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List of works by Norbert Polacek

A small ribosome-associated ncRNA globally inhibits translation by restricting ribosome dynamics

scientific article published on 13 June 2021

A tRNA half modulates translation as stress response in Trypanosoma brucei

scientific article published in Nature Communications

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress.

scientific article published on 28 November 2016

Alterations of the translation apparatus during aging and stress response.

scientific article

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

scientific article published on 26 July 2007

An mRNA-derived noncoding RNA targets and regulates the ribosome.

scientific article published on 27 March 2014

Atomic mutagenesis of the ribosome: towards a molecular understanding of translation.

scientific article published in January 2013

Context-specific action of macrolide antibiotics on the eukaryotic ribosome

scientific article published on 14 May 2021

Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 11 May 2016

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain.

scientific article

Deoxyribozyme-based, semisynthetic access to stable peptidyl-tRNAs exemplified by tRNAVal carrying a macrolide antibiotic resistance peptide.

scientific article published in January 2012

Dynamic 23S rRNA modification ho5C2501 benefits <i>Escherichia coli</i> under oxidative stress

scientific article published in 2021

Efficient Ribosomal Peptidyl Transfer Critically Relies on the Presence of the Ribose 2‘-OH at A2451 of 23S rRNA

scientific article published on 01 April 2006

Evidence for Pseudoknot Formation of Class I preQ1Riboswitch Aptamers

article

Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome

scientific article published on 14 August 2009

Expression of the vault RNA protects cells from undergoing apoptosis

scientific article published on 8 May 2015

Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis.

scientific article published on 7 April 2011

Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells

scientific article published on 16 April 2020

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth

scientific article published on 01 December 2019

Mechanism of ribosomal peptide bond formation.

scientific article

Metal ion probing of rRNAs: evidence for evolutionarily conserved divalent cation binding pockets.

scientific article published in October 1998

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 30 January 2015

Native chemical ligation of hydrolysis-resistant 3'-peptidyl-tRNA mimics

scientific article published on 03 November 2011

Non-coding RNAs: hope or hype?

scientific article

Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center

scientific article published on 4 January 2018

Periodic conformational changes in rRNA: monitoring the dynamics of translating ribosomes

scientific article published on 01 July 2000

Probing functions of the ribosomal peptidyl transferase center by nucleotide analog interference.

scientific article published in January 2012

Reliable semi-synthesis of hydrolysis-resistant 3'-peptidyl-tRNA conjugates containing genuine tRNA modifications.

scientific article published on 4 June 2010

Revealing stable processing products from ribosome-associated small RNAs by deep-sequencing data analysis ⬇️

scientific article published on January 20, 2012

Ribosomal catalysis: the evolution of mechanistic concepts for peptide bond formation and peptidyl-tRNA hydrolysis.

scientific article published in January 2008

Ribosome Shut-Down by 16S rRNA Fragmentation in Stationary-Phase Escherichia coli.

scientific article

Ribosome-associated GTPases: the role of RNA for GTPase activation.

scientific article published on September 2010

Ribosome-associated ncRNAs: an emerging class of translation regulators

scientific article

Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.

scientific article published on 4 May 2015

SPARK--a novel method to monitor ribosomal peptidyl transferase activity.

scientific article published in October 2002

Slicing tRNAs to boost functional ncRNA diversity

scientific article

Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells

scientific article

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

scientific article published in January 2003

The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis

scientific article

The regulatory world of tRNA fragments beyond canonical tRNA biology

scientific article published on 01 August 2020

The ribosome meets synthetic biology.

scientific article published on 22 July 2011

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis.

scientific article

The role of the universally conserved A2450-C2063 base pair in the ribosomal peptidyl transferase center.

scientific article published on 7 April 2010

cDNA library generation for the analysis of small RNAs by high-throughput sequencing.

scientific article published on January 2015

mRNA-specific translation regulation by a ribosome-associated ncRNA in Haloferax volcanii

scientific article published in Scientific Reports

pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive ⬇️

scientific article published on October 1, 2001

rRNA expansion segment 27Lb modulates the factor recruitment capacity of the yeast ribosome and shapes the proteome

scientific article published on 01 April 2020

tRNA Biology in Trypanosomes

scientific article published on 01 May 2019

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