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List of works by Simon J Brookes

4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus.

scientific article

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

scientific article published on 05 August 2013

A Novel Method for Electrophysiological Analysis of EMG Signals Using MesaClip

scientific article published on 09 June 2020

A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead

scientific article published on 30 November 2015

A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract

scientific article published on 01 April 2011

A novel mode of sympathetic reflex activation mediated by the enteric nervous system

scientific article published on 16 July 2020

A teaching module on cellular control of small intestinal motility.

scientific article

A teaching module on irritable bowel syndrome

scientific article published on 01 October 2005

Activation of intestinal spinal afferent endings by changes in intra-mesenteric arterial pressure.

scientific article

All calbindin-immunoreactive myenteric neurons project to the mucosa of the guinea-pig small intestine

scientific article published on 01 October 1994

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

scientific article published on 11 April 2013

Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon

scientific article published on 01 May 2013

CGRPα within the Trpv1-Cre population contributes to visceral nociception

scientific article

Characterisation of One Class of Group III Sensory Neurons Innervating Abdominal Muscles of the Mouse

scientific article published on 01 November 2019

Characterization of alkaline phosphatase-reactive neurons in the guinea-pig small intestine

scientific article published on 01 December 1994

Characterization of alternating neurogenic motor patterns in mouse colon

scientific article published on 30 November 2020

Characterization of excitatory and inhibitory motor neurons to the guinea pig lower esophageal sphincter

scientific article published on 01 July 1996

Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?

scientific article published on 29 September 2011

Characterization of projections of longitudinal muscle motor neurons in human colon

scientific article published on 29 July 2019

Characterization of putative interneurons in the myenteric plexus of human colon

scientific article published on 24 August 2020

Characterization of the colonic response to bisacodyl in children with treatment-refractory constipation

scientific article published on 13 April 2020

Choline acetyltransferase immunoreactivity in the human small and large intestine

scientific article published on 01 August 1996

Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon.

scientific article published on July 2002

Comparison of extrinsic efferent innervation of guinea pig distal colon and rectum

scientific article published on 01 June 2006

Computer vision-based diameter maps to study fluoroscopic recordings of small intestinal motility from conscious experimental animals.

scientific article published on 16 March 2017

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders.

scientific article published on 10 August 2015

Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse

scientific article published on 8 May 2014

CrossTalk opposing view: 5-HT is not necessary for peristalsis

scientific article published on 01 August 2015

Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

scientific article published on 22 August 2014

Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia.

scientific article published on 14 April 2016

Discriminating movements of liquid and gas in the rabbit colon with impedance manometry

scientific article published on 13 December 2017

Distension-evoked ascending and descending reflexes in the isolated guinea-pig stomach

scientific article published on 01 January 1997

Distinct patterns of myogenic motor activity identified in isolated human distal colon with high-resolution manometry

scientific article published on 06 May 2020

Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea-pig distal colon

scientific article published on 04 January 2019

Effects of Lactate on One Class of Group III (CT3) Muscle Afferents

scientific article published on 06 August 2020

Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot study

scientific article published on 22 February 2016

Electrophysiological characterization of human rectal afferents

scientific article published on 27 October 2016

Expression of Notch1 and Jagged2 in the enteric nervous system

scientific article published in July 2003

Extrinsic Sensory Innervation of the Gut: Structure and Function.

scientific article

Extrinsic primary afferent signalling in the gut.

scientific article published on 26 February 2013

Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon

scientific article published on 24 May 2012

Function and morphology correlates of rectal nerve mechanoreceptors innervating the guinea pig internal anal sphincter.

scientific article published on 27 August 2010

Functional GABAB receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings.

scientific article

Functional changes in low- and high-threshold afferents in obstruction-induced bladder overactivity

scientific article published on 25 March 2019

High-resolution colonic motility recordings in vivo compared with ex vivo recordings after colectomy, in patients with slow transit constipation.

scientific article published on 9 June 2016

Human enteric neurons: morphological, electrophysiological, and neurochemical identification

scientific article

Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder.

scientific article published on 28 October 2016

Identification and mechanosensitivity of viscerofugal neurons ⬇️

scientific article published on August 27, 2012

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle

scientific article published on 28 May 2018

Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse

scientific article published on 28 January 2016

Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice

scientific article published on 24 January 2008

Identification of medium/high-threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract.

scientific article published on 05 March 2009

Identification of multiple distinct neurogenic motor patterns that can occur simultaneously in the guinea-pig distal colon

scientific article published on 18 October 2018

Identification of the visceral pain pathway activated by noxious colorectal distension in mice.

scientific article

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

scientific article

Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice

scientific article

Immunohistochemical characterization of the innervation of human colonic mesenteric and submucosal blood vessels

scientific article published on 14 July 2008

Initiation of peristalsis by circumferential stretch of flat sheets of guinea-pig ileum

scientific article published on 01 April 1999

Insights into the mechanisms underlying colonic motor patterns

scientific article published on 15 March 2016

Intestinal peristalsis: a mammalian motor pattern controlled by enteric neural circuits

scientific article published on 01 November 1998

Intraganglionic laminar endings act as mechanoreceptors of vagal afferent nerve in guinea pig esophagus

scientific article published on 01 April 2006

Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach

scientific article

Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon?

scientific article

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine.

scientific article

Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice

scientific article published on 10 August 2021

Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.

scientific article published on 29 March 2012

Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease.

