List of works - Alan W Stitt

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats.

scientific article published on 22 January 2008

AGEs and diabetic retinopathy.

scientific article published on October 2010

AGEs, RAGE, and Diabetic Retinopathy ⬇️

scientific article published on August 1, 2011

Abnormal Glycogen Storage by Retinal Neurons in Diabetes

scientific article published on 01 December 2015

Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors

scientific article published on 10 December 2012

Advanced glycation as a basis for understanding retinal aging and noninvasive risk prediction.

scientific article published on April 2008

Advanced glycation end products accumulate in the reproductive tract of men with diabetes.

scientific article

Advanced glycation end products and diabetic complications

scientific article published in September 2002

Advanced glycation end products and diabetic retinopathy.

scientific article published on January 2013

Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.

scientific article published on 28 February 2007

Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats

scientific article published on 01 June 2000

Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.

scientific article published in March 2008

Advanced glycation: an important pathological event in diabetic and age related ocular disease

scientific article

Advances in our understanding of diabetic retinopathy.

scientific article published on 13 March 2013

Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales' Disease patients

scientific article

Animal Models of Retinal Vein Occlusion.

scientific article

Anti-angiogenic therapy for uveal melanoma--more haste, less speed

scientific article published on April 2002

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

scientific article published on 29 April 2019

Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy ⬇️

scientific article published on May 15, 2012

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

scientific article published on 13 November 2015

Characterisation of WE-14 in porcine ocular tissue.

scientific article published in May 2003

Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epithelium

scientific article

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

scientific article published on 01 March 2018

Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells

scientific article (publication date: 24 March 1999)

Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products.

scientific article published in June 1998

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 7 November 2017

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.

scientific article

Diabetes-related adduct formation and retinopathy.

scientific article published on June 2011

Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments.

scientific article

Differences in mouse models of diabetes mellitus in studies of male reproduction.

scientific article published on 16 November 2009

Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy

scientific article (publication date: 29 July 2010)

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

scientific article

Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus

scientific article published on 21 June 2007

Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy.

scientific article published on 15 October 2009

Endostatin modulates VEGF-mediated barrier dysfunction in the retinal microvascular endothelium.

scientific article published in July 2005

Endothelial Progenitors: A Consensus Statement on Nomenclature

scientific article

Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells

scientific article

Endothelial progenitor cells in diabetic retinopathy

scientific article

Endothelial progenitors as tools to study vascular disease.

scientific article published on 15 March 2012

Endothelin-like immunoreactivity and receptor binding in the choroid and retina

scientific article published on 01 January 1996

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells through ESM1 Signalling

scientific article published on 17 November 2018

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

scientific article

Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

scientific article published in August 2013

Expression of the 67 kDa laminin receptor (67LR) during retinal development: correlations with angiogenesis.

scientific article

Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia

scientific article published on 01 August 1999

Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours

article by Alan W Stitt et al published 1 November 1998 in Journal of Pathology

Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.

scientific article published on 7 December 2011

Fasciola hepatica: disruption of spermatogenesis by the microfilament inhibitor cytochalasin B

scientific article published on 01 January 1991

Fasciola hepatica: localization and partial characterization of tubulin

scientific article published on 01 January 1992

Fasciola hepatica: the effect of the microfilament inhibitor cytochalasin B on the ultrastructure of the adult fluke ⬇️

scientific article published on January 1, 1991

Fasciola hepatica: the effect of the microtubule inhibitors colchicine and tubulozole-C on the ultrastructure of the adult fluke.

scientific article

Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity.

scientific article published on 23 March 2018

Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose

scientific article published on December 2005

Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients

scientific article

Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction. ⬇️

scientific article

Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE).

scientific article published on 12 September 2010

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.

scientific article

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

scientific article published on 03 December 2019

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

scientific article published on 01 November 1995

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

scientific article published on 01 July 1993

Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.

scientific article published on January 2007

Inhibition of advanced glycation end‐products protects against retinal capillary basement membrane expansion during long‐term diabetes ⬇️

scientific article published on October 1, 2003

Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy.

scientific article

Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy.

scientific article published on February 2005

Inhibition or deletion of 11β-HSD1 does not increase angiogenesis in ischemic retinopathy

scientific article published on 11 January 2017

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

scientific article

Involvement of MAPKs in endostatin-mediated regulation of blood-retinal barrier function

scientific article published on 01 December 2006

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

scientific article published on 13 October 2006

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes.

scientific article published on 13 June 2016

Localisation of actin in the liver fluke, Fasciola hepatica

scientific article published on January 1, 1992

MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.

scientific article published on 20 June 2017

Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.

scientific article

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

scientific article published on October 1996

Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane

scientific article

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products.

scientific article published on 30 November 2010

Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.

scientific article published on 2 February 2012

Neurodegeneration in diabetic retinopathy: does it really matter?

scientific article published on 20 July 2018

Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes.

scientific article published on April 1995

Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy

scientific article

Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

scientific article published on 4 February 2016

Posterior drug delivery via periocular route: challenges and opportunities.

scientific article

Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies

scientific article published on 22 November 2017

Profiling retinal biochemistry in the MPDZ mutant retinal dysplasia and degeneration chick: a model of human RP and LCA.

scientific article

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

scientific article published on 06 December 2011

Protein expression profiling during chick retinal maturation: a proteomics-based approach.

