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List of works by Xavier Decleves

A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein

scientific article published on 01 May 2000

A physiologically based modeling strategy during preclinical CNS drug development.

scientific article published on 29 January 2014

A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier.

scientific article

ABC drug transporter and nuclear receptor expression in human cytotrophoblasts: influence of spontaneous syncytialization and induction by glucocorticoids.

scientific article

ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells.

scientific article

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

scientific article

Antidepressant agents in short bowel syndrome.

scientific article

Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure.

scientific article published on 8 March 2017

Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier

scientific article published on 27 October 2015

Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation

scientific article published on 05 February 2019

Carrier-mediated cocaine transport at the blood-brain barrier as a putative mechanism in addiction liability.

scientific article published on 31 October 2014

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.

scientific article published on January 2007

Cerebral and plasma kinetics of a high dose of midazolam and correlations with its respiratory effects in rats.

scientific article published in October 2005

Challenges in the Optimisation of Post-operative Pain Management with Opioids in Obese Patients: a Literature Review ⬇️

scientific article published on September 1, 2013

Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

scientific article published on 27 April 2020

Classification of and risk factors for estrogen deprivation pain syndromes related to aromatase inhibitor treatments in women with breast cancer: a prospective multicenter cohort study.

scientific article published on 21 December 2013

Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodo

scientific article published in August 2012

Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging.

scientific article published on 3 August 2016

Double or Simple Emulsion Process to Encapsulate Hydrophilic Oxytocin Peptide in PLA-PEG Nanoparticles

scientific article published on 05 March 2018

Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood-Brain Barrier

scientific journal article

Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.

scientific article published on 4 August 2010

Electronic prescribing reduces prescribing error in public hospitals.

scientific article published on 31 May 2011

Etonorgestrel concentrations in morbidly obese women following Roux-en-Y gastric bypass surgery: three case reports ⬇️

scientific article published on May 8, 2011

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

scientific article published on 17 October 2017

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

scientific article

Expression of drug transporters at the blood-brain barrier using an optimized isolated rat brain microvessel strategy.

scientific article published on 28 December 2006

Functionalized PLA-PEG nanoparticles targeting intestinal transporter PepT1 for oral delivery of acyclovir.

scientific article published on 10 July 2017

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

scientific article published on 18 February 2016

High brain distribution of a new central nervous system drug candidate despite its P-glycoprotein-mediated efflux at the mouse blood-brain barrier

scientific article published on 7 February 2018

High levels of P-glycoprotein activity in human lymphocytes in the first 6 months of life.

scientific article published on 26 November 2008

How to obtain DNA from injection drug users?

scientific article published on 17 June 2011

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

scientific article published on 06 July 2018

Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells.

scientific article

Ibogaine labeling with 99mTc-tricarbonyl: synthesis and transport at the mouse blood-brain barrier.

scientific article published in December 2009

Imaging Probes and Modalities for the Study of Solute Carrier O (SLCO)-Transport Function In Vivo.

scientific article

Impact of prescriber’s handwriting style and nurse’s duty duration on the prevalence of transcription errors in public hospitals ⬇️

scientific article published on December 10, 2012

Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation ⬇️

scientific article published on September 3, 2012

Influence of PLA-PEG nanoparticles manufacturing process on intestinal transporter PepT1 targeting and oxytocin transport

scientific article published on 24 May 2018

Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates.

scientific article published on 2 January 2018

Is P-glycoprotein (ABCB1) a phase 0 or a phase 3 colchicine transporter depending on colchicine exposure conditions?

scientific article published on 10 August 2006

Is extracorporeal treatment useful for managing severe baclofen poisoning? – The debate is still open

scientific article published on 04 February 2016

Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships

scientific article published on 03 July 2018

Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain

scientific article published in Scientific Reports

LC-MS/MS-based quantification of efflux transporter proteins at the BBB

scientific article published on 08 November 2018

Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes.

scientific article published on 19 May 2010

Liquid chromatography high resolution mass spectrometry for the determination of baclofen and its metabolites in plasma: Application to therapeutic drug monitoring

scientific article

Mechanisms of respiratory insufficiency induced by methadone overdose in rats.

scientific article published in January 2010

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity

scientific article published on June 2015

Morphine and metabolites plasma levels after administration of sustained release morphine in Roux-en-Y gastric bypass subjects versus matched control subjects

scientific article published on 3 August 2017

Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.

scientific article published on January 2004

Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.

scientific article published on 3 May 2017

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

scientific article published on 22 January 2016

P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes

scientific journal article

P-glycoprotein is more efficient at limiting uptake than inducing efflux of colchicine and vinblastine in HL-60 cells.

scientific article published in May 1998

Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line

scientific article

Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach

scientific article published on 20 June 2013

Placental transfer of maraviroc in an ex vivo human cotyledon perfusion model and influence of ABC transporter expression.

scientific article published on 7 January 2013

Population pharmacokinetic modeling of sustained release lithium in the serum, erythrocytes and urine of patients with bipolar disorder

scientific article published on 15 December 2018

Population pharmacokinetics and dosing optimization of teicoplanin in children with malignant haematological disease.

scientific article

Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.

scientific article published on 14 December 2009

Purification of Mouse Brain Vessels

scientific article published on 10 November 2015

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

scientific article published on 27 June 2016

RYGB and Drug Disposition: How to Do Better? Analysis of Pharmacokinetic Studies and Recommendations for Clinical Practice.

scientific article published on 26 January 2017

Respiratory effects of diazepam/methadone combination in rats: a study based on concentration/effect relationships.

scientific article

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.

scientific article published in December 2012

Role of ABC transporters in the chemoresistance of human gliomas.

scientific article published on August 2006

Sensory impairment in obese patients? Sensitivity and pain detection thresholds for electrical stimulation after surgery-induced weight loss, and comparison with a nonobese population.

scientific article

Sodium Transporters Are Involved in Lithium Influx in Brain Endothelial Cells

scientific article published on 14 June 2018

Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

scientific article

Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA).

scientific article published on 23 September 2009

Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.

scientific article published on 12 May 2008

Synthetic lipid nanoparticles targeting steroid organs

scientific article published on 26 September 2013

TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model

scientific article published in 2022

Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels.

scientific article

The effect of morbid obesity on morphine glucuronidation

scientific article published on 5 September 2016

The effect of morbid obesity on morphine glucuronidation

scientific article published on 28 September 2016

Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

scientific article published on 28 March 2017

Usefulness of plasma drug monitoring in severe baclofen poisoning

scientific article

Validity of leg-to-leg bioelectrical impedance analysis to estimate body fat in obesity

scientific article published on 01 July 2011

Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

scientific article

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

scientific article published on 07 June 2018

[New formats for improving brain drug delivery of antibodies: the blood-brain barrier case]

scientific article published on 01 December 2019

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