Search filters

List of works by Steven V. Ley

( S )- and ( R )-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis

(1′S,2′S)-Methyl-3O,4O-(1′,2′-Dimethoxycyclohexane-1′,2′-Diyl)-α-D-Mannopyranoside

(π-Allyl)tricarbonyliron Lactone Complexes in Organic Synthesis: A Useful and Conceptually Unusual Route to Lactones and Lactams

article

1,2-Diacetals in Synthesis: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei

scientific article published on 01 January 2000

1,2-Diacetals: A New Opportunity for Organic Synthesis

article

1,5-Asymmetric induction of chirality using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-functionalised carbonyl compounds

scientific article published on 01 September 2003

1,5-Asymmetric induction of chirality: diastereoselective addition of organoaluminium reagents and allylstannanes into aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes

article

1,5-Asymmetric induction of chirality: highly diastereoselective addition reactions of organoaluminium reagents into ketone groups in the side-chain of π-allyltricarbonyliron lactone complexes

article

1,5-Asymmetric induction of chirality: highly diastereoselective synthesis of homoallylic tertiary alcohols by the Lewis acid-mediated addition of allylstannanes into ketones in the side-chain of π-allyltricarbonyliron lactone complexes

article

1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-substituted β-hydroxy carbonyl compounds

1,7-Induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates

5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins

scientific article

8,9,10,10a-Tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction

A 2,3-butanedione protected chiral glycine equivalent--a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids

scientific article published in February 2003

A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles

A Clean Conversion of Aldehydes to Nitriles Using a Solid-Supported Hydrazine

A Comment on Continuous Flow Technologies within the Agrochemical Industry

scientific article published in 2021

A Concise Synthesis of the Natural Product Carpanone Using Solid-Supported Reagents and Scavengers

A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives

scientific article published in 2003

A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

A Facile One-Pot Synthesis of a Trisaccharide Unit from the Common Polysaccharide Antigen of Group BStreptococci Using Cyclohexane-1, 2-diacetal(CDA) Protected Rhamnosides

scholarly article by Steven V. Ley & Henning W. M. Priepke published 5 December 1994 in Angewandte Chemie International Edition

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist

A Flow Reactor Process for the Synthesis of Peptide Utilizing Immobilized Reagents, Scavengers and Catch and Release Protocols

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

article

A General Organocatalytic Enantioselective Nitrocyclopropanation Reaction

A Highly Selective, Organocatalytic Route to Chiral Dihydro-1,2-oxazines

scientific article published in 2005

A Homo-Proline Tetrazole as an Improved Organocatalyst for the Asymmetric Michael Addition of Carbonyl Compounds to Nitro-Olefins

article

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters.

scientific article published on 11 October 2017

A Microcapillary Flow Disc Reactor for Organic Synthesis

article

A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

scientific article published in 2013

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

scientific article published on 26 May 2011

A New Focused Microwave Approach to the Synthesis of Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-Component Coupling Process

article published in 2008

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

scientific article

A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging

article

A New Strategy for Oligosaccharide Assembly Exploiting Cyclohexane-1,2-diacetal Methodology: An Efficient Synthesis of a High Mannose Type Nonasaccharide

A New World for Chemical Synthesis?

scientific article published on 01 October 2019

A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis

scientific article (publication date: 19 February 2016)

A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow

scientific article published on 23 July 2019

A Polymer-supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds

scholarly article by Ian R. Baxendale et al published 2002 in Synlett

A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters

scientific article published on 13 December 2019

A Practical and Efficient Synthesis of the C-16−C-28 Spiroketal Fragment (CD) of the Spongistatins

scientific article published in 2003

A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin

scientific article published on 01 November 2000

A Short and Efficient Stereoselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin

scientific article published on 01 January 2000

A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977

A Total Synthesis of Epothilones Using Solid-Supported Reagents and Scavengers

scholarly article by R. Ian Storer et al published 6 June 2003 in Angewandte Chemie International Edition

A Total Synthesis of Millingtonine A

scientific article published on 19 January 2012

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds

scientific article published on 26 May 2015

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions

scientific article published on 31 October 2017

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor

scientific article

A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

article

A concise synthesis of carpanone using solid-supported reagents and scavengers

A concise total synthesis of (+)-okaramine C.

scientific article

A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect

A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist

scientific article published on November 2010

A convenient preparation of 2-haloenones from enones using phenylselenium halides

A facile route to imidazol-4-yl anions and their reaction with carbonyl compounds

A fascination with 1,2-diacetals

scientific article published on 13 April 2007

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

scientific article published on 24 March 2006

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

scientific article published on 01 December 2006

A flow-based synthesis of imatinib: the API of Gleevec

scientific article published on 5 March 2010

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

scientific article published on 31 January 2011

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols—synthesis and utility of (R ′,R ′,S,R)-2,3-butane diacetal protected butane tetrol

A general organocatalytic enantioselective malonate addition to alpha,beta-unsaturated enones

scientific article published in January 2008

A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones

scientific article

A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1

A highly enantioselective total synthesis of (+)-goniodiol

scientific article published on 27 March 2006

A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones

A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.

scientific article published on 16 April 2013

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement

article

A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

article

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

scientific article published on 12 March 2008

A multicomponent approach for the preparation of homoallylic alcohols

scientific article published on 08 July 2016

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

scientific article published on 07 January 2016

A new asymmetric organocatalytic nitrocyclopropanation reaction

scientific article published on 01 December 2006

A new route to functionalised π-allyltricarbonyliron lactam complexes from aziridines and their use in stereoselective synthesis and oxidative conversion to β-lactams

A new route to spiro-ketals using the Horner-Wittig reaction of 2-diphenylphosphinoxy cyclic ethers

A new ruthenium(VI) oxidant: preparation, X-ray crystal structure, and properties of (Ph4P)[RuO2(OAc)Cl2]

article

A new synthesis of (−)-epipyriculol: a phytotoxic metabolite

A new synthetic approach towards adriamycin

A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis

scientific article published on 27 July 2005

A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an ugi reaction

scientific article published in July 2002

A polymer-supported thionating reagent

A practical catalytic method for the preparation of steroidal 1,4-dien-3-ones by oxygen atom transfer from iodoxybenzene to diphenyl diselenide

