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List of works by Hanna-Kirsti S Leiros

A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.

scientific article published on 30 December 2017

A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement

scientific article published on 10 March 2014

Atomic resolution structures of trypsin provide insight into structural radiation damage

scientific article

Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp

scientific article

Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

scientific article

Cold adapted enzymes.

scientific article

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

scientific article

Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -Lactamases

scientific article

Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5

scientific article

DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases.

scientific article published in September 2018

Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

scientific article

Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila

article

Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.

scientific article published on 2 May 2016

Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark

scientific article published on 23 October 2017

Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface.

scientific article

Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase

scientific article published on 2 January 2018

Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.

scientific article

Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library

scientific article

High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans

scientific article

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo- -Lactamase VIM-7

scientific article

Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?

scientific article

Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.

scientific article published on 14 April 2017

MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability.

scientific article

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

scientific article published on 27 March 2019

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.

scientific article published on 7 December 2015

Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening

scientific article

Specific radiation damage can be used to solve macromolecular crystal structures

scientific article (publication date: February 2003)

Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.

scientific article published on 30 May 2017

Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases

scientific article

Structural and biophysical analysis of interactions between cod and human uracil-DNAN-glycosylase (UNG) and UNG inhibitor (Ugi)

scientific article

Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability

scientific article

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophila

scientific article

Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.

scientific article

Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10

scientific article published on 19 July 2020

Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation

scientific article published on 01 August 2019

Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis

scientific article published on 02 October 2017

Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies

scientific article published on 14 April 2005

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

scientific article

The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida

scientific article published on 24 March 2015

The biological assembly of OXA-48 reveals a dimer interface with high charge complementarity and very high affinity

scientific article published on 07 September 2018

The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 A resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains

scientific article

The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor.

scientific article published on 24 October 2016

ZN148 - a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivo

scientific article published on 16 March 2020

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