scientific article published on 10 December 2008

Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.

scientific article

Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis.

scientific article published on 16 February 2017

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

scientific article

Raman Spectroscopy for the Detection of AGEs/ALEs ⬇️

scientific article published on January 1, 2013

Recombinant alpha2(IV)NC1 domain of type IV collagen is an effective regulator of retinal capillary endothelial cell proliferation and inhibits pre-retinal neovascularisation

scientific article published on 17 August 2006

Retinal and choroidal response to panretinal photocoagulation and ultrastructural perspective

scientific article published on 01 May 1996

Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells

scientific article published on 27 May 2009

Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.

scientific article

Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.

scientific article

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.

scientific article

Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression.

scientific article

Sclera as a surrogate marker for determining AGE-modifications in Bruch's membrane using a Raman spectroscopy-based index of aging

scientific article

Stereological estimation of Weibel-Palade bodies in the retinal vasculature of normal and diabetic dogs

scientific article published on 01 September 1994

Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor.

scientific article published on 22 October 2004

Synthetic peptides interacting with the 67-kd laminin receptor can reduce retinal ischemia and inhibit hypoxia-induced retinal neovascularization

scientific article

The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

scientific article published in September 2002

The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis ⬇️

scientific article published on October 1, 2003

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.

scientific article published on 9 March 2018

The combined effects of diabetes and ionising radiation on the rat retina: an ultrastructural study

scientific article published on 01 January 1994

The effect of triclabendazole ("Fasinex") on protein synthesis by the liver fluke, Fasciola hepatica

scientific article published on 01 April 1995

The expression of membrane-associated 67-kDa laminin receptor (67LR) is modulated in vitro by cell-contact inhibition

scientific article (publication date: 2000)

The pathogenic role of Maillard reaction in the aging eye.

scientific article published on 21 October 2010

The pathology associated with diabetic retinopathy.

scientific article

The progress in understanding and treatment of diabetic retinopathy.

scientific article published on 18 August 2015

The role of advanced glycation end products in retinal ageing and disease.

scientific article

The role of advanced glycation in the pathogenesis of diabetic retinopathy.

scientific article

The role of immune-related myeloid cells in angiogenesis.

scientific article published on 08 July 2013

The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases

scientific article published on 30 October 2018

Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease.

scientific article published on February 2013

Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells

scientific article published on 16 August 2012

Upregulation of oxidative stress markers in human microvascular endothelial cells by complexes of serum albumin and digestion products of glycated casein.

scientific article published on September 2009

Vascular stem cells and ischaemic retinopathies.

scientific article

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

scientific article published on 20 January 2021

List of works by Alan W Stitt

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats.

AGEs and diabetic retinopathy.

AGEs, RAGE, and Diabetic Retinopathy ⬇️

Abnormal Glycogen Storage by Retinal Neurons in Diabetes

Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors

Advanced glycation as a basis for understanding retinal aging and noninvasive risk prediction.

Advanced glycation end products accumulate in the reproductive tract of men with diabetes.

Advanced glycation end products and diabetic complications

Advanced glycation end products and diabetic retinopathy.

Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.

Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats

Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.

Advanced glycation: an important pathological event in diabetic and age related ocular disease

Advances in our understanding of diabetic retinopathy.

Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales' Disease patients

Animal Models of Retinal Vein Occlusion.

Anti-angiogenic therapy for uveal melanoma--more haste, less speed

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy ⬇️

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

Characterisation of WE-14 in porcine ocular tissue.

Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epithelium

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells

Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products.

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.

Diabetes-related adduct formation and retinopathy.

Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments.

Differences in mouse models of diabetes mellitus in studies of male reproduction.

Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus

Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy.

Endostatin modulates VEGF-mediated barrier dysfunction in the retinal microvascular endothelium.

Endothelial Progenitors: A Consensus Statement on Nomenclature

Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells

Endothelial progenitor cells in diabetic retinopathy

Endothelial progenitors as tools to study vascular disease.

Endothelin-like immunoreactivity and receptor binding in the choroid and retina

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells through ESM1 Signalling

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Expression of the 67 kDa laminin receptor (67LR) during retinal development: correlations with angiogenesis.

Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia

Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours

Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.

Fasciola hepatica: disruption of spermatogenesis by the microfilament inhibitor cytochalasin B

Fasciola hepatica: localization and partial characterization of tubulin

Fasciola hepatica: the effect of the microfilament inhibitor cytochalasin B on the ultrastructure of the adult fluke ⬇️

Fasciola hepatica: the effect of the microtubule inhibitors colchicine and tubulozole-C on the ultrastructure of the adult fluke.

Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity.

Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose

Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients

Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction. ⬇️

Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE).

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.

Inhibition of advanced glycation end‐products protects against retinal capillary basement membrane expansion during long‐term diabetes ⬇️

Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy.

Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy.

Inhibition or deletion of 11β-HSD1 does not increase angiogenesis in ischemic retinopathy

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

Involvement of MAPKs in endostatin-mediated regulation of blood-retinal barrier function

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes.

Localisation of actin in the liver fluke, Fasciola hepatica

MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.

Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products.

Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.

Neurodegeneration in diabetic retinopathy: does it really matter?

Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes.

Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy