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List of works by Irmela Jeremias

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia

scientific article published on 24 September 2018

Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids

scientific article published on December 2013

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

scientific article

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.

scientific article published on 19 October 2015

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations

scientific article

Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells

scientific article

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

scientific article published on 4 August 2015

CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.

scientific article published on 10 February 2005

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.

scientific article published on 6 December 2017

Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.

scientific article published on 6 June 2013

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

scientific article published on 01 January 2018

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

scientific article published on 01 October 2018

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

scientific article published on October 2004

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

scientific article published on 24 November 2014

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia

scientific article published on 17 October 2014

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics.

scientific article published in January 2018

Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo

scientific article published on 24 June 2015

Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice.

scientific article

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice

scientific article published on 20 September 2018

Glucocorticoids augment survival and proliferation of tumor cells

scientific article published on October 1, 2012

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

scientific article published on 10 May 2019

Important role of caspase-8 for chemosensitivity of ALL cells.

scientific article

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

scientific article published on 27 September 2021

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

scientific article published on 16 September 2020

Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation

scientific article published on 01 October 1998

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

scientific article published on 01 August 2000

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

scientific article published on 08 January 2019

Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.

scientific article published on 9 March 2012

Loss of KDM6A confers drug resistance in acute myeloid leukemia

scientific article published on 14 June 2019

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

scientific article published on 12 December 2016

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

scientific article

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

scientific article published on 05 December 2011

MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

scientific article published on July 1998

NOXA as critical mediator for drug combinations in polychemotherapy

scientific article

Optimized anti–tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule ⬇️

scientific article published on September 16, 2011

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

scientific article published on 18 November 2019

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

scientific article

Requirement for LIM kinases in acute myeloid leukemia

scientific article published on 26 June 2020

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

scientific article published in Nature Communications

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

scientific article

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

scientific article published on 25 November 2008

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

scientific article

Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

scientific article published on 27 May 2021

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

scientific article published on 27 January 2020

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

scientific article

Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP

scientific article published on 12 June 2008

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

scientific article

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

scientific article

TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation

scientific article published on 12 September 2014

Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics

scientific article published on 11 October 2018

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on 11 July 2016

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.

scientific article

The target landscape of clinical kinase drugs

scientific article

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

scientific article published on 13 September 2021

Tumor Cell Dormancy-Triggered by the Niche

scientific article published on 01 May 2019

Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects

scientific article published on September 2005

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

scientific article published on 14 August 2017

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells

scientific article published on 02 March 2020

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