scientific article published on March 2017

Comparative genomic analysis reveals a high prevalence of inter-species in vivo transfer of carbapenem-resistance plasmids in patients with haematological malignancies

scientific article published on 23 October 2019

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis

scientific article published on 27 December 2017

Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis

scientific article

Comparison of the BD Max methicillin-resistant Staphylococcus aureus (MRSA) assay and the BD GeneOhm MRSA achromopeptidase assay with direct- and enriched-culture techniques using clinical specimens for detection of MRSA.

scientific article published on 18 July 2012

Control of local immunity by airway epithelial cells

scientific article

CpG DNA in the prevention and treatment of infections

scientific article

CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections

scientific article published on 22 August 2007

CpG oligonucleotides with modified termini and nicked dumbbell structure show enhanced immunostimulatory activity

scientific article published on November 2003

CpG-DNA as immune response modifier

scientific article

Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells

scientific article published on 9 February 2017

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of and

scientific article published on 21 February 2019

Cutting Edge: TLR13 Is a Receptor for Bacterial RNA ⬇️

scientific article published on August 15, 2012

DAMP signaling is a key pathway inducing immune modulation after brain injury.

scientific article

DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells

scientific article

Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.

scientific article

Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells

scientific article published on 25 November 2020

Detection of carbapenemases by real-time PCR and melt curve analysis on the BD Max system

scientific article published on 12 February 2014

Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii on the fully automated BD MAX platform

scientific article published on 15 May 2013

Development of a Real-Time PCR Protocol Requiring Minimal Handling for Detection of Vancomycin-Resistant Enterococci with the Fully Automated BD Max System

scientific article published on 29 June 2016

Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria

scientific article published on 01 October 2006

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages

scientific article published on September 2007

Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance

scientific article

Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells

scientific article published on 01 March 2007

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Draft Genome Sequence of Staphylococcus aureus Strain HD1410, Isolated from a Persistent Nasal Carrier.

scientific article

Early Detection of Infection Chains & Outbreaks: Use Case Infection Control

scientific article published on 01 January 2019

Early blood-based microbiological testing is ineffective in severe stroke patients ⬇️

scientific article published on December 28, 2012

Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide

scientific article published on 10 May 2013

Effects of caspofungin, Candida albicans and Aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs

scientific article published on October 2010

Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells.

scientific article published on 16 July 2016

Evaluation of the BD Max MRSA XT assay for use with different swab types

scientific article published on 17 September 2014

Evaluation of the BD Max StaphSR Assay for Rapid Identification of Staphylococcus aureus and Methicillin-Resistant S. aureus in Positive Blood Culture Broths

scientific article published on 19 August 2015

Evaluation of the fully automated BD MAX Cdiff and Xpert C. difficile assays for direct detection of Clostridium difficile in stool specimens

scientific article

First outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in Germany.

scientific article published on 7 March 2010

Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

scientific article published in 2019

HDAC inhibitors block innate immunity

scientific article published in January 2011

Heart transplantation as salvage therapy for progressive prosthetic valve endocarditis due to methicillin-resistant Staphylococcus epidermidis (MRSE).

scientific article published on 11 July 2016

Hematoma size as major modulator of the cellular immune system after experimental intracerebral hemorrhage.

scientific article published on 3 December 2010

Higher prevalence of colonization with Gardnerella vaginalis and gram-negative anaerobes in patients with recurrent miscarriage and elevated peripheral natural killer cells

scientific article

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

article

Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages

scientific article published on 31 January 2012

Identification of a nuclear localization signal in suppressor of cytokine signaling 1.

scientific article

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

scientific article

Identification of an optimized 2'-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

scientific article published on 02 June 2017

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

scientific article published on 6 February 2012

Immunopharmacology of CpG DNA.

scientific article

Immunostimulatory CpG oligonucleotides form defined three-dimensional structures: results from an NMR study

scientific article published on 01 April 2007

Immunostimulatory CpG oligonucleotides reduce tumor burden after intravesical administration in an orthotopic murine bladder cancer model.

scientific article published on 9 August 2005

Immunostimulatory CpG-DNA activates murine microglia

scientific article

Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3' sequence modifications

scientific article published on February 2003

In vitro and in vivo effects of CpG-Oligodeoxynucleotides (CpG-ODN) on murine transitional cell carcinoma and on the native murine urinary bladder wall.

scientific article

Inactivation of LPS and RNase A on photocatalytically active surfaces

scientific article published on 16 July 2011

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

scientific article

Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling

scientific article published on February 2006

Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection.

