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List of works by Karen Vousden

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

scientific article published on 25 September 2013

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

scientific article published on 16 August 2018

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

scientific article published on 8 March 2007

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

A role for Numb in p53 stabilization

scientific article published on 09 May 2008

Activation of the p53 tumor suppressor protein

scientific article

Alternative fuel--another role for p53 in the regulation of metabolism

scientific article

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

scientific article

An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence ⬇️

scientific article published on November 8, 2011

Apoptosis. p53 and PUMA: a deadly duo

scientific article published on 01 September 2005

Brexit negotiations: what is next for science?

scientific article published on 15 March 2019

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

scientific article published on 18 March 2007

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

scientific article published on 16 August 2016

Cancer research: past, present and future.

scientific article published on 15 September 2011

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

scientific article published on 01 January 2020

Cancer: guarding the guardian?

scientific article published on 01 January 2004

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

scientific article published on 22 August 2019

Complicating the complexity of p53

scientific article

Contribution of membrane localization to the apoptotic activity of PUMA

scientific article

Control of metabolism by p53 - Cancer and beyond

Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation

correction of a scholarly article

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

scientific article

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

scientific article published on November 2010

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo

scientific article

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

scientific article published on January 2012

Dietary Approaches to Cancer Therapy

scientific article published on 27 April 2020

Direct Estimation of Metabolic Flux by Heavy Isotope Labeling Simultaneous with Pathway Inhibition: Metabolic Flux Inhibition Assay

scientific article published on 01 January 2019

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

scientific article published on 23 January 2020

Erratum to: Metabolic regulation by p53.

scientific article published on 30 March 2011

Erratum: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2

scientific article published in Nature

Finding clues in the p53 maze: an interview with Karen Vousden

scientific article published on 27 July 2018

Functions of p53 in metabolism and invasion

scientific article

Genetic and cellular mechanisms of oncogenesis

scientific article published on 25 January 2011

HDM2 phosphorylation by MAPKAP kinase 2.

scientific article published on March 2005

Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation

scientific article published on 07 May 2015

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

scientific article published on June 2002

Identification and Characterization of a Minimal Apoptotic Domain from p53

scientific article published on 15 November 2001

Induction of p57(KIP2) expression by p73beta.

scientific article

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

scientific article

Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity

scientific article

Karen Vousden: getting the big picture on p53. Interview by Caitlin Sedwick

scientific article

Localization of NADPH production: a wheel within a wheel

scientific article published on 01 July 2014

Location, location, location

scientific article published on 01 September 2016

Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53.

scientific article published in July 2004

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

scientific article

Lucifer's labyrinth--ten years of path finding in cell death

scientific article published on December 2007

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

scientific journal article

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

scientific article

Metabolic regulation by p53 family members.

scientific article published on 15 August 2013

Metabolic regulation by p53.

scientific article published on 23 February 2011

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death ⬇️

scientific article published on November 26, 2012

Modifications of p53: competing for the lysines

scientific article published on February 2009

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

scientific article

Modulation of intracellular ROS levels by TIGAR controls autophagy

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mutant p53 drives invasion by promoting integrin recycling

scientific article

Mutant p53 in cancer: new functions and therapeutic opportunities

scientific article published on March 2014

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

scientific article

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype

scientific article published on 12 November 2013

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ⬇️

scientific article published in Nature Communications

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers ⬇️

scientific article published on March 1, 2012

Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability ⬇️

scientific article published on May 31, 2012

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

scientific article published on 01 July 2019

One carbon, many roads

scientific article published on 6 January 2017

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

scientific article published on 17 December 2015

Outcomes of p53 activation--spoilt for choice

scientific article published on December 2006

P53 and prognosis: new insights and further complexity

scientific article

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

scientific article published on 19 August 2015

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

scientific article

Partners in death: a role for p73 and NF-kB in promoting apoptosis

scientific article published on 28 March 2009

Phosphorylation of HDM2 by Akt.