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1

A prototype continuous-flow liquid-liquid extraction system using open-source technology

scientific article

A prototype device for evaporation in batch and flow chemical processes

article by Benjamin J. Deadman et al published 2013 in Green Chemistry

A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-diones

scientific article published in October 2003

A relay route for the synthesis of azadirachtin

scientific article published in January 2007

A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F.

scientific article published in December 2003

A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines

scientific article published on 01 August 2007

A sequential tetra-n-propylammonium perruthenate (TPAP)–Wittig oxidation olefination protocol

article

A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction

A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences

scientific article published on 5 November 2014

A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement

A total synthesis of the ammonium ionophore, (−)-enniatin B

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions ⬇️

scholarly article

A versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones

article

A “Catch–React–Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

scientific article published on 19 July 2012

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles

scientific article

Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

Across-the-world automated optimization and continuous flow synthesis of pharmaceutical agents operating through a cloud-based server

article by Daniel E. Fitzpatrick et al published 24 October 2018 in Angewandte Chemie International Edition

Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (-)- and (+)-polygodial.

scientific article

Addition of Dithiols to Bis-Ynones:  Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

article

Alkali metal reduction studies of cis- and trans-bicyclo[6.1.0]nona-2,4,6-trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions

scientific article published in 1974

Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis

Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid-binding Globulins

scientific article

An Asymmetric Tandem Conjugative Addition-Intramolecular Cyclisation Process to Provide Functionalised 3,6-Dihydropyrans and 4,5-Epoxytetrahydropyrans

article

An Enantioselective Organocatalytic Route to Chiral 3,6-Dihydropyridazines from Aldehydes

scientific article

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

An Intramolecular Organocatalytic Cyclopropanation Reaction

scientific article published on 01 May 2004

An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

article published in 2009

An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

article

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

scientific article published on 18 December 2012

An intramolecular Diels-Alder approach to the synthesis of the right hand half of the ionophore antibiotic X-14547A

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals ⬇️

scientific article

An unexpected rearrangement of 4-alkylaminoindoles

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

article

Analytical construct resins for analysis of solid-phase chemistry

scientific article

Analytical techniques for small molecule solid phase synthesis

scientific article

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (gamma)- and pyranyl (delta)-lactols

scientific article published on 18 March 2004

Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4

article

Application of Polymer-Supported Enzymes and Reagents in the Synthesis of γ-Aminobutyric Acid (GABA) Analogues

Application of ReactArray Robotics and Design of Experiments Techniques in Optimisation of Supported Reagent Chemistry

article

Application of ultrasound to the preparation of tricarbonyliron diene complexes

Aryne chemistry. Part XXXIII. Reactions of tetrahalogenobenzynes with methoxyarenes and the photolysis and thermolysis of some of the products

article

Aryne chemistry. Part XXXIV. Reactions of NN-dimethylarylamines with tetrahalogenobenzynes

Aryne chemistry. Part XXXV. Reactions of arynes with 1-aminocycloalkenes and hydrolyses of the adducts

Assembly of dendritic glycoclusters from monomeric mannose building blocks

Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes

article

Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst

scientific article

AuCl3-Catalyzed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five- and Six-Membered Cyclic Acetals

Autoradiographic localization of [22,23-(3)H(2)] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility.

scientific article

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei

scientific article

Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

scientific article published on 12 March 2008

Back Pressure Regulation of Slurry-Forming Reactions in Continuous Flow

article

Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase

article by Helen C. Hailes et al published January 1994 in Tetrahedron Letters

Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase

Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin

Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)

article published in 1995

Bis(p-methoxyphenyl) telluroxide: a new, mild oxidising agent

Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito

scientific article published in August 2001

Butane-2,3-Diacetal-Desymmetrized Glycolic Acid—A New Building Block for the Stereoselective Synthesis of Enantiopureα-Hydroxy Acids

scientific article published on 01 August 2001

Butane-2,3-diacetals of glyceraldehyde: a stable alternative to glyceraldehyde acetonide

scientific article published in October 2002

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

scientific article

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation

scientific article published on 31 July 2015

Camera-enabled techniques for organic synthesis

scientific article

Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors

scientific article published on July 2009

Catalytic oxidation of thiocarbonyl compounds involving the use of 1,2-Dibrometatrachloroethane as a brominating reagent for diaryl teII species

ChemInform Abstract: A Base-Catalyzed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles

ChemInform Abstract: A Clean Conversion of Aldehydes to Nitriles Using a Solid-Supported Hydrazine

ChemInform Abstract: A Concise Synthesis of the Natural Product Carpanone Using Solid-Supported Reagents and Scavengers

ChemInform Abstract: A Microfluidic Flow Chemistry Platform for Organic Synthesis: The Hofmann Rearrangement

ChemInform Abstract: A Prototype Continuous-Flow Liquid-Liquid Extraction System Using Open-Source Technology.

scientific article published in 2013

ChemInform Abstract: Dispiroketals in Synthesis. Part 16. Functionalized Dispiroketals as New Chiral Auxiliaries; the Synthesis of Dihydroxylated Dispiroketals in Optically Pure Form and Their Application as Bifunctional, C2‐ Symmetrical, Chiral Au

scientific article published on 17 October 1995

ChemInform Abstract: KMnO4-Mediated Oxidation as a Continuous Flow Process

ChemInform Abstract: Microwave Reactions under Continuous Flow Conditions

ChemInform Abstract: Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools

ChemInform Abstract: Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

ChemInform Abstract: Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

ChemInform Abstract: Synthesis of Nornicotine, Nicotine and Other Functionalized Derivatives Using Solid-Supported Reagents and Scavengers

ChemInform Abstract: The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

ChemInform Abstract: Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine Using Solid-Supported Reagents

Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis

article

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives

article by Giovanna Zinzalla et al published 2006 in Organic and Biomolecular Chemistry

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives

scientific article (publication date: 2007)

Chemistry of insect antifeedants from (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons

article by John N. Bilton et al published January 1988 in Tetrahedron Letters

Chemistry of insect antifeedants from (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology

article by Maria Gabriella Brasca et al published January 1988 in Tetrahedron Letters

Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage

article

Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin

article by Alastair A. Denholm et al published June 1995 in Tetrahedron

Chemistry of insect antifeedants from Azadirachta Indica (part 18): Demethylation and methylation of the C-8 position of the decalin portion of azadirachtin

Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin

article

Chemistry of insect antifeedants from Azadirachta indica (Part 16): Synthesis of several derivatives of azadirachtin containing fluorescent or immunogenic reporter groups

article

Chemistry of insect antifeedants from Azadirachta indica (Part 17): Synthesis of model compounds of azadirachtin. Unusual effect of remote substituents on the course of the oxidative ring contraction reaction.

scholarly article

Chemistry of insect antifeedants from Azadirachta indica (part 11): Characterisation and structure activity relationships of some novel rearranged azadirachtins

article by Steven V. Ley et al published November 1991 in Tetrahedron

Chemistry of insect antifeedants from Azadirachta indica(part 12): use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin

Chemistry of insect antifeedants from Azadirachta indica(part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans-fused hydrobenzofuran fragments for azadirachtin synthesis

Chemistry of insect antifeedants from Azadirachta indica(part 20): synthesis of biologically active, simple analogues of azadirachtin, containing the hydroxytetrahydrofurancarboxylate hemiketal moiety

article

Chemistry of insect antifeedants from Azadirachta indica(part 21): synthesis of model compounds of azadirachtin using a decalin framework as a functional group scaffolding

Chemistry of insect antifeedants from Azadirachta indica, Part 14: absolute configuration of azadirachtin

article by Steven V. Ley et al published 1992 in Journal of the Chemical Society. Chemical communications

Chemistry of insect antifeedants from azadirachta indica (Part 9): oxidative reactions of azadirachtin derivatives leading to C8-C14 bond cleavage

article

Chemistry of insect antifeedants from azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to 22,23-dihydro-23-β-methoxyazadirachtin

article by Steven V. Ley et al published 1988 in Tetrahedron Letters

Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment

article by Steven V. Ley et al published January 1989 in Tetrahedron

Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants

Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin

Chemistry of insect antifeedants from azadirachta indica (part 8): Synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferases

scientific article published on 01 August 2000

Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V

scientific article published on 01 October 2000

Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols

Chiral Glycolate Equivalents for the Asymmetric Synthesis of α-Hydroxycarbonyl Compounds

article

Chromatography-Free Suzuki Reactions Using a Polymer-Assisted Solution-Phase (PASP) Approach

Clean and efficient synthesis of azo dyes using polymer-supported reagents

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

article

Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents

article

Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents

article published in 1999

Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents

article by Frank Haunert et al published 1998 in Journal of the Chemical Society. Perkin transactions 1

Clerodane diterpenoids

scientific article published on June 1, 1992

Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species

article

Concepts and strategies for oligosaccharide synthesis. Foreword

scientific article published on 01 January 2011

Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative

scholarly article by Darren J. Dixon et al published 17 December 2001 in Angewandte Chemie International Edition

Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

article published in 2007

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride

scientific article

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

article

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

article

Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source

scientific article published on 29 October 2019

Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Continuous Processing and Efficient in Situ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

article

Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides

Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters

scientific article published on 20 May 2009

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

article by Jan Hartwig et al published 2014 in Organic and Biomolecular Chemistry

Continuous flow reaction monitoring using an on-line miniature mass spectrometer

scientific article published on 01 September 2012

Continuous multiple liquid-liquid separation: diazotization of amino acids in flow

scientific article published on 6 August 2012

Continuous stream processing: a prototype magnetic field induced flow mixer

Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations

Controlled generation and use of CO in flow

scientific article published in 2016

Convergent Total Syntheses of Callipeltosides A, B, and C

scholarly article by James R. Frost et al published 22 August 2012 in Angewandte Chemie International Edition

Conversion of thiocarbonyl compounds into their corresponding oxo derivatives using benzeneseleninic anhydride

Conversion of thiocarbonyl compounds into their corresponding oxoderivatives using benzeneseleninic anhydride

Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions

Copper-Catalyzed Arylations of Amines and Alcohols with Boron-Based Arylating Reagents

article

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

scholarly article by Daniela de Lucia et al published October 2015 in European Journal of Medicinal Chemistry

Cover Picture: Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C (Chem. Eur. J. 10/2004)

article published in 2004

Cover Picture: Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C (Chem. Eur. J. 10/2004)

Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration

article

Cyclohexan-1,2-diacetale (CDA): eine neue Schutzgruppe für vicinale Diole in Kohlenhydraten

Cyclohexane-1,2-diacetals(CDA): A New Protecting Group for Vicinal Diols in Carbohydrates

scholarly article by Steven V. Ley et al published 5 December 1994 in Angewandte Chemie International Edition

Cyclopropanation using flow-generated diazo compounds

scientific article published in March 2015

C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow

scholarly article by Paul Dingwall et al published 16 October 2018 in Chemical Communications

Dehydrogenation of lactones using benzeneseleninic anhydride. X-Ray crystal structure of 3β-acetoxy-14α-hydroxy-17a-oxa-D-homo-5α-androst-15-en-17-one

Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride

article

Dehydrogenation of steroidal ketones using benzeneseleninic anhydride

article published in 1978

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

article

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin

scientific article published on 23 March 2007

Design of a Specific Oxidant for Phenols ⬇️

scientific article published on January 1, 1978

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists

scientific article published on 20 January 2015

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

scientific article published on 15 July 2015

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes

scientific article published on 24 October 2013

Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring

article

Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

article

Development of a flow method for the hydroboration/oxidation of olefins

article

Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines

article

Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system

article

Development of a web-based platform for studying lithiation reactions in silico

scientific article published on April 2015

Development of an indole safety-catch linker using analytical constructs

scientific article

Development of fluorination methods using continuous-flow microreactors

article

Development of methods suitable for natural product synthesis: The azadirachtin story

article

Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis

article

Diaryl telluroxides as new mild oxidising reagents

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

scientific article published on 23 February 2011

Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of π-allyltricarbonyliron lactone complexes

article

Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes

article

Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes

article

Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives

Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S )-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet

Direct Oxidation of Csp 3 −H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow

scientific article published on 14 December 2018

Direct Protection of 1,2-Diols from α-Diketones

Direct preparation of diacetals from 1,2-diketones and their use as 1,2-diol protecting groups

Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents

Directed syntheses of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction

article

Dispiroketals in synthesis (Part 11): Concomitant enantioselective and regioselective protection of 2,5- dibenzoyl-myo-inositol