scientific article published on 6 August 2009

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling

scientific article published in 2022

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

scientific article published on 30 October 2015

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

scientific article published on 01 March 2011

Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells

scientific article published on 29 September 2017

Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells

scientific article published on October 2002

Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway

scientific article published on 21 July 2005

Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation

scientific article published on 08 August 2006

Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction

scientific article published in February 2009

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease

scientific article

Loss of ceramide synthase 3 causes lethal skin barrier disruption

scientific article

Microbial DNA induces a host defense reaction of human respiratory epithelial cells

scientific article

Microbial immune evasion employing suppressor of cytokine signaling (SOCS) proteins

scientific article published on September 2007

Modifications in small interfering RNA that separate immunostimulation from RNA interference

scientific article

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

scientific article

Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1

scientific article published on 12 August 2020

Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression

scientific article published on 01 June 2008

Next-Generation Sequencing-Based RiboMethSeq  Protocol for Analysis of tRNA 2'-O-Methylation

scientific article published on 9 February 2017

Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung

scientific article

One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis

scientific article published on 11 January 2018

Oxidative injury to endothelial cells due to Epstein-Barr virus-induced autoantibodies against manganese superoxide dismutase

scientific article published in November 2003

PD‐L1 expression on tolerogenic APCs is controlled by STAT‐3 ⬇️

scientific article published on January 11, 2011

Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity

scientific article published on December 2010

Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.

scientific article

Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo

scientific article

Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytes

scientific article

Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells

scientific article published on 04 February 2020

Pulmonary microbiome patterns correlate with the course of the disease in patients with sepsis-induced ARDS following major abdominal surgery

scientific article published on 24 April 2020

QuantiFERON TB-Gold--a new test strengthening long-suspected tuberculous involvement in serpiginous-like choroiditis

scientific article published on 21 August 2008

Quantitative detection of periodontopathogens by real-time PCR.

scientific article

RNA Modifications Modulate Activation of Innate Toll-Like Receptors

RNA mediated Toll-like receptor stimulation in health and disease

scientific article

Real-time polymerase chain reaction for detection and quantification of bacteria in periodontal patients.

scientific article

Recognition of Specified RNA Modifications by the Innate Immune System

scientific article

Reduced efficacy of circulating costimulatory cells after focal cerebral ischemia.

scientific article

Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins

scientific article

Regulation of local immunity by airway epithelial cells

scientific article

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes

scientific article published on 10 March 2018

Signal integration following Toll-like receptor triggering.

scientific article

Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases

scientific article

Structural and functional analysis of a nuclear localization signal in SOCS1.

scientific article

Structural requirements for uptake and recognition of CpG oligonucleotides

scientific article published on 13 August 2007

Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells

scientific article

Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus

scientific article

Suppressor of cytokine signaling proteins as regulators of innate immune signaling ⬇️

scientific article published on January 1, 2012

Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

scientific article

Suppressors of cytokine signaling proteins in innate and adaptive immune responses

scientific article

Surveillance of siRNA integrity by FRET imaging

scientific article

Synergistic and antagonistic interactions between LPS and superantigens ⬇️

scientific article published on January 1, 2003

TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity

scientific article

TLR7 inhibition: A novel strategy for pancreatic cancer treatment?

scientific article published on January 2013

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes

scientific article

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.

scientific article published on 27 June 2007

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease ⬇️

scientific article published on June 1, 2011

The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis

scientific article published on 30 January 2008

The microbiome: a reservoir to discover new antimicrobials agents

scientific article published on 20 March 2020

The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation.

scientific article

Three years of experience with QuantiFERON-TB gold testing in patients with uveitis

scientific article published on 10 January 2014

Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter

scientific article published on 23 January 2004

Triggering of Toll-like receptors modulates IFN-gamma signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling

scientific article

Underdiagnosing of Mycoplasma pneumoniae infections as revealed by use of a respiratory multiplex PCR panel

scientific article published on 17 June 2016

Usefulness of serum procalcitonin levels for the early diagnosis of stroke-associated respiratory tract infections.

scientific article published in June 2011

Varicella-like cutaneous toxoplasmosis in a patient with aplastic anemia

scientific article published on 6 February 2013

Workflow optimization for syndromic diarrhea diagnosis using the molecular Seegene Allplex™ GI-Bacteria(I) assay

scientific article published on 06 February 2020

[Immunological basics of vaccination]

scientific article published on 07 April 2009

[Molecular biology-based methods for pathogen detection in endophthalmitis]

scientific article published on 01 November 2007

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