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List of works by Kenneth S. Kosik

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

scientific article published on 17 October 2019

A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein to Facilitate the Detection of SARS-CoV-2

scientific article published on 08 December 2020

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA

scientific article published on 31 May 2016

A Scalable, Easy-to-Deploy, Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material

scientific article published on 22 April 2020

A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation

scientific article published on December 2009

A delta-catenin signaling pathway leading to dendritic protrusions

scientific article published on 22 September 2008

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

scientific article published on 01 March 2019

A microRNA array reveals extensive regulation of microRNAs during brain development

scientific article

A microRNA-mRNA expression network during oral siphon regeneration in Ciona.

scientific article published on 21 April 2017

A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

scientific article published on 2 August 2017

A post-synaptic scaffold at the origin of the animal kingdom

scientific article published on 6 June 2007

A quantitative framework to evaluate modeling of cortical development by neural stem cells

scientific article

Action potential propagation recorded from single axonal arbors using multielectrode arrays

scientific article published on 11 April 2018

Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species

scientific journal article

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments

scientific article

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

scientific article published in August 2003

Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats

scientific article

BACE1 Suppression by RNA Interference in Primary Cortical Neurons ⬇️

scientific article published on November 3, 2003

Better read than dread

scientific article published in Nature

Beyond phrenology, at last

scientific article

Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

scientific article published on 12 February 2004

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

scientific article

CADASIL mutations impair Notch3 glycosylation by Fringe

scientific article published on 27 April 2005

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival ⬇️

scientific article (publication date: 6 February 2004)

COVID-19 in older people with cognitive impairment in Latin America

scientific article published on 01 September 2020

Cell biology in support of neurological research: 2018 highlights

scientific article published on 01 January 2019

Cofactors are essential constituents of stable and seeding-active tau fibrils

scientific article published on 11 December 2018

Control over single-cell distribution of G1 lengths by WNT governs pluripotency

scientific article published on 26 September 2019

Deep annotation of mouse iso-miR and iso-moR variation

scientific article

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

scientific article published in July 2005

Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction

scientific article

Delta-catenin at the synaptic-adherens junction

scientific article published in March 2005

Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome

scientific article

Detection of a microRNA signal in an in vivo expression set of mRNAs

scientific article

Development of a fluorescent high throughput assay for tau aggregation

scientific article

Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.

scientific article published in March 2004

Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs

scientific article published on 17 September 2015

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models

scientific article published on 04 June 2013

Discovery of compounds that will prevent tau pathology

scientific article

Diseases: Study neuron networks to tackle Alzheimer's

scientific article published in November 2013

Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL

scientific article published on 01 January 2004

Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.

scientific article

Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation

scientific article published on 10 February 2022

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury

scientific article published on August 2017

Evolution of New miRNAs and Cerebro-Cortical Development

scientific article published on 04 April 2018

Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains

scientific article

Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers

scientific article

Exploring the early origins of the synapse by comparative genomics

scientific article published on February 2009

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

scientific article published on 15 February 2016

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

scientific article

Functionalization of a protosynaptic gene expression network ⬇️

scientific article published on June 20, 2012

Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

scientific article published on 3 November 2004

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

scientific article published on 29 August 2013

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)

scientific article published on 10 February 2019

Genetic testing must recognize impact of bad news on recipient.

scientific article published in July 2008

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

scientific article

Growth hormone is produced within the hippocampus where it responds to age, sex, and stress

scholarly article

Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways.

scientific article

Heterogeneous dysregulation of microRNAs across the autism spectrum.

scientific article published on 19 June 2008

Highly conserved O-fucose sites have distinct effects on Notch1 function

scientific article published on July 2005

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation

scientific article

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

scientific article published on September 2016

Human neural tube morphogenesis in vitro by geometric constraints

scientific article published on 27 October 2021

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

scientific article

Identification of piRNAs in the central nervous system.

scientific article

In vitro validation of in silico identified inhibitory interactions

scientific article published on 06 April 2019

LRP1 is a master regulator of tau uptake and spread

scientific article published on 01 April 2020

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs

scientific article published on December 2016

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

scientific article published on 03 December 2020

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice

scientific article

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

scientific article published on 22 June 2016

MEA Viewer: A high-performance interactive application for visualizing electrophysiological data

