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List of works by David J Loane

Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury

scientific article published on 30 January 2013

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

scientific article published on July 2009

Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase

scientific article published on 13 April 2009

Acute drivers of neuroinflammation in traumatic brain injury

scientific article published on 01 September 2019

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

scientific article

Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice

scientific article published on July 2017

CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation

scientific article published on 12 August 2016

CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury

scientific article published on 08 January 2014

CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury.

scientific article

Chronic Alterations in Systemic Immune Function After Traumatic Brain Injury.

scientific article published on 8 February 2018

Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?

scientific article

Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain.

scientific article published on 20 February 2007

Combination of Fluorescent in situ Hybridization (FISH) and Immunofluorescence Imaging for Detection of Cytokine Expression in Microglia/Macrophage Cells.

scientific article

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

scientific article published on 9 March 2012

Comparing the Predictive Value of Multiple Cognitive, Affective, and Motor Tasks after Rodent Traumatic Brain Injury ⬇️

scientific article published on August 27, 2012

Cyclin D1 gene ablation confers neuroprotection in traumatic brain injury

scientific article published on 13 January 2012

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

scientific article published on 28 February 2012

Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins

scientific article

Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus.

scientific article published on 22 May 2006

Endoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury.

scientific article published on 5 April 2016

Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

scientific article published on 11 January 2020

Inflammatory response of microglia to prions is controlled by sialylation of PrPSc.

scientific article published on 27 July 2018

Inhibition of BK channel activity by association with calcineurin in rat brain.

scientific article published on July 2006

Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice

scientific article published on 01 January 2019

Interferon-β Plays a Detrimental Role in Experimental Traumatic Brain Injury by Enhancing Neuroinflammation That Drives Chronic Neurodegeneration

scientific article published on 06 February 2020

Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain.

scientific article published on 22 October 2007

Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury.

scientific article

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

scientific article published on April 2009

Metabotropic glutamate receptor-mediated signaling in neuroglia

scientific article

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

scientific article published on January 2009

Microglia in the TBI brain: The good, the bad, and the dysregulated.

scientific article

Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits

scientific article published on 24 February 2020

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury.

scientific article published on 15 March 2017

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury.

scientific article published on 21 October 2015

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury

scientific article

Modulation of amyloid-β-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid

scientific article published in November 2007

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

scientific article published on 24 March 2017

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury.

scientific article published on 28 July 2016

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention ⬇️

scientific article published on June 21, 2012

Neuroprotection for traumatic brain injury

scientific article

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies ⬇️

scientific article published on October 29, 2010

Neuroprotective Effects of Geranylgeranylacetone in Experimental Traumatic Brain Injury ⬇️

scientific article published on August 14, 2013

Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

scientific article published on 18 December 2018

Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury

scientific article

Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

scientific article published on 20 February 2019

PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury

scientific article published on 29 January 2014

Primum non nocere: a call for balance when reporting on CTE

scientific article published on 12 February 2019

Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury

scientific article published on 4 May 2015

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.

scientific article

Role of microglia in neurotrauma

scientific article

S100B inhibition reduces behavioral and pathologic changes in experimental traumatic brain injury.

scientific article

Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma

scientific article published on 10 August 2011

Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells

scientific article published on 16 November 2018

Sexual dimorphism in the inflammatory response to traumatic brain injury

scientific article published on 13 June 2017

Somatic colocalization of rat SK1 and D class (Ca(v)1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons.

scientific article

The far-reaching scope of neuroinflammation after traumatic brain injury

scientific article published on 04 August 2017

The need to incorporate aged animals into the preclinical modeling of neurological conditions

scientific article published on 23 December 2019

Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice

scientific article published on 24 August 2021

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states ⬇️

scientific article published on December 27, 2012

Traumatic meningeal injury and repair mechanisms

scientific article published on 01 May 2018

miR-711 upregulation induces neuronal cell death after traumatic brain injury

scientific article published on 16 October 2015

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