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List of works by Jean Leandro Dos Santos

A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds ⬇️

scientific article published on January 1, 2011

A thalidomide-hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes

scientific article published on 3 November 2017

Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds

scientific article published on June 2017

Advances in Sickle Cell Disease Treatments

scientific article published on 10 June 2020

Advances in drug design based on the amino Acid approach: taurine analogues for the treatment of CNS diseases.

scientific article published on 23 October 2012

Advances in sickle cell disease treatment: from drug discovery until the patient monitoring

scientific article published on April 2011

Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach.

scientific article

Assessment of the In Vivo Genotoxicity of New Lead Compounds to Treat Sickle Cell Disease ⬇️

scientific article published on April 6, 2011

Challenges to the Treatment and New Perspectives for the Eradication of Helicobacter pylori

scientific article published on 22 May 2015

Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets.

scientific article published on 17 August 2015

Design, Synthesis and Characterization of N-oxide-containing Heterocycles with In vivo Sterilizing Antitubercular Activity.

scientific article published on 2 October 2017

Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds To Treat Sickle Cell Disease Symptoms ⬇️

scientific article published on July 25, 2011

Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor

scientific article published on 27 October 2017

Discovery of Benzofuroxan Derivatives as Potent Agents Active Against Multidrug-Resistant Mycobacterium tuberculosis

scientific article published on 06 January 2021

Epigenetic Regulatory Mechanisms Induced by Resveratrol.

scientific article published in November 2017

Evaluation of antimalarial activity and toxicity of a new primaquine prodrug

scientific article

Heterocyclic N-oxides - A Promising Class of Agents Against Tuberculosis, Malaria and Neglected Tropical Diseases

scientific article published on 17 April 2018

Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus

scientific article published in 2021

In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property.

scientific article published on 7 September 2012

Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives

scientific article

Mutagenicity of new lead compounds to treat sickle cell disease symptoms in a Salmonella/microsome assay

scientific article

Peptide prodrugs for the treatment of CNS disorders: a perspective for new drugs.

scientific article published on January 2014

Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect

scientific article published on 19 November 2012

Synthesis and Immunosuppressive Activity of New Mycophenolic Acid Derivatives.

scientific article published on 7 December 2016

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events

scientific article published on 07 October 2015

Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers

scientific article published on 16 May 2020

Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties

scientific article published on 4 April 2017

Tuberculosis: Challenges to Improve the Treatment

scientific article published on January 2015

Unraveling the Anticancer Effect of Curcumin and Resveratrol

scientific article

What are the most promising emerging therapies for sickle cell disease?

scientific article published on June 2014

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