List of works - Dennis Schade

Arylazoamidoximes and related compounds as NO-modulators.

scientific article published in January 2010

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

scientific article published on 10 July 2017

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways

scientific article published on 28 June 2018

Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

scientific article published on 27 November 2019

Design, Synthesis, and Bioactivation of O-Glycosylated Prodrugs of the Natural Nitric Oxide Precursor N(ω)-Hydroxy-l-arginine.

scientific article published on 22 August 2016

Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors

scientific article published on 14 March 2015

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase

scientific article published on 08 July 2011

Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.

scientific article

Differentiation of cardiomyocytes and generation of human engineered heart tissue

scientific article published on 11 May 2017

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.

scientific article published on 9 April 2018

Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)

scientific article published on 31 December 2019

Medicinal Chemistry Approaches to Heart Regeneration.

scientific article published on 19 August 2015

Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

scientific article published on 10 March 2010

New Prodrugs of the Antiprotozoal Drug Pentamidine ⬇️

scientific article published on October 7, 2011

Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background

scientific article

Prodrug design for the potent cardiovascular agent Nω-hydroxy-L-arginine (NOHA): synthetic approaches and physicochemical characterization

scientific article published on 31 May 2011

Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

scientific article published on 01 January 2011

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells

scientific article

Small molecules targeting in vivo tissue regeneration

scientific article published on 06 January 2014

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

scientific article published on 01 April 2016

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

scientific article published on 29 December 2015

Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

scientific article published on 29 October 2008

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

scientific article

Synthesis and biological evaluation of L-valine-amidoximeesters as double prodrugs of amidines

scientific article published on 03 February 2011

Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors

scientific article published on 21 March 2019

The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

scientific article published in October 2009

Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors

scientific article published on 28 February 2019

Unique photoaffinity probes to study TGFβ signaling and receptor fates

scientific article published on 01 April 2019

Wnt Inhibition Correlates with Human Embryonic Stem Cell Cardiomyogenesis: A Structure–Activity Relationship Study Based on Inhibitors for the Wnt Response ⬇️

scientific article published on January 13, 2012

List of works by Dennis Schade

Arylazoamidoximes and related compounds as NO-modulators.

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways

Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

Design, Synthesis, and Bioactivation of O-Glycosylated Prodrugs of the Natural Nitric Oxide Precursor N(ω)-Hydroxy-l-arginine.

Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase

Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.

Differentiation of cardiomyocytes and generation of human engineered heart tissue

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.

Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)

Medicinal Chemistry Approaches to Heart Regeneration.

Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

New Prodrugs of the Antiprotozoal Drug Pentamidine ⬇️

Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background

Prodrug design for the potent cardiovascular agent Nω-hydroxy-L-arginine (NOHA): synthetic approaches and physicochemical characterization

Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells

Small molecules targeting in vivo tissue regeneration

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

Synthesis and biological evaluation of L-valine-amidoximeesters as double prodrugs of amidines

Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors

The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors

Unique photoaffinity probes to study TGFβ signaling and receptor fates

Wnt Inhibition Correlates with Human Embryonic Stem Cell Cardiomyogenesis: A Structure–Activity Relationship Study Based on Inhibitors for the Wnt Response ⬇️