List of works by Gad Frankel

(1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC).

scientific article

3D structure of EspA filaments from enteropathogenic Escherichia coli.

scientific article

4D multimodality imaging of Citrobacter rodentium infections in mice

scientific article published on 13 August 2013

A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium

scientific article

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

scientific article published on 12 August 2014

A type III effector antagonizes death receptor signalling during bacterial gut infection

scientific article published on September 2013

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

scientific article

Adherence of enterohemorrhagic Escherichia coli O157, O26, and O111 strains to bovine intestinal explants ex vivo

scientific article

An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination

scientific article

Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors

scientific article published on 30 October 2017

Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal

scientific article published on 04 December 2007

Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion

scientific article published in Nature Communications

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors

scientific article

Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences

scientific article

Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.

scientific article

Bioluminescent Monitoring of In Vivo Colonization and Clearance Dynamics by Light-Emitting Bacteria

article

BopC is a type III secreted effector protein of Burkholderia pseudomallei

scientific article

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

scientific article published on 10 April 2018

Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium

scientific article

Cellulose mediates attachment of Salmonella enterica Serovar Typhimurium to tomatoes

scientific article published on 30 May 2011

Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium

scientific article published on September 2003

CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.

scientific article published in December 2003

CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD.

scientific article

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection

scientific article published on September 2006

Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens

scientific article published on December 2005

Citrobacter amalonaticus Inhibits the Growth of Citrobacter rodentium in the Gut Lumen

scientific article published on 05 October 2021

Citrobacter rodentium Infection Induces Persistent Molecular Changes and Interferon Gamma-Dependent Major Histocompatibility Complex Class II Expression in the Colonic Epithelium

scientific article published on 01 February 2022

Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo

scientific article

Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease

scientific article published on 30 October 2019

Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux

scientific article published in April 2011

Citrobacter rodentium mouse model of bacterial infection

scientific article

Citrobacter rodentium of mice and man.

scientific article

Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism

scientific article published on 20 September 2019

Citrobacter rodentium: infection, inflammation and the microbiota

scientific article

Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells

scientific article published on 30 December 2020

Coiled-coil proteins associated with type III secretion systems: a versatile domain revisited

scientific article

Comparison of Salmonella enterica serovars Typhi and Typhimurium reveals typhoidal-specific responses to bile

scientific article published on 11 December 2017

Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E. coli and Citrobacter rodentium.

scientific article

Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.

scientific article published on 24 October 2008

Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042

scientific article published on 20 January 2010

Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli

scientific article

Correction: Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection

scholarly article published by Gad Frankel in 2012

Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo

scientific article

Cryoelectron-microscopy structure of the enteropathogenic <i>Escherichia coli</i> type III secretion system EspA filament

scientific article published on 01 January 2021

Direct injection of functional single-domain antibodies from E. coli into human cells

scientific article

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo

scientific article

Distribution of espI among clinical enterohaemorrhagic and enteropathogenic Escherichia coli isolates

scientific article

Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli

scientific article

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

scientific article

Efa-1/LifA mediates intestinal colonization of calves by enterohaemorrhagic Escherichia coli O26 : H- in a manner independent of glycosyltransferase and cysteine protease motifs or effects on type III secretion

scientific article published on 13 May 2010

Efa1 influences colonization of the bovine intestine by shiga toxin-producing Escherichia coli serotypes O5 and O111.

scientific article published on September 2002

Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract

article by Siouxsie Wiles et al published August 2005 in Cellular Microbiology

Enterohemorrhagic Escherichia coli exploits EspA filaments for attachment to salad leaves

scientific article published on 29 February 2008

Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin

scientific article published on March 2004

Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2.

scientific article

Enteropathogenic Escherichia coli translocate Tir and form an intimin-Tir intimate attachment to red blood cell membranes.

scientific article

Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells

scientific article published on July 2005

Enteropathogenic Escherichia coli: unravelling pathogenesis

scientific article

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

scientific article

Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation

scientific article

Enteropathogenic and enterohemorrhagic Escherichia coli type III secretion effector EspV induces radical morphological changes in eukaryotic cells

scientific article

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

scientific article published on 13 February 2017

EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function

scientific article

EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics

scientific article

EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis

scientific article published on 14 January 2008

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

scientific article published on 13 January 2017

EspM2 is a RhoA guanine nucleotide exchange factor

scientific article published on 21 December 2009

EspT triggers formation of lamellipodia and membrane ruffles through activation of Rac-1 and Cdc42.