scientific article

Pinning a change on p53

scientific article published in Nature

Regulation of Cellular Metabolism and Hypoxia by p53.

scientific article

Regulation of HDM2 activity by the ribosomal protein L11

scientific article (publication date: June 2003)

Regulation of p53 stability and function by the deubiquitinating enzyme USP42 ⬇️

scientific article published on November 15, 2011

Regulation of the p53 pathway by ubiquitin and related proteins

scientific article published on 17 June 2010

Savior and slayer: the two faces of p53

scientific article published on 01 December 2005

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.

scientific article published on 6 January 2016

Serine and one-carbon metabolism in cancer

scientific article published on 16 September 2016

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

scientific article

Serine one-carbon catabolism with formate overflow

scientific article published on 28 October 2016

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

scientific article published on 16 December 2012

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

scientific article

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

scientific article published on June 2005

Small molecules that bind the Mdm2 RING stabilize and activate p53.

scientific article published on 2 February 2012

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.

scientific article

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

scientific article published on 29 April 2020

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

scientific article

Switching from life to death: the Miz-ing link between Myc and p53.

scientific article

Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

scientific article

TIGAR is required for efficient intestinal regeneration and tumorigenesis

scientific journal article

TIGAR, TIGAR, burning bright.

scientific article published on 3 January 2014

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

scientific journal article

Taking up the reins of power: metabolic functions of p53

scientific article published on 01 July 2019

The ERBB network facilitates KRAS-driven lung tumorigenesis

scientific article published on 01 June 2018

The Quid Pro Quo of the Tumor/Stromal Interaction

scientific article published in November 2016

The Regulation of TIGAR.

scientific article published on 28 May 2014

The Secret Life of Histones ⬇️

scientific article published on September 19, 2003

The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism.

scientific article

The in vivo function of the p53 target gene TIGAR.

scientific article

The role of ROS in tumour development and progression

scientific article published in 2022

The role of p53 in glucose metabolism

scientific article published on 12 January 2010

The role of ubiquitin modification in the regulation of p53.

scientific article published on 03 June 2013

The ubiquitin-protein ligase Itch regulates p73 stability

scientific article

Tumor Suppression by p53: Fall of the Triumvirate? ⬇️

scientific article published on June 8, 2012

Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis

scientific article published on 4 October 2013

Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity

scientific article

Ubiquitination and degradation of mutant p53.

scientific article

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

scientific article

Use of 13C315N1-Serine or 13C515N1-Methionine for Studying Methylation Dynamics in Cancer Cell Metabolism and Epigenetics

scientific article published on 01 January 2019

iRFP is a real time marker for transformation based assays in high content screening

scientific article (publication date: 2014)

iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.

scientific article published on 31 October 2013

p53 and Mdm2: an auld alliance.

scientific article published in March 2010

p53 and its mutants in tumor cell migration and invasion

scientific article published on January 2011

p53 in health and disease

scientific article (publication date: April 2007)

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

scientific article published on June 2015

p53 mutations in cancer ⬇️

scientific article published on January 1, 2013

p53 regulation of metabolic pathways

scientific article published on 02 December 2009

p53, ROS and senescence in the control of aging ⬇️

scientific article published on August 1, 2010

p53, cancer and the immune response

scientific article published on 06 March 2020

p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53.

scientific article

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

scientific article published on 03 December 2018

p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.

scientific article

p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl<sub>4</sub>

scientific article published on 09 October 2021

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

scientific article published on 16 November 2010

p53: new roles in metabolism

scientific article published on 3 May 2007

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

scientific article published on 21 November 2003

p73 supports cellular growth through c-Jun-dependent AP-1 transactivation

scientific article published on 13 May 2007

p73-alpha is capable of inducing scotin and ER stress

scientific article published in April 2004

p73: Friend or foe in tumorigenesis

scientific article published in August 2002

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis.

scientific article published on 21 November 2017

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