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List of works by Lukas J.A.C. Hawinkels

5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.

scientific article

Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence

scientific article published on 01 April 2009

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

scientific article published on 15 September 2015

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.

scientific article

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

scientific article published on 23 March 2017

Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer

scientific article published on 23 January 2020

Circulating bone morphogenetic protein levels and delayed fracture healing.

scientific article published on 28 December 2012

Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer

scientific article published on 02 July 2007

DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression

scientific article published on 09 November 2019

Determination of matrilysin activity in gastrointestinal neoplasia

scientific article published on 01 July 2007

ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis

scientific article published on 28 January 2014

Efficient degradation-aided selection of protease inhibitors by phage display.

scientific article

Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

scientific article published on 01 September 2010

Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy

scientific article published on 30 April 2015

Endoglin Targeting: Lessons Learned and Questions That Remain

scientific article published on 25 December 2020

Endoglin for tumor imaging and targeted cancer therapy.

scientific article published on 17 January 2013

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer.

scientific article

Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis

scientific article published on 01 July 2018

Endothelium specific matrilysin (MMP-7) expression in human cancers.

scientific article published on 26 October 2007

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

scientific article published on 01 March 2022

Exploring anti-TGF-β therapies in cancer and fibrosis ⬇️

scientific article published on June 30, 2011

Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment

scientific article published on 29 May 2020

Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.

scientific article

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.

scientific article published on 6 February 2017

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. ⬇️

scientific article

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

scientific article published on 30 March 2015

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts ⬇️

scientific article published on December 3, 2012

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.

scientific article published in April 2012

Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model

scientific article published in Scientific Reports

Multimodality imaging reveals a gradual increase in matrix metalloproteinase activity at aneurysmal lesions in live fibulin-4 mice.

scientific article published on 30 June 2010

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

scientific article published in Nature Communications

Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas.

scientific article published on 25 March 2016

Prostaglandin F2α-induced TGFβ-PMEPA1 pathway is a critical mediator of epithelial plasticity and ovarian carcinoma progression

scholarly article published 18 September 2018

Putting the Wnt up colon cancer.

scientific article

Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins

scientific article

Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis

scientific article

Targeting endoglin expressing regulatory T cells in the tumor microenvironment enhances the effect of PD1 checkpoint inhibitor immunotherapy

scientific article published on 24 April 2020

Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies

scientific article published on 15 November 2019

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.

scientific article published on 13 November 2014

The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

scientific article published on 28 September 2017

Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients

scientific article published on 17 July 2007

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.

scientific article published on 6 August 2008

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