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List of works by Roderick L Beijersbergen

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma

scientific article

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

scientific article published in April 2016

A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways

scientific article published on 19 April 2022

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

scientific article published on 27 November 2018

Bioassay development

article

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

scientific article published on 25 April 2016

EGFR overexpression induces activation of telomerase via PI3K/AKT‐mediated phosphorylation and transcriptional regulation through Hif1‐alpha in a cellular model of oral–esophageal carcinogenesis ⬇️

scientific article published on December 12, 2010

Exploration of Synthetic Lethal Interactions as Cancer Drug Targets ⬇️

scientific article published on November 1, 2010

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

scientific article published on 16 July 2021

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

scientific article published in October 2017

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

scientific article published on 22 June 2016

Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes ⬇️

scientific article published on 01 July 1997

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

scientific article published in December 2005

Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

scientific article

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

scientific article

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

scientific article

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

scientific article published on 01 June 2018

PIM kinases are a potential prognostic biomarker and therapeutic target in neuroblastoma

scientific article published on 13 February 2018

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

scientific article published on November 2008

Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer

scientific article published on 18 July 2018

Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform

scientific article published in January 2016

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer

scientific article

Screening for modulators of cisplatin sensitivity: Unbiased screens reveal common themes ⬇️

scientific article published on February 1, 2011

Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.

scientific article published on 11 May 2016

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

scientific article

The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.

scientific article

The ubiquitin-specific protease USP28 is required for MYC stability

scientific article

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

scientific article

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization ⬇️

scientific article published on August 22, 1997

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