scientific article

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation

scientific article published on 2 October 2012

Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium

scientific article

Faecal neutrophil elastase-antiprotease balance reflects colitis severity

scientific article published on 26 November 2019

FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections

scientific article

Fermented dairy products modulate Citrobacter rodentium-induced colonic hyperplasia

scientific article

Finding your niche: what has been learnt from STM studies on GI colonization

scientific article

Flagella mediate attachment of enterotoxigenic Escherichia coli to fresh salad leaves.

scientific article published in February 2011

Fresh fruit and vegetables as vehicles for the transmission of human pathogens

scientific article published on 15 July 2010

Fresh produce as a potential vector for bacterial human pathogens

scientific article published on 15 July 2009

Functional analysis of the enteropathogenic Escherichia coli type III secretion system chaperone CesT identifies domains that mediate substrate interactions

scientific article published in January 2002

Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism

scientific article published on April 2007

Genomic comparison of the O-antigen biosynthesis gene clusters of Escherichia coli O55 strains belonging to three distinct lineages.

scientific article

Helicobacter pylori has stimulatory effects on naive T cells.

scientific article published in February 2006

Host defences to Citrobacter rodentium

scientific article

Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization

scientific article published in January 2006

Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion

scientific article published in Nature Communications

Human intestinal tissue tropism in Escherichia coli O157 : H7--initial colonization of terminal ileum and Peyer's patches and minimal colonic adhesion ex vivo

scientific article published on March 2007

Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli.

scientific article published in January 2003

Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7.

scientific article published in October 2006

Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection

scientific article published on April 2004

Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium

scientific article

Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function

scientific article published on 4 January 2008

In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium

scientific article

In vivo imaging of gene transfer to the respiratory tract

scientific article published on 21 December 2007

Induction of cell death in T lymphocytes by invasin via beta1-integrin

scientific article published on April 2002

Infection strategies of enteric pathogenic Escherichia coli

scientific article published on March 2012

Inhibition of NF-κB Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia coli Effector Protein NleE ⬇️

scientific article published on September 10, 2010

Interaction between protein subunits of the type IV secretion system of Bartonella henselae

scientific article published on July 2004

Interaction of Salmonella enterica with basil and other salad leaves

scientific article published on 2 October 2008

Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture

scientific article published on March 2004

Interaction of enteroaggregative Escherichia coli with salad leaves.

scientific article

Interaction of enterohemorrhagic Escherichia coli O157:H7 with mouse intestinal mucosa.

scientific article

Interaction of enteropathogenic Escherichia coli with human intestinal mucosa: role of effector proteins in brush border remodeling and formation of attaching and effacing lesions

scientific article published on February 2005

Interaction of enteropathogenic Escherichia coli with red blood cell monolayers.

scientific article

Interactions of typical and atypical enteropathogenic Escherichia coli strains with the calf intestinal mucosa ex vivo

scientific article published on 24 July 2009

Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli

scientific article published on 03 September 2013

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops

scientific article

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection

scientific article published in January 2004

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

scientific article

Legionella pneumophila pathogenesis in the Galleria mellonella infection model

scientific article published on 29 May 2012

Legionella pneumophila secretes a mitochondrial carrier protein during infection

scientific article

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins

scientific article

LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.

scientific article published on 03 September 2013

Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses

scientific article

Modelling infectious disease - time to think outside the box?

scientific article

Modelling of infection by enteropathogenic Escherichia coli strains in lineages 2 and 4 ex vivo and in vivo by using Citrobacter rodentium expressing TccP

scientific article published on 02 February 2009

Molecular basis of antigenic polymorphism of EspA filaments: development of a peptide display technology

scientific article

Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells.

scientific article published on 12 March 2018

Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence

scientific article published on March 2002

N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins

scientific article

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

scientific journal article

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

scientific article

Non-invasive three-dimensional imaging of Escherichia coli K1 infection using diffuse light imaging tomography combined with micro-computed tomography

scientific article

Older leaves of lettuce (Lactuca spp.) support higher levels of Salmonella enterica ser. Senftenberg attachment and show greater variation between plant accessions than do younger leaves

scientific article

OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

scientific article published on 02 September 2019

Operon structure and gene expression of the espJ--tccP locus of enterohaemorrhagic Escherichia coli O157:H7.

scientific article

Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium

scientific article published in October 2004

PAK4 phosphorylates myosin regulatory light chain and contributes to Fcγ receptor-mediated phagocytosis

scientific article published on 3 September 2011

Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion

scientific article

Polymorphisms within EspA filaments of enteropathogenic and enterohemorrhagic Escherichia coli

scientific article

Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity

scientific article published on 17 August 2012

Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coli

scientific article published on August 2012

RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium

scientific article

Regulators encoded in the Escherichia coli type III secretion system 2 gene cluster influence expression of genes within the locus for enterocyte effacement in enterohemorrhagic E. coli O157:H7.

scientific article

Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.

scientific article published on 25 August 2008

Role of intimin-tir interactions and the tir-cytoskeleton coupling protein in the colonization of calves and lambs by Escherichia coli O157:H7.

scientific article published in January 2006

Salmonella bongori provides insights into the evolution of the Salmonellae

scientific article published in August 2011

Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene

scientific article

Salmonella enterica strains belonging to O serogroup 1,3,19 induce chlorosis and wilting of Arabidopsis thaliana leaves

scientific article published on 23 February 2011

SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal

scientific article published on 10 September 2010

SepL, a protein required for enteropathogenic Escherichia coli type III translocation, interacts with secretion component SepD.

scientific article published in June 2004

Sieving through gut models of colonization resistance

scientific article published on 22 January 2018

Structural and functional properties of chimeric EspA-FliCi filaments of EPEC.

scientific article published on 4 March 2008

Structure of the bundle-forming pilus from enteropathogenic Escherichia coli.

scientific article

Subcellular localization of legionella Dot/Icm effectors

scientific article published in January 2013

Subversion of actin dynamics by EPEC and EHEC.

scientific article

Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens

scientific article published on 5 March 2008

Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors

scientific article

TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton

scientific article

TccP2 of O157:H7 and non-O157 enterohemorrhagic Escherichia coli (EHEC): challenging the dogma of EHEC-induced actin polymerization

scientific article published on 13 November 2006

The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli

scientific article published on 6 November 2009

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses

scientific article published on 26 October 2018

The Dot/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A/J mice

scientific article

The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner

scientific article published on 19 June 2017

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

scientific article published on 19 December 2014

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions

scientific article published on 22 January 2015

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase

scientific article published on 20 December 2018

The Rab-binding Profiles of Bacterial Virulence Factors during Infection

scientific article published on 11 January 2016

The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin

scientific article published on 29 May 2019

The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals

scientific article

The Type III Secretion System Effector SeoC of Salmonella enterica subsp. salamae and S. enterica subsp. arizonae ADP-Ribosylates Src and Inhibits Opsonophagocytosis

scientific article published on 10 October 2016

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi

scientific article

The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner

scientific article published on 14 September 2011

The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells

scientific article published on 6 November 2014

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).

scientific article published on 16 March 2012

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B. ⬇️

scientific article published on 11 March 2010

The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea

scientific article

The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH

scientific article

The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium

scientific article

The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics

scientific article

The motor protein myosin 1G functions in FcγR-mediated phagocytosis

scientific journal article

The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium

scientific article published on 11 August 2008

The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection

scientific article published in 2024

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

scientific article

The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection

scientific article

Tir Triggers Expression of CXCL1 in Enterocytes and Neutrophil Recruitment during Citrobacter rodentium Infection

scientific article

Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models

scientific article published on May 2007

Trained ILC3 responses promote intestinal defense

scientific article published in 2022

Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes

scientific article

Translation of a minigene in the 5' leader sequence of the enterohaemorrhagic Escherichia coli LEE1 transcription unit affects expression of the neighbouring downstream gene

scientific article published on January 2012

Type 3 secretion effectors

Typhoidal Salmonella: Distinctive virulence factors and pathogenesis

Tyrosine residues at the immunoglobulin-C-type lectin inter-domain boundary of intimin are not involved in Tir-binding but implicated in colonisation of the host

scientific article published in November 2002

Use of Galleria mellonella as a model organism to study Legionella pneumophila infection

scientific article

Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents.

scientific article

Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.

scientific article published on 23 February 2007

Very long O-antigen chains of Salmonella Paratyphi A inhibit inflammasome activation and pyroptotic cell death

scientific article published on 23 December 2020

Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions

scientific article published on 01 April 2020

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