scientific article published on 9 February 2018

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements

scientific journal article

MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state

scientific article

MUC1* mediates the growth of human pluripotent stem cells

scientific article

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

scientific article

MicroRNA profiling of the murine hematopoietic system

scientific article

MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states

scientific article published on December 2010

MicroRNA regulation of neural stem cells and neurogenesis

scientific article

MicroRNA-124: micromanager of neurogenesis

scientific article

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

scientific article

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

scientific article

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

scientific article

MicroRNAs and Cellular Phenotypy ⬇️

scientific article published on October 1, 2010

MicroRNAs potentiate neural development

scientific article

MicroRNAs tell an evo-devo story

scientific article published on 9 September 2009

MicroRNAs: regulators of oncogenesis and stemness

scientific article published on 24 June 2008

Microglial microRNAs mediate sex-specific responses to tau pathology

scientific article published on 23 December 2019

Molecular biology: Circles reshape the RNA world

scientific article published on 27 February 2013

NMDA mediated contextual conditioning changes miRNA expression

scientific article

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

scientific article published on 05 April 2019

Neuroscience gears up for duel on the issue of brain versus deity.

scientific article published in January 2006

New approaches to the discovery of cdk5 inhibitors

scientific article

Non-contact monitoring of extra-cellular field potentials with a multi-electrode array

scientific article published on 01 April 2019

Noncoding RNAs in Long-Term Memory Formation

scientific article published on October 2008

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns

scientific article

Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells

scientific article

Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease

scientific article

Parallel discovery of Alzheimer's therapeutics

scientific article published on June 2014

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

scientific article published on May 2002

Particle display: a quantitative screening method for generating high-affinity aptamers.

scientific article

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

scientific article published on 18 September 2019

Personalized medicine for effective Alzheimer disease treatment

scientific article

PhDs: what's left if science abdicates?

scientific article published in May 2011

Phosphorylated tau and the neurodegenerative foldopathies

scientific article

Postsynaptic Element Contributes to the Delay in Synaptogenesis in Synapsin I-Deficient Neurons

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate.

scientific article published on 23 March 2016

RNA stores tau reversibly in complex coacervates

scientific article

RNAi functions in cultured mammalian neurons

scientific article

Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony

scientific article

Regulation of AMPA receptor trafficking by delta-catenin.

scientific article

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development

scientific article published on 19 November 2018

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

scientific article published on 04 November 2019

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

scientific article published on 21 May 2015

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

scientific article published on 01 May 2016

SMN regulates axonal local translation via miR-183/mTOR pathway

scientific article

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

scientific article

Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.

scientific article published on 25 June 2007

Spatial learning and memory is preserved in rats after early development in a microgravity environment

scientific article published on September 2002

Specific microRNAs modulate embryonic stem cell-derived neurogenesis.

scientific article published on 15 December 2005

Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing

scientific article

Staged miRNA re-regulation patterns during reprogramming

scientific article

Statistical analysis of dendritic spine distributions in rat hippocampal cultures

scientific article

Structure–activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors ⬇️

scientific article published on February 3, 2011

Synaptic dysregulation in a human iPS cell model of mental disorders

scientific article published on 17 August 2014

Synaptic tagging -- who's it?

scientific article

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

scientific article

Tau Condensates

scientific article published on 01 January 2019

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

scientific article

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

scientific article published on 10 November 2020

Tau immunization: a cautionary tale?

scientific article published on 30 December 2014

Tau-er of Power

scientific article published on May 2015

Teaching resources. A model for local regulation of translation near active synapses

scientific article

The Amphimedon queenslandica genome and the evolution of animal complexity ⬇️

scientific article

The Elegance of the MicroRNAs: A Neuronal Perspective

scientific article

The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF

scientific article (publication date: 12 April 2002)

The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation

scientific article published on 17 October 2017

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

scientific article published on February 2009

The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons

scientific journal article

The message and the messenger: delivering RNA in neurons

scientific article

The neuronal microRNA system

scientific article published on December 2006

The outer subventricular zone and primate-specific cortical complexification.

scientific article

The proline-rich domain promotes Tau liquid-liquid phase separation in cells

scientific article published on 01 November 2020

Tracking Down Mutations Cell by Cell

scientific article published in March 2016

Transcriptional profiling reveals regulated genes in the hippocampus during memory formation.

scientific article

Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions ⬇️

scientific article published on May 30, 2012

Traveling the tau pathway: a personal account.

scientific article

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

scientific article published on 09 April 2013

Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology

scientific article

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.

scientific article

f-divergence cutoff index to simultaneously identify differential expression in the integrated transcriptome and proteome

scientific article published on 14 March 2016

iPSCs-derived nerve-like cells from familial Alzheimer's disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome

scientific article published on 20 March 2019

iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases

scientific article published on 19 October 2017

β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

scientific article published on January 2015

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