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List of works by Kay Davies

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

scientific article published on 01 January 2018

2-Arylbenzo[d]oxazole phosphinate esters as second-generation modulators of utrophin for the treatment of Duchenne Muscular Dystrophy

scientific article published on 18 June 2020

2015 William Allan Award

scientific article published on March 2016

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling

scientific article published in Journal of Biological Chemistry

A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet

scientific article published on 16 January 2019

A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart

scientific article published on 3 April 2008

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

scientific article

A functional genetic link between distinct developmental language disorders

scientific article

A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments

scientific article

A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila

scientific article

A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.

scientific article

A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes

scientific article published on 20 December 2005

A new editor to mark another era in genetics

scientific article published on 01 October 2008

A new way to regulate the NMJ

scientific article published on 01 May 2007

A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology

scientific article

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

scientific article

A study of short utrophin isoforms in mice deficient for full-length utrophin

scientific article published in January 2003

A- and B-utrophin have different expression patterns and are differentially up-regulated in mdx muscle

scientific article published on 15 September 2002

A-utrophin up-regulation in mdx skeletal muscle is independent of regeneration

scientific article published on January 2004

AAV genome loss from dystrophic mouse muscles during AAV-U7 snRNA-mediated exon-skipping therapy.

scientific article published on 11 June 2013

AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development.

scientific article

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study

scientific article

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

scientific article published on 14 August 2018

Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression

scientific article

Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function

scientific article

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication

article

Advances in genetic therapeutic strategies for Duchenne muscular dystrophy

scientific article published on 03 July 2015

Alterations of neuromuscular junctions in Duchenne muscular dystrophy

scientific article published on 17 August 2020

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy

scientific article

Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy.

scientific article published on 30 May 2018

Analysis of human neurological disorders using mutagenesis in the mouse

scientific article

Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse

scientific article published on May 2008

Association of syncoilin and desmin: linking intermediate filament proteins to the dystrophin-associated protein complex

scientific journal article

Behavioural characterisation of the robotic mouse mutant

scientific article

Candidate screening of the TRPC3 gene in cerebellar ataxia

scientific article

Cardiac α-actin over-expression therapy in dominant ACTA1 disease.

scientific article published on 4 June 2013

Caudal additives do not improve the analgesia afforded by levobupivacaine after hypospadias repair

scientific article published on January 2012

Challenges to oligonucleotides-based therapeutics for Duchenne muscular dystrophy.

scientific article published on 09 February 2011

Chapter 7 Spinal muscular atrophies and hereditary motor neuropathies

scientific article published on 01 January 2007

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

scientific article published on 03 January 2020

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy

scientific journal article

Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease

scientific article published on 11 October 2015

Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease

scientific article

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins

scientific article published on 5 August 2003

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies

scientific article

Current status of pharmaceutical and genetic therapeutic approaches to treat DMD.

scientific article

Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse

scientific article published on 6 May 2011

Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan

scientific article published on October 2008

Developing an integrated paediatric low vision service

scientific article

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice

scientific article published on 09 November 2010

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

scientific article published on 15 December 2009

Disrupted circadian rhythms in a mouse model of schizophrenia.

scientific article

Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment

scientific article published in September 2004

Dystrophin- and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins

scientific article published on 19 October 2004

EagI andNotI linking clones from human chromosomes 11 and Xp

Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD

article

Engineering Multiple U7snRNA Constructs to Induce Single and Multiexon-skipping for Duchenne Muscular Dystrophy ⬇️

scientific article published on February 21, 2012

Engineering exon-skipping vectors expressing U7 snRNA constructs for Duchenne muscular dystrophy gene therapy.

scientific article

Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy

scientific article

Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression

scientific article published on March 2003

Evaluating the links between schizophrenia and sleep and circadian rhythm disruption

scientific article published on 10 May 2012

Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms

scientific article

Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration

scientific article published on 06 June 2006

Expression profiling in spinal muscular atrophy reveals an RNA binding protein deficit.

scientific article

Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain

scientific article

From diagnosis to therapy in Duchenne muscular dystrophy

scientific article published on 29 June 2020

Function and genetics of dystrophin and dystrophin-related proteins in muscle

scientific article

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.

scientific article published on 2 February 2015

Functional genetic analysis of mutations implicated in a human speech and language disorder

scientific article

Gene expression profiling studies on Caenorhabditis elegans dystrophin mutants dys-1(cx-35) and dys-1(cx18).

scientific article published on 7 September 2006

Generation and Characterization of Transgenic Mice with the Full-length HumanDMDGene

scientific article published in Journal of Biological Chemistry

Genes Involved in the Formation of the Earliest Cortical Circuits

article

Genes involved in the formation of the earliest cortical circuits.

scientific article published on January 2007

Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis.

scientific article published on 09 May 2008

High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders

scientific article

Highway to HHGE: An Interview with Dame Kay E. Davies

scientific article published on 01 October 2020

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

scientific journal article

Human genetics: conceptual and practical advances in the post-genome era.

scientific article published on 27 May 2009

Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells

scientific journal article

Identification of a new Pmp22 mouse mutant and trafficking analysis of a Pmp22 allelic series suggesting that protein aggregates may be protective in Pmp22-associated peripheral neuropathy

scientific article published in September 2002

Identification of serum protein biomarkers for utrophin based DMD therapy

scientific article published on 02 March 2017

Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors

scientific article

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.

scientific article published on 3 January 2012

Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk

scientific article

Intermediate filament-like protein syncoilin in normal and myopathic striated muscle

scientific article published on 12 July 2007

Is good housekeeping the key to motor neuron survival?

