List of works - Lourdes Isaac

Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum.

scientific article published on 11 March 2016

Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients.

scientific article

Basal physiological parameters of two congenic mice strains: C5 deficient C57BL/6 and C5 sufficient A/J.

scientific article published on 7 March 2014

Binding of human complement C1 sterase inhibitor to Leptospira spp.

scientific article

C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease

scientific article published on 13 September 2015

Chemical chaperones curcumin and 4-phenylbutyric acid improve secretion of mutant factor H R127H by fibroblasts from a factor H-deficient patient

scientific article published on 17 August 2012

Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H.

scientific article

Colostral Mononuclear Phagocytes are Able to Kill Enteropathogenic Escherichia coli Opsonized with Colostral IgA ⬇️

scientific article published on July 1, 1997

Complement C5 controls liver lipid profile, promotes liver homeostasis and inflammation in C57BL/6 genetic background.

scientific article published on February 2016

Complement Evasion by Pathogenic Leptospira.

scientific article published on 21 December 2016

Complement Immune Evasion by Spirochetes.

scientific article

Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins

scientific article published on 25 March 2019

Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

scientific article published on 07 October 2019

Deficiency of the human complement regulatory protein factor H associated with low levels of component C9.

scientific article

Dysregulation of adaptive immune responses in complement C3-deficient patients

scientific article published on 19 January 2015

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.

scientific article published on 30 October 2015

Functional characterization of LcpA, a surface-exposed protein of Leptospira spp. that binds the human complement regulator C4BP

scientific article

Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene

scientific article published on 19 November 2007

Homozygous hereditary C3 deficiency due to a premature stop codon

scientific article published on 01 November 2002

Human monocyte-derived dendritic cells are a source of several complement proteins.

scientific article

Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins

scientific article published on 26 October 2013

Immune evasion of leptospira species by acquisition of human complement regulator C4BP.

scientific article

Impaired dendritic cell differentiation and maturation in the absence of C3

scientific article published on 03 December 2007

Interaction of Leptospira elongation factor Tu with plasminogen and complement factor H: a metabolic leptospiral protein with moonlighting activities

scientific article

Interaction of human complement factor H variants Tyr⁴⁰² and His⁴⁰² with Leptospira spp.

scientific article published on 5 October 2011

Is immunity in diabetic patients influencing the susceptibility to infections? Immunoglobulins, complement and phagocytic function in children and adolescents with type 1 diabetes mellitus

scientific article published on 01 December 2005

Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host.

scientific article

Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3.

scientific article published on 19 June 2018

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

scientific article published on 30 January 2012

Leptospirosis: aspects of innate immunity, immunopathogenesis and immune evasion from the complement system

scientific article published on May 2011

Lytic, agglutinating, and opsonizing effect of? 2-macroglobulin on sheep red blood cells ⬇️

scientific article published on 01 June 1990

Native conformations of human complement components C3 and C4 show different dependencies on thioester formation ⬇️

scientific article published on February 1, 1998

On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni.

scientific article

Pasteurella pneumotropica evades the human complement system by acquisition of the complement regulators factor H and C4BP.

scientific article

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition.

scientific article published on 30 May 2017

Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA.

scientific article published on 22 December 2014

Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.

scientific article

Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion

scientific article published on 7 January 2016

Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans

scientific article published on 8 March 2018

Screening for C3 deficiency in newborns using microarrays.

scientific article

Skipping of exon 27 in C3 gene compromises TED domain and results in complete human C3 deficiency.

scientific article published on 23 January 2016

Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability.

scientific article

Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3 ⬇️

scientific article published on May 15, 1992

Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli

scientific article published on 4 June 2015

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway

scientific article

The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins.

scientific article

The complement component C5 promotes liver steatosis and inflammation in murine non-alcoholic liver disease model.

scientific article published on 28 July 2016

Trypanosoma cruzi: Killing and enhanced uptake by resident peritoneal macrophages treated with alpha-2-macroglobulin ⬇️

scientific article published on January 1, 1990

List of works by Lourdes Isaac

Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum.

Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients.

Basal physiological parameters of two congenic mice strains: C5 deficient C57BL/6 and C5 sufficient A/J.

Binding of human complement C1 sterase inhibitor to Leptospira spp.

C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease

Chemical chaperones curcumin and 4-phenylbutyric acid improve secretion of mutant factor H R127H by fibroblasts from a factor H-deficient patient

Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H.

Colostral Mononuclear Phagocytes are Able to Kill Enteropathogenic Escherichia coli Opsonized with Colostral IgA ⬇️

Complement C5 controls liver lipid profile, promotes liver homeostasis and inflammation in C57BL/6 genetic background.

Complement Evasion by Pathogenic Leptospira.

Complement Immune Evasion by Spirochetes.

Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins

Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

Deficiency of the human complement regulatory protein factor H associated with low levels of component C9.

Dysregulation of adaptive immune responses in complement C3-deficient patients

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.

Functional characterization of LcpA, a surface-exposed protein of Leptospira spp. that binds the human complement regulator C4BP

Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene

Homozygous hereditary C3 deficiency due to a premature stop codon

Human monocyte-derived dendritic cells are a source of several complement proteins.

Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins

Immune evasion of leptospira species by acquisition of human complement regulator C4BP.

Impaired dendritic cell differentiation and maturation in the absence of C3

Interaction of Leptospira elongation factor Tu with plasminogen and complement factor H: a metabolic leptospiral protein with moonlighting activities

Interaction of human complement factor H variants Tyr⁴⁰² and His⁴⁰² with Leptospira spp.

Is immunity in diabetic patients influencing the susceptibility to infections? Immunoglobulins, complement and phagocytic function in children and adolescents with type 1 diabetes mellitus

Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host.

Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3.

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

Leptospirosis: aspects of innate immunity, immunopathogenesis and immune evasion from the complement system

Lytic, agglutinating, and opsonizing effect of? 2-macroglobulin on sheep red blood cells ⬇️

Native conformations of human complement components C3 and C4 show different dependencies on thioester formation ⬇️

On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni.

Pasteurella pneumotropica evades the human complement system by acquisition of the complement regulators factor H and C4BP.

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition.

Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA.

Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.

Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion

Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans

Screening for C3 deficiency in newborns using microarrays.

Skipping of exon 27 in C3 gene compromises TED domain and results in complete human C3 deficiency.

Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability.

Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3 ⬇️

Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway

The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins.

The complement component C5 promotes liver steatosis and inflammation in murine non-alcoholic liver disease model.

Trypanosoma cruzi: Killing and enhanced uptake by resident peritoneal macrophages treated with alpha-2-macroglobulin ⬇️