scientific article published on 14 February 2011

Major classes of sensory neurons to the urinary bladder

scientific article published on 03 April 2006

Measurement of strains experienced by viscerofugal nerve cell bodies during mechanosensitive firing using digital image correlation

scientific article published on 11 August 2016

Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut.

scientific article

Mechanisms of mechanotransduction by specialized low-threshold mechanoreceptors in the guinea pig rectum.

scientific article published on 2 June 2005

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

scientific article

Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium.

scientific article published on 26 May 2009

Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus

scientific article published on 18 September 2003

Morphological and neurochemical characterisation of anterogradely labelled spinal sensory and autonomic nerve endings in the mouse bladder

scientific article published on 01 July 2020

NADPH-diaphorase and other neuronal markers in nerves and ganglia supplying the guinea-pig vas deferens

scientific article published on 01 June 1994

NADPH-diaphorase reactivity in nerves supplying the rat anococcygeus muscle ⬇️

scientific article published on August 20, 1993

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.

scientific article published on 16 April 2014

Neural motor complexes propagate continuously along the full length of mouse small intestine and colon

scientific article published on 11 November 2019

Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum

scientific article published on 13 November 2014

Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies.

scientific article published on December 2009

Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract.

scientific article published on April 2004

Neurochemical characterization of extrinsic innervation of the guinea pig rectum

scientific article published in March 2004

Neurochemical characterization of extrinsic nerves in myenteric ganglia of the guinea pig distal colon

scientific article published on 10 December 2014

Neurochemical coding compared between varicose axons and cell bodies of myenteric neurons in the guinea-pig ileum.

scientific article published on 2 November 2012

Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat.

scientific article published on 19 September 2013

Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon

scientific article published on May 3, 2012

Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon.

scientific article published on 18 April 2017

Neuromechanical factors involved in the formation and propulsion of fecal pellets in the guinea-pig colon.

scientific article published on 6 August 2015

New insights into neurogenic cyclic motor activity in the isolated guinea-pig colon.

scientific article published on 26 April 2017

Non-peristaltic patterns of motor activity in the guinea-pig proximal colon

scientific article published on 7 January 2010

Orally projecting interneurones in the guinea‐pig small intestine ⬇️

scientific article published on 01 December 1997

Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon.

scientific article published on 10 October 2013

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

scientific article

Postoperative ileus-An ongoing conundrum

scientific article published on 30 November 2020

Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine

scientific article published on 01 December 1992

Projections of nitric oxide synthase and vasoactive intestinal polypeptide-reactive submucosal neurons in the human colon

scientific article published on 01 December 1999

Propagating contractions of the circular muscle evoked by slow stretch in flat sheets of guinea-pig ileum

scientific article published on 01 December 2001

Properties of the major classes of mechanoreceptors in the guinea pig bladder.

scientific article published on 4 October 2007

Pudendal afferent innervation of the guinea pig external anal sphincter.

scientific article

Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.

scientific article published on 11 August 2014

Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase

scientific article published on 01 February 2007

Quantitative analysis of peristalsis in the guinea-pig small intestine using spatio-temporal maps

scientific article published in June 1999

Quantitative immunohistochemical co-localization of TRPV1 and CGRP in varicose axons of the murine oesophagus, stomach and colorectum

scientific article published on 14 May 2015

Rapid anterograde and retrograde tracing from mesenteric nerve trunks to the guinea-pig small intestine in vitro

scientific article published on 01 March 1999

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating

scientific article published on 01 August 2015

Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum.

scientific article published in September 2003

Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum.

scientific article

Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation.

scientific article published on 25 July 2008

Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea-pig distal colon

scientific article published on 01 October 2019

Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum.

scientific article published on 7 November 2016

Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum

scientific article

Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon

scientific article

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry.

scientific article published on 2 April 2016

Spinal afferent nerve endings in visceral organs: recent advances

scientific article published on 17 November 2016

Spontaneous release of acetylcholine from autonomic nerves in the bladder

scientific article published on 03 April 2009

Structure-function relationship of sensory endings in the gut and bladder.

scientific article published on 14 August 2009

Sympathetic Pathways Target Cholinergic Neurons in the Human Colonic Myenteric Plexus

scientific article published on 17 March 2022

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon

scientific article published on 21 September 2017

TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig

scientific article published on 28 August 2008

Targeted electrophysiological analysis of viscerofugal neurons in the myenteric plexus of guinea-pig colon

article

Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine

scientific article published on 30 December 2010

The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine.

scientific article

The enteric nervous system

The morphology and projections of retrogradely labeled myenteric neurons in the human intestine ⬇️

scientific article published on 01 September 1995

The neurochemical changes in the innervation of human colonic mesenteric and submucosal blood vessels in ulcerative colitis and Crohn's disease

scientific article published on 05 March 2014

The neurochemical coding and projections of circular muscle motor neurons in the human colon ⬇️

scientific article published on 01 December 1997

The polarity of neurochemically defined myenteric neurons in the human colon ⬇️

scientific article published on 01 August 1997

The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia

article

Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse

scientific article

Transduction sites of vagal mechanoreceptors in the guinea pig esophagus.

scientific article published in August 2000

Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice

scientific article published on 01 April 2019

Ultrastructural studies of the myenteric plexus and smooth muscle in organotypic cultures of the guinea-pig small intestine ⬇️

scientific article published on June 1, 1995

Viscerofugal neurons recorded from guinea‐pig colonic nerves after organ culture ⬇️

scientific article published on July 19, 2012

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