scientific article published on 01 May 2008

Isolation and culture of motor neurons from the newborn mouse spinal cord

scientific article published in February 2004

Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid

scientific article published on 25 October 2019

Keep the directive that protects research animals

journal article; published in Nature on 2015-05-06

Knockdown of SMN by RNA interference induces apoptosis in differentiated P19 neural stem cells.

scientific article published on 21 September 2007

Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex

scientific article

Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing

Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes

scientific article

MLP accumulation and remodelling in the infarcted rat heart

scientific article published on 2 December 2005

Mediation of Af4 protein function in the cerebellum by Siah proteins

scholarly article

Micro-dystrophin Genes Bring Hope of an Effective Therapy for Duchenne Muscular Dystrophy

scientific article published on 12 February 2019

Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/ Mice

scientific article published on 16 October 2018

Microarray analysis of mdx mice expressing high levels of utrophin: therapeutic implications for dystrophin deficiency.

scientific article

Modified patient stem cells as prelude to autologous treatment of muscular dystrophy.

scientific article published on December 2007

Molecular mechanisms of muscular dystrophies: old and new players

scientific article published on 13 September 2006

Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies

scientific article published on 08 February 2011

Muscular dystrophies related to the cytoskeleton/nuclear envelope

scientific article

Muscular dystrophy--reason for optimism?

scientific article

Musculoskeletal diseases: from complex genetics to therapy

scientific article published on 01 June 2003

Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans

scientific article

Neuromuscular defects in a Drosophila survival motor neuron gene mutant.

scientific article

Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis

scientific article published on 9 March 2015

Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo

scientific article published on 01 November 2019

New insights into behaviour using mouse ENU mutagenesis ⬇️

scientific article published on August 13, 2012

Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex

scientific article

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

scientific article published on 24 October 2013

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations

scientific article

Oxr1 is essential for protection against oxidative stress-induced neurodegeneration

scientific article

Pharmacological advances for treatment in Duchenne muscular dystrophy

scientific article published on 6 May 2017

Pharmacological strategies for muscular dystrophy ⬇️

scientific article published on May 1, 2003

Pharmacologically Targeting the Primary Defect and Downstream Pathology in Duchenne Muscular Dystrophy ⬇️

scientific article published on June 1, 2012

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.

scientific article

Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism

scientific article published on 6 March 2015

Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping

scientific article

Publisher Correction: Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

scientific article published on 01 April 2020

Recent advances in Duchenne muscular dystrophy

scientific article published on 11 October 2012

Regenerative biomarkers for Duchenne muscular dystrophy

scientific article published on 01 August 2019

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

scientific article published on 10 October 2013

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping

scientific article

Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin

scientific article published on 25 May 2009

SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses.

scientific article

Safety, Tolerability, and Pharmacokinetics of SMT C1100, a 2-Arylbenzoxazole Utrophin Modulator, following Single- and Multiple-Dose Administration to Pediatric Patients with Duchenne Muscular Dystrophy

scientific article

Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers

scientific article published on 20 February 2015

Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.

scientific article

Second-generation compound for the modulation of utrophin in the therapy of DMD.

scientific article published on May 2015

Spinal muscular atrophy at the crossroads of basic science and therapy.

scientific article

Surrogate gene therapy for muscular dystrophy

scientific article published on 01 October 2019

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model.

scientific article published on 28 March 2009

Survival of motor neuron gene downregulation by RNAi: towards a cell culture model of spinal muscular atrophy.

scientific article published on January 2004

Syncoilin accumulation in two patients with desmin-related myopathy

scientific article

Syncoilin isoform organization and differential expression in murine striated muscle.

scientific article

Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.

scientific article

Syncoilin upregulation in muscle of patients with neuromuscular disease

scientific article

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model

scientific article published on 01 January 2020

Temporal transcriptomics suggest that twin-peaking genes reset the clock

scientific article published on 2 November 2015

The ARRIVE guidelines, a welcome improvement to standards for reporting animal research

scientific article published on 01 July 2010

The Cellular Processing Capacity Limits the Amounts of Chimeric U7 snRNA Available for Antisense Delivery

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress

scientific journal article

The Long Journey from Diagnosis to Therapy

scientific article published on 02 March 2020

The Pathogenesis and Therapy of Muscular Dystrophies

scientific article published on 04 June 2015

The allure of stem cell therapy for muscular dystrophy.

scientific article published on 15 February 2007

The antioxidant protein Oxr1 influences aspects of mitochondrial morphology

scientific article

The dystrophin-associated protein complex

scientific article (publication date: 15 July 2002)

The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy

scientific article published on 13 October 2004

The elusive muscular dystrophy gene. Fifth Muscular Dystrophy Group Workshop on the X chromosome and muscular dystrophies, April 1986.

scientific article published in December 1986

The era of genomic medicine.

scientific article published on December 2013

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

scientific article published on 29 November 2006

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

scientific article published on 23 April 2015

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.

scientific article

The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function

scientific article published on 02 April 2009

The role of intermediate filament proteins in the development of neurological disease

scientific article published on January 2007

The role of utrophin in the potential therapy of Duchenne muscular dystrophy

scientific article

Therapeutic approaches to muscular dystrophy.

scientific article

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

scientific article published on 13 December 2019

Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches ⬇️

scientific article published on April 23, 2013

Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders

scientific article published on 01 September 2004

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia

scientific article

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

scientific article published in February 2013

Treating muscular dystrophy with stem cells?

scientific article published on 01 December 2006

Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle

scientific article

Utrophin up-regulation by an artificial transcription factor in transgenic mice

scientific article

Verifying Nomenclature of DNA Variants in Submitted Manuscripts: Guidance for Journals

scientific article published on 30 November 2020

ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to beta-dystroglycan

scientific article published on 12 February 2004

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