List of works - Paul F Alewood

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

scientific article published on 14 March 2019

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

scientific article

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity

scientific article

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins.

scientific article published in July 2006

A proteomic approach to detect lactosylation and other chemical changes in stored milk protein concentrate

scientific article published on 12 November 2011

Accelerated chemical synthesis of peptides and small proteins

scientific article

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia

scientific article published on 30 July 2015

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7.

scientific article published on 19 February 2020

Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.

scientific article

Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor.

scientific article published on 13 May 2003

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists

scientific article published on 24 February 2006

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

scientific article published on 17 March 2016

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.

scientific article published on 8 April 2014

Ancient Venom Systems: A Review on Cnidaria Toxins

scientific article

Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor

scientific article

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

scientific article published on 21 September 2020

Bioactive components in fish venoms

scientific article

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

scientific article

Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.

scientific article published in February 2004

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

scientific article

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

scientific article published on 21 March 2009

Chemical synthesis and structure of the prokineticin Bv8

scientific article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

scientific article published on 31 August 2015

Cone snail venomics: from novel biology to novel therapeutics

scientific article

Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

scientific article published on 9 February 2016

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

scientific article published on 2 January 2008

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa

scientific article published on 01 August 2000

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure

scientific article published in August 2000

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

scientific article published on 5 October 2017

Conotoxins: Chemistry and Biology

scientific article published on 21 October 2019

Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter

scientific article published on 01 November 2006

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

scientific article

Cyclization of peptides by using selenolanthionine bridges.

scientific article

Cysteine-rich mini-proteins in human biology.

scientific article published on January 2012

D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus

scientific article (publication date: 31 July 2002)

Deep venomics of the Pseudonaja genus reveals inter- and intra-specific variation

scientific article published on 26 November 2015

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

scientific article published on February 2017

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

scientific article published on 29 March 2016

Differential evolution and neofunctionalization of snake venom metalloprotease domains

scientific article published on 12 December 2012

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy

scientific article published in January 2009

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

scientific article published on 7 September 2017

Discovery, synthesis, and structure-activity relationships of conotoxins.

scientific article published on 10 April 2014

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

scientific article published on 19 June 2013

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

scientific article

Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications

scientific article published on 01 January 2002

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

scientific article

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

scientific article published on 09 February 2020

Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus

scientific article

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

scientific article published on 5 August 2014

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

scientific article

Identification of a Novel Class of Nicotinic Receptor Antagonists

scientific article published in Journal of Biological Chemistry

Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.

scientific article published on 07 October 2013

Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues

scientific article

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

scientific article published on 22 February 2016

Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.

scientific article published on 7 October 2014

Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail.

scientific article published on 16 June 2006

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

scientific article published on 4 August 2013

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

scientific article

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

scientific article published in December 2006

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

scientific article published on 16 May 2012

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

scientific article

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

scientific article published on 19 February 2014

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

scientific article

Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function

scientific article published in September 2008

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

scientific article published on 30 December 2013

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

scientific article

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

scientific article published on 3 June 2008

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain

scientific article published in 2024

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

scientific article published in Scientific Reports

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

scientific article published on 24 April 2019

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

scientific article published in December 2018

Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.

scientific article published on 20 October 2013

Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.

scientific article published on 6 July 2015

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold

article

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

scientific article

Privileged frameworks from snake venom.

scientific article

Rapid Access to ω-Conotoxin Chimeras using Native Chemical Ligation

article

Rapid sensitive analysis of cysteine rich peptide venom components.

scientific article

Re-engineering the μ-conotoxin SIIIA scaffold.

scientific article published in April 2014

RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.

scientific article published on 16 November 2011

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

scientific journal article

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

scientific article published in Nature Communications

Single Amino Acid Substitutions in α-Conotoxin PnIA Shift Selectivity for Subtypes of the Mammalian Neuronal Nicotinic Acetylcholine Receptor

scientific article published in Journal of Biological Chemistry

Site-Specific pKa Determination of Selenocysteine Residues in Selenovasopressin by Using 77Se NMR Spectroscopy

scientific article published on 14 October 2011

Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance

scientific article

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter

scientific article

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels

scientific article

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

scientific article published in March 2010

Structure determination of the three disulfide bond isomers of α-conotoxin GI: a model for the role of disulfide bonds in structural stability 1 1Edited by P. E. Wright ⬇️

scientific article published on May 1, 1998

Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics ⬇️

scientific article

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

scientific article

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.

scientific article published in March 2003

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies

scientific article

The 1.1 Å Resolution Crystal Structure of [Tyr15]EpI, a Novel α-Conotoxin fromConus episcopatus, Solved by Direct Methods ⬇️

scientific article published on August 18, 1998

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

scientific article

The role of defensive ecological interactions in the evolution of conotoxins.

scientific article published on 28 November 2015

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity

scientific article

Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

scientific article

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

article

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

scientific article published on 28 October 2015

Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

scientific article published on 16 September 2013

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

scientific article

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

scientific article

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail,

scientific article published on 21 January 2019

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

scientific article published on 24 September 2013

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

scientific article published in November 2009

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

scientific article published on 17 May 2017

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

scientific article published on 15 September 2011

α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

scientific article

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

scientific article

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

scientific article (publication date: 22 July 2015)

List of works by Paul F Alewood

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins.

A proteomic approach to detect lactosylation and other chemical changes in stored milk protein concentrate

Accelerated chemical synthesis of peptides and small proteins

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7.

Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.

Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor.

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.

Ancient Venom Systems: A Review on Cnidaria Toxins

Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

Bioactive components in fish venoms

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

Chemical synthesis and structure of the prokineticin Bv8

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

Cone snail venomics: from novel biology to novel therapeutics

Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

Conotoxins: Chemistry and Biology

Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Cyclization of peptides by using selenolanthionine bridges.

Cysteine-rich mini-proteins in human biology.

D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus

Deep venomics of the Pseudonaja genus reveals inter- and intra-specific variation

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Discovery, synthesis, and structure-activity relationships of conotoxins.

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

Identification of a Novel Class of Nicotinic Receptor Antagonists

Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.

Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.

Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail.

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.

Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

Privileged frameworks from snake venom.

Rapid Access to ω-Conotoxin Chimeras using Native Chemical Ligation

Rapid sensitive analysis of cysteine rich peptide venom components.