Dispiroketals in synthesis (Part 12): Functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form

article

Dispiroketals in synthesis (Part 13): Functionalised dispiroketals as new chiral auxiliaries; highly stereoselective diels-alder reactions using a bifunctional, C2- symmetrical chiral auxiliary

Dispiroketals in synthesis (Part 14): Functionalised dispiroketals as new chiral auxiliaries; highly stereoselective Michael additions to a bifunctional, C2- symmetrical chiral auxiliary

article

Dispiroketals in synthesis (Part 16): Functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form and their application as bifunctional, C2-symmetrical, chiral auxiliaries for highly st

Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates

article

Dispiroketals in synthesis (Part 5): A new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors

Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates

article

Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols

article

Dispiroketals in synthesis (part 2): A new group for the selective protection of diequatorial vicinal diols in carbohydrates

Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran

Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates

article

Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates

Dispiroketals in synthesis (part 8): Regioselective protection of D-glucopyranose substrates

Dispiroketals in synthesis (part 9): Resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran

Dispiroketals in synthesis. Part 23.1 A new route to (+)-D-conduritol B from myo-inositol

article

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

article

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

Dispiroketals: a new functional group for organic synthesis

article

Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems To Generate Protected 1,3-Dicarbonyl Compounds

article

Double diastereodifferentiation in the Mukaiyama aldol reactions of π-allyltricarbonyliron lactone complexes: 1,7- vs. 1,2-asymmetric induction

article

Dynamic flow synthesis of porous organic cages

article

Editorial – Flow Chemistry and Catalysis

article

Editorial: Harmonische Zusammenarbeit von Mensch und Maschine in der chemischen Synthese

Effect of azadirachtin-derived decalin (perhydronaphthalene) and dihydrofuranacetal (furo[2, 3-fo]pyran) fragments on the feeding behaviour ofSpodoptera littoralis

Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts

scientific article published on 9 March 2005

Efficient synthesis of (-)-triquinacene-2-carboxylic acid

article

Enabling Technologies for the Future of Chemical Synthesis

scientific article

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

scientific article published on 21 December 2018

Enantiopure 2-Substituted Glyceraldehyde Derivatives by Aza-Claisen Rearrangement or C-Alkylation of Enamines

scientific article published on 25 September 2008

Enantioselective Catalytic Intramolecular Cyclopropanation using Modified Cinchona Alkaloid Organocatalysts

scholarly article by Carin C. C. Johansson et al published 11 September 2006 in Angewandte Chemie International Edition

Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides

scholarly article by Charles D. Papageorgiou et al published 6 September 2004 in Angewandte Chemie International Edition

Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core

Enantioselective Synthesis of the Tetrahydrobenzylisoquinoline Alkaloid (-)-Norarmepavine Using Polymer Supported Reagents

Enantioselective Synthesis of the Tetrahydrobenzylisoquinoline Alkaloid (-)-Norarmepavine Using Polymer-Supported Reagents

Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603)

Encapsulation of palladium in polyurea microcapsules

scientific article

Engineering chemistry for the future of organic synthesis

scholarly article published in June 2018

Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes

Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology.

scientific article

Experiments on the synthesis of tetracycline. Part 15. Oxidation of phenols and ring A model phenols to o-hydroxy-dienones with benzeneseleninic anhydride

Experiments on the synthesis of tetracycline. Part 16. Improved photocyclic preparation of 12-keto-derivatives and their deprotection using benzeneseleninic anhydride

Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst

scientific article

Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

Fast continuous alcohol amination employing a hydrogen borrowing protocol

Fe2(co)g in tetrahydrofuran or under sonochemical conditions as convenient practical routes to π-allyltricarbonyliron lactone complexes

article published in 1984

FeCl3-Catalysed Cleavage of 1,2-Butanediacetal Protected Diols

Flow Chemistry Meets Advanced Functional Materials

Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes

Flow Microwave Technology and Microreactors in Synthesis

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines

scientific article published on 19 July 2007

Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds.

scientific article

Flow chemistry syntheses of natural products

scientific article published on 02 September 2013

Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor

scientific article

Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas-liquid contact.

scientific article

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

article

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

scientific article published on 24 April 2012

Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Foreword

Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating

scientific article published in May 2005

Formation of lactones from dienes via iron carbonyl complexes

Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation

scientific article published in 1976

Formation of β-lactams from tricarbonyliron lactone complexes

article

Fragment-based hit identification: thinking in 3D.

scientific article

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

scientific article

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system

scientific article

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

scientific article published on 01 July 2003

Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles

scientific article

Functionalised butanediacetal-protected 1,2-diols as suitable partners for Pd-catalysed cross-coupling reactions

Further reactions of t-butyl 3-oxobutanthioate and t-butyl 4-diethyl-phosphono-3-oxobutanthioate : Carbonyl coupling reactions, amination, use in the preparation of 3-acyltetramic acids and application to the total synthesis of fuligorubin A

Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation

Grignard additions to 2-uloses: synthesis of stereochemically pure tertiary alcohols

article

Highly Diastereoselective Desymmetrisation of Cyclicmeso-Anhydrides and Derivatisation to Mono-Protected 1,4-Diols

Highly Diastereoselective Lithium Enolate Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid and Deprotection to Enantiopureanti-2,3-Dihydroxy Esters

scientific article published on 01 November 2001

Highly Diastereoselective Michael Addition Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid. Preparation of α-Hydroxy-γ-amino Acid Derivatives

article

Highly cis- or trans-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone

scholarly article

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis

scientific article published on 6 January 2009

Highly diastereoselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction

Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

scientific article published in August 2014

Highly selective entry to the azadirachtin skeleton via a Claisen rearrangement/radical cyclization sequence.

scientific article published in October 2002

Homotropylium-8-sulfinate complexes by antimony pentafluoride-promoted ring opening of 9-thiabicyclo[4.2.1]nona-2,4,7-triene and 9-thiabarbaralane 9,9-dioxides

scholarly article by Leo A. Paquette et al published January 1976 in Journal of the American Chemical Society

Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure

Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat 30NP

scientific article

Hydroxide, Polymer-supported

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

scientific article published on 27 April 2016

Identification of Azadirachtin in Tissue-Cultured Cells of Neem (Azadirachta Indica)

Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells

scientific article

Immobilization of thallium by tandem oxidation/reduction-complexation of thallium(I/III)

scholarly article by Ishenkumba A. Kahwa et al published September 1992 in Inorganic Chemistry

In silico rationalisation of selectivity and reactivity in Pd-catalysed C-H activation reactions

scientific article published on 25 June 2020

In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.

scientific article published on 18 January 2012

Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids

article by Steven V. Ley et al published January 1989 in Tetrahedron

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

scientific article published on 17 July 2020

Integrated plug flow synthesis and crystallisation of pyrazinamide

Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

scientific article

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor

scientific article

Isolation, Characterisation and Oxidation of Isomeric Ferrelactone Complexes

article published in 1979

Iterative reactions of transient boronic acids enable sequential C-C bond formation

scientific article published on 8 February 2016

KMnO4-Mediated Oxidation as a Continuous Flow Process

scientific article published on 01 August 2010

Lesser-Known Enabling Technologies for Organic Synthesis

article

Luminescence dynamics and carbon-13 NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs

article published in 1992

Machine-Assisted Organic Synthesis

scientific article

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

scientific article published on 16 June 2015

Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Dihydropyridines

scholarly article by Katy L. Bridgwood et al published August 2008 in Organic Letters

Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides

scholarly article by Gemma E. Veitch et al published August 2008 in Organic Letters

Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles

scholarly article by Steven V. Ley et al published 1 October 2008 in Synlett

Mechanism of the thermal decomposition of tetra-aryltellurium species

article

Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids

scientific article

Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives

scientific article published on 19 October 2005

Microbial Oxidation in Synthesis: Preparation of (+)- and (−)-Pinitol from Benzene

Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene

article by Steven V. Ley et al published January 1987 in Tetrahedron Letters

Microbial oxidation in synthesis: Preparation from benzene of the cellular secondary messenger myo-inositol-1,4,5-trisphosphate (IP3) and related derivatives

article published in 1988

Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene

article published in 1989

Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene

Microencapsulation of Osmium Tetroxide in Polyurea

scholarly article by Steven V. Ley et al published January 2003 in Organic Letters

Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

article

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines

scientific article

Microwave reactions under continuous flow conditions

scientific article published on December 2007

Microwave-Assisted Leimgruber—Batcho Reaction for the Preparation of Indoles, Azaindoles and Pyrroylquinolines

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations

scientific article

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

article by Claudio Battilocchio et al published 5 February 2014 in Organic Letters

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.

scientific article

Model studies towards the insect antifeedant Jodrellin A using an organoselenium mediated cyclization reaction

article

Modern Synthetic Methods for Copper-Mediated C(aryl)–O, C(aryl)–N, and C(aryl)–S Bond Formation

scientific article (publication date: 17 November 2003)

Modified mesoporous silicate MCM-41 materials: immobilised perruthenate—a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen

article

Mukaiyama aldol reactions of π-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains. Not just formal, but genuine 1,7 induction of chirality

Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C

scientific article published on 01 May 2004

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

article

Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis

scientific article published on 01 January 2010

Multiple Microcapillary Reactor for Organic Synthesis

article

Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.

scientific article published in January 2009

N-alkylation of indole and pyrroles in dimethyl sulphoxide

NEW POLYETHYLENE GLYCOL POLYMERS AS KETAL PROTECTING GROUPS – A POLYMER SUPPORTED APPROACH TO SYMMETRICALLY SUBSTITUTED SPIROKETALS

Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools

Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide

Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia

scientific article

Neo-clerodane insect antifeedants from Scutellaria galericulata

article

New Routes to Biologically Active Heterocyclic Natural Products

New Tools and Concepts for Modern Organic Synthesis

New building blocks for efficient and highly diastereoselective polyol production—synthesis and utility of (R ′,R ′,S,S ) and (S′,S′,R,R)-2,3-butane diacetal protected butane tetrol derivatives

article

New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N-phenylselenophthalimide

article

New tools and concepts for modern organic synthesis

scientific article

Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides

scholarly article published on 19 January 2024

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes

scientific article published on 11 August 2005

Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)

Novel rearrangement of the ionophore antibiotic X-14547A (indanomycin) and related derivatives induced by lithium tetrafluoroborate

On Being Green: Can Flow Chemistry Help? ⬇️

scientific article published on June 18, 2012

On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones

On the reaction of thioacetals with sulphuryl chloride

One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines

scientific article

One-pot Synthesis of Penta- and Hepta-saccharides from Monomeric Mannose Building Blocks Using the Principles of Orthogonality and Reactivity Tuning

Organic Chemistry in Ionic Liquids Using Non-Thermal Energy-Transfer Processes

article

Organic Chemistry in Microreactors

Organic Synthesis in a Changing World

article

Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

scholarly article by Fabio Lima et al published 2018 in Chemical Communications

Organic synthesis in a changing world

scientific article

Organic synthesis: march of the machines

scientific article

Organic-Catalyst-Mediated Cyclopropanation Reaction

article

Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions

scientific article published on 29 November 2004

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Oxidation of alcohols using benzeneseleninic anhydride

Oxidation of aldehyde hydrazones, hydrazo compounds, and hydroxylamines with benzeneseleninic anhydride

Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions

Oxidation of ketone and aldehyde hydrazones, oximes, and semicarbazones and of hydroxylamines and hydrazo-compounds, using benzeneseleninic anhydride

article published in 1980

Oxidation of phenols to ortho-quinones using diphenylseleninic anhydride

Oxidation of phenols, pyrocatechols, and hydroquinones to ortho-quinones using benzeneseleninic anhydride

Oxo complexes of ruthenium(VI) and (VII) as organic oxidants

article

Oxygen atom transfer from iodylbenzene to diphenyl diselenide - a convenient method for dehydrogenation of steroidal 3-ketones

article

Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: an investigation of the reaction mechanism via a double isotopic labelling crossover study

Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplingsElectronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b3/b308465e/

scientific article published on 01 November 2003

Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants

article

Pd-EnCatTMTPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions

Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones

article

Pharmaceutical strategy and innovation: an academics perspective

scientific article published on June 2007

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow

scientific article published on 29 November 2018

Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins

scientific article published on 25 June 2020

Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines

article

Piperazic acid-containing natural products: isolation, biological relevance and total synthesis

scientific article published on 05 July 2011

Polymer Supported Reagents in Synthesis: Preparation of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Combinatorial Decoration

article

Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis

article

Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors

Polymer-supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential application in combinatorial chemistry

article

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

article

Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media

scientific article

Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-Reactor Hydrogenolysis

Preface

Preparation and reactions of 2-benzenesulphonyltetrahydropyran

Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols

article

Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole

Preparation of O-methyl 3-acyl tetronic acids by the direct acylation of stannyl tetronates

Preparation of Unsymmetrical Ketones from Tosylhydrazones and Aromatic Aldehydes via Formyl C–H Bond Insertion

scientific article published on 12 May 2014

Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

article

Preparation of aldehydes and ketones by oxidation of benzylic hydrocarbons with benzeneseleninic anhydride

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

scientific article published on 27 September 2010

Preparation of cyclic ether acetals from 2-benzenesulphonylderivatives: a new mild glycosidation procedure

Preparation of desymmetrised meso-tartrate derivatives—synthesis and utility of (R′,R′,R,S)-2,3-butane diacetal protected dimethyl tartrate

Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to α-hydroxyacid and amide derivatives

Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts

article

Preparation of homoallylic amines via a three-component coupling process

Preparation of lactones via tricarbonyliron–lactone complexes

Preparation of phenylselenoimines from phenols using diphenylseleninic anhydride and hexamethyldisilazane

Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins

Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides

Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process

Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone

Preparation of β-ketomacrolactones and β-ketodiolides using S-t-butyl 3-oxobutanethioate and S-t-butyl 4-diethylphosphono-3-oxobutanethioate

article published in 1989

Preparation, structure, derivatisation and NMR data of cyclohexane-1,2-diacetal protected carbohydrates

Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate

article published in 2014

Professor Steven V Ley CBE FRS FMedSci

scholarly article published in June 2018

Progress towards avermectins and milbemycins

article

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

scientific article published on 12 October 2016

Protecting Groups: Effects on Reactivity, Glycosylation Stereoselectivity, and Coupling Efficiency

PtCl4-Catalyzed Domino Synthesis of Fused Bicyclic Acetals

scientific article published on 01 January 2008

Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei

scientific article published on 01 December 1998

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines

scientific article published on 11 January 2017

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Rapid access to rare natural pyranosides using 1,2-diacetal protected intermediates

article

Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R′,R′,S,R)-2,3-butane diacetal protected butanetetraol derivatives

article

Rapid assembly of oligosaccharides: 1,2-diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

scientific article (publication date: 19 March 2010)

Reaction of tetracycline hydrochloride with N-chlorosuccinimide: X-ray crystal structure of the major product

Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow

Rearrangement reactions of bicyclic systems. Part I. Synthesis of a model compound related to flavothebaone trimethyl ether. The abnormal ultraviolet absorption spectrum of flavothebaone and its trimethyl ether

Rearrangement reactions of bicyclic systems. Part II. Rearrangements of 1-dimethylamino-5,6,7,8-tetrahalogeno-1,4-dihydro-1,4-ethenonaphthalene derivatives and the analogous 5,6,7,8-tetrafluoro-1,4-dihydro-N-methyl-1,4-iminonaphthalene in aqueous sol

Rearrangement reactions of bicyclic systems. Part III. Acid-catalysed rearrangements of 1,4-dihydro-1-methoxy-1,4-ethenonaphthalene (1-methoxybenzobarrelene) and its 5,6,7,8-tetrahalogeno-derivatives

article published in 1974

Rearrangement reactions of bicyclic systems. Part IV. Acid-catalysed rearrangements of 5,6,7,8-tetrafluoro-1,4-dihydro-1-methoxy-3,9-dimethyl-1,4-ethenonaphthalene (1-methoxy-3,5-dimethyltetrafluorobenzobarrelene)

article published in 1974

Reconfiguration of a Continuous Flow Platform for Extended Operation: Application to a Cryogenic Fluorine-Directed ortho-Lithiation Reaction

article

Recyclable polyurea-microencapsulated Pd(0) nanoparticles: an efficient catalyst for hydrogenolysis of epoxides.

scientific article published in November 2003

Reductive decomplexation of pi-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols

scientific article published in September 2003

Reductive decomplexation of pi-allyltricarbonyliron lactone complexes; a new route to stereo-defined 1,7-diols and 2,3-diene-1,7-diols

scientific article published in September 2002

Reductive decomplexation of π-allyltricarbonyliron lactone complexes: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols

article

Regeneration of ketones from hydrazones, oximes, and semicarbazones by benzeneseleninic anhydride

Regioselective Preparation of Saturated Spirocyclic and Ring-Expanded Fused Pyrazoles

article

Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids

article published in 1983

Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications

Removal of 1,3-dithiolan protecting groups by benzeneseleninic anhydride

Removal of thioacetal protecting groups by benzeneseleninic anhydride

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme

scientific article

Rotamers or diastereomers? An overlooked NMR solution

scientific article published on 22 May 2012

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

scientific article published on 16 December 2010

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia

article

Schwesinger Base, Polymer-supported

Second-generation synthesis of azadirachtin: a concise preparation of the propargylic mesylate fragment

scientific article published in January 2009

Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters

article

Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi-synthetic analogues

article

Sexual development of malaria parasites is inhibited in vitro by the neem extract azadirachtin, and its semi-synthetic analogues

scientific article published in July 1994

Solid supported reagents in multi-step flow synthesis

article

Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs

scientific article published in July 2001

Solid-supported reagents for multi-step organic synthesis: preparation and application.

scientific article

Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

article published in 2016

Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic

scientific article published in 1995

Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties

scientific article published in October 2006

Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols

scholarly article by Roman Lenz et al published July 1998 in Tetrahedron: Asymmetry

Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives

Stereoselective synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2-(4-fluorophenoxymethyl)-3,4-O-isopropylidene tetrahydrofuran from mannose

Stereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)oxepane: a potential anti-asthmatic drug candidate

Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity

Structural reappraisal of the limonoid insect antifeedant azadirachtin

article

Studies in the chemistry of benzobicyclo systems

doctoral thesis

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides

Studies towards the total synthesis of rapamycin: A convergent and stereoselective synthesis of the C22C32 carbon framework

Studies towards the total synthesis of rapamycin: Preparation of the C10C17 carbon unit

Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33C42 fragment and further coupling to afford the C22C42 carbon unit

Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles

Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone

Sulphuration of Electron-Rich Arenes with Sulphenamides and Aminosulphenyl Chlorides

Supported Reagents and Scavengers in Multi-Step Organic Synthesis

article

Supported Reagents and Scavengers in Multi-step Organic Synthesis

article

Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.

scientific article published on 25 October 2013

Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor

Synthesis and chemistry of the ionophore antibiotic tetronasin.

scientific article published on March 1996

Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions

article

Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction

Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from Viverra civetta, using organoselenium-mediated cyclisation reactions

Synthesis of (±)warburganal

Synthesis of (−)-Gloeosporone, a fungal autoinhibitor of spore germination using a π-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction

scientific article published on 01 October 2003

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

Synthesis of Enantiomerically Enriched 3-Amino-2-oxindoles through a Palladium-Mediated Asymmetric Intramolecular Arylation of α-Ketimino Amides

scholarly article by Päivi Tolstoy et al published 4 September 2012 in Organic Letters

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

article

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry

scientific article published on 4 February 2016

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

scientific article published on 08 July 2014

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

Synthesis of a Ceramide Sphingolipid as a Potential Sex Pheromone of the Hair CrabErimacrus isenbeckiiUsing Butane-2,3-diacetal Desymmetrised Glycolic Acid Building Blocks

Synthesis of a Precursor to Sacubitril Using Enabling Technologies

scientific article published in 2015

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

scientific article

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

article by Steven V. Ley et al published January 1987 in Tetrahedron Letters

Synthesis of a novel 3, 4-dihydromilbemycin analogue

article published in 1987

Synthesis of a substituted cis-decalin as a potential insect antifeedant

article

Synthesis of a trans-decalin as a potential insect antifeedant

article by Steven V. Ley et al published 1981 in Journal of the Chemical Society. Chemical communications

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates

scientific article published on 28 September 2009

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

scientific article published on 01 July 1999

Synthesis of azadirachtin: a long but successful journey

scientific article

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

scientific article

Synthesis of cinnamolide and polygodial

Synthesis of euryfuran, valdiviolide, and confertifolin

Synthesis of high-mannose type neoglycolipids: active targeting of liposomes to macrophages in gene therapy

scientific article published in April 2000

Synthesis of isoxazolidines using polymer supported perruthenate (PSP)

article

Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclization reactions

Synthesis of natural products from the Indian neem tree Azadirachta indica

scientific article published on 15 January 2008

Synthesis of polyoxygenated trans-decalins as potential insect antifeedants

article by Steven V. Ley et al published 1982 in Journal of the Chemical Society. Perkin transactions 1

Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X-Ray molecular structure of (2S,8R)-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4(R)-ol

Synthesis of spongistatin 2 employing a new route to the EF fragment

article

Synthesis of substituted cis-decalins as potential insect antifeedants

article

Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes

article

Synthesis of the Alkaloid Natural Products (+)-Plicane and (−)-Obliquine, Using Polymer-Supported Reagents and Scavengers†

Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1

scientific article published in 2003

Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

Synthesis of the EF Fragment of Spongistatin 1

Synthesis of the Nonamannan Residue of a Glycoprotein with High Mannose Content

scholarly article by Peter Grice et al published 2 February 1996 in Angewandte Chemie International Edition

Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)

article

Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

Synthesis of the alkaloids (−)-heliotridane and (−)-isoretronecanol via π-allyltricarbonyliron lactam complexes

article

Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents

scientific article published in October 2002

Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide

Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins

article published in 1987

Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C15 to C16 bond

article published in 1985

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

article

Synthesis of the spiroacetal unit related to the avermectins and milbemycins

article

Synthesis of the thapsigargins

scientific article

Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex

Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes

Synthesis of trifluoromethyl ketones using polymer-supported reagents

scientific article published in May 2002

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

scientific article

Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex

Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex

Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes

article

Synthesis, Chiroptical Properties, and Absolute Configuration of (+)-2,3-Dihydrotriquinacen-2-one. Effect of Rigid Triquinacene Geometry on the Inherently Dissymmetric Chromophore

article

Synthesis, structure revision, and absolute configuration of (+)-didemniserinolipid B, a serinol marine natural product from a tunicate Didemnum sp.

scientific article published in September 2002

Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V

article by Stephen E. de Laszlo et al published 1986 in Journal of the Chemical Society. Chemical communications

Synthetic studies towards the acyltetronic acid iohophore M 139603

Synthetic studies towards the clerodane insect antifeedant jodrellin A: preparation of a polycyclic model compound with antifeedant activity

article by Ana C. Cuñat et al published 1996 in Journal of the Chemical Society. Perkin transactions 1

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

scientific article published on 16 April 2007

Taming hazardous chemistry by continuous flow technology

scientific article

Targeting C-reactive protein for the treatment of cardiovascular disease.

scientific article

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Tetra-N-propylammonium perruthenate: a case study in catalyst recovery and re-use involving tetraalkylammonium salts

scientific article published in November 2001

Tetra-n-propylammonium perruthenate (TPAP)-catalysed oxidations of alcohols using molecular oxygen as a co-oxidant

article

Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts

article

Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis

article

The Changing Face of Organic Synthesis

article

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

scientific article published on 22 December 2010

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

The Diels–Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal

The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony

scholarly article by Steven V. Ley published 30 March 2018 in Angewandte Chemie International Edition

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

scientific article published on 21 September 2011

The Rapid Preparation of 2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Microwave Heating

The Total Synthesis of the Annonaceous Acetogenin 10-Hydroxyasimicin

scholarly article by Gillian L. Nattrass et al published 13 December 2004 in Angewandte Chemie International Edition

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C We thank the EPSRC (D.J.D. and D.J.R.), the Novartis Research Fellowship (S.V.L.), and the BP Research Endowment (S.V.L.) for generous financial support for this work

scientific article published on 01 October 2000

The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B.

scientific article

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

article

The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum

article by James R. Hanson et al published 1982 in Journal of the Chemical Society. Perkin transactions 1

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

scientific article published on 8 December 2011

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

scientific article published on 2 September 2013

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.

scientific article published in April 2010

The azadirachtin story

scientific article published on January 2008

The clerodane ring system: investigating the viability of a direct Diels–Alder approach

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

scientific article published on 10 February 2010

The crystal structure of 3-epicaryoptin and the reversal of the currently accepted absolute configuration of clerodin

The development and application of supported reagents for multi-step organic synthesis

article

The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells

scientific article

The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal–metal pair interactions

The flow synthesis of heterocycles for natural product and medicinal chemistry applications ⬇️

scientific article published on October 20, 2010

The formation of unusual sultones during the rearrangement reactions of bicyclic ketones

The preparation and alkylation of a butanedione-derived chiral glycine equivalent and its use for the synthesis of α-amino acids and α,α-disubstituted amino acids

The question of delocalization in "anchored" ions with potential trishomoaromatic character. 1. Reduction of tricyclo[5.4.1.04,12]dodeca-2,5,8,10-tetraene as a route to the 10.pi.11C dianion

scientific article published in 1977

The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids

article published in 2002

The stability of NN-dialkylthiohydroxylamines

The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B

article by James C. Anderson et al published January 1989 in Tetrahedron Letters

The synthesis and Diels–Alder reactions of 2-prop-2-enylidene-1,3-dioxolan

article

The synthesis and assay of radiolabelled benzene derivatives

article published in 1995

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

scientific article published on 18 December 2012

The synthesis of azadirachtin: a potent insect antifeedant.

scientific article published in January 2008

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahydropyranyl ether derivatives

The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.

scientific article published on 6 May 2013

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers

scientific article

The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction

article

The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol

scholarly article by Darren J. Dixon et al published 2001 in Canadian Journal of Chemistry

The total synthesis of agglomerin A and (±)-carolinic acid. A general method for the preparation of 3-acyl tetronic acids via direct acylation of O-methyl 3-stannyl tetronates

article published in 1991

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

scientific article

The total synthesis of the clerodane diterpene insect antifeedant ajugarin I

article

The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives

article

The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

article published in 2005

The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

article

The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol

article published in 2002

The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol

article published in 2000

The use of π-allyltricarbonyliron lactone complexes in the synthesis of the β-lactone esterase inhibitor (−)-valilactone

article

Thermal decomposition of tricarbonyliron lactone complexes

article

Thermal isomerization of homoazocines

scientific article published in 1978

Thermal rearrangement reactions of tricarbonyliron lactone complexes

Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor

scientific article published in 2018

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

article by Jörg Habermann et al published 1999 in Journal of the Chemical Society. Perkin transactions 1

Total Synthesis of Chloptosin

article

Total Synthesis of Chloptosin: A Dimeric Cyclohexapeptide

article

Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition

scientific article published on 01 January 2007

Total Synthesis of Iso- and Bongkrekic Acids: Natural Antibiotics Displaying Potent Antiapoptotic Properties

Total Synthesis of Polycephalin C and Determination of the Absolute Configurations at the 3″,4″ Ring Junction

scientific article published on 01 August 2002

Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B

scientific article published on 01 January 2007

Total Synthesis of Rapamycin

scientific article published on 01 January 2007

Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry

scholarly article by Matthew Ball et al published 26 August 2005 in Angewandte Chemie International Edition

Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research f

Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids

article by Antoine Francais et al published 15 January 2010 in Organic Letters

Total Synthesis of the Cyclic Heptapeptide Argyrin B:  A New Potent Inhibitor of T-Cell Independent Antibody Formation

scientific article published on 01 March 2002

Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B.

scientific article published on 25 November 2014

Total syntheses of subereamollines A and B

article by James W. Shearman et al published 2011 in Organic and Biomolecular Chemistry

Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44

article published in 2010

Total synthesis of (+)-milbemycin β1

article

Total synthesis of antascomicin B.

scientific article

Total synthesis of rapamycin

scientific article published in January 2009

Total synthesis of thapsigargin, a potent SERCA pump inhibitor

scientific article

Total synthesis of the Fusarium toxin equisetin

scientific article published on 7 December 2004

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents

article by Ian R. Baxendale et al published August 2002 in Tetrahedron

Total synthesis of the anthelmintic macrolide avermectin B1a

article

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

article

Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)

article by David Díez-Martin et al published January 1992 in Tetrahedron

Total synthesis of the ionophore antibiotic X-14547A (Indanomycin)

article by Martin P. Edwards et al published September 1984 in Journal of Organic Chemistry

Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid

article

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine †

article

Total synthesis of the polyenoyltetramic acid polycephalin C

Total synthesis of the potent antifungal agents bengazole C and E

Total synthesis of the protein phosphatase inhibitor okadaic acid

article

Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction

Total synthesis of the spiroketal macrolide (+) milbemycin α1

article

Total synthesis of the structurally unique ionophore antibiotic X–14547 A

Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin

scientific article

Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin

scientific article published on January 2008

Towards the synthesis of the C37-C42 fragment of rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones

Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones

scientific article published in March 2003

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

scientific article

Tuning glycoside reactivity: New tool for efficient oligosaccharide synthesis

Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)

Ultrasonic formation and reactions of sodium phenylselenide

Unsaturated heterocyclic systems. XCII. Nitrogen analogs of 1,6-methano[12]annulene. Effect on valence tautomerism of the locus of aza substitution

article published in 1975

Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids.

scientific article published on 15 June 2017

Use of 2-phenylsulphonyl cyclic ethers in the preparation of tetrahydropyran and tetrahydrofuran acetals and in some glycosidation reactions

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation

article

Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A

Use of the Potassium Ion as a Template for the Selective Derivatization of the Antibiotic X-206

Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[(p-benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one

Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase

article

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

scientific article published in April 2017

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow

scientific article published on 6 October 2016

Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)-C(sp3) Cross-Couplings in Flow

article

Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives

scientific article published on 9 November 2017

Wittig and horner-wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis

X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin

article by Howard B. Broughton et al published 1986 in Journal of the Chemical Society. Chemical communications

X-Ray evidence for partial bonding between sulphur or selenium and oxygen in thio- and seleno-imines

article

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

article

π-Allyltricarbonyliron lactone complexes in synthesis: application to the synthesis of the β-lactam antibiotic (+)-thienamycin

‘The changing face of organic synthesis’

article

“Connectivist” approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin

article

Paulina is supported by:

About Paulina

Help